iPSCs for Studying Infectious Diseases
- 1st Edition - May 29, 2021
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 8 0 8 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 1 8 9 - 9
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Studyi… Read more
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Request a sales quoteThe series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Studying Infectious Diseases, Volume 8 addresses how important induced pluripotent stems cells are and how can they can help treat certain infectious diseases.
Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different infectious diseases, such as corona virus, coxsackievirus, salmonella infection, influenza virus and much more.
The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.
Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different infectious diseases, such as corona virus, coxsackievirus, salmonella infection, influenza virus and much more.
The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.
- Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics
- Covers infections by several pathogens, such as coronavirus, coxsackievirus, influenza virus, herpes simplex virus 1, T. gondii, T. cruzi, S. agalactiae, N. meningitidis, Salmonella, and more
- Is contributed by world-renowned experts in the field
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Advances in Stem Cell Biology
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. The application of iPSCs to questions in virology: a historical perspective
- A brief history of virology
- Viruses as obligate parasites
- The advent of cell biology
- Stem cells, embryonic stem cells, and induced pluripotent stem cells
- Current applications of iPSCs to virology
- The family Caliciviridae
- The family Coronaviridae
- The family Flaviviridae
- The family Hepadnaviridae
- The family Hepeviridae
- The family Herpesviridae
- The family Orthomyxoviridae
- The family Paramyxoviridae
- The family Picornaviridae
- The family Polyomaviridae
- The family Retroviridae
- The family Togaviridae
- Future directions
- Chapter 2. Transplantation of iPSC-derived neural progenitor cells promotes clinical recovery and repair in response to murine coronavirus-induced neurologic disease
- Introduction
- Conclusions
- Chapter 3. iPSCs for modeling influenza infection
- Introduction
- IAV-induced cell death in iPSCs
- Differentiation potentials of IAV-infected iPSCs
- iPSC-derived tissues and organoids for modeling influenza infection
- Concluding remarks
- Chapter 4. Human induced pluripotent stem cells for modeling of herpes simplex virus 1 infections
- Introduction
- Concluding remarks
- Future directions
- Chapter 5. iPSCs for modeling coxsackievirus infection
- Biology of coxsackieviruses
- Coxsackievirus-associated disease in humans
- Experimental models for coxsackievirus infection
- iPSC modeling of coxsackievirus infection
- Concluding remarks and future perspectives
- Chapter 6. Pluripotent stem-cell-derived oligodendrocyte progenitors to model demyelination caused by Theiler’s murine encephalomyelitis virus and other viruses
- Importance of myelin in the CNS
- Virus-induced demyelination
- Steps to myelination: OPC proliferation, migration, and maturation
- Disruption of myelination by viruses
- Induced pluripotent stem cells (iPSCs) as a model system to study demyelinating viruses
- Conclusions and future perspectives
- Chapter 7. iPSCs for modeling hepatotropic pathogen infections
- The liver is a target organ for many pathogens
- Hepatitis viruses
- Plasmodium
- Addressing open questions in hepatotropic infection research with HLCs
- Systems integrating diverse hepatic cell types to improve liver pathogenesis studies
- 3D systems to study hepatotropic infections
- Personalized modeling and treatment of hepatotropic infections
- Limitations of iPSCs and future directions for the study of hepatotropic infections
- Outlook
- Chapter 8. Use of human induced pluripotent stem cells (hiPSC)-derived neuronal models to study the neuropathogenesis of the protozoan parasite, Toxoplasma gondii
- Introduction
- Overview of principles and methods for generation of neurons from hiPSCs
- T. gondii: biology of chronic infection in the brain
- Future trends and direction: use of hiPSC-derived 2D and 3D models to model human parasitic infections
- Chapter 9. Induced pluripotent stem cells for modeling Chagas disease
- Cardiomyopathy
- Chagas disease
- Chagas disease pathogenesis
- Clinical Chagas disease
- Immune response in Chagas disease
- Role of therapy in Chagas disease and relation to immune response
- New approaches to therapy
- Models to study Chagas disease
- iPSC for modeling Chagas disease
- Chapter 10. Induced pluripotent stem-cell derived brain-like endothelial cells to study host–pathogen interactions with the bacterial pathogens Streptococcus agalactiae and Neisseria meningitidis
- Introduction
- Bacterial meningitis
- Brain endothelial cell models and infection
- Current iPSC models
- Group B Streptococcus
- Bacterial interaction with iPSC-BECs
- Current iPSC-BEC models and future outlook
- iPSC based models and infections
- Chapter 11. Human induced pluripotent stem cells for modeling of Salmonella infection
- Introduction
- iPSCs: bridging the gap between human and animal research
- Establishing iPSC-derived cellular systems as a model for Salmonella infection
- Differentiation of iPSCs to other Salmonella infection-relevant cell types
- Using iPSCs to investigate the role of host genotype on Salmonella response phenotype
- Using iPSCs for modeling the molecular consequences of human genetic variants
- Future trends and directions
- Conclusions
- Index
- No. of pages: 332
- Language: English
- Edition: 1
- Published: May 29, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128238080
- eBook ISBN: 9780128241899
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead iPSCs for Studying Infectious Diseases on ScienceDirect