Hematopathology

3rd Edition - May 30, 2024
Authors: Elaine Sarkin Jaffe, Daniel A. Arber, Elias Campo, Leticia Quintanilla-Fend, Attilio Orazi, Lisa M. Rimsza, Steven H. Swerdlow
Language: English
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eBook ISBN:
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Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative informati… Read more

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Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Part I. Technical Aspects
Chapter 1. Processing of the Lymph Node Biopsy Specimen
ASSESSING AND PRIORITIZING FRESH TISSUE
GROSS PROCESSING OF THE LYMPH NODE BIOPSY
ROUTINE HISTOLOGIC, HISTOCHEMICAL, AND SPECIAL STAINS
REPORTING THE LYMPH NODE BIOPSY
Pearls and Pitfalls
Chapter 2. Fine-Needle Aspiration of Lymph Nodes
SPECIMEN COLLECTION AND PROCESSING
ANCILLARY STUDIES
NON-NEOPLASTIC ASPIRATES
ASPIRATES OF LYMPHOID NEOPLASMS
LIMITATIONS OF FINE-NEEDLE ASPIRATION
ROLE OF CORE NEEDLE BIOPSY IN LYMPHOMA DIAGNOSIS
Pearls and Pitfalls
Chapter 3. Immunohistochemistry for the Hematopathology Laboratory
INTRODUCTION
BASIC IMMUNOHISTOCHEMISTRY
ANTIGENS OF HEMATOPATHOLOGIC INTEREST
BEYOND DIAGNOSTICS: THE EVOLVING ROLE OF IMMUNOHISTOCHEMISTRY
IN SITU HYBRIDIZATION
APPROACH TO USING IMMUNOHISTOCHEMISTRY
Pearls and Pitfalls
Chapter 4. Flow Cytometry
GENERAL PRINCIPLES
TECHNICAL CONSIDERATIONS
MATURE B-CELL NEOPLASMS
PLASMA CELL NEOPLASMS
MATURE T-CELL NEOPLASMS
NATURAL KILLER CELL NEOPLASMS
FLOW CYTOMETRY IN DIAGNOSIS AND CLASSIFICATION OF ACUTE LEUKEMIA
CHRONIC MYELOID NEOPLASMS
Acknowledgements
Pearls and Pitfalls
Chapter 5. Molecular Pathology of Hematologic Neoplasms
INTRODUCTION
BIOLOGICAL AND TECHNOLOGIC ISSUES
LYMPHOID NEOPLASMS
MYELOID NEOPLASMS
POTENTIAL PITFALLS OF MOLECULAR TESTING
SUMMARY AND CONCLUSIONS
Acknowledgments
Pearls and Pitfalls
Chapter 6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
TYPES OF CHROMOSOMAL ABERRATIONS IN HEMATOLOGIC MALIGNANCIES
CONVENTIONAL CYTOGENETIC METHODS
MOLECULAR CYTOGENETIC METHODS
CLINICAL RELEVANCE OF CHROMOSOMAL ABNORMALITIES IN HEMATOLOGIC MALIGNANCIES
CONCLUSION
Pearls and Pitfalls
Acknowledgments
Part II. Normal and Reactive Conditions of Hematopoietic Tissues
Chapter 7. Normal Lymphoid Organs and Tissues
NORMAL LYMPHOID TISSUES
B-CELL AND T-CELL DIFFERENTIATION
Acknowledgements
Pearls and Pitfalls
Chapter 8. Reactive Lymphadenopathies
FOLLICULAR AND NODULAR PATTERNS
PREDOMINANTLY SINUS PATTERN
INTERFOLLICULAR OR MIXED PATTERNS
DIFFUSE PATTERN
Pearls and Pitfalls
Chapter 9. The Normal Bone Marrow
INTRODUCTION
MEDICAL INDICATIONS FOR BONE MARROW EXAMINATION
COMPONENTS OF A BONE MARROW EVALUATION
COLLECTION OF BONE MARROW ASPIRATE AND CORE BIOPSY
PROCESSING OF MARROW TREPHINE BIOPSY AND ASPIRATE
BONE MARROW EVALUATION
CYTOCHEMISTRY AND HISTOCHEMISTRY
BONE MARROW EXAMINATION AND REPORTING
CONCLUSION
Acknowledgments
Pearls and Pitfalls
Chapter 10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia
EVALUATION OF ANEMIA
EVALUATION OF LEUKOPENIA
EVALUATION OF THROMBOCYTOPENIA
EVALUATION OF SPECIFIC BONE MARROW FAILURE SYNDROMES
Pearls and Pitfalls
Chapter 11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
REACTIVE NEUTROPHILIA
REACTIVE LYMPHOCYTOSIS
REACTIVE EOSINOPHILIA
REACTIVE BASOPHILIA
REACTIVE MONOCYTOSIS
BONE MARROW IN INFECTIOUS DISORDERS
BONE MARROW IN NON-INFECTIOUS SYSTEMIC AND INFLAMMATORY DISORDERS
CONCLUSION
Pearls and Pitfalls
Part III. Lymphoid Neoplasms
Chapter 12. Principles of Classification of Lymphoid Neoplasms
