Imaging Neuroinflammation
- 1st Edition, Volume 9 - April 13, 2023
- Imprint: Academic Press
- Authors: Cornelia Laule, John D Port
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 7 7 1 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 7 2 2 4 - 6
Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available… Read more
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Request a sales quoteImaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.This book is an authoritative reference on imaging neuroinflammation, MRI, neuroinflammation, MR Spectroscopy of inflammation, Iron imaging in inflammation, and more.
- Explains how inflammation in the central nervous system impacts tissue microstructure.
- Presents imaging methods that are useful for assessing neuroinflammation.
- Describes preclinical models of neuroinflammation.
- Summarizes the role of neuroinflammation in various human injury and disease states
Physicists, radiologists, neurologists, neuroscientists, and imaging scientists working in MRI, PET and neuroinflammation
- Cover image
- Title page
- Table of Contents
- Series page
- Copyright
- List of contributors
- Preface
- Part 1 Overview
- Chapter 1: Molecular and tissue basis of neuroinflammation in health and disease
- Abstract
- General introduction
- Blood-brain barrier alterations
- Conclusion
- References
- Part 2 Imaging approaches to inflammation
- Chapter 2: Sensitivity and specificity of diffusion MRI to neuroinflammatory processes
- Abstract
- What is diffusion MRI?
- Sensitivity of diffusion MRI to cellular inflammatory processes
- Specificity of diffusion MRI to cellular inflammatory processes
- Conclusion and outlook
- References
- Chapter 3: Iron imaging in neuroinflammation
- Abstract
- Introduction
- Magnitude techniques and relaxation time measurements
- Phase-based iron imaging
- Susceptibility-based iron quantification
- Miscellaneous considerations
- Conclusions
- Acknowledgments
- References
- Chapter 4: MRS in neuroinflammation
- Abstract
- Abbreviations
- Introduction
- Brain metabolism accessible with MRS
- MRS data acquisition
- MRS data analysis
- Summary
- References
- Further reading
- Chapter 5: Magnetization transfer and chemical exchange saturation transfer in neuroinflammation
- Abstract
- Abbreviations
- Introduction
- Central nervous system inflammation
- Magnetization transfer as an umbrella term
- MTC phenomenon and observations
- The MT experiment
- Quantification of the MT effect
- MT imaging of acute inflammation: Histopathological and clinical validations
- MT imaging of chronic inflammation: Histopathological and clinical validations
- MT applications: Concluding remarks
- Chemical exchange saturation transfer
- Confounds to the asymmetry measurement of the CEST effect
- Summary of confounds
- CEST imaging of acute inflammation: Histopathological and clinical validations
- CEST imaging of chronic inflammation: Histopathological and clinical validations
- CEST applications: Concluding remarks
- Unmet needs and application opportunities
- Conclusion
- References
- Chapter 6: Gadolinium-based imaging of the blood brain barrier and brain waste clearance pathways
- Abstract
- Introduction
- Brain waste clearance pathways
- Gadolinium-based magnetic resonance imaging of brain waste clearance pathways and blood-brain barrier disruption
- Gadolinium-based MRI techniques and the disrupted blood-brain barrier
- Conclusions
- References
- Chapter 7: Magnetic particle imaging
- Abstract
- In vivo cellular imaging with magnetic resonance imaging
- In vivo cellular imaging with magnetic particle imaging
- Basic principles of MPI
- Nanoparticles for MPI
- Analysis and quantification of MPI data
- MPI of inflammation
- MPI in the brain
- Challenges and limitations of MPI
- Future of MPI cell tracking
- References
- Chapter 8: Positron emission tomography imaging of neuroinflammation
- Abstract
- Abbreviations
- Introduction to neuroinflammation
- Biomarkers of neuroinflammation
- Conclusion
- Acknowledgment
- References
- Part 3 Animal models
- Chapter 9: The use of animal models of neuroinflammation for imaging studies
- Abstract
- Introduction
- Animal models of central nervous system neuroinflammation
- Hypoxia
- Sex and hormone differences in animal models of CNS inflammation
- Gut microbiome—CNS axis
- Applicability and clinical relevance: Are there bad animal models of disease?
