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From Cellular Mechanisms to Therapeutic Strategies
1st Edition - May 11, 2021
Editors: Calogero Caruso, Giuseppina Candore
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Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms… Read more
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Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging.
The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.
Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging
Offers the ability to access cross-sectional knowledge more easily
Written by expert researchers in biogerontology who are actively involved in various fields within aging research
Graduate and PhD students as well as researchers interested or working in various aspects of aging. Clinical researchers and medical professionals in biogerontology and geriatrics
1. Aging and longevity: An evolutionary approach
2. Demographic aspects of aging
3. Pathobiology of aging: An introduction to age-related diseases
4. Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
5. The role of inflammaging in the development of chronic diseases of older people
6. A new perspective on ROS in aging with an integrated view of the gut microbiota
7. Aging of immune system
8. Vaccination in old age: Challenges and promises
9. Resilience signaling and hormesis in brain health and disease
10. Different components of frailty in the aging subjects—The role of sarcopenia
11. Hormones in aging
12. Chronobiology and chrononutrition: Relevance for aging
13. Nutraceutical approach to age-related diseases—The clinical evidence on cognitive decline
14. Ways to become old: Role of lifestyle in modulation of the hallmarks of aging
15. Nutritional biomarkers in aging research
16. The role of cytomegalovirus in organismal and immune aging
17. Ethics of aging
18. Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?
No. of pages: 382
Published: May 11, 2021
Imprint: Academic Press
Paperback ISBN: 9780128225691
eBook ISBN: 9780128227374
Calogero Caruso is Professor Emeritus in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at University of Palermo. He has authored 371 papers, mostly on ageing and longevity. He was founder and editor in chief of Immunity & Ageing from 2004 to 2018. He was Coordinator of the PhD program in Molecular Medicine and Biotechnology (formerly Pathobiology) (1998-2018). Finally, with Prof. Giuseppina Candore he is responsible for the local unit of the project “Improved Vaccination Strategies for Older Adults (ISOLDA)” just funded by European Commission. The national and international recognition of his scientific achievements in the field of Biogerontology is documented by funded projects, by the number of citations of his papers, by invitations to national and international congresses and meetings, by his activity as a project reviewer and by organization of international conferences.
Affiliations and expertise
Professor Emeritus, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy
Giuseppina Candore is an Associate Professor of General Pathology with the Laboratory of Immunopathology and Immunosenescence in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at University of Palermo. She has authored 244 papers, mostly on ageing and longevity. She is Co-coordinator of Italian Ministerial Project on Centenarians and Longevity, and with Prof. Calogero Caruso she is responsible for the local unit of the project “Improved Vaccination Strategies for Older Adults (ISOLDA)” just funded by European Commission. She is Director of School od Specialty in Clinical Biochemistry and Pathology. The national and international recognition of her scientific achievements in the field of Biogerontology is documented by the number of citations of her papers and by organization of national and international conferences.
Affiliations and expertise
Associate Professor of General Pathology, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy