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In Situ Tissue Regeneration

Host Cell Recruitment and Biomaterial Design

  • 1st Edition - July 17, 2016
  • Latest edition
  • Editors: Sang Jin Lee, Anthony Atala, James J Yoo
  • Language: English

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the lates… Read more

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Description

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.

Key features

  • Explores the body’s ability to mobilize endogenous stem cells to the site of injury
  • Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity
  • Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume
  • Features chapter authors and editors who are authorities in this emerging field
  • Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Readership

Biomedical researchers engaged in cell biology, stem cell research, regenerative medicine, and engineering biomaterials.

Table of contents

1. Fundamentals of In Situ Tissue Regeneration
Sang Jin Lee, James J. Yoo and Antony Atala

2. Stem Cell Homing
Mariusz Z. Ratajczak and Ahmed A. Ismail

3. Immunology – Host Responses to Biomaterials
John D. Jackson

4. Foreign Body Reaction and Stem Cell Responses
Ashwin Nair and Liping Tang

5. Roles of endogenous growth factors and small peptides in in situ tissue regeneration
Suna Kim, Hyun Sook Hong and Youngsook Son

6. Small molecules: Controlling cell fate and function
Baisong Lu and Anthony Atala

7. Small RNA Delivery for In Situ Tissue Regeneration
NaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee

8. Micro and Nano Topographical cues guiding biomaterial host response
Deepak M. Kalaskar and Feras Alshomer

9. Mechanobiology and Mechanotherapy in Tissue Engineering
Rei Ogawa

10. A biomimetic strategy to design biomaterials for in situ tissue regeneration
Ji Hyun Kim and Sang Jin Lee

11. Impact of Matrix Dynamic Properties on Stem Cell Viability
Marc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu

12. Cell-free Scaffolds for In situ Tissue Regeneration
Seung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim

13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design
T. Konrad Rajab and Harald Ott

14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells
Solaiman Tarafder and Chang H. Lee

15. Bioengineered strategies for tendon regeneration
Ana I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes

16. Volumetric Muscle Repair In Situ
Lindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee, James J. Yoo and Anthony Atalaa

17. Mending The Heart Through In Situ Cardiac Regeneration
Jeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou

18. Skin Wound Healing – Skin Regeneration with Pharmacological Mobilized Stem Cells
Zhaoli Sun and George Melville Williams

19. In situ renal regeneration
Hung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo

20. Regulatory Aspects: regulation aspects of cell-free biomaterial implants
Nan Zhang, Alexander Baume, Richard Payne, Julie Allickson

21. Business Perspective – case study: commercialized cell-free cardiovascular implant
Alexander Sheehy, Byron Lambert and Richard Rapoza

Product details

  • Edition: 1
  • Latest edition
  • Published: August 5, 2016
  • Language: English

About the editors

SL

Sang Jin Lee

Dr. Lee has extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. His research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. Dr. Lee’s research team also demonstrated the principle of “in situ tissue regeneration” that is to take advantage of the body’s own regenerating capacity by using the host's ability to mobilize endogenous stem cells to the site of injury. Currently, his research has focused on development of strategies for in situ tissue regeneration in terms of mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system from the perspective of regenerative medicine and tissue engineering.
Affiliations and expertise
Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

AA

Anthony Atala

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.
Affiliations and expertise
G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine; W. Boyce Professor and Chair, Department of Urology, and G. Link Professor and Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University. Winston Salem, North Carolina, USA

JY

James J Yoo

Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
Affiliations and expertise
Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

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