
Human Aging
From Cellular Mechanisms to Therapeutic Strategies
- 1st Edition - May 11, 2021
- Imprint: Academic Press
- Editors: Calogero Caruso, Giuseppina Candore
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 5 6 9 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 7 3 7 - 4
Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associate… Read more

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Request a sales quoteHuman Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging.
The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.
- Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging
- Offers the ability to access cross-sectional knowledge more easily
- Written by expert researchers in biogerontology who are actively involved in various fields within aging research
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- About the editors
- Preface
- Chapter 1: Aging and longevity: An evolutionary approach
- Abstract
- 1.1: Introduction
- 1.2: Why does aging occur?
- 1.3: Mechanisms of aging
- 1.4: Causality and chance in aging and longevity
- 1.5: Conclusions and future perspectives
- Chapter 2: Demographic aspects of aging
- Abstract
- 2.1: Introduction
- 2.2: Understanding the process: Browsing around the demographic transition theories
- 2.3: Aging inequalities
- 2.4: Conclusions and perspectives
- Chapter 3: Pathobiology of aging: An introduction to age-related diseases
- Abstract
- 3.1: Introduction
- 3.2: Complexity
- 3.3: Hallmarks of aging
- 3.4: Genomic instability
- 3.5: Epigenetic alteration
- 3.6: Deregulated nutrient sensing pathways
- 3.7: Loss of proteostasis
- 3.8: Mitochondrial dysfunction
- 3.9: Telomere attrition
- 3.10: Cellular senescence
- 3.11: Stem cell exhaustion
- 3.12: Altered intercellular communication
- 3.13: Cancer and aging
- 3.14: Conclusion and future perspectives
- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
- Abstract
- 4.1: Introduction
- 4.2: Signaling pathway stimulating the appearance of SASP
- 4.3: SASP components
- 4.4: MiRNA and extracellular vesicles as new regulators and components of SASP
- 4.5: SASP profile in different cell types
- 4.6: Cellular senescence, SASP, and aging
- 4.7: Conclusions and future perspectives
- Chapter 5: The role of inflammaging in the development of chronic diseases of older people
- Abstract
- 5.1: Introduction
- 5.2: Basic mechanisms: Cellular senescence, inflammaging, molecular inflammation, and senoinflammation
- 5.3: Is chronic inflammatory state a common denominator of ARDs?
- 5.4: The case of COVID-19
- 5.5: Proposed interventions to prevent ARDs
- 5.6: Conclusion and future perspective
- Chapter 6: A new perspective on ROS in aging with an integrated view of the gut microbiota
- Abstract
- Acknowledgments
- 6.1: Introduction
- 6.2: The reactive oxygen species
- 6.3: The biological function of ROS
- 6.4: The oxidative stress theory of aging
- 6.5: ROS signaling in gut barrier, inflammation, and dysbiosis of gut microbiota in aging
- 6.6: Conclusion and future perspective
- Chapter 7: Aging of immune system
- Abstract
- 7.1: Introduction
- 7.2: Changes in the adaptive immunity
- 7.3: Changes in the innate immunity
- 7.4: Inflammaging
- 7.5: Conclusions and future perspectives
- Chapter 8: Vaccination in old age: Challenges and promises
- Abstract
- Funding
- 8.1: Introduction
- 8.2: The state of the art
- 8.3: Challenges and promises
- 8.4: Conclusion and future perspectives
- Note added in proof
- Chapter 9: Resilience signaling and hormesis in brain health and disease
- Abstract
- 9.1: Introduction
- 9.2: Regional specificity of brain resilience and vulnerability to stress
- 9.3: Hydrogen sulfide: A resilient signaling molecule in brain disorders
- 9.4: Plant polyphenols improve resilience and brain health via “Vitagenes”
- 9.5: Conclusions and future perspectives
- Chapter 10: Different components of frailty in the aging subjects—The role of sarcopenia
- Abstract
- 10.1: Frailty definition and assessment
- 10.2: Physical frailty and sarcopenia: two sides of the same coin
- 10.3: Cellular and molecular mechanisms of Sarcopenia
- 10.4: Genetic components of sarcopenia
- 10.5: Lifestyle risk factors for sarcopenia
- 10.6: Management of sarcopenia
- 10.7: Conclusions and future perspectives
- Chapter 11: Hormones in aging
- Abstract
- 11.1: Introduction
- 11.2: Endocrine physiology: The role of the pituitary gland and hypothalamus
- 11.3: Gonadal function in aging
- 11.4: Growth hormone and aging
- 11.5: Adrenal function in aging
- 11.6: Thyroid function in aging
- 11.7: Conclusions and future perspective
- Chapter 12: Chronobiology and chrononutrition: Relevance for aging
- Abstract
- 12.1: Introduction
- 12.2: Biorhythms
- 12.3: Central oscillator and peripheral oscillators
- 12.4: Clock-controlled genes
- 12.5: Biological clock modulation and chronodisruption
- 12.6: Diet, circadian rhythm, aging, and longevity
- 12.7: Meals composition for successful aging
- 12.8: Conclusion and future perspectives
- Chapter 13: Nutraceutical approach to age-related diseases—The clinical evidence on cognitive decline
- Abstract
- 13.1: Introduction
- 13.2: Data selection
- 13.3: The state of the art
- 13.4: Conclusions and future perspectives
- Chapter 14: Ways to become old: Role of lifestyle in modulation of the hallmarks of aging
- Abstract
- 14.1: Introduction
- 14.2: Primary hallmarks and lifestyle
- 14.3: Antagonistic hallmarks and lifestyle
- 14.4: Integrative hallmarks and lifestyle
- 14.5: Conclusion and future perspectives
- Chapter 15: Nutritional biomarkers in aging research
- Abstract
- 15.1: Introduction
- 15.2: Minerals (zinc and selenium)
- 15.3: Vitamins
- 15.4: Polyunsaturated fatty acids
- 15.5: Carotenoids
- 15.6: Polyphenols
- 15.7: Molecular biomarkers of aging and nutrition
- 15.8: Conclusions and future perspectives
- Chapter 16: The role of cytomegalovirus in organismal and immune aging
- Abstract
- 16.1: Introduction
- 16.2: Host immune response to CMV
- 16.3: CMV, longevity, and chronic diseases
- 16.4: CMV and immune aging
- 16.5: Conclusion and future perspectives
- Chapter 17: Ethics of aging
- Abstract
- 17.1: Population aging: The challenges
- 17.2: Moral and social attitudes to old age
- 17.3: Ethics of aging
- 17.4: Fair allocation of medical resources
- 17.5: Conclusion and future perspectives
- Chapter 18: Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?
- Abstract
- 18.1: Introduction
- 18.2: Aging and gender medicine
- 18.3: The role of immune-inflammatory responses in aging and age-related diseases, and therapeutic interventions
- 18.4: Slowing aging and fighting age-related diseases
- 18.5: Conclusions and future perspectives
- Index
- Edition: 1
- Published: May 11, 2021
- Imprint: Academic Press
- No. of pages: 382
- Language: English
- Paperback ISBN: 9780128225691
- eBook ISBN: 9780128227374
CC
Calogero Caruso
GC