Hydrogels for Tissue Engineering and Regenerative Medicine

From Fundamentals to Applications

1st Edition - September 18, 2023
Imprint: Academic Press
Editors: J. Miguel Oliveira, Joana Silva-Correia, Rui L. Reis
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 9 4 8 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 2 2 5 - 4

Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resour… Read more

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Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field.

Cover image
Title page
Table of Contents
Copyright
List of Contributors
Preface
Part 1: Fundamentals, open issues and challenges
Chapter 1. Fundamentals of hydrogels I—mechanical characterization
Abstract
1.1 Introduction
1.2 Macroscale characterization of mechanical properties of hydrogels
1.3 Microscale and nanoscale indentation of hydrogels
1.4 Conclusions
Acknowledgments
Declaration of conflict of interest
References
Chapter 2. Fundamentals of hydrogels II—architecture and biodegradability
Abstract
2.1 Hydrogel architecture: structure and preparation
2.2 Hydrogel properties
2.3 Degradation mechanisms
2.4 Conclusions
References
Chapter 3. Natural hydrogels: synthesis, composites, and prospects in wound management
Abstract
3.1 Introduction
3.2 Drug delivery systems
3.3 Hydrogels
3.4 Natural polymers
3.5 Polymer-based systems for compromised wounds
3.6 Challenges in treatment of compromised wounds
3.7 Conclusion
Abbreviations
References
Chapter 4. Elastin-like hydrogels as tissue regeneration scaffolds
Abstract
4.1 Introduction
4.2 Chemically crosslinked elastin-like hydrogel
4.3 Physically crosslinked elastin-like hydrogels
4.4 Conclusions
References
Chapter 5. In silico simulation for designing hydrogels
Abstract
5.1 Introduction
5.2 Down to the atomistic scale (10−10 m)
5.3 Zooming out to the nanoscale (10−9 m)
5.4 The microscale (10−6 m)
5.5 The millimeter scale (10−3 m)
5.6 Machine learning and other open challenges
5.7 Cells and hydrogels
5.8 Conclusions
Acknowledgments
References
Chapter 6. Hydrogel functionalization and crosslinking strategies for biomedical applications
Abstract
6.1 Introduction
6.2 Natural hydrogels
6.3 Synthetic hydrogel
6.4 Conclusion
References
Chapter 7. Sterilization methods
Abstract
7.1 Introduction
7.2 Conventional sterilization methods
7.3 Alternative sterilization methods
7.4 Selection of the ideal sterilization method
7.5 Conclusions
References
Chapter 8. Patent and regulatory issues of hydrogel for tissue engineering and regenerative medicine
Abstract
8.1 Introduction
8.2 Concept of hydrogel in tissue engineering and regenerative medicine applications
8.3 Regulatory consideration of hydrogel-based tissue engineering and regenerative medicine products
8.4 Patents in hydrogel-based tissue regeneration
8.5 Patent search
8.6 Hydrogel in dressings
8.7 Hydrogel in bone repair
8.8 Peptide-based hydrogel
8.9 Two layered hydrogel composites
8.10 Cell-biomaterial-loaded hydrogel
8.11 Biological elastomer
8.12 Decellularized tissue-based hydrogel
8.13 Oxygen generating hydrogel
8.14 Keratin-based hydrogel
8.15 Summary
References
Part 2: Types and processing
Chapter 9. Ionic- and photo-crosslinked hydrogels
Abstract
9.1 Introduction
9.2 Ionic/electrostatic-crosslinking
9.3 Photo-crosslinking
9.4 Conclusion and future trends
Acknowledgments
References
Chapter 10. Enzymatic crosslinked hydrogels
Abstract
10.1 Introduction
10.2 Enzymatic polymer crosslinking reactions
10.3 Advanced crosslinking methodologies
10.4 Conclusion and outlook
Acknowledgements
References
Chapter 11. Thermoresponsive hydrogel: a carrier for tissue engineering and regenerative medicine
Abstract
11.1 Introduction
11.2 Hydrogel in the field of tissue engineering
11.3 Temperature-responsive hydrogel in the field of tissue engineering
11.4 Design criteria for thermoresponsive hydrogel in tissue engineering and regenerative medicine application
11.5 Application of thermoresponsive hydrogels in the field of tissue engineering
11.6 Neural tissue engineering
11.7 Cardiac tissue engineering
11.8 Bone and cartilage tissue engineering
11.9 Skin tissue engineering
11.10 Cornea tissue engineering
11.11 Tendon tissue engineering
11.12 Meniscus tissue engineering
11.13 Summary
Abbreviations
References
Chapter 12. pH-responsive hydrogels: synthesis and physicochemical properties
Abstract
12.1 Introduction
12.2 pH-responsive cationic hydrogels
12.3 pH-responsive acid hydrogels
12.4 Perspectives
References
Chapter 13. Conductive hydrogels for tissue engineering applications
Abstract
13.1 Introduction
13.2 Types and mechanism of conductive hydrogels
13.3 Conductive hydrogel based on conducting material/particles
13.4 Conductive hydrogels based on conducting polymers
13.5 Conclusion
References
Chapter 14. Self-assembling hydrogels based on polymer networks
Abstract
14.1 Host–guest supramolecular polymer hydrogels
14.2 Supramolecular peptide/polymer hydrogels
14.3 Conclusions
Acknowledgments
References
Chapter 15. Memory-shape hydrogels
Abstract
15.1 Introduction
15.2 Memory-shape polymers
15.3 Memory-shape hydrogels
15.4 Applications of memory-shape hydrogels in TERM
15.5 Conclusions and future perspectives
Acknowledgements
References
Chapter 16. Hydrogels formed by polyelectrolyte complexation
Abstract
16.1 Fundamental principles and terms
16.2 Biomimicking electrostatic complexation
16.3 Factors influencing polyelectrolyte charge and complexation outcome
16.4 Classification of hydrogel complexes
16.5 Conclusions
Acknowledgments
References
Chapter 17. Interpenetrating polymer networks hydrogels
Abstract
17.1 Definition and development of interpenetrating polymer network hydrogels
17.2 Classification of interpenetrating polymer network hydrogels