INTRODUCTION
HISTORICAL BACKGROUND
THE ICC AND WHO 5TH ED. PROPOSALS: SIMILARITIES AND DIFFERENCES
CONCLUSION
Pearls and Pitfalls
Section 1. MATURE B-CELL NEOPLASMS
Chapter 13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA
MONOCLONAL B-CELL LYMPHOCYTOSIS
B-CELL PROLYMPHOCYTIC LEUKEMIA
Pearls and Pitfalls
Chapter 14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
DEFINITION OF THE DISEASE
SYNONYMS AND RELATED TERMS
EPIDEMIOLOGY
CLINICAL FEATURES
MORPHOLOGY
IMMUNOPHENOTYPE
MOLECULAR GENETIC FINDINGS
POSTULATED NORMAL COUNTERPART AND PATHOGENESIS
CLINICAL COURSE, TREATMENT, AND PROGNOSIS
DIFFERENTIAL DIAGNOSIS
Pearls and Pitfalls
Chapter 15. Hairy Cell Leukemia
DEFINITION OF DISEASE AND NOMENCLATURE
EPIDEMIOLOGY
ETIOLOGY
CLINICAL FEATURES
MORPHOLOGY
PHENOTYPE
GENETICS AND MOLECULAR FINDINGS
POSTULATED CELL OF ORIGIN AND NORMAL COUNTERPART
VARIANTS
DIFFERENTIAL DIAGNOSIS
CLINICAL COURSE AND TREATMENT
PROGNOSTIC AND PREDICTIVE FACTORS
Pearls and Pitfalls
Chapter 16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
DEFINITION
SYNONYMS AND RELATED TERMS
EPIDEMIOLOGY
ETIOLOGY
CLINICAL FEATURES
MORPHOLOGY
IMMUNOPHENOTYPE
GENETICS
OTHER SPLENIC B-CELL LYMPHOMAS
Pearls and Pitfalls
Chapter 17. Follicular Lymphoma
Definition
Epidemiology
Clinical Features
Morphologic Features
Grading and Terminology
Related B-Cell Lymphomas and Follicular Proliferations
Immunophenotype
Cytogenetic and Genetic Features
Postulated Normal Counterpart and Pathogenesis
Etiology
Clinical Course
Differential Diagnosis
Pearls and Pitfalls
Chapter 18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma
Definition
Synonyms and Related Terms
Epidemiology
Etiology
Histopathology of Acquired Malt
Pathology of Malt Lymphoma
Immunohistochemistry
Genetic Features of Malt Lymphoma
Postulated Cell of Origin
Clinical Course
Differential Diagnosis
Pearls and Pitfalls
Chapter 19. Primary Cutaneous B-Cell Lymphomas
Historical Background
Primary Cutaneous MARGINAL ZONE Lymphoproliferative Disorder
Primary Cutaneous FOLLICLE CENTER Lymphoma
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
Intravascular Large B-Cell Lymphoma
B-Lymphoblastic Lymphoma
Ebv-Positive Mucocutaneous Ulcer and Other Cutaneous Immunodeficiency-Associated B-Cell LymphOproliferative Disorders
Pearls and Pitfalls
Chapter 20. Nodal Marginal Zone Lymphoma
Definition
Epidemiology, Etiology, and Cofactors
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course and Prognostic Factors
PEDIATRIC-TYPE NODAL MARGINAL ZONE LYMPHOMA (PT-NMZL)
Differential Diagnosis
Pearls and Pitfalls
Chapter 21. Mantle Cell Lymphoma
DEFINITION
EPIDEMIOLOGY
CLINICAL MANIFESTATIONS
MORPHOLOGY
IMMUNOPHENOTYPE
MANTLE CELL LYMPHOMA VARIANTS
CYTOGENETIC FINDINGS
MOLECULAR CHARACTERISTICS
POSTULATED CELL OF ORIGIN
MULTISTEP DEVELOPMENT OF MANTLE CELL LYMPHOMA
Clinical Course
PROGNOSTIC PARAMETERS
THERAPY
DIFFERENTIAL DIAGNOSIS
Pearls and Pitfalls
Chapter 22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas
INTRODUCTION
DEFINITIONS, SYNONYMS, AND TERMS
DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
T-CELL/HISTIOCYTE–RICH LARGE B-CELL LYMPHOMA
PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA
INTRAVASCULAR LARGE B-CELL LYMPHOMA
Pearls and Pitfalls
Chapter 23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
Why These Four Entities in One Chapter? A Historical Perspective On the Development of Disease Concepts
BURKITT LYMPHOMA
LARGE/HIGH-GRADE B-CELL LYMPHOMA WITH 11Q ABERRATION
