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Immunology
- 10th Edition - May 14, 2025
- Editors: David Male, R. Stokes Peebles, Victoria Male
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 8 8 9 - 4
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 5 9 6 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 8 9 0 - 0
Immunology is highly valued by medical students and medical science students everywhere for demystifying a complex and rapidly developing area of medicine.The book integrates bas… Read more
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Request a sales quoteImmunology is highly valued by medical students and medical science students everywhere for demystifying a complex and rapidly developing area of medicine.
The book integrates basic and clinical immunology, providing up-to-date information that links the laboratory with clinical practice. It covers all the core immunology concepts that students need for their coursework, including immunity, immune responses, defence against infectious agents, and hypersensitivity.
The book's structure makes it easy to understand, presenting immunology in the order that aligns with typical teaching methods. Ideal for USMLE and MLA preparation, it comes complete with accompanying online animations, cases studies, and self-assessment.
The book integrates basic and clinical immunology, providing up-to-date information that links the laboratory with clinical practice. It covers all the core immunology concepts that students need for their coursework, including immunity, immune responses, defence against infectious agents, and hypersensitivity.
The book's structure makes it easy to understand, presenting immunology in the order that aligns with typical teaching methods. Ideal for USMLE and MLA preparation, it comes complete with accompanying online animations, cases studies, and self-assessment.
- Carefully structured layout - easy to follow and identify high yield information
- Explains the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context
- More learning opportunities online, including USMLE-style questions and clinical cases – ideal for exam revision and practice
- Animations offer a visual overview of immunological concepts
- An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customise your content, make notes and highlights, and have content read aloud
Medical students, biomedical science students
- Title of Book
- Cover image
- Title page
- Table of Contents
- Any screen, Any time, Anywhere
- Copyright
- Preface to the 10th Edition
- Contributors
- Section 1: The Immune System and Innate Immunity
- 1. Introduction to the Immune System
- Abstract
- CELLS AND SOLUBLE MEDIATORS OF THE IMMUNE SYSTEM
- INFLAMMATION
- IMMUNE RESPONSES TO PATHOGENS
- ANTIGEN RECOGNITION
- ANTIGEN PRESENTATION
- PATHOGEN ELIMINATION
- VACCINATION
- IMMUNOPATHOLOGY
- Normal but Inconvenient Immune Reactions
- 2. Cells, Tissues and Organs of the Immune System
- Abstract
- CELLS OF THE IMMUNE SYSTEM
- MYELOID CELLS
- EOSINOPHILS, BASOPHILS AND MAST CELLS IN INFLAMMATION
- ANTIGEN-PRESENTING CELLS
- LYMPHOCYTES
- INNATE LYMPHOID CELLS
- LYMPHOCYTE DEVELOPMENT
