Introductory Biomaterials
An Overview of Key Concepts
- 1st Edition - September 23, 2021
- Imprint: Academic Press
- Authors: Lia Stanciu, Susana Diaz-Amaya
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 0 9 2 6 3 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 9 5 2 4 - 9
Introductory Biomaterials enables undergraduate students in Biomedical, Chemical, Materials and other relevant Engineering disciplines to become familiar with the key concepts… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteIntroductory Biomaterials enables undergraduate students in Biomedical, Chemical, Materials and other relevant Engineering disciplines to become familiar with the key concepts of Biomaterials principles: biocompatibility, structure-property-applications relationships, mechanical response of natural tissues, and cellular pathways for tissue-material ingrowth. Written in a clear, concise manner that weds theory with applications, this book helps students to understand the often intricate relationships between materials the implant devices that are made from them, and how the human body reacts to them. The book includes such concepts as requirements for metals, alloys, and ceramic materials to be used in load bearing implants (corrosion concepts, stress shielding, mechanical properties, composition), what properties of polymers impact their use in medicine (leaching and swelling, creep and stress relaxation); the tissue response to biomaterials, concepts related to drug delivery applications (polymer degradation, encapsulation), and tissue engineering (scaffold porosity, diffusion of nutrients, mechanical properties).
- Begins with structure-properties, followed immediately by their impact on actual biomaterials classes and devices, thus directly relating theory to applications (e.g. polymers to polymeric stents; metals to fracture fixation devices)
- Explains concepts in a clear, progressive manner, with numerous examples and figures to enhance student learning
- Covers all key biomaterials classes: metallic, ceramic, polymeric, composite and biological
- Includes a timely chapter on medical device regulation
Undergraduate students in Biomedical Engineering and Bioengineering Programs, as well as undergraduate and graduate students in Mechanical, Materials and Chemical Engineering Departments
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Acknowledgments
- Chapter 1. Introduction
- Historical background on biomaterials
- Biomaterials properties and device performance
- Biomaterials classification
- Who studies biomaterials and how do they use the knowledge?
- Summary
- Chapter 2. Structure and bonding
- Fundamentals of atomic bonding
- Crystallography concepts
- Defects in solids
- Summary
- Chapter 3. Metallic biomaterials
- Introduction
- Mechanical properties of metallic biomaterials
- Challenges of metallic materials under physiological conditions
- Biomedical alloys
- Summary
- Chapter 4. Bioceramics
- Ceramics in biomedical devices
- Structure of ceramics
- Summary
- Chapter 5. Polymeric biomaterials
- Introduction
- Biomedical applications: material design rationale
- Classification of polymers
- Polymer synthesis
- Material properties of polymers
- Polymers in drug delivery
- Polymers in implantable prosthesis
- Polymers in tissue replacement
- Sterilization of polymers
- Summary
- Chapter 6. Hard tissues and orthopedic soft tissues
- Proteins and proteoglycans of the extracellular matrix of tissues
- Hard tissues
- Orthopedic soft tissues
- Summary
- Chapter 7. Composite biomaterials
- Introduction
- Rational design of composites for biomedical applications
- Composites for orthopedic tissue repair
- Natural biopolymer-hydroxyapatite composites for orthopedic repair
- Composites for hard-tissue repair
- Mechanical properties of composites
- Composite materials-tissue interactions
- Summary
- Chapter 8. Tissue-biomaterials interactions
- Introduction
- Injury and repair of natural tissues and the immune response
- The complement cascade
- Tissue response to permanent implants
- Protein adsorption on the surface of biomedical implants
- Biomaterials degradation
- Porosity effects on implant-tissue interactions
- Blood compatibility
- Biomaterials testing
- Carcinogenicity and mutagenicity
- Summary
- Chapter 9. Orthopedic and dental biomedical devices
- Introduction
- Biomaterials properties and tissue interactions for hard-tissue implants
- Biomaterials for orthopedics and dentistry
- Biomaterials for dental implants
- Biomaterials for spinal implants
- Summary
- Chapter 10. Soft tissue replacement and repair
- Introduction
- Collagen
- Elastin
- Ground substance
- Mechanical properties of soft tissues
- Vascular soft tissue
- Vascular architecture
- Vascular pathogenesis
- Vascular tissue repair
- Vascular mechanics
- Vascular stents
- Vascular grafts
- Substitute heart valves
- Bioprosthetic heart valve replacement
- Tissue-engineered heart valves
- Intraocular lens implants
- Breast implants
- Biomaterials for breast implants
- Regulatory constraints
- Summary
- Chapter 11. Materials and devices for sensors and detectors: biocatalysts, bioimaging, and devices with integrated biological functionality
- Introduction
- Ideal criteria and common challenges for biosensors
- Metallic nanoparticles for applications in imaging and sensors
- Surface optical properties of MNPs: localized surface plasma resonance
- Label-free optical biosensors: surface plasma resonance
- Label-free optical biosensors: bilayer interferometry
- Spectroscopic applications: SERS-based biosensors
- MNPs: effect of size on optical (colorimetric) properties
- Optical density
- MNPs: effect of interparticle distance on optical (colorimetric) properties
- MNPs: surface modifications
- Biorecognition: NPs-bioconjugates
- Colorimetric applications
- Paper-based chromatographic assays
- Particle aggregation as a detection strategy
- MNPs as contrast agents
- Functionalization and targeting of AuNPs for cancer detection
- Electrochemical biosensors
- Basic concepts
- Classification by biochemical recognition approach
- Classification by electrochemical method
- Summary
- Chapter 12. Biodegradable materials for medical applications
- Introduction
- Performance characteristics of biodegradable implants
- Performance characteristics of biodegradable materials for tissue engineering and drug delivery applications
- Biodegradable polymers
- Biodegradable metals
- Methods for assessing biomaterial degradation
- Summary
- Index
- Edition: 1
- Published: September 23, 2021
- No. of pages (Paperback): 368
- No. of pages (eBook): 368
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128092637
- eBook ISBN: 9780128095249
LS
Lia Stanciu
Lia Stanciu Ph.D., is a Professor of Materials and Biomedical Engineering at Purdue University. She received her Ph.D. in Materials Science in 2003 from University of California Davis. She is the instructor of an introductory Biomaterials class at Purdue, which she has been teaching since 2007. She has authored over 130 peer reviewed journal articles and her current research focuses on Biosensors and Biolelectronic Devices.
Affiliations and expertise
Professor of Materials and Biomedical Engineering, Purdue University, IN, USASD
Susana Diaz-Amaya
Susana Diaz-Amaya is a Ph.D. candidate in Materials Engineering at Purdue University with a strong background in bio-nanotechnology. She earned her bachelor’s degree in industrial microbiology from the Pontifical Javeriana University, Colombia in 2010. She joined academia in 2012 as an assistant professor at University of Tolima, and simultaneously worked for more than 5 years in the agroindustry as leader of R&D. Susana's current research interest is focused on the design, characterization and manufacturing of low-cost, novel nanomaterials for the high-throughput fabrication of biosensing platforms, and drug delivery systems.
Affiliations and expertise
School of Materials Engineering, Purdue University, West Lafayette, IN, USARead Introductory Biomaterials on ScienceDirect