DIFFUSE LARGE B-CELL LYMPHOMA/HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS
PROVISIONAL ENTITY: HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS
HIGH-GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
Pearls and Pitfalls
Chapter 24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
Plasmablastic Lymphoma
Alk-Positive Large B-Cell Lymphoma
Pearls and Pitfalls
Chapter 25. Plasma Cell Neoplasms
Classification Of Plasma Cell Neoplasms
Pathogenesis of Plasma Cell Neoplasms
Multiple Myeloma
Monoclonal Gammopathy Of Undetermined Significance
Plasmacytoma
Immunoglobulin Deposition Diseases
Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome
Pearls and Pitfalls
Chapter 26. Nodular Lymphocyte-Predominant B-Cell Lymphoma
Definition
SYNONYMS AND RELATED TERMS
Historical Background
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Relationship With Progressively Transformed Germinal Centers
Transformation To Diffuse Large B-Cell Lymphoma
Relationship With T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Other Differential Diagnoses
Treatment
Prognosis
Conclusion
Pearls and Pitfalls
Chapter 27. Classic Hodgkin Lymphoma
Definition
Synonyms and Related Terms
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course and Prognostic Factors
Related Lesions and Differential Diagnoses
Pearls and Pitfalls
Chapter 28. Virally Associated B-Cell Lymphoproliferative Disease
Ebv-Associated Lymphoproliferative Disorders
HHV-8-Associated Lymphoproliferative Disorders
Pearls and Pitfalls
Section 2. MATURE T-CELL AND NK-CELL NEOPLASMS
Chapter 29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders
INTRODUCTION
Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
Chronic Active Epstein-Barr Virus Disease
Severe Mosquito Bite Allergy
Hydroa Vacciniforme Lymphoproliferative Disorder
Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood
Extranodal NK/T-Cell Lymphoma, Nasal Type
Extranasal NK/T-Cell Lymphoma
Aggressive Nk-Cell Leukemia
Primary Nodal Epstein-Barr Virus–Positive T/Nk-Cell Lymphoma
Pearls and Pitfalls
Chapter 30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
History and Classification
Definitions
Synonyms and Related Terms
Etiology and Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin and Pathogenesis
Clinical Management and Prognosis
Differential Diagnosis
Pearls and Pitfalls
Chapter 31. T-Cell Prolymphocytic Leukemia
Definition
Consensus Criteria For Diagnosis
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course
Treatment
Differential Diagnosis
Pearls and Pitfalls
Chapter 32. Adult T-Cell Leukemia/Lymphoma
Definition
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics, Molecular Findings, and Role of HTLV-1
Postulated Normal Counterpart
Clinical Course
Differential Diagnosis
Pearls and Pitfalls
Chapter 33. Hepatosplenic T-Cell Lymphoma
Definition
Epidemiology
Etiology
Clinical Features
Morphology
Phenotype
Cytogenetic and Molecular Findings
Postulated Cell of Origin
CLINICAL Course
Differential Diagnosis
Pearls and Pitfalls
Chapter 34. Peripheral T-Cell Lymphoma, Not Otherwise Specified
Definition
SYNONYMS AND RELATED TERMS
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetic and Molecular Characteristics
Variants and Subgroups
Extranodal Peripheral T-Cell Lymphoma, Not Otherwise Specified
Prognosis and Predictive Features
Primary Nodal Epstein-Barr Virus–Positive T/Natural Killer–Cell Lymphoma
Diagnostic Approach To Peripheral T-Cell Lymphoma, Not Otherwise Specified And Differential Diagnoses
Pearls and Pitfalls
