Hormone Receptors: Structures and Functions
- 1st Edition, Volume 123 - September 11, 2023
- Imprint: Academic Press
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 4 5 5 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 4 5 6 - 2
Hormone Receptors: Structures and Functions, Volume 123 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting c… Read more
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Request a sales quoteHormone Receptors: Structures and Functions, Volume 123 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Vitamins and Hormones series
- Updated release includes the latest information on Hormone Receptors
Undergraduates, graduates, academics, and researchers in the field of vitamins and hormones
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Former Editors
- Contributors
- About the editor
- Preface
- Chapter One: Signaling mechanism of growth hormone-releasing hormone receptor
- Abstract
- 1: Overview of growth hormone-releasing hormone (GHRH) and GHRH receptors (GHRH-R)
- 2: Signaling mechanism and regulation of GHRH-R
- 3: Expression and regulation of GHRH-R and the role of GHRH agonists and antagonists in diseases and therapy
- Acknowledgments
- References
- Chapter Two: Unraveling corticotropin-releasing factor family-orchestrated signaling and function in both sexes
- Abstract
- 1: Overview of the CRF family
- 2: Transcriptional regulation of CRF system
- 3: The CRF receptors
- 4: Sex differences mediated by CRF2 in the periphery
- 5: Conclusions and future directions
- Acknowledgments
- References
- Chapter Three: Structures of the arginine-vasopressin and oxytocin receptor signaling complexes
- Abstract
- 1: Arginine-vasopressin and oxytocin receptors, biological functions and therapeutic value
- 2: Antagonist-bound OT receptor structure
- 3: Hormone-bound G protein-coupled V2 and OT receptor signaling complexes
- 4: Hormone-bound β-arrestin1-coupled V2 receptor signaling complex
- 5: Conserved AVP/OT binding site in the receptor family
- 6: Molecular mechanisms of V2R/OTR activation
- 7: Gs/Gq coupling interface in V2/OT receptors
- 8: Gs/βarrestin1 coupling interface in V2 receptor
- 9: Future perspectives: From structure to clinic
- Acknowledgments
- References
- Chapter Four: Growth hormone receptor gene disruption
- Abstract
- 1: Introduction
- 2: GHRKO mice
- 3: Inducible GHRKO mice
- 4: Liver-specific GHRKO mice
- 5: Muscle GHRKO mice
- 6: Adipose tissue GHRKO mice
- 7: Disruption of GHR in brain or specific neurons
- 8: Macrophage-specific GHRKO
- 9: Hematopoietic stem cell GHRKO mice
- 10: Intestine-specific GHRKO
- 11: β cell-specific GHRKO
- 12: Bone-specific GHRKO
- 13: Heart-specific GHRKO mice
- 14: Concluding remarks
- References
- Chapter Five: The three-dimensional structure of insulin and its receptor
- Abstract
- 1: General introduction
- 2: Structure of insulin
- 3: Structure of the insulin receptor
- 4: Concluding remarks
- Acknowledgments
- References
- Chapter Six: Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
- Abstract
- 1: Introduction
- 2: Crystal and nuclear magnetic resonance (NMR) structures of insulin
- 3: Crystal and NMR structures of IGF-1 and IGF-2
- 4: Localization of binding site 1 in insulin
- 5: Kinetic studies and the first evidence for the existence of site 2 in insulin
- 6: Mutagenesis of hypothetical site 2 residues in insulin and in IGF-1 and IGF-2
- 7: Localization of site 2 residues based on cryoEM structures of hormone: Receptor complexes
- 8: Correlation of cryoEM structures with site 2 mutagenesis results in insulin
- 9: Correlation of cryoEM structures with site 2 mutagenesis results in IGF-1
- 10: Correlation of cryoEM structures with site 2 mutagenesis results in IGF-2
- Acknowledgments
- References
- Chapter Seven: A structural perspective of liver X receptors
- Abstract
- 1: Introduction
- 2: Structural features of DBD domain
- 3: Structural features of LBD domain
- 4: Multi-domain structure
- 5: The N-terminal domain
- References
- Chapter Eight: Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease
- Abstract
- 1: Introduction
- 2: Regulation of iron metabolism
- 3: Physiological regulation of hepcidin expression
- 4: Hepcidin regulation by inflammation
- 5: Hepcidin regulation by erythropoiesis
- 6: Hepcidin regulation and hepcidin-independent regulation of iron absorption by hypoxia
- 7: Hepcidin-ferroportin axis regulates iron flows
- 8: Hepcidin-ferroportin axis in disease
- 9: Targeting the hepcidin:ferroportin axis for therapeutic purposes
- 10: Conclusion
- References
- Chapter Nine: Structure-function relationships of the aldosterone receptor
- Abstract
- 1: Nuclear receptor superfamily
- 2: Structural characterization of the MR
- 3: The MR DNA-binding domain (DBD)
- 4: The ligand-binding domain (LBD)
- 5: Coactivators and corepressors
