Inorganic Nanosystems

Theranostic Nanosystems, Volume 2

1st Edition - March 22, 2023
Imprint: Academic Press
Editors: Md Saquib Hasnain, Amit Kumar Nayak, Tejraj M. Aminabhavi
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 7 8 4 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 5 7 8 - 2

Inorganic Nanosystems: Theranostic Nanosystems, Volume Two examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the la… Read more

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Inorganic Nanosystems: Theranostic Nanosystems, Volume Two examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glycolide, polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials.

It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Inorganic Nanosystems
Chapter 1. Inorganic-based nanotheranostics: current status and challenges
Abstract
1.1 Introduction
1.2 Carbon-based nanomaterials
1.3 Ceramic-based nanomaterials
1.4 Metallic nanomaterials
1.5 Quantum dots and quantum dot-based nanomaterials
1.6 Challenges of inorganic-based nanotheranostics
1.7 Conclusion
References
Further reading
Chapter 2. Carbon nanotubes: superfabric nanoscale theranostic materials
Abstract
2.1 Introduction
2.2 Synthesis of carbon nanotube
2.3 Structure and properties of carbon nanotubes
2.4 Functionalization of carbon nanotubes
2.5 Internalization and cellular uptake of carbon nanotubes
2.6 Biodistribution of carbon nanotubes
2.7 Biomedical applications of carbon nanotubes
2.8 Carbon nanotube–based bioimaging
2.9 Photoluminescent carbon nanotubes
2.10 Near-infrared fluorescence imaging and carbon nanotubes as near-infrared bioimaging agent
2.11 Global near-infrared hyperspectral imaging of carbon nanotubes in biological systems
2.12 Carbon nanotubes–based Raman imaging
2.13 Carbon nanotubes and photoacoustic imaging
2.14 Carbon nanotubes and magnetic resonance imaging
2.15 Carbon nanotubes and positron emission tomography/SPECT
2.16 Carbon nanotubes and multimodality imaging
2.17 Conclusion and future perspective
References
Chapter 3. Graphene-based nanomaterials for theranostic applications
Abstract
3.1 Introduction
3.2 About graphene
3.3 Synthesis of graphene
3.4 Biomedical applications of graphene nanomaterials
3.5 Conclusions and future outlook
References
Chapter 4. Graphene and graphene oxide-based nanocomposites for theranostic applications
Abstract
4.1 Introduction
4.2 Makeover of graphene-based nanocomposites for theranostic applications
4.3 Graphene-based nanocomposites: methods of fabrication and their properties
4.4 Biomedical/theranostic applications of graphene-nanohybrids
4.5 Concluding remarks
References
Chapter 5. Silver nanoparticles for theranostic applications
Abstract
5.1 Introduction
5.2 Silver nanoparticles
5.3 Synthesis of silver nanoparticles
5.4 Targeting strategies for surface functionalization, biomolecule immobilization, and regulated cellular uptake strategies
5.5 Targeting of nanoparticles with metal
5.6 Immobilization of biomolecules for drug delivery and colorimetric assays
5.7 Pathways of metal nanoparticles cellular internalization
5.8 Nanotoxicity
5.9 Silver nanoparticles as theranostic platforms
5.10 Conclusion
Acknowledgments
Author disclosure statement
References
Chapter 6. Zinc and zinc oxide nanoparticles for theranostic applications
Abstract
6.1 Introduction
6.2 Zinc oxide nanoparticles
6.3 Synthesis methodologies for zinc oxide nanoparticles
6.4 ZnO nanoparticles theragnostic application
6.5 ZnO nanoparticles for theragnostic in cancer
6.6 ZnO nanoparticles in theragnostic for antibacterial activity
6.7 ZnO nanoparticles in theragnostic for the treatment of diabetes
6.8 Conclusion
Acknowledgment
References
Chapter 7. Superparamagnetic iron oxide nanoparticles for theranostics
Abstract
7.1 Introduction
7.2 Superparamagnetic iron oxide nanoparticles
7.3 Synergistic therapy of superparamagnetic iron oxide nanoparticles in biomedical engineering
7.4 Summary and perspectivies
References
Chapter 8. Copper-based nanoparticles for theranostic applications
Abstract
8.1 Introduction
8.2 Synthesis approaches of copper-based nanoparticles
8.3 Copper-based nanoparticles in diagnostic applications
8.4 Copper-based nanoparticles in therapeutic applications
8.5 Future perspective and conclusions
References
Chapter 9. Titanium dioxide nanoparticles: prospects and applications in nanotheranostics
Abstract
9.1 Introduction
9.2 Synthesis and characterization of the titanium dioxide nanoparticles
9.3 Applications of the titanium dioxide nanoparticles
