Immunomodulatory Biomaterials

Regulating the Immune Response with Biomaterials to Affect Clinical Outcome

1st Edition - July 30, 2021
Imprint: Woodhead Publishing
Editors: Stephen F. Badylak, Jennifer Elisseeff
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 4 4 0 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 4 5 6 - 5

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “i… Read more

Purchase options

BLOOM INTO SPRING SAVINGS

Save up to 25% on books and eBooks!

Shop now

Institutional subscription on ScienceDirect

Request a sales quote

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype.

Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition.

There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response.

The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
1: Engineering physical biomaterial properties to manipulate macrophage phenotype: From bench to bedside
Abstract
1.1: Introduction
1.2: Role of macrophages in tissue repair and the foreign body response
1.3: Modulation of macrophage function via physical biomaterial properties in vitro
1.4: Macrophage response to implanted biomaterials in vivo
1.5: Clinical insight into the effect of physical biomaterial properties on macrophages during tissue repair
1.6: Conclusions and future directions
2: Early factors in the immune response to biomaterials
Abstract
2.1: Introduction
2.2: Protein adsorption
2.3: Foreign body giant cells
2.4: Fibrous capsule
2.5: Signaling pathways activated
2.6: Conclusion
3: Nanotechnology and biomaterials for immune modulation and monitoring
Abstract
3.1: Introduction
3.2: Autoimmunity
3.3: Allergy
3.4: Transplant rejection
3.5: Clinical trials of tolerogenic nanotherapies
3.6: Precision diagnostics
3.7: Outlook and conclusion
4: Immune-instructive materials and surfaces for medical applications
Abstract
4.1: Introduction
4.2: Naturally occurring biomaterials with immune modulatory properties and their application in wound healing and reduction of FBR
4.3: Bioinstructive synthetic materials and their application in regenerative medicine
4.4: Developing “immune-instructive” biomaterials
4.5: Concluding remarks
5: Electrospun tissue regeneration biomaterials for immunomodulation
Abstract
Graphical abstract
5.1: Introduction
5.2: Acknowledging immunomodulation in tissue engineering
5.3: Well-studied areas
5.4: Areas gaining attention
5.5: Areas needing attention
5.6: Future directions
5.7: Conclusion
6: Biomaterials and immunomodulation for spinal cord repair
Abstract
Acknowledgments
6.1: Spinal cord injury
6.2: Immune response after SCI
6.3: Immunomodulation after spinal cord injury
6.4: Biomaterials for spinal cord repair
6.5: Immunomodulatory biomaterials for spinal cord injury
6.6: Natural immunomodulatory materials for spinal cord injury
6.7: Considerations and future directions
6.8: Conclusions and summary
7: Biomaterial strategies to treat autoimmunity and unwanted immune responses to drugs and transplanted tissues
Abstract
7.1: Introduction
7.2: Scope
7.3: Biomaterials in development for autoimmunity and anti-drug antibodies
7.4: Biomaterials in development for transplant tolerance
7.5: Future of the field
8: Lipids as regulators of inflammation and tissue regeneration
Abstract
8.1: Introduction
8.2: LC-MS based approaches to analyze lipids and their oxidation products
8.3: Free PUFA and their oxidation products as signals for immunomodulation and tissue regeneration
8.4: Oxidized phospholipids as modulators of the inflammatory response
8.5: Phospholipid signatures of EV
8.6: Hydrolysis of MBV derived oxygenated lipids and their possible role in inflammation and tissue regeneration
9: Biomaterials modulation of the tumor immune environment for cancer immunotherapy
Abstract
9.1: Introduction
9.2: Fundamentals of cancer immunology and immunotherapy
9.3: Immunomodulatory biomaterials in cancer therapy
9.4: Summary
10: Circumventing immune rejection and foreign body response to therapeutics of type 1 diabetes
Abstract
Graphical abstract
10.1: Introduction
10.2: Immune rejection for cells/grafts
10.3: Biological hurdles to preventing graft rejection
10.4: Advances in eliminating rejection of non-encapsulated grafts
10.5: Advances in preventing FBR to bulk encapsulation systems
10.6: Pre/clinical observations, and models for translation
10.7: Future prospects and perceived challenges/difficulties
10.8: Summary/conclusion
11: Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials
Abstract
11.1: Biomaterials, inflammation, and wound healing
11.2: Inflammation and wound healing as prototypical complex systems
11.3: Computational modeling approaches to inflammation and wound healing: Pros and cons
11.4: Model development
11.5: Control development
11.6: Biomaterials and their potential role in computationally driven rational inflammation reprogramming
11.7: Conclusions and future prospects
Index

Stephen F. Badylak

Dr. Badylak is Professor in the Departments of Surgery and BioEngineering at the University of Pittsburgh and Deputy Director of the McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA. The focus of Dr. Badylak's work has been the mechanisms by which extracellular matrix signals host tissues to promote and support functional tissue reconstruction.

Affiliations and expertise

Professor in the Departments of Surgery and BioEngineering, University of Pittsburgh; Deputy Director of McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA

Jennifer Elisseeff

Dr. Elisseeff began her career at Carnegie Mellon University and Harvard-MIT. After this, she was a Fellow at the National Institute of General Medical Sciences Pharmacology Research Associate Program, and later became an assistant professor in the Department of Biomedical Engineering at Johns Hopkins University. In 2004, Elisseeff cofounded Cartilix, Inc., a startup that translated adhesive and biomaterial technologies for treating orthopedic disease, acquired by Biomet Inc in 2009.In 2009, she also founded Aegeria Soft Tissue and Tissue Repair, new startups focused on soft tissue regeneration and wound healing. Dr. Elisseeff serves on the Scientific Advisory Boards of Bausch and Lomb, Kythera Biopharmaceutical, and Cellular Bioengineering Inc. She has received the Carnegie Mellon Young Alumni Award, Arthritis Investigator Award from the Arthritis Foundation, Yasuda Award from the Society of Physical Regulation in Medicine and Biology and was named by Technology Review magazine as a top innovator under 35 in 2002 and top 10 technologies to change the future. In 2008, Dr. Elisseeff was elected a fellow in the American Institute for Medical and Biological Engineering and a Young Global Leader in the World Economic Forum. She has published over 120 articles, book chapters and patent applications and given over 130 national and international invited lectures.

Affiliations and expertise

Morton Goldberg Professor, Wilmer Eye Institute and Biomedical Engineering, John Hopkins Medicine, Baltimore, MD, USA

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health