Infection and Autoimmunity
- 3rd Edition - December 23, 2023
- Editors: Naim Mahroum, Abdulla Watad, Yehuda Shoenfeld
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 3 0 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 3 1 - 5
In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make th… Read more
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Request a sales quoteIn 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual.
The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic.
Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus.
- Fully revised and updated by a global group of experts, dedicated to and in honor of Noel Rose
- Includes 52 completely updated chapters with the latest developments in the field
- Is the only book directed specifically at the interactions between infectious agents and autoimmunity
- Describes the prevalence and incidence of global issues and current therapeutic approaches
- Addresses in full, details of the mechanisms behind the emergence of autoimmune diseases secondary to infections
- Brings the reader up-to-date and allows easy access to individual topics in one place
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1 Infection and Autoimmunity – An Introductory Note
- Abstract
- 1 Introduction
- 2 Autoimmunity Versus Autoimmune Disease
- 3 An Animal Model-Based Theory
- 4 The Example of COVID-19
- 5 The Example of Acute Rheumatic Fever
- 6 The Example of Systemic Lupus Erythematosus
- 7 Conclusion
- References
- Part 1: Mechanisms in Infections and Autoimmunity
- Chapter 2 Molecular Mimicry and Autoimmunity in a Glance
- Abstract
- 1 Introduction
- 2 Common Infectious Agents and Their Role in Setting Autoimmune Disorders
- 3 Vice Versa – Autoimmune Diseases and Implicated Pathogens
- 4 Rheumatic Autoimmune Diseases
- References
- Chapter 3 Perspectives on Molecular Mimicry Between Human, SARS-CoV-2, and Plasmodium Species Through a Probabilistic and Evolutionary Insight
- Abstract
- 1 Introduction
- 2 Identification of Similar or the Same Human and SARS-CoV-2 Peptide Sequence Pairs
- 3 HLA Binding Strength Predictions
- 4 Discussion Through a Probabilistic and Evolutionary Insight
- 5 Conclusion
- References
- Chapter 4 Molecular Mimicry Study Between Peptides of SARS-CoV-2 and Neutrophil Extracellular Traps-Related Proteins
- Abstract
- 1 Introduction
- 2 Conclusion
- References
- Chapter 5 Epitope Spreading in Autoimmune Diseases
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Examples of Epitope Spreading in Autoimmune Diseases
- 3 Mechanisms Underlying Epitope Spreading During the Course of an Autoimmune Disease
- 4 Concluding Remarks
- References
- Chapter 6 Infections and B1 Cells
- Abstract
- 1 Introduction
- 2 Characteristics of B1 Cells
- 3 CD5 Molecule
- 4 B1 Cells and Disease
- 5 Conclusion
- References
- Chapter 7 Anti-Saccharomyces cerevisiae Antibodies and Autoimmune Diseases
- Abstract
- 1 Crohn’s Disease
- 2 Behcet’s Disease
- 3 Celiac Disease
- 4 Ankylosing Spondylitis
- 5 Autoimmune Liver Diseases
- 6 Systemic Lupus Erythematosus and Anti-phospholipid Syndrome
- 7 Other Autoimmune Diseases
- References
- Chapter 8 Lymphocytes and Infection in Autoimmune Diseases
- Abstract
- 1 Introduction
- 2 Lymphocytes and Their Subsets in Autoimmune Diseases
- 3 Lymphocyte Subsets and Infection in Autoimmune Diseases
- 4 Causes of Lymphopenia in Autoimmune Diseases
- 5 Preventing Infection in Lymphopenic Autoimmune Patients
- References
- Chapter 9 Infections and Endothelial Cell Autoreactivity
- Abstract
- 1 Introduction
- 2 Methodological Approaches and Pitfalls in AECA Detection
- 3 AECA and Infections
- 4 Pathogenic Effects of AECA: Lessons From Autoimmune Diseases
- 5 The Targets of AECA in Infectious Diseases
- 6 Conclusions
- References