17.3 Functionalities of interpenetrating polymer network hydrogels
17.4 Concluding remarks
References
Chapter 18. Biocomposites hydrogel-based scaffolds in tissue engineering and regeneration
Abstract
18.1 Introduction
18.2 Organic–inorganic hydrogel-based scaffolds
18.3 Conclusions and future perspectives
Acknowledgements
References
Chapter 19. DNA-based programmable hydrogels for tissue engineering and regenerative medicine
Abstract
19.1 Introduction
19.2 Types of DNA hydrogels
19.3 Characterization of DNA hydrogels
19.4 Biomedical application of DNA hydrogels
19.5 Future perspectives and outlook
Acknowledgements
Conflict of interest
References
Part 3: Applications
Chapter 20. Hydrogels as three-dimensional scaffold materials in tissue engineering and as organoid platforms
Abstract
20.1 Introduction
20.2 Classification of hydrogels
20.3 Three-dimensional scaffolds versus three-dimensional embedded cells cultures
20.4 Application of three-dimensional hydrogels as a three-dimensional organoid platform and tissue engineering
20.5 Conclusion and perspectives
References
Chapter 21. Hydrogels as filler materials
Abstract
21.1 Introduction
21.2 Natural hydrogel filler materials
21.3 Synthetic hydrogel filler material
21.4 Physicochemical properties of hydrogel fillers
21.5 Application of hydrogel filler
21.6 Physical form and use of hydrogel filler
21.7 Immunoreaction
21.8 Conclusion
References
Chapter 22. Hydrogels as tissue barriers
Abstract
22.1 Introduction
22.2 Hydrogels as tissue barriers
22.3 Future trends
Acknowledgments
References
Chapter 23. Hydrogels as stents
Abstract
23.1 Introduction
23.2 Urinary stents
23.3 Esophageal stents
23.4 Coronary stents
23.5 Other hydrogel-based stents
23.6 Conclusion
Acknowledgments
References
Chapter 24. Silk hydrogel-based delivery of cell and bioactive molecules for osteochondral tissue engineering applications
Abstract
24.1 Introduction
24.2 Silk hydrogels
24.3 Silk fibroin hydrogels-based delivery vehicles for cell and macromolecule delivery for osteochondral repair
24.4 Advanced manufacturing techniques for fabricating silk hydrogels for osteochondral repair
24.5 Conclusion and future prospects
Acknowledgments
References
Chapter 25. Hydrogels for development of bioinks
Abstract
25.1 Introduction
25.2 Additive manufacturing technologies suitable to process bioinks and process parameters
25.3 Classification and requirements of hydrogels for bioinks: final properties and applications
25.4 Conclusions
References
Chapter 26. Hydrogel-inorganic filler composites for 3D bioprinting
Abstract
26.1 Introduction
26.2 Tuning of properties in hydrogel composites
26.3 Hydrogel-inorganic filler composites and their applications
26.4 Discussion
26.5 Conclusions
References
Chapter 27. Hydrogels for microfluidics
Abstract
27.1 Introduction
27.2 Hydrogels for microfluidics applications
27.3 Future trends
27.4 Conclusions
Acknowledgements
References
Chapter 28. Hydrogels for three-dimensional tissue engineering models
Abstract
28.1 Introduction
28.2 Hydrogels
28.3 Three-dimensional in vitro models
28.4 Concluding remarks
Acknowledgments
References
Chapter 29. Hydrogels for imaging
Abstract
29.1 Introduction
29.2 Opportunities and challenges of hydrogels imaging
29.3 Modalities for hydrogels imaging
29.4 Imaging hydrogels in the clinic
29.5 Conclusions
References
Chapter 30. Hydrogels as dynamic covalent networks for skin repair
Abstract
30.1 Introduction
30.2 The role of dynamic covalent hydrogels in wound healing and skin repair
30.3 Bioengineered dynamic covalent hydrogels as skin-extracellular matrix mimetic materials
30.4 Concluding remarks and future perspectives
Acknowledgments
References
Chapter 31. Hydrogels for cancer treatment
Abstract
31.1 Introduction
31.2 Types of hydrogels and properties
31.3 Hydrogel-based systems in cancer research
31.4 Concluding remarks
Acknowledgments
References
Chapter 32. Natural-based injectable hydrogels for osteoarthritis treatment
Abstract
32.1 Introduction
32.2 Natural-based injectable hydrogels
32.3 Crosslinking methods
32.4 Incorporating cells into injectable hydrogels
32.5 Conclusions and future trends
Acknowledgments
References
Chapter 33. Hydrogels as biologics/gene delivery systems
Abstract
33.1 Introduction
33.2 Hydrogels for musculoskeletal regenerative medicine
33.3 Hydrogels as delivery systems of biologics in musculoskeletal regenerative medicine
33.4 Hydrogels as delivery systems of therapeutic genes in musculoskeletal regenerative medicine
33.5 Conclusions
Acknowledgments
Conflicts of interest
References
Chapter 34. Current design and advances of hydrogel for retinal tissue engineering and regenerative medicine
Abstract
34.1 Introduction
34.2 Tissue engineering and regenerative medicine
34.3 Retinal tissue engineering and regenerative medicine
34.4 Hydrogel-based retinal tissue engineering
34.5 Conclusion (challenges and outlooks)
Abbreviations
Acknowledgments
References
Chapter 35. Hydrogels for dental applications
Abstract
35.1 Introduction
35.2 Fabrication of hydrogel-based biomaterials for dental applications
35.3 Application of hydrogels in dentistry
35.4 Conclusion
References
Chapter 36. Biological applications of hydrogel coatings
Abstract
36.1 Introduction
36.2 Hydrogel coating for drug delivery system
36.3 Hydrogel coating for tissue engineering scaffold
36.4 Hydrogel coating for implantable materials
36.5 Hydrogel coating for biosensors
36.6 Conclusion
References
Chapter 37. Macrophage polarization guided by immunomodulatory hydrogels
Abstract
37.1 The immunomodulatory response
37.2 Short introduction to hydrogels in regenerative medicine
37.3 The ability of hydrogels to guide the immunomodulatory response
37.4 Conclusions
References
Index