- 6: Conclusions and future directions
- References
- Chapter Ten: Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
- Abstract
- 1: Introduction
- 2: Biologic actions of the 1,25-dihydroxyvitamin D hormone receptor
- 3: Closing comments
- References
- Chapter Eleven: Cryo-EM technique and its application: Structure of steroid hormone receptors
- Abstract
- 1: Introduction
- 2: General cryo-EM approaches and technology
- 3: Structure of steroid hormone receptors using cryo-EM
- 4: Summary and perspectives
- References
- Chapter Twelve: Structure and functions of the N-terminal domain of steroid hormone receptors
- Abstract
- 1: Introduction
- 2: The structure and functions of the SHRs
- 3: The structure and functions of the N-terminal domain (NTD) of the SHRs
- 4: The functional folding of the NTD/AF1 of the SHRs
- 5: Role of coregulatory proteins in the structure and functions of the SHRs' NTD/AF1
- 6: Summary and future perspectives
- References
- Chapter Thirteen: The human glucocorticoid receptor
- Abstract
- 1: Introduction
- 2: Evolution of glucocorticoid receptor
- 3: The human glucocorticoid receptor (hGR)
- 4: Glucocorticoid signaling
- 5: NR3C1 gene polymorphisms
- 6: NR3C1 genetic defects
- 7: Recent advances in tissue glucocorticoid sensitivity
- 8: Conclusions and future perspectives
- References
- Chapter Fourteen: The androgen receptor
- Abstract
- 1: Introduction
- 2: Androgen receptor structure
- 3: Androgen receptor signaling
- 4: Androgen receptor splice variants
- 5: Androgen receptor detection & quantitation
- 6: Androgen receptor pharmacology
- 7: Conclusions and future directions
- Acknowledgments
- References
- Chapter Fifteen: Steroid-receptor coactivator complexes in thyroid hormone-regulation of Xenopus metamorphosis
- Abstract
- 1: Introduction
- 2: Transcriptional regulation by TR and its dual functions in Xenopus development
- 3: A role of histone acetylation in gene regulation by TR
- 4: Critical involvement of steroid-receptor coactivator complexes in regulating metamorphosis by liganded TR
- 5: Conclusion
- Acknowledgment
- References
- Chapter Sixteen: Essential and subtype-dependent function of thyroid hormone receptors during Xenopus metamorphosis
- Abstract
- 1: Introduction
- 2: Molecular mechanisms of gene regulation by TR and their implications in Xenopus development
- 3: Molecular and transgenic studies on TR in Xenopus laevis
- 4: Gene knockout studies in Xenopus tropicalis
- 5: Conclusion
- Acknowledgment
- References
- Chapter Seventeen: Steroid hormone signaling: What we can learn from insect models
- Abstract
- 1: Introduction
- 2: Phylogenetic relationships of biosynthetic pathways and nuclear receptors
- 3: Cholesterol homeostasis
- 4: Hormone transport mechanisms
- 5: Concluding remarks
- Acknowledgments
- References
- Chapter Eighteen: Membrane estrogen receptor and follicle-stimulating hormone receptor
- Abstract
- 1: Gonadotropins and estrogens in ovarian physiology
- 2: Expression and physiology of the FSH receptor
- 3: The membrane estrogen receptor is expressed in the ovary
- 4: A new view of antral follicular growth
- 5: Physiological significance of FSHR and GPER co-expression in the ovary
- 6: Conclusions
- Acknowledgments
- References
- Chapter Nineteen: Structure-function of DHEA binding proteins
- Abstract
- 1: Introduction
- 2: DHEA binds steroid hormone receptors
- 3: DHEA activates hepatic nuclear receptors
- 4: DHEA activates G-protein-coupled receptors (GPCRs)
- 5: DHEA activates GPER1
- 6: DHEA inhibits T-type Ca2+ channels: CaV3.1, CaV3.2 or CaV3.3
- 7: DHEA is an agonist for TRPM3
- 8: DHEA and DHEA-S are neurosteroids
- 9: DHEA-S action via chaperone protein SIG-1R
- 10: DHEA binds NGFR and TRKA
- 11: DHEA and mitochondrial function
- 12: Conclusions and future directions
- References
- Chapter Twenty: Juvenile hormone receptor Methoprene tolerant: Functions and applications
- Abstract
- 1: Introduction
- 2: JH receptor discovery
- 3: Two JH receptor genes identified in fruit flies, moths and butterflies
- 4: JH receptor functions-RNAi studies
- 5: JH receptor functions-gene editing studies
- 6: Development of JH receptor-based applications in agriculture and medicine
- 7: Conclusions and future directions
- Acknowledgments
- References
- Chapter Twenty-One: Structural dynamics of chemokine receptors
- Abstract
- 1: Chemokine receptors
- 2: CXCR4 and CCR5
- 3: Conclusions and future directions
- Acknowledgments
- References
- Edition: 1
- Volume: 123
- Published: September 11, 2023
- No. of pages (Hardback): 686
- No. of pages (eBook): 300
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443134555
- eBook ISBN: 9780443134562
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United StatesRead Hormone Receptors: Structures and Functions on ScienceDirect