- Chapter 10 Infection and Inflammation: A Double-Edged Sword
- Abstract
- 1 Introduction
- 2 COVID-19
- 3 Shigellosis
- 4 Host Inflammatory Response as an Aid in Diagnosis
- References
- Chapter 11 Infection, Autoimmunity, and Vitamin D
- Abstract
- 1 Introduction
- 2 Vitamin D and Immunity
- 3 Infection and Vitamin D
- 4 Vitamin D and Autoimmunity
- 5 Vitamin D and Autoimmune Diseases
- 6 Optimal Levels of 25(OH)D3
- 7 Conclusions
- References
- Chapter 12 Seasonality and Autoimmunity
- Abstract
- 1 Introduction
- 2 Seasonality and Immune System
- 3 Seasonality, Infections, and Autoimmunity
- 4 Vitamin D, Sun Exposure, and Autoimmunity
- 5 Melatonin, Seasonality, and Immune System
- 6 Seasonality in Autoimmune Diseases – Infectious Agents, Vitamin D, and Melatonin
- 7 Conclusion
- Further Reading
- Part 2: Viruses and Autoimmunity
- Chapter 13 Autoimmunity on the Rise: COVID-19 as a Trigger of Autoimmunity
- Abstract
- 1 The Mosaic of Autoimmunity
- 2 Environmental Factors Contributing to Autoimmunity
- 3 COVID-19 as an Environmental Factor Contributing to Autoimmunity
- 4 Post-COVID-19 Syndrome: A Possible Autoimmune Phenomenon
- 5 Genetic Predisposition Contributing to Autoimmunity
- 6 Hormones Contributing to Autoimmunity
- 7 Autoimmunity on the Rise: Opinion
- References
- Chapter 14 Coronavirus-Triggered Ocular Autoimmune Reactivity: Experimental Coronavirus Retinopathy
- Abstract
- 1 Introduction: Infections and Autoimmunity in the Retina
- 2 Background: Ocular Autoimmunity
- 3 History: Coronaviruses
- 4 Autoimmunity and Coronavirus Infections
- 5 Development: ECOR
- 6 Summary
- References
- Chapter 15 Viral Infections and Type 1 Diabetes Mellitus – Guilty Viruses in the Court of Autoimmunity
- Abstract
- 1 Introduction
- 2 Coxsackievirus B and T1D – A Popular Offender
- 3 Rubella and T1D – An Early Cause
- 4 EBV and T1D – The Offender
- 5 SARS-CoV-2 and T1D – A New Suspect
- 6 Conclusion
- References
- Chapter 16 The Role of Viruses and Viral-Like Sequences in Sjogren’s Syndrome
- Abstract
- 1 Introduction
- 2 Clinical Picture
- 3 Immunopathology [16]
- 4 Viruses and SS
- 5 Activation of Type I Interferon Pathway in SS – Role of Long Interspersed Nuclear Element-1 Retrotransposable Elements
- 6 Conclusions
- References
- Chapter 17 Hepatitis C and Mixed Cryoglobulinemia: An Update
- Abstract
- 1 Introduction
- 2 Etiopathogenesis
- 3 Clinical and Laboratory Features
- 4 Classification Criteria
- 5 Therapeutic Approaches
- References
- Chapter 18 Vasculitides and Hepatitis C Infection
- Abstract
- 1 Introduction
- 2 HCV-Associated CV
- 3 HCV-Associated Medium-Sized Vasculitis
- References
- Chapter 19 HIV and Autoimmunity
- Abstract
- 1 Introduction
- 2 Autoimmune Diseases in HIV Infection
- 3 Conclusion
- References
- Chapter 20 Human T-Lymphotropic Virus Type 1 and Autoimmunity
- Abstract
- Conflict of interest
- 1 HTLV, the Immune System, and Autoimmunity
- 2 HTLV and Arthropathy
- 3 HTLV and Sjögren’s Syndrome
- 4 HTLV and Other Rheumatic Diseases
- References
- Chapter 21 Parvovirus and Autoimmune Diseases
- Abstract
- 1 Introduction
- 2 Clinical Manifestations of Parvovirus Infection
- 3 Parvovirus and Autoimmunity
- 4 Possible Mechanisms Behind the Immune Response Evoked by Human Parvovirus B19 Infection
- 5 Roles of Human Parvovirus B19V Infection in Various Autoimmune Diseases
- 6 Discussion and Future Perspective
- References
- Chapter 22 Viral Infections, Myocarditis, and Autoimmune Heart Disease
- Abstract
- 1 Introduction
- 2 COVID-19 and Myocarditis
- 3 Evidence of Autoimmunity
- 4 Animal Models Coxsackievirus B3-Induced Myocarditis
- 5 Genetic Susceptibility to Myocarditis
- 6 Disease Progression: From Viral Entry to Heart Failure
- 7 Conclusion
- References
- Part 3: Bacteria and Autoimmunity
- Chapter 23 Can Antibiotics Cure Autoimmune Diseases?
