Immunopathology of Celiac Disease

1st Edition, Volume 358 - March 2, 2021
Editors: Lorenzo Galluzzi, Ainara Castellanos
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 1 1 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 1 2 - 5

Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covere… Read more

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Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covered in this new volume include Omics of Celiac Disease, Implication of HLA genes in Celiac Disease, Macrophages & Dendritic Cells in Celiac Disease, Tight junction disruption in the development of celiac disease, Implication of epithelial cell dysfunction in CeD, Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response, The biology of refractory celiac disease, Involvement of lncRNAs in Celiac disease pathogenesis, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter One: Celiac disease susceptibility: The genome and beyond
Abstract
1: Introduction
2: Genomics of CeD
3: DNA methylation in CeD
4: Non-coding RNAs in CeD
5: Conclusions
Chapter Two: The HLA complex and coeliac disease
Abstract
1: Introduction
2: Genetic susceptibility
3: Risk gradient
4: Heritability
5: Familial risk
6: Pathogenesis
7: Role in diagnosis and clinical practice
8: Influence of HLA on phenotypic variation
9: Microbiota and HLA
10: Evolutionary considerations
11: New therapies based on HLA
12: Common mistakes
Acknowledgments
Chapter Three: Human intestinal dendritic cell and macrophage subsets in coeliac disease
Abstract
1: Coeliac disease pathogenesis
2: Introduction to the human gut immune system
3: Dendritic cells in the healthy gut
4: Macrophages in the healthy gut
5: Intestinal dendritic cells and macrophages in coeliac disease
6: Concluding remarks and future perspectives
Chapter Four: The tight junction and the epithelial barrier in coeliac disease
Abstract
1: Intestinal epithelial barrier: Definition and function
2: The tight junction and the paracellular permeability
3: The role of the intestinal barrier in coeliac disease
4: Zonulin, a reversible regulator of the epithelial barrier in coeliac disease
5: Correlation between barrier dysfunction in coeliac disease and liver injury
6: Novel therapies targeting barrier defects in coeliac disease
7: Concluding remarks
Chapter Five: Epithelial cell dysfunction in coeliac disease
Abstract
1: Epithelial homeostasis
2: Genetic and epigenetic modifications in the coeliac epithelium
3: Epithelial cell profile and structural changes in coeliac disease
4: Direct effects of gluten in the intestinal epithelium
5: Epithelial damage driven by immune cells
6: Consequences of microbiota–epithelium interactions for coeliac disease
7: Diet and intestinal epithelial health in coeliac disease
8: Treatments targeting intestinal epithelial cells
9: Concluding remarks
Chapter Six: The gliadin p31–43 peptide: Inducer of multiple proinflammatory effects
Abstract
1: Introduction
2: Wheat prolamins: A very particular group of proteins
3: Early evidence of the toxic effects of gliadin peptides
4: Biochemistry of p31–43
5: Signaling pathways and pathological effects induced by p31–43
6: Use of experimental mice models to unveil the in vivo effects of p31–43
7: Inflammasome activation by p31–43
8: A modern view of the role of p31–43 in CD pathogenesis
9: Conclusions
Chapter Seven: Cellular and molecular bases of refractory celiac disease
Abstract
1: Introduction
2: Epidemiology
3: Genetic and epigenetic risk factors
4: Pathogenesis
5: Diagnostic considerations
6: Limitations of the current RCD classification
7: Management
8: Unanswered questions and future directions
Chapter Eight: Involvement of lncRNAs in celiac disease pathogenesis
Abstract
1: Introduction
2: AC104820.2 and CD altered genes
3: Lnc13 and inflammatory gene expression
4: Carlr and NFKB signaling
5: HCG14 and innate response
6: RP4-587D13.2 lncRNA and tight junction network
7: LncRNAs predicted to be involved in CD
8: Concluding remarks
Acknowledgments

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

Ainara Castellanos

Ainara Castellanos-Rubio obtained her PhD on Genetics from the University of the Basque Country (Spain) in 2010. During her PhD she studied gene expression alterations and genetic polymorphisms associated to Celiac Disease. She did a short term research stay in the University of Tampere (Finland) under the supervision of Dr Marku Makki and Dr Katri Lindfors where she used three dimensional cell cultures to describe different pathways involved in Celiac Disease development. On 2011 she joined the Laboratory of Dr Sankar Ghosh in Columbia University (NY, USA) where she carried out her postdoctoral studies. During her postdoctoral training, she studied the implication of long noncoding RNAs (lncRNAs) in the immune and inflammatory response and she discovered and functionally characterized a novel lncRNA involved in the susceptibility to Celiac Disease. Since 2017 she is an Ikerbasque Researcher in the University of the Basque Country, where she leads her own group. She is interested in the involvement of noncoding RNAs in the pathogenesis of autoimmune and inflammatory diseases and studies the influence of disease associated SNPs in the functional disturbance of these RNAs. More recently, she has become interested on the epitranscriptomic alterations involved in different aspects of RNA regulation and her group studies how SNPs and environmental factors can alter these epitranscriptomic signals influencing the inflammatory response that finally evolves in disease development.

Affiliations and expertise

Ikerbasque Researcher, University of the Basque Country, Bizkaia, Spain

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