Hormones and Transport Systems
- 1st Edition, Volume 98 - March 25, 2015
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 3 0 0 8 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 3 0 2 8 - 8
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Read more
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.
The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.
This volume focuses on hormone and transport systems.
- Expertise of the contributors
- Coverage of a vast array of subjects
- In depth current information at the molecular to the clinical levels
Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.
- Former Editors
- Preface
- Chapter One: Dietary I− Absorption: Expression and Regulation of the Na+/I− Symporter in the Intestine
- Abstract
- 1 The Importance of Iodide in Human Health
- 2 The Na+/I− Symporter
- 3 NIS Expression Beyond the Thyroid
- 4 Targeting of NIS to the Plasma Membrane
- 5 Hormonal Regulation of NIS Expression
- 6 Dietary I− Absorption
- 7 Regulation of Intestinal NIS Expression
- 8 Conclusions and Future Directions
- Acknowledgments
- Chapter Two: Apical Iodide Efflux in Thyroid
- Abstract
- 1 Introduction
- 2 Iodide and Thyroid Hormone Synthesis
- 3 Vectorial Transport Processes in Epithelia and Thyroid I− Accumulation
- 4 Chloride Transport Proteins and Luminal I− Translocation
- 5 Conclusions
- Acknowledgment
- Chapter Three: The Sodium/Multivitamin Transporter: A Multipotent System with Therapeutic Implications
- Abstract
- 1 Introduction
- 2 “Active” Transport
- 3 Identification of the Multivitamin Transporter
- 4 The hSMVT Gene
- 5 From Gene to Protein
- 6 Family Ties
- 7 The Predicted Structure of hSMVT
- 8 The (Co)Substrates of hSMVT
- 9 The Characterization of the Cloned hSMVT
- 10 Medical Implications
- 11 Conclusion and Future Directions
- Acknowledgments
- Chapter Four: Regulation of αENaC Transcription
- Abstract
- 1 Introduction
- 2 Dot1a–Af9 Complex Mediates Repression of αENaC
- 3 Dot1a–Af9-Mediated αENaC Repression is Relieved by Multiple Mechanisms
- 4 Transcriptional Changes in ENaC Genes are Translated into Changes in ENaC Activity
- 5 Mouse Models with Genetic Defects in ENaC Regulators
- 6 Regulation of ENaC Activity by Other Regulatory Proteins
- 7 Conclusion and Future Directions
- Acknowledgment
- Chapter Five: Control of ENaC-Mediated Sodium Reabsorption in the Distal Nephron by Bradykinin
- Abstract
- 1 Introduction
- 2 KKS Components
- 3 KKS Expression in the Kidney
- 4 Molecular Mechanisms of the Distal Nephron Sodium Reabsorption
- 5 Regulation of Distal Nephron Sodium Reabsorption by BK: A Role for ENaC
- 6 Signaling Pathways Mediating BK Actions on ENaC
- 7 Salt Sensitivity of BK Actions on Distal Nephron Sodium Reabsorption
- 8 Inhibition of ENaC by BK Promotes ACE-Dependent Natriuresis
- 9 Conclusions
- Acknowledgments
- Chapter Six: Inhibition of ENaC by Endothelin-1
- Abstract
- 1 Introduction
- 2 Regulation of Sodium Reabsorption: The Role of ENaC
- 3 Endothelin Signaling and Control of Blood Pressure
- 4 Collecting Duct: ET-1 and ENaC
- 5 Lung, Smooth Muscle, and Distal Colon: ET-1 and ENaC
- 6 Molecular Mechanisms of Inhibition of ENaC by ET-1
- 7 Conclusions and Future Directions
- Acknowledgments
- Chapter Seven: Pharmacological Regulation of the Cholesterol Transport Machinery in Steroidogenic Cells of the Testis
- Abstract
- 1 Introduction
- 2 Role of T in Health and Well-Being
- 3 T-Replacement Therapy
- 4 Steroid Biosynthesis
- 5 Can Serum Testosterone Levels Be Increased by Stimulating the Leydig Cells Themselves?
- 6 Conclusion
- Acknowledgments
- Chapter Eight: Insulin Transport into the Brain and Cerebrospinal Fluid
- Abstract
- 1 Introduction
- 2 Insulin Synthesis, Secretion, and Action
- 3 Transport of Insulin into the CNS
- 4 The Effects of Insulin on the CNS
- 5 Central Insulin and Leptin as Adiposity Signals
- 6 Conclusion and Future Directions
- Chapter Nine: Regulation of Hormone-Sensitive Renal Phosphate Transport
- Abstract
- 1 Introduction
- 2 Biological Forms of Phosphate
- 3 Renal Phosphate Transporters
- 4 Hormone Regulation of Renal Phosphate Transport
- 5 Other Hormones
- 6 Adapter Proteins Modifying Hormone-Dependent Phosphate Transport
- 7 Genetic Disorders of Renal Phosphate Transport Due to Hormonal Dysregulation
- 8 Regulation of Phosphate in CKD and End Stage Renal Disease
- Chapter Ten: Regulation of Aquaporins by Vasopressin in the Kidney
- Abstract
- 1 Introduction
- 2 Aquaporins in the Kidney
- 3 Vasopressin Signaling
- 4 Aquaporins Regulated by Vasopressin (General Aspects)
- 5 Short-Term Regulation of Aquaporin-2 by Vasopressin
- 6 Long-Term Regulation of Aquaporin-2 by Vasopressin
- 7 Disorders Due to Abnormalities of the Vasopressin–Aquaporin-2 Axis
- 8 Conclusion and Future Directions
- Acknowledgments
- Chapter Eleven: The Structure and Function of the Dopamine Transporter and its Role in CNS Diseases
- Abstract
- 1 Introduction
- 2 The Dopaminergic System
- 3 The Dopamine Transporter
- 4 The Dopamine Transporter and Disease
- 5 Pharmacological Targeting of the DAT
- 6 Conclusion
- Acknowledgments
- Chapter Twelve: Regulation of the Norepinephrine Transporter by Endothelins: A Potential Therapeutic Target
- Abstract
- 1 Introduction
- 2 Neuronal NE Uptake
- 3 Endothelins
- 4 ET and NE Neuronal Uptake Interaction
- 5 Conclusion
- Acknowledgments
- Chapter Thirteen: Vitamin D-Enhanced Duodenal Calcium Transport
- Abstract
- 1 Introduction
- 2 Sources of 1,25(OH)2D3 for Stimulation of Duodenal Calcium Transport
- 3 Vitamin D-Enhanced Transcellular Calcium Transport
- 4 Vitamin D-Enhanced Paracellular Calcium Transport
- 5 Regulation of Calcium Transport by the Parathyroid–Kidney–Intestinal Axis
- 6 Novel Concept of the Bone–Kidney–Intestinal Axis of Calcium Regulation
- 7 Vitamin D-Independent Intestinal Calcium Transport
- 8 Conclusion and Perspectives
- Acknowledgments
- Chapter Fourteen: Endocannabinoid Transport Revisited
- Abstract
- 1 The Endocannabinoid System
- 2 AEA Cellular Uptake and Intracellular Transport—A Primer
- 3 AEA and 2-AG Transport at the Synapse
- 4 Transport of 2-AG and Other Suggested Endocannabinoids
- 5 Conclusions
- Acknowledgments
- Chapter Fifteen: Adenosine Transporters and Receptors: Key Elements for Retinal Function and Neuroprotection
- Abstract
- 1 Introduction
- 2 The Nucleoside Adenosine in the CNS
- 3 Neuromodulatory Actions of Adenosine in the Retina
- 4 Nucleoside Transporters
- 5 Adenosine and Neuroprotection in the Retina
- 6 Concluding Remarks
- Index
- Edition: 1
- Volume: 98
- Published: March 25, 2015
- Language: English
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United StatesRead Hormones and Transport Systems on ScienceDirect