- Abstract
- 1 Introduction
- 2 Acute Rheumatic Fever and Streptococcus Group A
- 3 Helicobacter pylori
- 4 Granulomatosis with Polyangiitis and Staphylococcus aureus
- 5 Crohn’s Disease and Enteric Infections
- 6 Reactive Arthritis and Gastrointestinal/Genitourinary Infection
- 7 Guillain-Barré Syndrome and Campylobacter Infection
- 8 Rheumatoid Arthritis and Proteus mirabilis
- 9 Immune Thrombocytopenic Purpura and Dapsone
- 10 Discussion
- References
- Chapter 24 Rheumatic Fever: How Streptococcal Throat Infection Triggers an Autoimmune Disease
- Abstract
- 1 Introduction
- 2 Streptococcus pyogenes
- 3 Genetic Markers
- 4 Pathogenesis
- 5 Animal Model
- 6 Rheumatic Fever/Rheumatic Heart Disease and COVID-19 Infection
- 7 Conclusions
- 8 Perspective of Vaccine Development
- References
- Chapter 25 Streptococcus pneumoniae and Autoimmunity
- Abstract
- 1 Streptococcal family
- 2 Streptococcus pneumoniae
- 3 Clinical Manifestations of S. pneumoniae Infections Related to Autoimmunity
- 4 S. pneumonia Exacerbates Autoimmune Encephalomyelitis
- 5 Septic Shock Syndrome Caused by S. pneumoniae
- 6 Pericarditis
- 7 Autoimmune Diseases Predisposing to S. pneumoniae Infections
- 8 Pathophysiology and Influential Factors in Autoimmune Diseases and S. pneumoniae
- 9 The Immunological Pathways Involved in the Immune Response to Pneumococcal Polysaccharides
- References
- Chapter 26 Helicobacter pylori Infection and Gastric Autoimmunity
- Abstract
- 1 Introduction
- 2 Epidemiology
- 3 Transmission Routes
- 4 Chronic Atrophic Gastritis
- 5 Autoimmune Gastritis
- 6 Pathogenesis
- 7 H. pylori and Immune Mechanisms
- 8 Antibodies and H. pylori
- 9 Does H. pylori Induce Autoimmune Gastritis?
- 10 Diagnosis and Management
- 11 Conclusion
- References
- Chapter 27 Lyme Disease and Autoimmune Diseases
- Abstract
- 1 Introduction
- 2 Bacterial Infections and Autoimmunity
- 3 Characteristics of Borrelia burgdorferi Bacteria
- 4 Lyme Disease, Borrelia burgdorferi, and Molecular Mimicry
- 5 Neurological or “Brain” Autoimmunity and Lyme Disease
- 6 Blood–Brain Barrier Infiltration and Neurological Autoimmunity
- 7 Microglial Activation and Neurological Autoimmunity
- 8 Toll-Like Receptors, Lyme Disease, and Autoimmunity
- 9 Lyme Disease, Co-Infections, and Autoimmunity
- 10 HLA Genes and Lyme Disease-Triggered Autoimmunity
- 11 Conclusion
- References
- Chapter 28 Mycobacteria and Autoimmunity
- Abstract
- 1 The Presence of Mycobacteria in Tissues of Patients With Autoimmunologic Disorders
- 2 Mycobacteria and the Immune Response
- References
- Chapter 29 Tuberculosis and Autoimmunity: Well-Coordinated Duo
- Abstract
- Competing Interests
- 1 Introduction
- 2 AI Spectra Found in TB
- 3 Pathogenesis of AI in TB
- 4 Conclusion
- References
- Chapter 30 BCG and Autoimmunity
- Abstract
- 1 Introduction
- 2 Autoimmune-Related Effects of BCG
- 3 BCG Treatment in Bladder Cancer
- 4 Complications of BCG
- References
- Chapter 31 Mycobacterium avium ss. paratuberculosis and Human Disease: Bridging Infection and Autoimmunity
- Abstract
- 1 Introduction
- 2 MAP and Crohn’s Disease – The Hundred-Year War
- 3 Detection
- 4 Mycobacterium avium ss. paratuberculosis
- 5 MAP and Human Exposure
- 6 Genetic Lessons From Tuberculosis
- 7 Genetic Lessons From Leprosy
- 8 Genetic Lessons From Blau Syndrome – CARD15
- 9 SLC11A1
- 10 SLC11A1 in Infectious and Autoimmune Disease
- 11 MAP and Type 1 Diabetes
- 12 Molecular Mimicry/Heat-Shock Proteins – HSP65
- 13 MAP and Rheumatoid Arthritis
- 14 MAP and Multiple Sclerosis
- 15 MAP and Parkinson’s Disease
