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2nd Edition - July 9, 2020
Editors: Shuguang Ma, Swapan Chowdhury
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last… Read more
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.
Drug metabolism scientists and toxicologists, medicinal chemists, clinical chemists, non-clinical and clinical pharmacologists in the pharmaceutical and biotechnology industries, scientists working in organizations for pharmacokinetic studies and quality control labs, biochemists working in metabolomics. Researchers and graduate students in pharmaceutical sciences, pharmacology, translational sciences, biochemistry, drug metabolism and pharmacokinetics
Part I: Techniques for Identifying and Quantifying Drugs and Metabolites
1. Bioanalysis of Small and Large Molecule Drugs, Metabolites, and Biomarkers by LC-MS
2. Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites
3. High-resolution mass spectrometry-based data acquisition and data mining technologies for detecting and characterizing drug metabolites and herbal medicine components
4. Metabolite Generation and Metabolite Characterization by NMR
5. Application of SFC for bioanalysis
6. AMS in drug development: Exploring the current utility of AMS and future opportunities for Absolute Bioavailability and ADME investigations
Part II: Drug Metabolism Enzymes, Transporters and Drug-Drug Interaction
Part III: Strategy Related to Drug Metabolism and Safety
Part IV: Translational Sciences
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