Chapter 35. Follicular Helper T-Cell Lymphoma
Definition
Synonyms and Related Terms
Epidemiology
Etiology
Follicular Helper T Cells
Clinical Features
Morphology
Immunophenotype
Genetics
Clinical Course and Prognosis
Differential Diagnosis
Pearls and Pitfalls
Chapter 36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
Definition and Background
Anaplastic Large Cell Lymphoma, Alk Positive
Anaplastic Large Cell Lymphoma, Alk Negative
Breast Implant–Associated Anaplastic Large Cell Lymphoma
Differential Diagnosis of Anaplastic Large Cell Lymphoma
Pearls and Pitfalls
Chapter 37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
Enteropathy-Associated T-Cell Lymphoma
Refractory Celiac Disease
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
Intestinal T-Cell Lymphoma, Not Otherwise Specified
Indolent Natural Killer–Cell and T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract
Pearls and Pitfalls
Chapter 38. Mycosis Fungoides and Sézary Syndrome
Mycosis Fungoides
Sézary Syndrome
Pearls and Pitfalls
Chapter 39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
Definition
SYNONYMS AND RELATED TERMS
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course
Differential Diagnosis
Pearls and Pitfalls
Chapter 40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes
Introduction
Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma
Primary Cutaneous γδ T-Cell Lymphoma
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder
Primary Cutaneous Acral CD8-Positive T-Cell Lymphoproliferative Disorder
Other Types of Cutaneous T-Cell Lymphoma
Pearls and Pitfalls
Section 3. PRECURSOR B-AND T-CELL NEOPLASMS
Chapter 41. Precursor B-Cell and T-Cell Neoplasms
Classification of Precursor Lymphoid Neoplasms
B-Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
T-Cell Lymphoblastic Lymphoma/Lymphoblastic Leukemia
Conclusion
Pearls and Pitfalls
Chapter 42. Acute Leukemias of Ambiguous Lineage
Definitions
Synonyms and Related Terms
Epidemiology
Clinical Features
Diagnostic Criteria and Lineage Assignment
Genetic and Molecular Findings
Clinical Course
Lineage Switch
Differential Diagnosis
Pearls and Pitfalls
Part IV. Myeloid, Histiocytic, and Related Proliferations
Chapter 43. Principles of Classification of Myeloid Neoplasms
Introduction
Evaluation of Myeloid Neoplasms
International Consensus Classification
Conclusion
Acknowledgment
Chapter 44. The Myelodysplastic Syndromes
Incidence
Synonyms and Related Terms
Clinical Features
Laboratory Features
Diagnosis
Classification
Differential Diagnosis
Etiology and Pathogenesis
Conclusion
Pearls and Pitfalls
Chapter 45. Myeloid and Hematologic Neoplasms With Germline Predisposition
Definition and Introduction
Synonyms and Related Terms
Hematologic Neoplasms with Germline Predisposition Without A Constitutional Disorder Affecting Multiple Organ Systems
Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Platelet Disorder
Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Disorder Affecting Multiple Organ Systems
Acute Lymphoblastic Leukemia with Germline Predisposition
Pearls and Pitfalls
Chapter 46. Acute Myeloid Leukemia
SYNONYMS AND RELATED TERMS
EPIDEMIOLOGY
ETIOLOGY
CLINICAL FEATURES
MORPHOLOGY
CYTOCHEMISTRY
IMMUNOPHENOTYPE
GENETICS
PROGNOSIS
ACUTE MYELOID LEUKEMIA DISEASE TYPES
MYELOID PROLIFERATIONS OF DOWN SYNDROME
MYELOID SARCOMA
DIAGNOSTIC QUALIFIERS IN ACUTE MYELOID LEUKEMIA
INTEGRATED APPROACH TO THE DIAGNOSIS OF ACUTE MYELOID LEUKEMIA
Pearls and Pitfalls
Chapter 47. Myeloproliferative Neoplasms
