Hematopathology
- 3rd Edition - May 30, 2024
- Authors: Elaine Sarkin Jaffe, Daniel A. Arber, Elias Campo, Leticia Quintanilla-Fend, Attilio Orazi, Lisa M. Rimsza, Steven H. Swerdlow
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 3 1 6 5 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 5 1 1 6 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 3 1 6 6 - 6
Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative informati… Read more
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Request a sales quoteCovering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.
- Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification.
- Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria.
- Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each.
- Details the latest insights on the molecular biology of benign and malignant hematologic disorders.
- Features more than 1,100 high-quality color images that mirror the findings you encounter in practice.
- Uses an easy-to-navigate, templated format with standard headings in each chapter.
- Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis.
- Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.
Hematopathologists. General surgical pathologists in practice and in training (38,000)
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Part I. Technical Aspects
- Chapter 1. Processing of the Lymph Node Biopsy Specimen
- ASSESSING AND PRIORITIZING FRESH TISSUE
- GROSS PROCESSING OF THE LYMPH NODE BIOPSY
- ROUTINE HISTOLOGIC, HISTOCHEMICAL, AND SPECIAL STAINS
- REPORTING THE LYMPH NODE BIOPSY
- Pearls and Pitfalls
- Chapter 2. Fine-Needle Aspiration of Lymph Nodes
- SPECIMEN COLLECTION AND PROCESSING
- ANCILLARY STUDIES
- NON-NEOPLASTIC ASPIRATES
- ASPIRATES OF LYMPHOID NEOPLASMS
- LIMITATIONS OF FINE-NEEDLE ASPIRATION
- ROLE OF CORE NEEDLE BIOPSY IN LYMPHOMA DIAGNOSIS
- Pearls and Pitfalls
- Chapter 3. Immunohistochemistry for the Hematopathology Laboratory
- INTRODUCTION
- BASIC IMMUNOHISTOCHEMISTRY
- ANTIGENS OF HEMATOPATHOLOGIC INTEREST
- BEYOND DIAGNOSTICS: THE EVOLVING ROLE OF IMMUNOHISTOCHEMISTRY
- IN SITU HYBRIDIZATION
- APPROACH TO USING IMMUNOHISTOCHEMISTRY
- Pearls and Pitfalls
- Chapter 4. Flow Cytometry
- GENERAL PRINCIPLES
- TECHNICAL CONSIDERATIONS
- MATURE B-CELL NEOPLASMS
- PLASMA CELL NEOPLASMS
- MATURE T-CELL NEOPLASMS
- NATURAL KILLER CELL NEOPLASMS
- FLOW CYTOMETRY IN DIAGNOSIS AND CLASSIFICATION OF ACUTE LEUKEMIA
- CHRONIC MYELOID NEOPLASMS
- Acknowledgements
- Pearls and Pitfalls
- Chapter 5. Molecular Pathology of Hematologic Neoplasms
- INTRODUCTION
- BIOLOGICAL AND TECHNOLOGIC ISSUES
- LYMPHOID NEOPLASMS
- MYELOID NEOPLASMS
- POTENTIAL PITFALLS OF MOLECULAR TESTING
- SUMMARY AND CONCLUSIONS
- Acknowledgments
- Pearls and Pitfalls
- Chapter 6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
- TYPES OF CHROMOSOMAL ABERRATIONS IN HEMATOLOGIC MALIGNANCIES
- CONVENTIONAL CYTOGENETIC METHODS
- MOLECULAR CYTOGENETIC METHODS
- CLINICAL RELEVANCE OF CHROMOSOMAL ABNORMALITIES IN HEMATOLOGIC MALIGNANCIES
- CONCLUSION
- Pearls and Pitfalls
- Acknowledgments
- Part II. Normal and Reactive Conditions of Hematopoietic Tissues
- Chapter 7. Normal Lymphoid Organs and Tissues
- NORMAL LYMPHOID TISSUES
- B-CELL AND T-CELL DIFFERENTIATION
- Acknowledgements
- Pearls and Pitfalls
- Chapter 8. Reactive Lymphadenopathies
- FOLLICULAR AND NODULAR PATTERNS
- PREDOMINANTLY SINUS PATTERN
- INTERFOLLICULAR OR MIXED PATTERNS
- DIFFUSE PATTERN
- Pearls and Pitfalls
- Chapter 9. The Normal Bone Marrow
- INTRODUCTION
- MEDICAL INDICATIONS FOR BONE MARROW EXAMINATION
- COMPONENTS OF A BONE MARROW EVALUATION
- COLLECTION OF BONE MARROW ASPIRATE AND CORE BIOPSY
- PROCESSING OF MARROW TREPHINE BIOPSY AND ASPIRATE
- BONE MARROW EVALUATION
- CYTOCHEMISTRY AND HISTOCHEMISTRY
- BONE MARROW EXAMINATION AND REPORTING
- CONCLUSION
- Acknowledgments
- Pearls and Pitfalls
- Chapter 10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia
- EVALUATION OF ANEMIA
- EVALUATION OF LEUKOPENIA
- EVALUATION OF THROMBOCYTOPENIA
- EVALUATION OF SPECIFIC BONE MARROW FAILURE SYNDROMES
- Pearls and Pitfalls
- Chapter 11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
- REACTIVE NEUTROPHILIA
- REACTIVE LYMPHOCYTOSIS
- REACTIVE EOSINOPHILIA
- REACTIVE BASOPHILIA
- REACTIVE MONOCYTOSIS
- BONE MARROW IN INFECTIOUS DISORDERS
- BONE MARROW IN NON-INFECTIOUS SYSTEMIC AND INFLAMMATORY DISORDERS
- CONCLUSION
- Pearls and Pitfalls
- Part III. Lymphoid Neoplasms
- Chapter 12. Principles of Classification of Lymphoid Neoplasms
- INTRODUCTION
- HISTORICAL BACKGROUND
- THE ICC AND WHO 5TH ED. PROPOSALS: SIMILARITIES AND DIFFERENCES
- CONCLUSION
- Pearls and Pitfalls
- Section 1. MATURE B-CELL NEOPLASMS
- Chapter 13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
- CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA
- MONOCLONAL B-CELL LYMPHOCYTOSIS
- B-CELL PROLYMPHOCYTIC LEUKEMIA
- Pearls and Pitfalls
- Chapter 14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
- DEFINITION OF THE DISEASE
- SYNONYMS AND RELATED TERMS
- EPIDEMIOLOGY
- CLINICAL FEATURES
- MORPHOLOGY
- IMMUNOPHENOTYPE
- MOLECULAR GENETIC FINDINGS
- POSTULATED NORMAL COUNTERPART AND PATHOGENESIS
- CLINICAL COURSE, TREATMENT, AND PROGNOSIS
- DIFFERENTIAL DIAGNOSIS
- Pearls and Pitfalls
- Chapter 15. Hairy Cell Leukemia
- DEFINITION OF DISEASE AND NOMENCLATURE
- EPIDEMIOLOGY
- ETIOLOGY
- CLINICAL FEATURES
- MORPHOLOGY
- PHENOTYPE
- GENETICS AND MOLECULAR FINDINGS
- POSTULATED CELL OF ORIGIN AND NORMAL COUNTERPART
- VARIANTS
- DIFFERENTIAL DIAGNOSIS
- CLINICAL COURSE AND TREATMENT
- PROGNOSTIC AND PREDICTIVE FACTORS
- Pearls and Pitfalls
- Chapter 16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
- DEFINITION
- SYNONYMS AND RELATED TERMS
- EPIDEMIOLOGY
- ETIOLOGY
- CLINICAL FEATURES
- MORPHOLOGY
- IMMUNOPHENOTYPE
- GENETICS
- OTHER SPLENIC B-CELL LYMPHOMAS
- Pearls and Pitfalls
- Chapter 17. Follicular Lymphoma
- Definition
- Epidemiology
- Clinical Features
- Morphologic Features
- Grading and Terminology
- Related B-Cell Lymphomas and Follicular Proliferations
- Immunophenotype
- Cytogenetic and Genetic Features
- Postulated Normal Counterpart and Pathogenesis
- Etiology
- Clinical Course
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma
- Definition
- Synonyms and Related Terms
- Epidemiology
- Etiology
- Histopathology of Acquired Malt
- Pathology of Malt Lymphoma
- Immunohistochemistry
- Genetic Features of Malt Lymphoma
- Postulated Cell of Origin
- Clinical Course
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 19. Primary Cutaneous B-Cell Lymphomas
- Historical Background
- Primary Cutaneous MARGINAL ZONE Lymphoproliferative Disorder
- Primary Cutaneous FOLLICLE CENTER Lymphoma
- Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
- Intravascular Large B-Cell Lymphoma
- B-Lymphoblastic Lymphoma
- Ebv-Positive Mucocutaneous Ulcer and Other Cutaneous Immunodeficiency-Associated B-Cell LymphOproliferative Disorders
- Pearls and Pitfalls
- Chapter 20. Nodal Marginal Zone Lymphoma
- Definition
- Epidemiology, Etiology, and Cofactors
- Clinical Features
- Morphology
- Immunophenotype
- Genetics and Molecular Findings
- Postulated Cell of Origin
- Clinical Course and Prognostic Factors
- PEDIATRIC-TYPE NODAL MARGINAL ZONE LYMPHOMA (PT-NMZL)
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 21. Mantle Cell Lymphoma
- DEFINITION
- EPIDEMIOLOGY
- CLINICAL MANIFESTATIONS
- MORPHOLOGY
- IMMUNOPHENOTYPE
- MANTLE CELL LYMPHOMA VARIANTS
- CYTOGENETIC FINDINGS
- MOLECULAR CHARACTERISTICS
- POSTULATED CELL OF ORIGIN
- MULTISTEP DEVELOPMENT OF MANTLE CELL LYMPHOMA
- Clinical Course
- PROGNOSTIC PARAMETERS
- THERAPY
- DIFFERENTIAL DIAGNOSIS
- Pearls and Pitfalls
- Chapter 22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas
- INTRODUCTION
- DEFINITIONS, SYNONYMS, AND TERMS
- DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
- T-CELL/HISTIOCYTE–RICH LARGE B-CELL LYMPHOMA
- PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA
- INTRAVASCULAR LARGE B-CELL LYMPHOMA
- Pearls and Pitfalls
- Chapter 23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
- Why These Four Entities in One Chapter? A Historical Perspective On the Development of Disease Concepts
- BURKITT LYMPHOMA
- LARGE/HIGH-GRADE B-CELL LYMPHOMA WITH 11Q ABERRATION
- DIFFUSE LARGE B-CELL LYMPHOMA/HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS
- PROVISIONAL ENTITY: HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS
- HIGH-GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
- Pearls and Pitfalls
- Chapter 24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
- Plasmablastic Lymphoma
- Alk-Positive Large B-Cell Lymphoma
- Pearls and Pitfalls
- Chapter 25. Plasma Cell Neoplasms
- Classification Of Plasma Cell Neoplasms
- Pathogenesis of Plasma Cell Neoplasms
- Multiple Myeloma
- Monoclonal Gammopathy Of Undetermined Significance
- Plasmacytoma
- Immunoglobulin Deposition Diseases
- Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome
- Pearls and Pitfalls
- Chapter 26. Nodular Lymphocyte-Predominant B-Cell Lymphoma
- Definition
- SYNONYMS AND RELATED TERMS
- Historical Background
- Epidemiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetics and Molecular Findings
- Relationship With Progressively Transformed Germinal Centers
- Transformation To Diffuse Large B-Cell Lymphoma
- Relationship With T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
- Other Differential Diagnoses
- Treatment
- Prognosis
- Conclusion
- Pearls and Pitfalls
- Chapter 27. Classic Hodgkin Lymphoma
- Definition
- Synonyms and Related Terms
- Epidemiology
- Etiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetics and Molecular Findings
- Postulated Cell of Origin
- Clinical Course and Prognostic Factors
- Related Lesions and Differential Diagnoses
- Pearls and Pitfalls
- Chapter 28. Virally Associated B-Cell Lymphoproliferative Disease
- Ebv-Associated Lymphoproliferative Disorders
- HHV-8-Associated Lymphoproliferative Disorders
- Pearls and Pitfalls
- Section 2. MATURE T-CELL AND NK-CELL NEOPLASMS
- Chapter 29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders
- INTRODUCTION
- Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
- Chronic Active Epstein-Barr Virus Disease
- Severe Mosquito Bite Allergy
- Hydroa Vacciniforme Lymphoproliferative Disorder
- Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood
- Extranodal NK/T-Cell Lymphoma, Nasal Type
- Extranasal NK/T-Cell Lymphoma
- Aggressive Nk-Cell Leukemia
- Primary Nodal Epstein-Barr Virus–Positive T/Nk-Cell Lymphoma
- Pearls and Pitfalls
- Chapter 30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
- History and Classification
- Definitions
- Synonyms and Related Terms
- Etiology and Epidemiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetics and Molecular Findings
- Postulated Cell of Origin and Pathogenesis
- Clinical Management and Prognosis
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 31. T-Cell Prolymphocytic Leukemia
- Definition
- Consensus Criteria For Diagnosis
- Epidemiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetics and Molecular Findings
- Postulated Cell of Origin
- Clinical Course
- Treatment
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 32. Adult T-Cell Leukemia/Lymphoma
- Definition
- Epidemiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetics, Molecular Findings, and Role of HTLV-1
- Postulated Normal Counterpart
- Clinical Course
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 33. Hepatosplenic T-Cell Lymphoma
- Definition
- Epidemiology
- Etiology
- Clinical Features
- Morphology
- Phenotype
- Cytogenetic and Molecular Findings
- Postulated Cell of Origin
