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Human Lymphokines
The Biological Immune Response Modifiers
- 1st Edition - January 1, 1982
- Editor: Amanullah Khan
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 0 6 0 8 0 - 7
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 2 3 5 2 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 2 6 7 - 0
Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17,… Read more
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Request a sales quoteHuman Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.
Contributors
Preface
Acknowledgments
I. Assay Systems: Standardization and Nomenclature
Polyclonal B Cell Activator in Rheumatic Diseases
Interferon Activates Macrophages to Produce Plasminogen Activator
A Standardized Automated Computer Assisted Micro-Assay for Lymphotoxin
Problems Associated with Research on Human MIF
The Motility of the Cells of a Lymphoblastoid Cell, QIMR-WIL, Is Inhibited by Human and Murine Leukocyte Inhibitory Factor
A Standardized and Rapid MIF Assay Using U-937 Cell Line and Optical Density Measurement
Macrophage Activation by Lymphokine Factors (MAF) as Measured by Phagocytosis, Metabolic Products, and Tumor Cell Cytotoxicity: Correlation of Multiparameter Functional Assays
Standardization of the Indirect LIF Test by Reference to Lymphoid Cell-Line Lymphokine (LCL-LK) as a Standard Material
Value of Reference Preparations in Lymphokine Tests
Semimicromodification of the Indirect Migration Inhibition / MIF Production / Test
II. Production And Purification
Induction and Augmentation of Mitogen-Induced Lymphokine Production in Human PBL by Nα-Desacetylthymosin α1
Production of Human Interleukin-2(TCFG) Using Serum Free Culture Conditions
Morphological Characteristics of Interferon-Producing Cells in Human Peripheral Blood
Rapid Production of High Levels of Gamma Interferon by Human Thoracic Duct Leukocytes Stimulated with Staphylococcal Enterotoxin A
Gamma (Immune) Interferon Production by a Permanent Human T-Lymphocyte Cell Line
Purification of Lymphotoxin from RPMI-1788 Cell Line Supernate
The Identification of Two New Classes of Lymphotoxin Released by Lectin Activated Human T Lymphocytes that Possess IG-Like Receptors
Purification of the Alpha-Heavy Class of Human Lymphotoxin to Electrophoretic Homogeneity
Production of Leucocyte Migration Inhibitory Factor (LIF) by Human Natural Killer (NK) Cells
Spontaneous Production of Leucocyte Migration Inhibitory Factor (LIF) by Established Human Lymphoid Cell Lines
Lymphokine Induced Release of Basophilic Histamine: Separation of the Activity into Two Factors
The Physiological Interferon Response: The Sites and the Meaning
Interferons Induced in Human Leukocytes by Mitogens: Production, Partial Purification, and Characterization
III. Biological and Chemical Characterization
Human Interleukin 1: Purification and Properties
Human (T, G)-A—L Specific Helper Factors Possess VH as Well as HLA-DR Determinants
Production and Characterization of Human Gamma Interferon
Human Lymphocyte Production to Neuroendocrine Hormone-Related Substances
Neutrophil Migration Inhibition Factor from T-Lymphocytes (NIF-T): Specific Binding to Human Peripheral Blood Neutrophils and Neutrophil Precursors
Production and Biological Characterisation of Lymphoid Cell-Line Lymphokine (LCL-LK) Preparations
Macrophage Agglutination Activity of Human Plasma Proteins
Purification of Human Lymphokines by High Performance Liquid Chromatography
Human Serum Factor Inducing Giant Fat Cell Formation in Human Bone Marrow Culture: Normal and Leukemic
Human Leukocyte Interferon Comprises a Continuum of
IV. Mechanisms of Action In Vitro and Animal Models
Purification from the Serum of Patients with Rheumatoid Arthritis of a Polyclonal B Cell Activator with Esterase Activity and of Its Low Molecular Weight Inhibitor
Resistance to Natural-Killer Cells' Cytotoxicity and HLA Synthesis: Differing Regulatory Efficiency of the Type-I and Immune Interferons
Use of Cytofluorometric Techniques for Assay of Cell Cycle Regulating Lymphokines
Lymphokine Adjuvant Therapy: Bioassay of Human Lymphokine Fractions in a Mouse Tumor Model
The Species Specificity of Interleukin-2
Effect of Human α-Lymphotoxin on Target-Cell Plasma Membranes
Lymphotoxins: An NK-Like LT System
Selective Lysis of Natural Killer (NK) Sensitive Targets by Soluble Cytotoxic Factors (NKCF)
Phospholipase C Activity in Human Interferons
Mechanisms of Induction of Human Gamma Interferon
Enhancement of Natural Killing Activity by Different Types of Interferon
V. Immunoregulatory Effects
Genetic Regulation of the Immune Response to (T,G)-A—L in the Human
Induction of Concanavalin-A (Con-A) Stimulated Suppressive Factors in Acute Lymphocytic Leukemia (ALL)
Angiogenic Lymphokine from Transformed Lymphocytes. A Key to the Underlying Mechanisms in Angiolymphoproliferative Syndromes (ALPS)
Regulatory Aspects of LIF Production by Con-A Stimulated MNC Cultures
Cystic Fibrosis: Further Characterization of a "New" Cytokine which Modulates Neutrophil and Monocyte Chemotaxis
VI. Clinical Experience
Pre-Clinical and Phase
Phase
Systematic Lymphokine Treatment of Selected Cancer Patients
Hormonal, Haematological, and Acute Phase Protein Responses of Advanced Cancer Patients to the Intravenous Injection of Lymphoid-Cell Lymphokine (LCL-LK)
A Histological Study of Intradermal and Intralesional Injection of Human Lymphoid Cell Line Lymphokine (LCL-LK) in Patients with Advanced Cancer
The Monitoring of the Immunosuppressive Therapy of Systemic Lupus Erythematosus by Means of the MIF Production Test
Phase
Index
- No. of pages: 756
- Language: English
- Edition: 1
- Published: January 1, 1982
- Imprint: Academic Press
- Hardback ISBN: 9780124060807
- Paperback ISBN: 9780124123526
- eBook ISBN: 9780323142670