Introduction
Etiology and Pathogenesis
Chronic Myeloid Leukemia (CML)
Chronic Neutrophilic Leukemia (CNL)
Classic Bcr::Abl1-Negative Myeloproliferative Neoplasms
Essential Thrombocythemia (ET)
Primary Myelofibrosis (PMF)
Polycythemia Vera
Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS)
Myeloproliferative Neoplasms, Unclassifiable (MPN-U)
Conclusion
Acknowledgments
Pearls and Pitfalls
Chapter 48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions
Introduction
Chronic Myelomonocytic Leukemia (CMML)
Clonal Cytopenia With Monocytosis of Undetermined Significance and Clonal Monocytosis of Undetermined Significance
Atypical Chronic Myeloid Leukemia (aCML)
Myelodysplastic/Myeloproliferative Neoplasm With Sf3b1 Mutation and Thrombocytosis (MDS/MPN-SF3B1-T)
Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified (MDS/MPN-RS-T, NOS)
Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified (MDS/MPN, NOS)
Myelodysplastic/Myeloproliferative Neoplasm With Isolated Isochromosome (17q) (MDS/MPM With i[17q]; ICC Provisional Subentity)
Acknowledgments
Pearls and Pitfalls
Chapter 49. Mastocytosis
Definition
Synonyms and Related Terms
General Aspects
Epidemiology and Etiology
Postulated Cell of Origin and Normal Counterpart
Genetics and Molecular Findings
Cytologic and Histologic Diagnosis
Differential Diagnosis
Classification
Pearls and Pitfalls
Chapter 50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions
Overview
Introduction
Classification
Clinical Presentation
Approach To Diagnosis
Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangements Of PDGFRA, PDGFRB, FGFR1, FLT3, OR JAK2 or with ETV6::ABL1
CEL, NOS, IHE/IHES, and other Rare Reported Genetic Alterations Associated with Clonal Eosinophilia
Conclusion
Acknowledgments
Pearls and Pitfalls
Chapter 51. Blastic Plasmacytoid Dendritic Cell Neoplasm
Definition
Synonyms and Related Terms
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Cytochemistry
Genetics and Molecular Findings
Postulated Cell of Origin and Normal Counterpart
Clinical Course and Prognosis
Differential Diagnosis
Pearls and Pitfalls
Chapter 52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic
Non-Neoplastic Histiocytic Disorders
Histiocytic and Dendritic Cell Neoplasms
Acknowledgment
Pearls and Pitfalls
Part V. Immunodeficiency Disorders
Chapter 53. The Pathology of Primary Immunodeficiencies
Classification
Synonyms and Related Terms
Epidemiology
Severe Combined Immunodeficiency
PI3K-Related Immunodeficiencies
Defects that Affect Homeostasis of The Immune System
Defects in Synapse Formation and Crosstalk Between Antigen-Presenting Cells and T Cells
Pearls and Pitfalls
Chapter 54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
Definition
Synonyms and Related Terms
Classification
Posttransplant Lymphoproliferative Disorders
Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders in Nontransplant Settings
Pearls and Pitfalls
Part VI. Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
Chapter 55. Bone Marrow Evaluation for Lymphoma
Distinction Between Benign Lymphoid Aggregates and Lymphoma
Non-Hodgkin Lymphoma Involving Bone Marrow
B-Cell Lymphomas Involving Bone Marrow
T-Cell Lymphomas Involving Bone Marrow
Hodgkin Lymphoma Involving Bone Marrow
Nonlymphoid Malignancies That Mimic Lymphomas
Pearls and Pitfalls
Chapter 56. Evaluation of the Bone Marrow After Therapy
Effects of Selected Therapies and Bone Marrow Transplantation
Acute Leukemia or Myelodysplastic Syndrome
Chronic Myeloid Leukemia