9.4 Conclusions and future prospects
References
Chapter 10. Gold nanoparticles as theranostic platform
Abstract
10.1 Introduction
10.2 Types of gold nanostructures
10.3 Applications of gold nanostructures as theranostics
10.4 Conclusions
References
Chapter 11. Metal-organic frameworks (MOFs) as a unique theranostic nanoplatforms for therapy and imaging
Abstract
11.1 Introduction
11.2 Metal-organic frameworks (MOFs)
11.3 Synthesis, functionalization, and modification of MOFs
11.4 MOF-based diagnosis
11.5 Cancer therapy using MOFs
11.6 Conclusions
Acknowledgment
References
Chapter 12. Metallic nanoparticles for theranostic application
Abstract
12.1 Introduction
12.2 Transition metal nanoparticles as theranostic agents
12.3 Lanthanide-doped nanomaterials as theranostic agents
12.4 Conclusion
Acknowledgments
References
Chapter 13. Bioceramics: from bone substitutes to nanoparticles for bone drug delivery
Abstract
13.1 Introduction
13.2 Innate ceramics of our biological system
13.3 Nanobiomaterials
13.4 Development of nanoceramic materials from bone
13.5 Bone drug delivery
13.6 Nanobioceramics – bone drug delivery
13.7 Classical and conventional bone grafting materials
13.8 Potential pros and cons of nanocarriers
13.9 Applications of nanoparticles in bone drug delivery
13.10 Conclusion
References
Chapter 14. Calcium phosphate nanoparticles in therapeutics
Abstract
14.1 Inorganic nanoparticles
14.2 Calcium phosphate nanoparticles
14.3 Conclusions and perspectives
References
Chapter 15. Nanophase ceramic particles in bone regenerative therapeutics: theranostic platforms for bone disorders
Abstract
15.1 Worldwide burden of bone pathologies and the requirement of a new line of attack
15.2 Nanotechnology applied to bone tissue medical imaging and design
15.3 Theranostic technology: monitoring and healing bone disease
15.4 Bone tissue engineering networks designed to provide a theranostic therapy
15.5 Theranostic platforms: from bench to the beside
15.6 Closing remarks
References
Chapter 16. Metal-doped ceramic nanoparticles in bone therapeutics
Abstract
16.1 Introduction
16.2 Choice of biomaterials
16.3 Synthesis of nanoceramic particles
16.4 Metal-doped nanomaterials
16.5 Conclusion
References
Chapter 17. Metalloporphyrin nanoparticles for diverse theranostic applications
Abstract
17.1 Introduction
17.2 Porphyrin nanomaterials
17.3 Metalloporphyrin nanoparticles as therapeutic agents
17.4 Metalloporphyrin nanoparticles for drug delivery
17.5 Metalloporphyrin nanoparticles for imaging purpose
17.6 Metalloporphyrins in clinical trials
17.7 Conclusion and future prospective
Acknowledgment
References
Chapter 18. Inorganic nanosystems for cancer theranostics
Abstract
18.1 Introduction
18.2 Various inorganic nanosystems for cancer theranostics
18.3 Importance of inorganic nanoparticles in biomedicine
18.4 Toxicity and limitation of inorganic nanosystem
18.5 Challenges and future perspective
18.6 Conclusion
Acknowledgment
References
Chapter 19. Inorganic nanosystems for imaging diagnostics
Abstract
19.1 Introduction
19.2 Different imaging techniques
19.3 Advantage of nanomaterial-based imaging over conventional techniques
19.4 Targeting properties of nanomaterials
19.5 Inorganic nanoparticles for bioimaging
19.6 Conclusion
References
Further reading
Chapter 20. Inorganic bionanocomposites for bone tissue engineering
Abstract
20.1 Introduction
20.2 Components of biomedical composites
20.3 Inorganic biomedical composites and their applications in bone tissues engineering
20.4 Conclusion
Conflict of interest
Acknowledgments
References
Further reading
Index

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Marwadi University, Rajkot, Gujarat, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Tejraj M. Aminabhavi

Tejraj M. Aminabhavi is the Director of Research at the Center for Energy and Environment , School of Advanced Sciences, KLE Technological University, Hubballi, India. He works in the area of membrane transport processes, molecular modeling of polymer surfaces, wastewater treatment technologies, drug delivery polymers and sustainable environmental engineering.

Affiliations and expertise

Director of Research, Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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Inorganic Nanosystems

Theranostic Nanosystems, Volume 2

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Md Saquib Hasnain

Amit Kumar Nayak

Tejraj M. Aminabhavi

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