- Developing imaging methods to study CNS inflammation
- Gadolinium as a marker of neuroinflammation
- Inflammatory components for imaging consideration
- Imaging physiological, microstructural, and biochemical changes
- New horizons
- Acknowledgments
- References
- Part 4 Human inflammation-based diseases
- Chapter 10: Stroke
- Abstract
- Introduction
- Stroke pathophysiology
- Neuroinflammation in stroke
- The influence of systemic and neuroinflammation on stroke recovery
- Dynamic contrast enhanced imaging
- Diffusion imaging
- Magnetic resonance spectroscopy
- Positron emission tomography
- Superparamagnetic particles of iron oxide enhanced MRI
- Conclusion
- References
- Chapter 11: Central nervous system vasculitis
- Abstract
- Historical diagnostic approach
- Vessel wall magnetic resonance imaging (VWMRI)
- Differential diagnosis
- Combined value of biopsy and VWMRI
- Summary
- References
- Further reading
- Chapter 12: Dementia
- Abstract
- Abbreviations
- Dementia and inflammation
- In vivo imaging of inflammation in dementia
- Beyond TSPO PET: Other targets and novel tracers in dementia
- Conclusion
- References
- Chapter 13: Parkinson's disease
- Abstract
- Introduction
- Epidemiological evidence
- Genetic evidence
- Pathology and biology of inflammation
- Blood and CSF biomarkers
- Neuroimaging—Positron emission tomography
- Conclusion
- References
- Chapter 14: Amyotrophic lateral sclerosis
- Abstract
- Introduction
- Clinical landscape of ALS
- Neuroinflammation in ALS
- Imaging signatures of neuroinflammation in ALS
- Summary and future directions
- Conclusions
- References
- Chapter 15: Multiple sclerosis
- Abstract
- Introduction
- Part 1: Timeline of white matter lesion development
- Part 2: Inflammatory changes in nonlesioned white matter
- Part 3: Inflammatory changes in the cortex and meninges of MS patients
- Conclusion
- References
- Chapter 16: Pediatric leukodystrophies
- Abstract
- Introduction
- Aicardi-Goutières syndrome (AGS)
- Alexander disease
- Krabbe disease
- Metachromatic leukodystrophy (MLD)
- Vanishing white matter disease (VWMD)
- X-linked adrenoleukodystrophy (ALD)
- Conclusion
- References
- Chapter 17: Lupus
- Abstract
- Introduction to SLE and clinical aspects of NPSLE
- Conventional MRI
- Diffusion-weighted MRI
- Functional MRI
- Perfusion MRI
- Other imaging modalities for assessing SLE
- Conclusion
- References
- Chapter 18: Autoimmune encephalitis
- Abstract
- What is autoimmune encephalitis?
- Why is imaging important?
- What we will cover
- Limbic encephalitis
- PCD and autoimmune ataxia
- Brainstem encephalitis
- Movement disorders and involvement of basal ganglia, thalamus, and hypothalamus
- Immune checkpoint inhibitors (ICI)
- Encephalomyelitis and specific antibody syndromes
- Other differential diagnoses
- Encephalitis with normal MRI
- Body imaging
- Summary
- References
- Chapter 19: Schizophrenia spectrum disorders
- Abstract
- Abbreviations
- Introduction
- Neuroinflammation
- 1H-MRS
- Chemical exchange saturation transfer (CEST)
- Diffusion imaging
- Gadolinium-based imaging
- Positron emission tomography translocator protein (PET TSPO)
- Conclusion
- References
- Index
- Edition: 1
- Volume: 9
- Published: April 13, 2023
- No. of pages (Paperback): 512
- No. of pages (eBook): 512
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323917711
- eBook ISBN: 9780323972246
CL
Cornelia Laule
Dr. Cornelia (Corree) Laule is a physicist who has been involved with nuclear magnetic resonance and magnetic resonance imaging research for more than 25 years. She completed a postdoctoral fellowship in neuropathology focusing on MRI pathology correlation studies in multiple sclerosis brain tissue. She has been a faculty member at the University of British Columbia since 2013. Dr. Laule’s main interests are the development, validation, and application of quantitative magnetic resonance methods for brain and spinal cord imaging with emphasis on myelin, axons, and inflammation.
Affiliations and expertise
Associate Professor, Department of Radiology and Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, CanadaJP
John D Port
Dr. John D. Port received his BS in electrical engineering and computer science from MIT in 1986, then attended the University of Illinois at Chicago for his MD and PhD training. He completed his radiology residency and fellowship at Johns Hopkins Hospital in 2000 and has been working at Mayo Clinic since. Dr. Port’s main interests are the applications of novel magnetic resonance spectroscopy and imaging techniques to numerous psychiatric and neurological diseases, including demyelinating disorders.
Affiliations and expertise
Professor of Radiology and Associate Professor of Psychiatry at Mayo Clinic in Rochester, MN, United States.Read Imaging Neuroinflammation on ScienceDirect