BCR::ABL1-Negative Myeloproliferative Neoplasms
Chronic Lymphoproliferative and Plasma Cell Disorders
Other Bone Marrow Changes after Therapy
Pearls and Pitfalls
Chapter 57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes
Introduction
Metastatic Tumors of the Bone Marrow
Primary Tumors of Bone
Vascular Tumors Involving Bone
Other Soft-Tissue Tumors Involving Bone
Malignant Lymphomas Involving Bone and Bone Marrow
Benign Lesions of Bone
Metastatic Tumors to Lymph Nodes
Benign Lymph Node Inclusions
Mesenchymal Proliferations in Lymph Nodes
Conclusion
Pearls and Pitfalls
Chapter 58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions
The Normal Spleen
Gross Examination
Lymphoid Hyperplasia
Castleman Disease
Autoimmune Lymphoproliferative Syndrome
Hodgkin Lymphoma
Non-Hodgkin Lymphomas
Precursor Lymphoid Neoplasms
Systemic or Secondary Mature B-Cell Lymphomas and Leukemias
Primary B-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
Mature T-Cell and Natural Killer–Cell Neoplasms
T-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
Myeloid Neoplasms
Systemic Mastocytosis
Proliferations of the Monocyte-Macrophage System
Mesenchymal Tumors and Non-Neoplastic Disorders That Mimic Neoplasms
EPSTEIN-BARR VIRUS—POSITIVE INFLAMMATORY FOLLICULAR DENDRITIC CELL/FIBROBLASTIC RETICULAR CELL TUMOR AND REACTIVE PSEUDOTUMORAL LESIONS OF THE SPLEEN
Splenic Cysts
Other Tumors
Storage Diseases
Pearls and Pitfalls
Chapter 59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
Lymphomas of Immune-Privileged Sites
Lymphoma of The Nervous System and Meninges
Ocular Adnexal Lymphoma
Lymphomas of Waldeyer’s Ring
Lymphomas of The Nasal Cavity and Paranasal Sinuses
Salivary Gland Lymphomas
Lymphomas of The Oral Cavity
Thyroid Lymphomas
Laryngeal Lymphomas
Pulmonary Lymphomas
Lymphomas of The Pleura and Pleural Cavity
Lymphomas of The Thymus
Cardiac Lymphomas
Lymphomas of The Breast
Gastrointestinal Lymphomas
Gastric Lymphoma
Small and Large Intestinal Lymphomas
Lymphomas of The Liver and Pancreatobiliary Tract
Adrenal Lymphomas
Urinary Tract Lymphomas
Male Genital Tract Lymphomas
Lymphomas of The Female Genital Tract
Lymphomas of Bone
Pearls and Pitfalls
Appendix A. The International Consensus Classification of Myeloid, Lymphoid, and Histiocytic Neoplasms
Index

Elaine Sarkin Jaffe

Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard.

Affiliations and expertise

Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland

Daniel A. Arber

Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen.

Affiliations and expertise

Professor and Chair of Pathology, University of Chicago School of Medicine, USA

Elias Campo

the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium.

Affiliations and expertise

Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain

Leticia Quintanilla-Fend

Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks.

Affiliations and expertise

Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, Germany

Attilio Orazi

Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.

Affiliations and expertise

Chair, Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas

Lisa M. Rimsza

Affiliations and expertise

Department of Pathology Mayo Clinic

Steven H. Swerdlow

Affiliations and expertise

Professor of Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA

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Elaine Sarkin Jaffe

Daniel A. Arber

Elias Campo

Leticia Quintanilla-Fend

Attilio Orazi

Lisa M. Rimsza

Steven H. Swerdlow