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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
Concepts, Methods and Translational Sciences
- 2nd Edition - July 9, 2020
- Editors: Shuguang Ma, Swapan Chowdhury
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 0 1 8 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 0 1 9 - 3
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last deca… Read more
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Request a sales quoteIdentification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.
- Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues
- Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included
- Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics
- All chapters are written by experts with a wide range of practical experience from the industry and academia
Drug metabolism scientists and toxicologists, medicinal chemists, clinical chemists, non-clinical and clinical pharmacologists in the pharmaceutical and biotechnology industries, scientists working in organizations for pharmacokinetic studies and quality control labs, biochemists working in metabolomics. Researchers and graduate students in pharmaceutical sciences, pharmacology, translational sciences, biochemistry, drug metabolism and pharmacokinetics
- No. of pages: 708
- Language: English
- Edition: 2
- Published: July 9, 2020
- Imprint: Elsevier Science
- Paperback ISBN: 9780128200186
- eBook ISBN: 9780128200193
SM
Shuguang Ma
Dr. Ma is currently a Principal Scientist in the Department of Drug Metabolism and Pharmacokinetics at Genentech Inc. Previously he was a Senior Principal Scientist at Schering-Plough (now Merck) and a Senior Scientist at Amgen. He received his Ph.D. in Analytical Chemistry from Purdue University under the direction of Professor R. Graham Cooks. He also had two years of postdoctoral training in biological mass spectrometry at Vanderbilt University School of Medicine under Professor Richard Caprioli. Dr. Ma has authored 55 research articles in peer-reviewed journals and 4 book chapters, covering broad areas of mass spectrometry and its applications. His current research interests include the development of novel LC/MS-based techniques for metabolite detection and investigation of biotransformation and bioactivation of xenobiotics.
Affiliations and expertise
Principal Scientist, Department of Drug Metabolism and Pharmacokinetics, Genentech Inc.SC
Swapan Chowdhury
Dr. Chowdhury is currently a Director of DMPK at Takeda Pharmaceutical International Co. in Cambridge, MA, responsible for evaluating metabolism, toxicity, and potential for drug-drug interaction due to modulation of activities of metabolizing enzymes and transporters by compounds in discovery and development. Dr. Chowdhury obtained his Ph.D. from the University of Alberta in 1987. After spending a year and a half as a post-doctoral fellow at the University of Toronto, Dr. Chowdhury joined Rockefeller University as a Research Associate in the laboratory of Professor Brian Chait. At Rockefeller University, Dr. Chowdhury was involved in the early stage of the development of atmospheric pressure ionization (API) mass spectrometry. This early research on API led to the introduction of a novel API system for LC/MS. After leaving Rockefeller University, he worked on the applications of liquid chromatography/mass spectrometry techniques at several non-academic organizations, including at Schering-Plough Research Institute (SPRI), where he worked for fifteen years in the Department of Drug Metabolism and Pharmacokinetics. The focus of his research at SPRI was to investigate the biotransformation of drugs in support of drug discovery and development. He was involved with the development and registration of a number of pharmaceuticals including Temodar, Clarinex, Zetia, Noxafil, Nasonex/Asmanex, and Victrelis. Dr. Chowdhury is an author of nearly 100 original publications covering a broad area of drug metabolism and drug-drug interaction and analytical technologies to evaluate them.
Affiliations and expertise
Director of DMPK, Takeda Pharmaceutical International Co., Cambridge, MA, USARead Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters on ScienceDirect