Inhibition of Polyamine Metabolism

PrefaceIntroduction: Polyamine Metabolism1 Inhibition of Basic Amino Acid Decarboxylases Involved in Polyamine Biosynthesis I. Introduction II. Properties of ODC III. Mechanism of Action of ODC IV. Inhibition of ODC V. Inhibition of Arginine Decarboxylase and Lysine Decarboxylase VI. Conclusion References2 Pharmacologic Interference with Enzymes of Polyamine Biosynthesis and of 5'-Methylthioadenosine Metabolism I. Introduction II. S-Adenosylmethionine Decarboxylase (AdoMetDC) III. Spermidine Synthase IV. Spermine Synthase V. Enzymatic Degradation of 5'-Methylthioadenosine (MTA) References3 Inhibition of Enzymes Oxidizing Polyamines I. Introduction II. Copper Amine Oxidases III. Flavin-Dependent Enzymes in Polyamine Catabolism IV. Biological Consequences of Polyamine Oxidase Inactivation V. Conclusions References4 Molecular and Cellular Functions of the Polyamines I. Introduction II. Nucleic Acid Structure III. Macromolecular Synthesis III. Topoisomerase Activity IV. Membrane Structure and Function References5 The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake I. Introduction II. Studies of Ornithine Decarboxylase III. Studies of S-Adenosylmethionine Decarboxylase (AdoMetDC) IV. Studies of Polyamine Transport References6 Inhibitors of Polyamine Biosynthesis: Cellular and in Vivo Effects on Tumor Proliferation I. Introduction II. Polyamine Biosynthesis in Normal and Transformed Cells III. Inhibitors of Polyamine Biosynthesis IV. Cellular Effects of Polyamine Inhibitors V. Polyamine Inhibitors: In Vivo Effects Against Experimental Tumors VI. Summary References7 Polyamine Inhibition in Vivo and in Organ Growth and Repair I. Introduction II. In Vivo Biochemistry of Polyamine Biosynthesis Inhibitors III. Consequences of Polyamine Inhibition on Organ Growth and Repair IV. Conclusions References8 Polyamine Synthesis Inhibitors Act as Both Inducers and Suppressors of Cell Differentiation I. Introduction II. Germ Cells and Embryos III. Organ Systems IV. Primary Cell Cultures and Established Cell Lines V. Summary and Future Prospects References9 The Contragestational Effects of Ornithine Decarboxylase Inhibition I. Introduction II. Polyamine Biochemical Changes During Gestation in Mammals III. Effects of Inhibitors of ODC on Gestation IV. Clinical Significance of the Contragestational Effects of ODC Inhibition V. Conclusion References10 Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis I. Introduction II. Goals of Combination Chemotherapy III. Approaches to Combination Chemotherapy IV. DFMO Effects on Polyamine Biosynthesis V. Targeted Drug Interactions Using Polyamine Inhibitors VI. Summary References11 Inhibition of Carcinogenesis by Inhibitors of Putrescine Biosynthesis I. Introduction II. Experiments and Results III. Practical Consideration IV. Summary and Conclusions References12 Inhibition of Polyamine Biosynthesis in Microorganisms I. Introduction II. Inhibition of Ornithine Decarboxylase III. Inhibition of Arginine Decarboxylase IV. Inhibition of S-Adenosylmethionine Decarboxylase V. Inhibition of Spermidine Synthase VI. Spermine Synthase VII. Mycoplasma VIII. Summary References13 Inhibition of Viral Polyamine Biosynthesis I. Introduction II. Polyamine Metabolism and the Replication of Animal Viruses III. Qualitative and Quantitative Aspects of Antiviral Chemotherapy IV. Polyamines and Viral Disease V. Drug Combinations and Antiviral Chemotherapy VI. Concluding Remarks References14 Inhibition of Polyamine Biosynthesis in Plants and Plant Pathogenic Fungi I. Introduction II. Inhibition of Polyamine Biosynthesis and Catabolism in Plants III. Effects of Polyamine Biosynthesis Inhibitors on Plant Growth and Development IV. Control of Phytopathogenic Fungi with DFMO References15 Parasitic Protozoa and Polyamines I. Introduction II. Flagellates III. Sporozoea IV. Amoebae V. Conclusions References16 Clinical Aspects of Inhibition of Ornithine Decarboxylase with Emphasis on Therapeutic Trials of Eflornithine (DFMO) in Cancer and Protozoan Diseases I. Introduction II. Malignancies III. African Trypanosomiasis IV. Pneumocystis Carinii Pneumonia (PCP) V. Other Indications and Future Clinical Research VI. Conclusions ReferencesIndex