- CLINICAL Course
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 34. Peripheral T-Cell Lymphoma, Not Otherwise Specified
- Definition
- SYNONYMS AND RELATED TERMS
- Epidemiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetic and Molecular Characteristics
- Variants and Subgroups
- Extranodal Peripheral T-Cell Lymphoma, Not Otherwise Specified
- Prognosis and Predictive Features
- Primary Nodal Epstein-Barr Virus–Positive T/Natural Killer–Cell Lymphoma
- Diagnostic Approach To Peripheral T-Cell Lymphoma, Not Otherwise Specified And Differential Diagnoses
- Pearls and Pitfalls
- Chapter 35. Follicular Helper T-Cell Lymphoma
- Definition
- Synonyms and Related Terms
- Epidemiology
- Etiology
- Follicular Helper T Cells
- Clinical Features
- Morphology
- Immunophenotype
- Genetics
- Clinical Course and Prognosis
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
- Definition and Background
- Anaplastic Large Cell Lymphoma, Alk Positive
- Anaplastic Large Cell Lymphoma, Alk Negative
- Breast Implant–Associated Anaplastic Large Cell Lymphoma
- Differential Diagnosis of Anaplastic Large Cell Lymphoma
- Pearls and Pitfalls
- Chapter 37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
- Enteropathy-Associated T-Cell Lymphoma
- Refractory Celiac Disease
- Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
- Intestinal T-Cell Lymphoma, Not Otherwise Specified
- Indolent Natural Killer–Cell and T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract
- Pearls and Pitfalls
- Chapter 38. Mycosis Fungoides and Sézary Syndrome
- Mycosis Fungoides
- Sézary Syndrome
- Pearls and Pitfalls
- Chapter 39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
- Definition
- SYNONYMS AND RELATED TERMS
- Epidemiology
- Etiology
- Clinical Features
- Morphology
- Immunophenotype
- Genetics and Molecular Findings
- Postulated Cell of Origin
- Clinical Course
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes
- Introduction
- Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma
- Primary Cutaneous γδ T-Cell Lymphoma
- Subcutaneous Panniculitis-Like T-Cell Lymphoma
- Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder
- Primary Cutaneous Acral CD8-Positive T-Cell Lymphoproliferative Disorder
- Other Types of Cutaneous T-Cell Lymphoma
- Pearls and Pitfalls
- Section 3. PRECURSOR B-AND T-CELL NEOPLASMS
- Chapter 41. Precursor B-Cell and T-Cell Neoplasms
- Classification of Precursor Lymphoid Neoplasms
- B-Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
- T-Cell Lymphoblastic Lymphoma/Lymphoblastic Leukemia
- Conclusion
- Pearls and Pitfalls
- Chapter 42. Acute Leukemias of Ambiguous Lineage
- Definitions
- Synonyms and Related Terms
- Epidemiology
- Clinical Features
- Diagnostic Criteria and Lineage Assignment
- Genetic and Molecular Findings
- Clinical Course
- Lineage Switch
- Differential Diagnosis
- Pearls and Pitfalls
- Part IV. Myeloid, Histiocytic, and Related Proliferations
- Chapter 43. Principles of Classification of Myeloid Neoplasms
- Introduction
- Evaluation of Myeloid Neoplasms
- International Consensus Classification
- Conclusion
- Acknowledgment
- Chapter 44. The Myelodysplastic Syndromes
- Incidence
- Synonyms and Related Terms
- Clinical Features
- Laboratory Features
- Diagnosis
- Classification
- Differential Diagnosis
- Etiology and Pathogenesis
- Conclusion
- Pearls and Pitfalls
- Chapter 45. Myeloid and Hematologic Neoplasms With Germline Predisposition
- Definition and Introduction
- Synonyms and Related Terms
- Hematologic Neoplasms with Germline Predisposition Without A Constitutional Disorder Affecting Multiple Organ Systems
- Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Platelet Disorder
- Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Disorder Affecting Multiple Organ Systems
- Acute Lymphoblastic Leukemia with Germline Predisposition
- Pearls and Pitfalls
- Chapter 46. Acute Myeloid Leukemia