- LYMPHOID ORGANS
- LYMPHOCYTE RECIRCULATION
- FURTHER READING
- 3. Mechanisms of Innate Immunity
- Abstract
- INNATE IMMUNE RESPONSES
- INFLAMMATION: A RESPONSE TO TISSUE DAMAGE
- LEUKOCYTE MIGRATION TO LYMPHOID TISSUES
- MEDIATORS OF INFLAMMATION
- PATHOGEN-ASSOCIATED MOLECULAR PATTERNS
- INTEGRINS AND CELL-ADHESION MOLECULES—FAMILIES OF ADHESION MOLECULES
- SOLUBLE PATTERN RECOGNITION MOLECULES
- FURTHER READING
- 4. Complement
- Abstract
- COMPLEMENT AND INFLAMMATION
- COMPLEMENT ACTIVATION PATHWAYS
- COMPLEMENT PROTECTION SYSTEMS
- THE MEMBRANE ATTACK PATHWAY
- MEMBRANE RECEPTORS FOR COMPLEMENT PRODUCTS
- COMPLEMENT FUNCTIONS
- COMPLEMENT DEFICIENCIES
- COMPLEMENT POLYMORPHISMS AND DISEASE
- COMPLEMENT THERAPEUTICS
- FURTHER READING
- 5. Mononuclear Phagocytes in Immune Defence
- Abstract
- MACROPHAGES: THE ‘BIG EATERS’
- STUDYING MACROPHAGE PHENOTYPES
- PHAGOCYTOSIS AND ENDOCYTOSIS
- FUNCTIONS OF PHAGOCYTIC CELLS
- FURTHER READING
- Section 2: Adaptive Immune Responses
- 6. T-Cell Receptors and Major Histocompatibility Complex Molecules
- Abstract
- MAJOR HISTOCOMPATIBILITY COMPLEX GENES
- MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES
- MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-LIKE MOLECULES
- T-CELL RECEPTORS
- GENERATION OF T-CELL RECEPTOR DIVERSITY
- THE T-CELL RECEPTOR COMPLEX
- MAJOR HISTOCOMPATIBILITY COMPLEX HAPLOTYPE AND DISEASE SUSCEPTIBILITY
- FURTHER READING
- 7. Antigen Presentation
- Abstract
- ANTIGEN-PRESENTING CELLS
- ANTIGEN PROCESSING
- MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I PATHWAY
- MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II PATHWAY
- CD1 PATHWAY
- CO-STIMULATION
- T-CELL SIGNALLING
- FURTHER READING
- 8. Cell-Mediated Cytotoxicity
- Abstract
- CYTOTOXIC LYMPHOCYTES
- NATURAL KILLER CELL RECOGNITION OF TARGETS
- ADAPTIVE FEATURES OF NATURAL KILLER CELLS
- CYTOTOXICITY
- NON-LYMPHOID CYTOTOXIC CELLS
- FURTHER READING
- 9. B-Cell Development and the Antibody Response
- Abstract
- B-CELL DEVELOPMENT
- B-CELL ACTIVATION
- B-CELL DIFFERENTIATION AND THE ANTIBODY RESPONSE
- SOMATIC HYPERMUTATION AND CLASS-SWITCH RECOMBINATION
- FURTHER READING
- 10. Antibodies
- Abstract
- ANTIBODY STRUCTURAL AND SEROLOGICAL VARIATIONS
- ANTIGEN–ANTIBODY INTERACTIONS
- ANTIBODY-EFFECTOR FUNCTIONS
- FC RECEPTORS
- ANTIBODY ENGINEERING
- FURTHER READING
- 11. Immunological Tolerance
- Abstract
- GENERATION OF AUTOREACTIVE ANTIGEN RECEPTORS DURING LYMPHOCYTE DEVELOPMENT
- T-CELL TOLERANCE
- REGULATORY T CELLS
- T-CELL ANERGY AND DELETION
- B-CELL TOLERANCE
- FURTHER READING
- 12. Regulation of the Immune Response
- Abstract
- T-CELL AND B-CELL REGULATION BY ANTIGEN
- REGULATION BY ANTIGEN-PRESENTING CELLS
- T-CELL REGULATION OF THE IMMUNE RESPONSE
- IMMUNE REGULATION BY SELECTIVE CELL MIGRATION
- REGULATORY T CELLS
- REGULATION OF THE IMMUNE RESPONSE BY IMMUNOGLOBULINS
- APOPTOSIS IN THE IMMUNE SYSTEM
- METABOLIC REGULATION OF THE IMMUNE RESPONSE
- CROSS-SYSTEM REGULATION OF IMMUNE RESPONSES
- FURTHER READING
- 13. Immune Responses in Tissues
- Abstract
- TISSUE-SPECIFIC IMMUNE RESPONSES
- IMMUNE REACTIONS IN THE CENTRAL NERVOUS SYSTEM
- IMMUNE REACTIONS IN THE EYE
