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Hepatic Fibrosis

Mechanisms and Targets

  • 1st Edition - April 23, 2022
  • Latest edition
  • Author: Pablo Muriel
  • Language: English

Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrog… Read more

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Description

Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies.

Key features

  • Presents progression from inflammation to fibrosis, with a special focus on the molecular mechanisms involved
  • Didactically explains the participation of cells, cytokines and factors in profibrogenic pathways
  • Illuminates the causative participation of free radicals in liver fibrogenesis
  • Explains the role of gut dysbiosis in chronic liver diseases leading to fibrosis
  • Provides experimental models to study liver fibrosis and describes available, noninvasive monitoring methods

Readership

Basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver diseases, fibrosis, and those interested in molecular biology and mechanisms of diseases. Gastroenterologists, hepatologists, and other physicians. First degree and postgraduate students of medicine and other students in the biological area, molecular biologists, etc. Pharmaceutical companies may find this book useful for the development of new drugs based on the molecular targets described in each chapter

Table of contents

1. Healthy and diseased extracellular matrix of the liver

2. From inflammation to fibrosis

3. Cells, cytokines, and factors involved in profibrogenic pathways

4. Role of free radicals in hepatic fibrogenesis

5. Role of gut dysbiosis in chronic liver disease leading to fibrosis

6. Alcohol-induced fibrosis

7. From fatty liver to nonalcoholic steatohepatitis with fibrosis

8. Viral hepatitis-induced liver fibrosis

9. Biliary fibrosis

10. Experimental models of hepatic fibrosis

11. Monitoring hepatic fibrosis

Product details

  • Edition: 1
  • Latest edition
  • Published: April 27, 2022
  • Language: English

About the author

PM

Pablo Muriel

Dr. Muriel PhD has research experience in the pathophysiology and pharmacology of liver diseases including necrosis, fibrosis and cholestasis; the role of cytokines in liver diseases; and oxidative stress and its relation to liver disease. He has published over 100 articles (original and reviews) in addition to 7 book chapters in the area of the liver and has also directed the thesis on dozens of postgraduate students in the same area over the last 30 years. The majority of his work has been in the Medicine and Pharmacology areas. He shows strong and growing citation counts from 2010-2017.
Affiliations and expertise
Researcher and Professor, Cinvestav-IPN, Mexico City, Mexico

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