J. Miguel Oliveira

J. Miguel Oliveira, BSc, PhD is the Director of Pre-Clinical Research at the FIFA MEDICAL CENTER, Estádio do Dragão, Porto, PT since Fev. 2013. Currently, he is a Lecturer in Doctoral Programme in Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho, PT. He is also an Invited lecturer at the Faculty of Medicine, U. Porto (since Sept. 2013) and Dept. of Polymer Eng., UM, PT. Dr. Oliveira has published over 220 scientific contributions in scientific journals. Miguel Oliveira was approved 17 patents, published 5 books, 3 special issue in scientific journals, and more than 90 book chapters in books with international circulation. In addition, he is member of the advisory board of the Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, The Journal of Experimental Orthopaedics, Journal “Recent Patents on Corrosion Science”, and referee in more than 40 international journals.

Affiliations and expertise

Principal Investigator with Habilitation and Vice President of Institute 3B's, 3B’s Research Group, Institute 3B’s, University of Minho, Braga, Portugal

Joana Silva-Correia

Joana Silva-Correia, BSc, PhD is an Assistant Researcher at 3B’s Research Group of University of Minho. She graduated Applied Biology and successfully completed a PhD degree in Sciences (Biology) at UM, in 2009. Since then she’s worked as team member in several EU and PT funded projects that address different areas for TERM applications. She is/was PI of 4 national and 1 international funded-projects. Dr. Silva-Correia is author of 115 publications: 63 international peer-reviewed papers, 24 book chapters and 28 ISI indexed conference abstracts and proceedings. In addition, she is inventor of 6 international/national granted patents and presented more than 130 communications in major conferences in the field. She received 17 academic scientific awards/distinctions. She’s been acting as referee of several international peer-reviewed journals (15), including some of the most relevant in the field (i.e. Tissue Engineering, ACS Applied Materials and Interfaces, Journal of Tissue Engineering and Regenerative Medicine, among others).

Affiliations and expertise

Assistant Researcher, 3B’s Research Group, University of Minho, Braga, Portugal

Rui L. Reis

Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.

Affiliations and expertise

President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal

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Hydrogels for Tissue Engineering and Regenerative Medicine

From Fundamentals to Applications

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J. Miguel Oliveira

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Rui L. Reis

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