- IMMUNE RESPONSES IN THE GUT
- IMMUNE RESPONSES IN THE LUNG
- IMMUNE RESPONSES IN THE LIVER
- IMMUNE RESPONSES IN THE SKIN
- CONCLUSIONS
- FURTHER READING
- Section 3: Defence Against Infectious Agents
- 14. Immunity to Viruses
- Abstract
- INNATE IMMUNE DEFENCES AGAINST VIRUSES
- ADAPTIVE IMMUNE RESPONSES TO VIRAL INFECTION
- VIRUS STRATEGIES TO EVADE HOST IMMUNE RESPONSES
- PATHOLOGICAL CONSEQUENCES OF IMMUNE RESPONSES INDUCED BY VIRAL INFECTIONS
- FURTHER READING
- Further Reading
- 15. Immunity to Bacteria and Fungi
- Abstract
- BACTERIAL INFECTIONS
- INNATE IMMUNITY TO BACTERIA
- LYMPHOCYTE-INDEPENDENT EFFECTOR SYSTEMS
- ANTIBODY-DEPENDENT ANTIBACTERIAL DEFENCES
- BACTERIAL KILLING BY PHAGOCYTES
- DIRECT ANTIBACTERIAL ACTIONS OF T CELLS
- IMMUNOPATHOLOGICAL REACTIONS INDUCED BY BACTERIA
- FUNGAL INFECTIONS
- FURTHER READING
- 16. Immunity to Protozoa and Worms
- Abstract
- PARASITE INFECTIONS
- IMMUNE DEFENCES AGAINST PARASITES
- INNATE IMMUNE RESPONSES
- ADAPTIVE IMMUNE RESPONSES TO PARASITES
- IMMUNE EFFECTOR CELLS
- PARASITE ESCAPE MECHANISMS
- IMMUNOPATHOLOGICAL CONSEQUENCES OF PARASITE INFECTIONS
- FURTHER READING
- FURTHER READING
- 17. Vaccination
- Abstract
- VACCINATION
- ANTIGEN PREPARATIONS USED IN VACCINES
- ADJUVANTS
- VACCINE ADMINISTRATION
- VACCINE EFFICACY AND SAFETY
- VACCINES SUCCESS RATES
- PASSIVE IMMUNIZATION
- IMMUNIZATION AGAINST NON-INFECTIOUS CONDITIONS
- NEW VACCINE TECHNOLOGIES
- FURTHER READING
- Section 4: Immunodeficiency
- 18. Primary Immunodeficiencies
- Abstract
- B-LYMPHOCYTE DEFICIENCIES
- T-LYMPHOCYTE DEFICIENCIES
- DISORDERS OF IMMUNE REGULATION
- IMMUNODEFICIENCY SYNDROMES
- GENETIC DEFECTS OF PHAGOCYTES
- IMMUNODEFICIENCIES WITH SELECTIVE SUSCEPTIBILITY TO INFECTIONS
- GENETIC DEFICIENCIES OF COMPLEMENT PROTEINS
- GENETIC VARIATION AFFECTING COVID-19 DISEASE
- FURTHER READING
- 19. AIDS, Secondary Immunodeficiency and Immunosuppression
- Abstract
- OVERVIEW
- NUTRIENT DEFICIENCIES
- IMMUNODEFICIENCY SECONDARY TO DRUG THERAPIES
- OTHER CAUSES OF SECONDARY IMMUNODEFICIENCIES
- Further Reading
- Section 5: Immune Responses Against Tissues
- 20. Autoimmunity and Autoimmune Disease
- Abstract
- AUTOIMMUNITY AND AUTOIMMUNE DISEASE
- GENETIC FACTORS IN AUTOIMMUNITY
- AUTOIMMUNITY AND AUTOIMMUNE DISEASE
- INDUCTION OF AUTOIMMUNITY
- AUTOIMMUNE PROCESSES AND PATHOLOGY
- AUTOANTIBODIES FOR DIAGNOSIS, PROGNOSIS AND MONITORING
- TREATMENT OF AUTOIMMUNE DISEASES
- ‘BIOLOGICS’: KEY PLAYERS IN THE TREATMENT OF AUTOIMMUNE DISEASE
- FURTHER READING
- 21. Transplantation and Rejection
- Abstract
- TRANSPLANTATION IN CLINICAL PRACTICE
- GENETIC BARRIERS TO TRANSPLANTATION
- GRAFT REJECTION
- IMMUNE EFFECTOR MECHANISMS IN GRAFT REJECTION
- PREVENTING REJECTION
- FUTURE DIRECTIONS IN TRANSPLANT IMMUNOLOGY
- FURTHER READING
- 22. Immunity to Cancers
- Abstract
- TUMOUR IMMUNITY IN THE PRIMARY HOST
- CHARACTERIZATION OF TUMOUR ANTIGENS
- ANTI-TUMOUR IMMUNE RESPONSES
- IMMUNOTHERAPY FOR HUMAN CANCER
- FURTHER READING
- Section 6: Hypersensitivity
- 23. Immediate Hypersensitivity (Type I)
- Abstract
- CLASSIFICATION OF HYPERSENSITIVITY REACTIONS
- HISTORICAL PERSPECTIVE ON IMMEDIATE HYPERSENSITIVITY