- SYNONYMS AND RELATED TERMS
- EPIDEMIOLOGY
- ETIOLOGY
- CLINICAL FEATURES
- MORPHOLOGY
- CYTOCHEMISTRY
- IMMUNOPHENOTYPE
- GENETICS
- PROGNOSIS
- ACUTE MYELOID LEUKEMIA DISEASE TYPES
- MYELOID PROLIFERATIONS OF DOWN SYNDROME
- MYELOID SARCOMA
- DIAGNOSTIC QUALIFIERS IN ACUTE MYELOID LEUKEMIA
- INTEGRATED APPROACH TO THE DIAGNOSIS OF ACUTE MYELOID LEUKEMIA
- Pearls and Pitfalls
- Chapter 47. Myeloproliferative Neoplasms
- Introduction
- Etiology and Pathogenesis
- Chronic Myeloid Leukemia (CML)
- Chronic Neutrophilic Leukemia (CNL)
- Classic Bcr::Abl1-Negative Myeloproliferative Neoplasms
- Essential Thrombocythemia (ET)
- Primary Myelofibrosis (PMF)
- Polycythemia Vera
- Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS)
- Myeloproliferative Neoplasms, Unclassifiable (MPN-U)
- Conclusion
- Acknowledgments
- Pearls and Pitfalls
- Chapter 48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions
- Introduction
- Chronic Myelomonocytic Leukemia (CMML)
- Clonal Cytopenia With Monocytosis of Undetermined Significance and Clonal Monocytosis of Undetermined Significance
- Atypical Chronic Myeloid Leukemia (aCML)
- Myelodysplastic/Myeloproliferative Neoplasm With Sf3b1 Mutation and Thrombocytosis (MDS/MPN-SF3B1-T)
- Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified (MDS/MPN-RS-T, NOS)
- Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified (MDS/MPN, NOS)
- Myelodysplastic/Myeloproliferative Neoplasm With Isolated Isochromosome (17q) (MDS/MPM With i[17q]; ICC Provisional Subentity)
- Acknowledgments
- Pearls and Pitfalls
- Chapter 49. Mastocytosis
- Definition
- Synonyms and Related Terms
- General Aspects
- Epidemiology and Etiology
- Postulated Cell of Origin and Normal Counterpart
- Genetics and Molecular Findings
- Cytologic and Histologic Diagnosis
- Differential Diagnosis
- Classification
- Pearls and Pitfalls
- Chapter 50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions
- Overview
- Introduction
- Classification
- Clinical Presentation
- Approach To Diagnosis
- Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangements Of PDGFRA, PDGFRB, FGFR1, FLT3, OR JAK2 or with ETV6::ABL1
- CEL, NOS, IHE/IHES, and other Rare Reported Genetic Alterations Associated with Clonal Eosinophilia
- Conclusion
- Acknowledgments
- Pearls and Pitfalls
- Chapter 51. Blastic Plasmacytoid Dendritic Cell Neoplasm
- Definition
- Synonyms and Related Terms
- Epidemiology
- Etiology
- Clinical Features
- Morphology
- Immunophenotype
- Cytochemistry
- Genetics and Molecular Findings
- Postulated Cell of Origin and Normal Counterpart
- Clinical Course and Prognosis
- Differential Diagnosis
- Pearls and Pitfalls
- Chapter 52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic
- Non-Neoplastic Histiocytic Disorders
- Histiocytic and Dendritic Cell Neoplasms
- Acknowledgment
- Pearls and Pitfalls
- Part V. Immunodeficiency Disorders
- Chapter 53. The Pathology of Primary Immunodeficiencies
- Classification
- Synonyms and Related Terms
- Epidemiology
- Severe Combined Immunodeficiency
- PI3K-Related Immunodeficiencies
- Defects that Affect Homeostasis of The Immune System
- Defects in Synapse Formation and Crosstalk Between Antigen-Presenting Cells and T Cells
- Pearls and Pitfalls
- Chapter 54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
- Definition
- Synonyms and Related Terms
- Classification
- Posttransplant Lymphoproliferative Disorders
- Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders in Nontransplant Settings
- Pearls and Pitfalls
- Part VI. Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
- Chapter 55. Bone Marrow Evaluation for Lymphoma
- Distinction Between Benign Lymphoid Aggregates and Lymphoma
- Non-Hodgkin Lymphoma Involving Bone Marrow
- B-Cell Lymphomas Involving Bone Marrow
- T-Cell Lymphomas Involving Bone Marrow
- Hodgkin Lymphoma Involving Bone Marrow
- Nonlymphoid Malignancies That Mimic Lymphomas
