International Review of Cell and Molecular Biology

Chapter One: Sensing the Environment Through Sestrins: Implications for Cellular Metabolism

• Abstract
• Abbreviations
• 1. Introduction
• 2. Regulation and Function of Sestrins
• 3. Sestrins are Sensors of Nutrient Availability and are Involved in Regulation of Metabolism
• 4. Conclusions and Perspectives
• Acknowledgments

Chapter Two: Metabolic Regulation of Apoptosis in Cancer

• Abstract
• 1. Introduction
• 2. Overview of Apoptosis Pathways
• 3. Regulation of Apoptosis Through Glycolytic Pathway
• 4. p53 and Glucose Metabolism
• 5. Regulation of Apoptosis by Lipid Metabolism
• 6. Concluding Remarks
• Acknowledgments

Chapter Three: A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain

• Abstract
• 1. Introduction
• 2. Basics of Gene Therapy
• 3. Physiological Mechanisms of Nociception/Pain
• 4. Chronic Neuropathic Pain
• 5. Chronic Nociceptive or Inflammatory Pain
• 6. Chronic Mixed Pain (Cancer), Opioid Analgesia, and Gene Therapy
• 7. Conclusions
• Acknowledgments

Chapter Four: Roles and Regulation of Epithelial Splicing Regulatory Proteins 1 and 2 in Epithelial–Mesenchymal Transition

• Abstract
• 1. Introduction
• 2. Epithelial–Mesenchymal Transition Program
• 3. Alternative Splicing in EMT
• 4. ESRPs as Regulators of EMT
• 5. Regulation of ESRP Expression and Function
• 6. Linking ESRPs to Carcinogenesis
• 7. Concluding Remarks

Chapter Five: Orchestrating Lymphocyte Polarity in Cognate Immune Cell–Cell Interactions

• Abstract
• 1. Introduction
• 2. Membrane Microdomains and Nanoclusters Orchestrate Cell–Cell Contacts
• 3. Centrosome as Organelle-Organizing Center
• 4. Endoplasmic Reticulum and Golgi Apparatus
• 5. Multivesicular Bodies in Secretion, Recycling, and Renewal of Immune Synapse Components
• 6. Lysosomes and Autophagy: More Than Degradation
• 7. Mitochondria: Powering Immune Synapse
• 8. Lytic Granules: Polarizing Killing Machinery
• 9. Asymmetric Cell Division: Versus Clonal Expansion
• 10. Concluding Remarks
• Acknowledgments

Chapter Six: The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids

• Abstract
• 1. Introduction
• 2. Keratinization and Cornification are Continuous but not Equivalent Process
• 3. Anamniote Epidermis Keratinizes While Cornification Occurs in few Body Regions
• 4. Formation of the Corneous Layer in Amniotes
• 5. Increase of Protein Types in Amniote Epidermis Compared to Anamniotes
• 6. Alpha and Beta-Keratinization Indicate Prevalence of Corneous Proteins Containing Alpha-Helix or Beta-Sheets, not of Keratins
• 7. Differences Between IF-Alpha/Beta-Keratins and Sauropsid Beta-Keratins Indicate the Latter are Corneous Beta-Proteins
• 8. The Process of Cornification in Sauropsids
• 9. Evolution of the Process of Cornification in the Epidermis and Skin Appendages: A New Synthesis
• 10. Concluding Remarks and Future Directions
• Acknowledgements

Chapter Seven: The Calcium-Sensing Receptor in Health and Disease

• Abstract
• Abbreviations
• 1. Structure and Physiological Functions of the CaSR
• 2. Monitoring CaSR Activity in Living Cells
• 3. CaSR in Endocrine Pathology
• 4. CaSR in Cardiovascular Physiopathology
• 5. CaSR in Asthma
• 6. CaSR in Alzheimer's Disease
• 7. CaSR in Cancer
• Acknowledgments

Chapter Eight: Molecular Interactions Between Flowering Time and Abiotic Stress Pathways

• Abstract
• 1. Introduction
• 2. Developmental and Seasonal Control of Flowering Time
• 3. Key Molecular Regulators of Flowering Time
• 4. Abiotic Stresses Affecting Flowering Time
• 5. Stress-Signal Integration by Major Flowering Time Regulators
• 6. Role of GI in Influencing Flowering Time and Circadian Clock Components
• 7. Conclusions
• Acknowledgments