- CHARACTERISTICS OF TYPE I REACTIONS
- CHARACTERISTICS OF ALLERGENS
- MEDIATORS RELEASED BY MAST CELLS AND BASOPHILS
- GENETIC ASSOCIATIONS WITH ASTHMA
- SKIN TESTS FOR DIAGNOSIS AND TO GUIDE TREATMENT
- ALLERGENS CONTRIBUTE TO ASTHMA
- TREATMENTS FOR TYPE I HYPERSENSITIVITY
- FURTHER READING
- FURTHER READING
- 24. Hypersensitivity (Type II)
- Abstract
- MECHANISMS OF TISSUE DAMAGE
- TYPE II REACTIONS AGAINST BLOOD CELLS AND PLATELETS
- TYPE II HYPERSENSITIVITY REACTIONS IN TISSUES
- AUTOANTIBODIES AND AUTOIMMUNE DISEASE
- FURTHER READING
- FURTHER READING
- 25. Hypersensitivity (Type III)
- Abstract
- THE ROLE OF IMMUNE COMPLEXES IN HUMAN DISEASE
- IMMUNE COMPLEXES AND INFLAMMATION
- EXPERIMENTAL MODELS OF IMMUNE COMPLEX DISEASES
- IMMUNE COMPLEXES CLEARANCE BY THE MONONUCLEAR PHAGOCYTE SYSTEM
- IMMUNE COMPLEX DEPOSITION IN TISSUES
- DIAGNOSIS OF IMMUNE COMPLEX DISEASE
- FUTURE CONSIDERATIONS: CAR T-Cell Therapy
- FURTHER READING
- 26. Hypersensitivity (Type IV)
- Abstract
- DELAYED-TYPE HYPERSENSITIVITY REACTIONS
- TYPE IVa REACTIONS REQUIRE MACROPHAGES AS EFFECTOR CELLS
- TYPE IVb REACTIONS INVOLVE EOSINOPHILS AS EFFECTOR CELLS
- TYPE IVC REACTIONS INVOLVE CD8+ T CELLS AS EFFECTOR CELLS
- TYPE IVd REACTIONS INVOLVE NEUTROPHILS AS EFFECTOR CELLS
- FURTHER READING
- FURTHER READING
- Critical Thinking: Explanations
- 1 SPECIFICITY AND MEMORY IN VACCINATION
- 2 DEVELOPMENT OF THE IMMUNE SYSTEM
- 3 ROLE OF ADHESION MOLECULES IN T-CELL MIGRATION
- 4 COMPLEMENT DEFICIENCY
- 5 ROLE OF MACROPHAGES IN TOXIC SHOCK SYNDROME
- 6 MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION
- 7 ANTIGEN PROCESSING AND PRESENTATION
- 8 MECHANISMS OF CYTOTOXICITY
- 9 DEVELOPMENT OF THE ANTIBODY RESPONSE
- 10 SPECIFICITY OF ANTIBODIES
- 11 IMMUNOLOGICAL TOLERANCE
- 12 REGULATION OF THE IMMUNE RESPONSE
- 13 IMMUNE REACTIONS IN THE GUT
- 14 VIRUS–IMMUNE SYSTEM INTERACTIONS
- 15 IMMUNOENDOCRINE INTERACTIONS IN RESPONSE TO INFECTION
- 16 IMMUNITY TO PROTOZOA AND HELMINTHS
- 17 VACCINATION
- 18 HYPER-IgM IMMUNODEFICIENCY
- 19 SECONDARY IMMUNODEFICIENCY
- 20 AUTOIMMUNITY AND AUTOIMMUNE DISEASE
- 21 TRANSPLANTATION
- 22 IMMUNITY TO CANCERS
- 23 Severe Anaphylactic Shock
- 24 BLOOD GROUPS AND HAEMOLYTIC DISEASE OF THE NEWBORN
- 25 TYPE III SERUM SICKNESS AFTER FACTOR IX ADMINISTRATION
- 26 Hypersensitivity Type IV Reaction
- Glossary
- INDEX
- Confidence is ClinicalKey
- No. of pages: 448
- Language: English
- Edition: 10
- Published: May 14, 2025
- Imprint: Elsevier
- Paperback ISBN: 9780443248894
- Paperback ISBN: 9780443245961
- eBook ISBN: 9780443248900
DM
David Male
David Male is Professor of Biology in the Department of Life Sciences at The Open University, Milton Keynes.
Affiliations and expertise
Professor of Biology, Department of Life Sciences, The Open University, Milton Keynes, UKRP
R. Stokes Peebles
R. Stokes Peebles is Professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University Medical Center, Nashville, Tennessee.
Affiliations and expertise
Professor of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USAVM
Victoria Male
Affiliations and expertise
Sir Henry Dale Fellow, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom