Introduction to Mathematics in Physiology, Medicine, and Health Sciences provides a quantitative handbook for physiology and biological systems, so researchers, practitioners, and clinicians can have a quantitative foundation, and medicine can incorporate more precise diagnostics. This book’s purpose is to demonstrate how fundamental mathematics can be incorporated into biomedical engineering, physiology, medicine, and health sciences research, application, and clinical practice to make these disciplines more quantitative and computational, and hence more explanatory and informative. The book also provides more quantitative formulation of medical procedures, towards supporting the growing field of precision medicine. The book guides readers though the foundations of mathematics as it is applied to modeling of physiological systems, medicine, biology, and health sciences. Each chapter includes a robust introduction to the mathematical concepts and principles necessary to understand their application to the indicated medical and biological systems, beginning with the fundamental relationships among biological variables in Chapter 2, introduction to basic calculus and rate of change in biomedical variables in Chapter 3, and the principles of linear algebra and vectors applied to medicine in Chapter 4. Chapters 5-7 cover the fundamentals of exponential and logarithmic biomedical functions, maximum and minimum values of a function, and integration applications such as summation, area, and volume. Chapter 8 provides an in-depth look into biomedical applications of Ordinary and Partial Differential Equations, which are important modeling tools for flow and variable systems. Chapter 9 provides extensive coverage of Organ System Analyses, which is the core of the physiological system modeling in the book, with a wide range of applied examples. Chapters 10 and 11 extend the modeling applications to medical devices and signal processing. Each chapter provides in-depth guidance on the mathematical concepts, methodology, and procedures for applying the mathematical formulas and equations to the appropriate biomedical and physiological systems, as well as step-by-step procedures for creating models for a wealth of specific applications.