International Review of Cell and Molecular Biology

Chapter One: Breast Cancer Immunology and Immunotherapy: Current Status and Future Perspectives

• Abstract
• 1 Introduction
• 2 Mechanisms of the Immune Response Inhibition in BC: Role of MDSCs and Regulatory T Cells
• 3 Immune System in the Therapeutic Response in BC. The Immunogenic Cell Death
• 4 T-Infiltrating Lymphocytes Molecular and Genomic Characterization as a Strategic Tool to Better Understand BC Behavior
• 5 Neoantigen Prediction: Genomic Tools for Personalized Immunotherapy
• 6 Immunotherapeutic Approaches in BC. Clinical Trials With Immune Checkpoint Inhibitors
• 7 Conclusions
• Acknowledgments

Chapter Two: New Insights Into Cellular Stress Responses to Environmental Metal Toxicants

• Abstract
• 1 Introduction
• 2 ER Stress and UPR
• 3 Metal-Induced ER Stress
• 4 ER Stress and Its Impact on Oxidative Stress
• 5 Genomics Approaches in Metal-Induced Cell Stress Studies
• 6 Conclusions and Future Directions
• Acknowledgments

Chapter Three: An Update on Src Family of Nonreceptor Tyrosine Kinases Biology

• Abstract
• 1 Introduction
• 2 Regulation of SFKs Function
• 3 Redox-Dependent Regulation of SFK Function
• 4 Role of SFKs in PRL Signaling
• 5 Relevance of SFKs in Breast Cancer
• 6 Role of SFKs During Mammalian Embryo Development and in the Regulation of Embryonic and Somatic Stem Cells
• 7 Conclusions
• Acknowledgments

Chapter Four: STAT Transcription Factors in T Cell Control of Health and Disease

• Abstract
• 1 Engagement of the Jak-STAT Signaling Pathway
• 2 Jak-STAT Molecules in T Helper Cell Differentiation
• 3 STAT Molecules in the Development of Cytotoxic T Cells
• 4 STATs Mutations Result in Patient Immunodeficiency
• 5 STAT Molecules in Allergic Inflammation
• 6 Role of STAT Molecules in Intestinal Inflammation
• 7 Jak-STAT Molecules in Autoimmune Diseases
• 8 Blocking Cytokine Signaling to Treat Disease
• 9 Conclusion

Chapter Five: Chemokine Receptor Signaling and the Hallmarks of Cancer

• Abstract
• 1 Introduction
• 2 The Chemokine Superfamily
• 3 Chemokine Activity on Neoplastic Cells
• 4 Chemokine Activities on Stromal Cells
• 5 Concluding Remarks
• Acknowledgments

Chapter Six: Mitochondrion: A Common Organelle for Distinct Cell Deaths?

• Abstract
• 1 Introduction
• 2 Apoptosis
• 3 MPT-Driven Necrosis
• 4 Mitophagy
• 5 Implication of Mitophagy in Models of Neurological Diseases
• 6 Implication of Mitochondria-Dependent Cell Death in Cardiac Diseases
• 7 Conclusion and Perspectives
• Acknowledgments

Chapter Seven: Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches

• Abstract
• 1 Introduction
• 2 Monoclonal Antibodies
• 3 Effector Mechanisms and Activity of Tumor-Targeting Antibodies
• 4 Immunomodulatory Antibodies
• 5 Antibody Engineering to Improve Effector Functions
• 6 Alternative Antibody Formats
• 7 Antibody-Drug Conjugates
• 8 Antibody-Cytokine Fusion Proteins
• 9 CAR-Transfected T Cells
• 10 Conclusions