- 16 MAP and Autoimmune Thyroiditis
- 17 Potential Other MAP-Associated Diseases
- 18 What’s Next for MAP
- References
- Chapter 32 Leprosy and Autoimmunity
- Abstract
- 1 Introduction
- 2 Pathogenesis
- 3 Acute Reactions
- 4 Lucio’s Phenomenon
- 5 Leprosy and Autoantibodies
- 6 Leprosy and Other Diseases
- 7 Conclusion
- References
- Part 4: Parasites and Autoimmunity
- Chapter 33 The Protective Role of Helminths in Autoimmunity
- Abstract
- 1 Introduction
- 2 The Protective Role of Helminths in Autoimmune Diseases
- 3 Helminth Derivative to Treat Autoimmunity
- 4 Conclusion
- References
- Further Reading
- Chapter 34 Parasitic Infection and Autoimmunity
- Abstract
- 1 Peculiarities of Host Immune Response to Parasite Invasion
- 2 Molecular Mechanisms of Parasite-Associated Autoimmunity
- 3 Specific Parasites
- 4 Final Remarks
- References
- Chapter 35 Toxoplasma and Autoimmunity
- Abstract
- 1 Introduction
- 2 From Animals to Humans Through the Immune System
- 3 The Evidence of Autoimmunity
- 4 Discussion
- 5 Conclusion
- References
- Chapter 36 Malaria and Autoimmunity
- Abstract
- 1 Introduction
- 2 The Mechanisms Behind Malaria and Autoimmunity
- 3 Reciprocal Protective Effects of Malaria and Autoimmunity
- 4 Malaria-Induced Autoimmunity
- 5 Immunomodulatory Effects of Antimalarials
- 6 Association Between Malaria and COVID-19
- References
- Part 5: Autoimmune Diseases and Infections
- Chapter 37 The Infectious Origin of the Anti-Phospholipid Syndrome
- Abstract
- 1 Introduction
- 2 Autoimmune Diseases and Infections: The Role of Molecular Mimicry
- 3 Anti-β2GPI Antibodies
- 4 Infection and Anti-Phospholipid Antibodies
- 5 The Infectious Origin of Circulating Anti-B2GPI Antibodies
- 6 Therapeutic Considerations
- 7 Conclusions
- REFERENCES
- Chapter 38 Infections and SLE
- Abstract
- 1 Introduction
- 2 Mechanisms for Increased Risk of Infection in Lupus Patients
- 3 Hospitalizations and Mortality
- 4 Bacterial Infections
- 5 Viral Infections
- 6 Fungal Infections
- 7 Opportunistic Infections
- 8 Medications for SLE and the Onset of Infections
- 9 Conclusions
- References
- Chapter 39 The Role of Infection in Immune-Mediated Thrombocytopenia
- Abstract
- 1 Introduction
- 2 The Pathogenesis of ITP
- 3 ITP and Acute Infections
- 4 Chronic Infections and ITP
- 5 Vaccination and ITP
- 6 Conclusion
- References
- Chapter 40 Rheumatoid Arthritis and Infections: Not Only a Coincidence
- Abstract
- References
- Chapter 41 Post-Infectious Arthritis and Reactive Arthritis
- Abstract
- 1 Introduction
- 2 Epidemiology
- 3 Mechanisms Involved – HLA-B27-Associated and HLA-B27-Non-Associated ReA
- 4 Immune Response to Bacteria
- 5 Arthritogenic Mechanisms of Viral Infections
- 6 Clinical Manifestations
- 7 Treatment Options
- 8 Conclusions
- References
- Chapter 42 Infections and Systemic Sclerosis
- Abstract
- 1 Introduction
- 2 Conclusions
- References
- Chapter 43 Infections and Behçet Disease
- Abstract
- 1 Introduction
- 2 BD Pathogenesis and Infection
- 3 Infection as a Trigger of BD Exacerbation
- 4 Infections in Patients With BD
- 5 Infectious Complications Due to Immunosuppression in BD
- 6 Conclusion
- References
- Chapter 44 Infections in the Immune Interplay of Inflammatory Bowel Disease
- Abstract
- 1 Introduction
- 2 Human Gut Microbiota
- 3 Immunity and Gut Microbiota
- 4 Intestinal Microbiota in IBD and Dysbiosis
- 5 Pathogens Implicated in the Causation or Exacerbation of IBD
- 6 Infectious Agents Protecting From IBD
- 7 Conclusion
- References
- Chapter 45 Infections and Celiac Disease
