
Immunopathology of Celiac Disease
- 1st Edition, Volume 358 - March 2, 2021
- Imprint: Academic Press
- Editors: Ainara Castellanos, Lorenzo Galluzzi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 1 1 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 1 2 - 5
Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covere… Read more

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Request a sales quoteImmunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covered in this new volume include Omics of Celiac Disease, Implication of HLA genes in Celiac Disease, Macrophages & Dendritic Cells in Celiac Disease, Tight junction disruption in the development of celiac disease, Implication of epithelial cell dysfunction in CeD, Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response, The biology of refractory celiac disease, Involvement of lncRNAs in Celiac disease pathogenesis, and more.
- Provides up-to-date and extensive reviews of different aspects of celiac disease pathogenesis
- Includes original figures that help readers understand the complex pathways involved in the disease
- Covers research on different aspects of the disease which involves the introduction of a wide range of technologies
Clinical gastroenterologist interested in the molecular aspects of celiac disease pathogenesis. Molecular biologists studying the development of inflammatory intestinal diseases
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Celiac disease susceptibility: The genome and beyond
- Abstract
- 1: Introduction
- 2: Genomics of CeD
- 3: DNA methylation in CeD
- 4: Non-coding RNAs in CeD
- 5: Conclusions
- Chapter Two: The HLA complex and coeliac disease
- Abstract
- 1: Introduction
- 2: Genetic susceptibility
- 3: Risk gradient
- 4: Heritability
- 5: Familial risk
- 6: Pathogenesis
- 7: Role in diagnosis and clinical practice
- 8: Influence of HLA on phenotypic variation
- 9: Microbiota and HLA
- 10: Evolutionary considerations
- 11: New therapies based on HLA
- 12: Common mistakes
- Acknowledgments
- Chapter Three: Human intestinal dendritic cell and macrophage subsets in coeliac disease
- Abstract
- 1: Coeliac disease pathogenesis
- 2: Introduction to the human gut immune system
- 3: Dendritic cells in the healthy gut
- 4: Macrophages in the healthy gut
- 5: Intestinal dendritic cells and macrophages in coeliac disease
- 6: Concluding remarks and future perspectives
- Chapter Four: The tight junction and the epithelial barrier in coeliac disease
- Abstract
- 1: Intestinal epithelial barrier: Definition and function
- 2: The tight junction and the paracellular permeability
- 3: The role of the intestinal barrier in coeliac disease
- 4: Zonulin, a reversible regulator of the epithelial barrier in coeliac disease
- 5: Correlation between barrier dysfunction in coeliac disease and liver injury
- 6: Novel therapies targeting barrier defects in coeliac disease
- 7: Concluding remarks
- Chapter Five: Epithelial cell dysfunction in coeliac disease
- Abstract
- 1: Epithelial homeostasis
- 2: Genetic and epigenetic modifications in the coeliac epithelium
- 3: Epithelial cell profile and structural changes in coeliac disease
- 4: Direct effects of gluten in the intestinal epithelium
- 5: Epithelial damage driven by immune cells
- 6: Consequences of microbiota–epithelium interactions for coeliac disease
- 7: Diet and intestinal epithelial health in coeliac disease
- 8: Treatments targeting intestinal epithelial cells
- 9: Concluding remarks
- Chapter Six: The gliadin p31–43 peptide: Inducer of multiple proinflammatory effects
- Abstract
- 1: Introduction
- 2: Wheat prolamins: A very particular group of proteins
- 3: Early evidence of the toxic effects of gliadin peptides
- 4: Biochemistry of p31–43
- 5: Signaling pathways and pathological effects induced by p31–43
- 6: Use of experimental mice models to unveil the in vivo effects of p31–43
- 7: Inflammasome activation by p31–43
- 8: A modern view of the role of p31–43 in CD pathogenesis
- 9: Conclusions
- Chapter Seven: Cellular and molecular bases of refractory celiac disease
- Abstract
- 1: Introduction
- 2: Epidemiology
- 3: Genetic and epigenetic risk factors
- 4: Pathogenesis
- 5: Diagnostic considerations
- 6: Limitations of the current RCD classification
- 7: Management
- 8: Unanswered questions and future directions
- Chapter Eight: Involvement of lncRNAs in celiac disease pathogenesis
- Abstract
- 1: Introduction
- 2: AC104820.2 and CD altered genes
- 3: Lnc13 and inflammatory gene expression
- 4: Carlr and NFKB signaling
- 5: HCG14 and innate response
- 6: RP4-587D13.2 lncRNA and tight junction network
- 7: LncRNAs predicted to be involved in CD
- 8: Concluding remarks
- Acknowledgments
- Edition: 1
- Volume: 358
- Published: March 2, 2021
- Imprint: Academic Press
- No. of pages: 276
- Language: English
- Hardback ISBN: 9780323853118
- eBook ISBN: 9780323853125
AC
Ainara Castellanos
Ainara Castellanos-Rubio obtained her PhD on Genetics from the University of the Basque Country (Spain) in 2010. During her PhD she studied gene expression alterations and genetic polymorphisms associated to Celiac Disease. She did a short term research stay in the University of Tampere (Finland) under the supervision of Dr Marku Makki and Dr Katri Lindfors where she used three dimensional cell cultures to describe different pathways involved in Celiac Disease development. On 2011 she joined the Laboratory of Dr Sankar Ghosh in Columbia University (NY, USA) where she carried out her postdoctoral studies. During her postdoctoral training, she studied the implication of long noncoding RNAs (lncRNAs) in the immune and inflammatory response and she discovered and functionally characterized a novel lncRNA involved in the susceptibility to Celiac Disease. Since 2017 she is an Ikerbasque Researcher in the University of the Basque Country, where she leads her own group. She is interested in the involvement of noncoding RNAs in the pathogenesis of autoimmune and inflammatory diseases and studies the influence of disease associated SNPs in the functional disturbance of these RNAs. More recently, she has become interested on the epitranscriptomic alterations involved in different aspects of RNA regulation and her group studies how SNPs and environmental factors can alter these epitranscriptomic signals influencing the inflammatory response that finally evolves in disease development.
Affiliations and expertise
Ikerbasque Researcher, University of the Basque Country, Bizkaia, SpainLG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USARead Immunopathology of Celiac Disease on ScienceDirect