- Pearls and Pitfalls
- Chapter 56. Evaluation of the Bone Marrow After Therapy
- Effects of Selected Therapies and Bone Marrow Transplantation
- Acute Leukemia or Myelodysplastic Syndrome
- Chronic Myeloid Leukemia
- BCR::ABL1-Negative Myeloproliferative Neoplasms
- Chronic Lymphoproliferative and Plasma Cell Disorders
- Other Bone Marrow Changes after Therapy
- Pearls and Pitfalls
- Chapter 57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes
- Introduction
- Metastatic Tumors of the Bone Marrow
- Primary Tumors of Bone
- Vascular Tumors Involving Bone
- Other Soft-Tissue Tumors Involving Bone
- Malignant Lymphomas Involving Bone and Bone Marrow
- Benign Lesions of Bone
- Metastatic Tumors to Lymph Nodes
- Benign Lymph Node Inclusions
- Mesenchymal Proliferations in Lymph Nodes
- Conclusion
- Pearls and Pitfalls
- Chapter 58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions
- The Normal Spleen
- Gross Examination
- Lymphoid Hyperplasia
- Castleman Disease
- Autoimmune Lymphoproliferative Syndrome
- Hodgkin Lymphoma
- Non-Hodgkin Lymphomas
- Precursor Lymphoid Neoplasms
- Systemic or Secondary Mature B-Cell Lymphomas and Leukemias
- Primary B-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
- Mature T-Cell and Natural Killer–Cell Neoplasms
- T-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
- Myeloid Neoplasms
- Systemic Mastocytosis
- Proliferations of the Monocyte-Macrophage System
- Mesenchymal Tumors and Non-Neoplastic Disorders That Mimic Neoplasms
- EPSTEIN-BARR VIRUS—POSITIVE INFLAMMATORY FOLLICULAR DENDRITIC CELL/FIBROBLASTIC RETICULAR CELL TUMOR AND REACTIVE PSEUDOTUMORAL LESIONS OF THE SPLEEN
- Splenic Cysts
- Other Tumors
- Storage Diseases
- Pearls and Pitfalls
- Chapter 59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
- Lymphomas of Immune-Privileged Sites
- Lymphoma of The Nervous System and Meninges
- Ocular Adnexal Lymphoma
- Lymphomas of Waldeyer’s Ring
- Lymphomas of The Nasal Cavity and Paranasal Sinuses
- Salivary Gland Lymphomas
- Lymphomas of The Oral Cavity
- Thyroid Lymphomas
- Laryngeal Lymphomas
- Pulmonary Lymphomas
- Lymphomas of The Pleura and Pleural Cavity
- Lymphomas of The Thymus
- Cardiac Lymphomas
- Lymphomas of The Breast
- Gastrointestinal Lymphomas
- Gastric Lymphoma
- Small and Large Intestinal Lymphomas
- Lymphomas of The Liver and Pancreatobiliary Tract
- Adrenal Lymphomas
- Urinary Tract Lymphomas
- Male Genital Tract Lymphomas
- Lymphomas of The Female Genital Tract
- Lymphomas of Bone
- Pearls and Pitfalls
- Appendix A. The International Consensus Classification of Myeloid, Lymphoid, and Histiocytic Neoplasms
- Index
- No. of pages: 1312
- Language: English
- Edition: 3
- Published: May 30, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780323831659
- eBook ISBN: 9780443351167
- eBook ISBN: 9780323831666
EJ
Elaine Sarkin Jaffe
Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard.
Affiliations and expertise
Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, MarylandDA
Daniel A. Arber
Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen.
Affiliations and expertise
Professor and Chair of Pathology, University of Chicago School of Medicine, USAEC
Elias Campo
the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium.
Affiliations and expertise
Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, SpainLQ
Leticia Quintanilla-Fend
Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks.
Affiliations and expertise
Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, GermanyAO
Attilio Orazi
Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.
Affiliations and expertise
Chair, Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TexasLR
Lisa M. Rimsza
Affiliations and expertise
Department of Pathology
Mayo ClinicSS
Steven H. Swerdlow
Affiliations and expertise
Professor of Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA