Innovative Approaches in Drug Discovery
Ethnopharmacology, Systems Biology and Holistic Targeting
- 1st Edition - October 3, 2016
- Authors: Bhushan Patwardhan, Rathnam Chaguturu
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 0 1 8 1 4 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 1 8 2 2 - 4
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Appro… Read more
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Request a sales quoteDespite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.
- Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned
- Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines
- Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Chapter 1. Need for Innovative ApproachesChapter 2. Why and How Drugs FailChapter 3. Holistic Drug TargetingChapter 4. Reverse PharmacologyChapter 5. Network Pharmacology and Multi-target FormulationChapter 6. Genome-driven Drug Discovery ProcessChapter 7. PharmacogenomicsChapter 8. Transcriptomics and EpigenomicsChapter 9. ProteomicsChapter 10.Chemical InformaticsChapter 11.Vaccines and Immunodrugs DiscoveryChapter 12.Curcumin as an example of holistic targeting agentChapter 13.New Approaches to Quality and Safety of Traditional Medical ProductsChapter 14.Lifestyle and Behavioral ApproachesChapter 15.Collaborative Strategies for Future Drug DiscoveryChapter 16.Righting the ship: The Data Reproducibility Conundrum
- No. of pages: 480
- Language: English
- Edition: 1
- Published: October 3, 2016
- Imprint: Academic Press
- Paperback ISBN: 9780128018149
- eBook ISBN: 9780128018224
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Bhushan Patwardhan
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