- Abstract
- 1 Introduction
- 2 Extra-Intestinal Manifestations
- 3 Immune and Autoimmune Diseases Associated With Celiac Disease
- 4 Pathogenesis of CD
- 5 Infectious Pathogens Associated With Celiac Disease
- 6 SARS-CoV-2 and Celiac Disease
- 7 Conclusion
- References
- Chapter 46 Infection and Autoimmune Liver Diseases
- Abstract
- 1 Primary Biliary Cholangitis
- 2 Autoimmune Hepatitis
- References
- Chapter 47 Infection and Autoimmune Thyroid Diseases
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Graves' Disease and Infection
- 3 Autoimmune (Hashimoto’s) Thyroiditis and Infection
- 4 Mechanisms of Induction of Autoimmunity by Infectious Agents
- 5 Conclusion
- References
- Chapter 48 Renal Autoimmunity: The Role of Bacterial and Viral Infections – An Extensive Review†
- Abstract
- 1 Introduction
- 2 Renal Autoimmunity Syndromes
- 3 Bacterial Infections and Renal Autoimmunity
- 4 Viral Infections and Renal Autoimmunity
- 5 Conclusion
- References
- Chapter 49 Infection and Guillain–Barre Syndrome – A Lifelong Relation
- Abstract
- 1 Introduction
- 2 Epidemiology of GBS in Association With the Epidemiology of Autoimmune Diseases
- 3 Treatment of GBS Based on Autoimmune Mechanisms
- 4 Infectious Agents and Their Role in the Etiology and Pathogenesis of GBS
- 5 Pathogenetic Background of the Correlation Between GBS and Infections
- 6 Pathomechanism of AIDP
- References
- Chapter 50 Pathophysiology of Acute Disseminated Encephalomyelitis – Immune and Autoimmune Aspects
- Abstract
- 1 Introduction
- 2 Epidemiology
- 3 Immunopathogenesis of ADEM
- 4 Pathology of ADEM
- 5 Do ADEM and MS Represent Part of an Immune-Mediated Spectrum of Demyelinating Disorders?
- 6 Conclusion
- References
- Chapter 51 Oral Infections, SARS-CoV-2 Infection, and Autoimmunity
- Abstract
- Acknowledgment
- 1 Introduction
- 2 Recent Development in Oral Infections and Autoimmunity
- 3 Revisiting Peptidyl Arginine Deiminases
- 4 Emerging Anti-Inflammatory Proteins, Potential Autoimmune Treatment Targets?
- 5 SARS-CoV-2 Infection and Oral Infection
- 6 COVID-19 and Autoimmunity
- 7 Conclusion and Future Directions
- References
- Chapter 52 Pemphigus and Infection
- Abstract
- 1 Introduction
- 2 Clinical Evidence of an Infectious Agent in Pemphigus
- 3 Possible Pathogenetic Mechanisms of Infection-Induced Pemphigus
- 4 Implications for Treatment
- 5 Conclusions
- References
- Index
- No. of pages: 1118
- Language: English
- Edition: 3
- Published: December 23, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323991308
- eBook ISBN: 9780323991315
NM
Naim Mahroum
Dr Naim Mahroum specialized in internal medicine, infectious diseases and HIV in Sheba medical center. He worked in Sheba medical center for more than 13 years, one of the top 10 hospitals in the world for a third year consequently according to Newsweek. Moreover, Dr. Mahroum, worked at COVID-19 department more than 9 months during the COVID-19 pandemic, which earned him as an infectious disease specialist. He was a member of the teaching committee in Sackler faculty of medicine at Tel-Aviv university since 2012. Has received a senior lecturer degree at the university due to its scientific, academic and research works. In 2022, Dr. Mahroum joined the teaching committee of the international medical school, at Istanbul Medipol University, Istanbul, Turkey. Published more than 75 scientific papers in infections and its relation to autoimmune and rheumatologic diseases. Dr. Mahroum has presented his works in several national and international conferences.
AW
Abdulla Watad
YS