
Hormones and Transport Systems
- 1st Edition, Volume 98 - March 25, 2015
- Imprint: Academic Press
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 3 0 0 8 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 3 0 2 8 - 8
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteFirst published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.
The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.
This volume focuses on hormone and transport systems.
- Expertise of the contributors
- Coverage of a vast array of subjects
- In depth current information at the molecular to the clinical levels
Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.
- Former Editors
- Preface
- Chapter One: Dietary I− Absorption: Expression and Regulation of the Na+/I− Symporter in the Intestine
- Abstract
- 1 The Importance of Iodide in Human Health
- 2 The Na+/I− Symporter
- 3 NIS Expression Beyond the Thyroid
- 4 Targeting of NIS to the Plasma Membrane
- 5 Hormonal Regulation of NIS Expression
- 6 Dietary I− Absorption
- 7 Regulation of Intestinal NIS Expression
- 8 Conclusions and Future Directions
- Acknowledgments
- Chapter Two: Apical Iodide Efflux in Thyroid
- Abstract
- 1 Introduction
- 2 Iodide and Thyroid Hormone Synthesis
- 3 Vectorial Transport Processes in Epithelia and Thyroid I− Accumulation
- 4 Chloride Transport Proteins and Luminal I− Translocation
- 5 Conclusions
- Acknowledgment
- Chapter Three: The Sodium/Multivitamin Transporter: A Multipotent System with Therapeutic Implications
- Abstract
- 1 Introduction
- 2 “Active” Transport
- 3 Identification of the Multivitamin Transporter
- 4 The hSMVT Gene
- 5 From Gene to Protein
- 6 Family Ties
- 7 The Predicted Structure of hSMVT
- 8 The (Co)Substrates of hSMVT
- 9 The Characterization of the Cloned hSMVT
- 10 Medical Implications
- 11 Conclusion and Future Directions
- Acknowledgments
- Chapter Four: Regulation of αENaC Transcription
- Abstract
- 1 Introduction
- 2 Dot1a–Af9 Complex Mediates Repression of αENaC
- 3 Dot1a–Af9-Mediated αENaC Repression is Relieved by Multiple Mechanisms
- 4 Transcriptional Changes in ENaC Genes are Translated into Changes in ENaC Activity
- 5 Mouse Models with Genetic Defects in ENaC Regulators
- 6 Regulation of ENaC Activity by Other Regulatory Proteins
- 7 Conclusion and Future Directions
- Acknowledgment
- Chapter Five: Control of ENaC-Mediated Sodium Reabsorption in the Distal Nephron by Bradykinin
- Abstract
- 1 Introduction
- 2 KKS Components
- 3 KKS Expression in the Kidney
- 4 Molecular Mechanisms of the Distal Nephron Sodium Reabsorption
- 5 Regulation of Distal Nephron Sodium Reabsorption by BK: A Role for ENaC
- 6 Signaling Pathways Mediating BK Actions on ENaC
- 7 Salt Sensitivity of BK Actions on Distal Nephron Sodium Reabsorption
- 8 Inhibition of ENaC by BK Promotes ACE-Dependent Natriuresis
- 9 Conclusions
- Acknowledgments
- Chapter Six: Inhibition of ENaC by Endothelin-1
- Abstract
- 1 Introduction
- 2 Regulation of Sodium Reabsorption: The Role of ENaC
- 3 Endothelin Signaling and Control of Blood Pressure
- 4 Collecting Duct: ET-1 and ENaC
- 5 Lung, Smooth Muscle, and Distal Colon: ET-1 and ENaC
- 6 Molecular Mechanisms of Inhibition of ENaC by ET-1
- 7 Conclusions and Future Directions
- Acknowledgments
- Chapter Seven: Pharmacological Regulation of the Cholesterol Transport Machinery in Steroidogenic Cells of the Testis
- Abstract
- 1 Introduction
- 2 Role of T in Health and Well-Being
- 3 T-Replacement Therapy
- 4 Steroid Biosynthesis
- 5 Can Serum Testosterone Levels Be Increased by Stimulating the Leydig Cells Themselves?
- 6 Conclusion
- Acknowledgments
- Chapter Eight: Insulin Transport into the Brain and Cerebrospinal Fluid
- Abstract
- 1 Introduction
- 2 Insulin Synthesis, Secretion, and Action
- 3 Transport of Insulin into the CNS
- 4 The Effects of Insulin on the CNS
- 5 Central Insulin and Leptin as Adiposity Signals
- 6 Conclusion and Future Directions
- Chapter Nine: Regulation of Hormone-Sensitive Renal Phosphate Transport
- Abstract
- 1 Introduction
- 2 Biological Forms of Phosphate
- 3 Renal Phosphate Transporters
- 4 Hormone Regulation of Renal Phosphate Transport
- 5 Other Hormones
- 6 Adapter Proteins Modifying Hormone-Dependent Phosphate Transport
- 7 Genetic Disorders of Renal Phosphate Transport Due to Hormonal Dysregulation
- 8 Regulation of Phosphate in CKD and End Stage Renal Disease
- Chapter Ten: Regulation of Aquaporins by Vasopressin in the Kidney
- Abstract
- 1 Introduction
- 2 Aquaporins in the Kidney
- 3 Vasopressin Signaling
- 4 Aquaporins Regulated by Vasopressin (General Aspects)
- 5 Short-Term Regulation of Aquaporin-2 by Vasopressin
- 6 Long-Term Regulation of Aquaporin-2 by Vasopressin
- 7 Disorders Due to Abnormalities of the Vasopressin–Aquaporin-2 Axis
- 8 Conclusion and Future Directions
- Acknowledgments
- Chapter Eleven: The Structure and Function of the Dopamine Transporter and its Role in CNS Diseases
- Abstract
- 1 Introduction
- 2 The Dopaminergic System
- 3 The Dopamine Transporter
- 4 The Dopamine Transporter and Disease
- 5 Pharmacological Targeting of the DAT
- 6 Conclusion
- Acknowledgments
- Chapter Twelve: Regulation of the Norepinephrine Transporter by Endothelins: A Potential Therapeutic Target
- Abstract
- 1 Introduction
- 2 Neuronal NE Uptake
- 3 Endothelins
- 4 ET and NE Neuronal Uptake Interaction
- 5 Conclusion
- Acknowledgments
- Chapter Thirteen: Vitamin D-Enhanced Duodenal Calcium Transport
- Abstract
- 1 Introduction
- 2 Sources of 1,25(OH)2D3 for Stimulation of Duodenal Calcium Transport
- 3 Vitamin D-Enhanced Transcellular Calcium Transport
- 4 Vitamin D-Enhanced Paracellular Calcium Transport
- 5 Regulation of Calcium Transport by the Parathyroid–Kidney–Intestinal Axis
- 6 Novel Concept of the Bone–Kidney–Intestinal Axis of Calcium Regulation
- 7 Vitamin D-Independent Intestinal Calcium Transport
- 8 Conclusion and Perspectives
- Acknowledgments
- Chapter Fourteen: Endocannabinoid Transport Revisited
- Abstract
- 1 The Endocannabinoid System
- 2 AEA Cellular Uptake and Intracellular Transport—A Primer
- 3 AEA and 2-AG Transport at the Synapse
- 4 Transport of 2-AG and Other Suggested Endocannabinoids
- 5 Conclusions
- Acknowledgments
- Chapter Fifteen: Adenosine Transporters and Receptors: Key Elements for Retinal Function and Neuroprotection
- Abstract
- 1 Introduction
- 2 The Nucleoside Adenosine in the CNS
- 3 Neuromodulatory Actions of Adenosine in the Retina
- 4 Nucleoside Transporters
- 5 Adenosine and Neuroprotection in the Retina
- 6 Concluding Remarks
- Index
- Edition: 1
- Volume: 98
- Published: March 25, 2015
- Imprint: Academic Press
- No. of pages: 556
- Language: English
- Hardback ISBN: 9780128030080
- eBook ISBN: 9780128030288
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)