Hematopathology

3rd Edition - September 1, 2024
Authors: Elaine Sarkin Jaffe, Daniel A. Arber, Elias Campo, Leticia Quintanilla-Fend, Attilio Orazi, Lisa M. Rimsza, Steven H. Swerdlow
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 1 6 5 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 1 6 6 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 1 6 7 - 3

Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative informati… Read more

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Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.

Part I: TECHNICAL ASPECTS

1. Processing of the Lymph Node Biopsy Specimen　

2. Fine Needle Aspiration of Lymph Nodes　

3. Collection, Processing, and Examination of Bone Marrow Specimens　

4. Immunohistochemistry for the Hematopathology Laboratory　

5. Flow Cytometry　

6. Molecular Diagnosis in Hematopathology　

7. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them

Part II: NORMAL and REACTIVE CONDTIONS of HEMATOPOIETIC TISSUES

8. Normal Lymphoid Organs and Tissues

9. The Reactive Lymphadenopathies

10. The Normal Bone Marrow

11. Evaluation of Anemia, Leukopenia, and Thrombocytopenia

12. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders

Part III: LYMPHOID NEOPLASMS

13. Principles of Classification of Lymphoid Neoplasms

Section 1: Mature B-Cell Neoplasms

14. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia

15. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia

16. Hairy Cell Leukemia

17. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen　

18. Follicular Lymphoma

19. Extranodal Marginal Zone Lymphoma: MALT Lymphoma

20. Primary Cutaneous B-Cell Lymphomas

21. Nodal Marginal Zone Lymphoma

22. Mantle Cell Lymphoma

23. Diffuse Large B-Cell Lymphoma

24. Burkitt Lymphoma and its Mimics

25. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma

26. Plasma Cell Neoplasms

27. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma

28. Classical Hodgkin's Lymphoma and Related Lesions

29. Virally Associated B-Cell Lymphoproliferative Disease

Section 2: MATURE T-CELL AND NK-CELL NEOPLASMS

30. Virally Associated T-Cell and NK-Cell Neoplasms

31. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations

32. T-Cell Prolymphocytic Leukemia

33. Adult T-Cell Leukemia/Lymphoma

34. Hepatosplenic T-Cell Lymphoma

35. Peripheral T-Cell Lymphoma, Not Otherwise Specified

36. Angioimmunoblastic T-Cell Lymphoma

37. Anaplastic Large-Cell Lymphoma, ALK Positive and ALK Negative

38. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas

39. Mycosis Fungoides and Sézary Syndrome

40. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders

41. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes

Section 3: Precursor B- and T-Cell Neoplasms

42. Precursor B- and T-Cell Neoplasms

43. Acute Leukemias of Ambiguous Lineage

Part IV: MYELOID NEOPLASMS

44. Principles of Classification of Myeloid Neoplasms

45. The Myelodysplastic Syndromes

46. Acute Myeloid Leukemia

47. Myeloproliferative Neoplasms

48. Myelodysplastic/Myeloproliferative Neoplasms

49. Mastocytosis

50. Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2

51. Blastic Plasmacytoid Dendritic Cell Neoplasm

Part V: HISTIOCYTIC PROLIFERATIONS

52. Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow

53. Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Part VI: IMMUNODEFICIENCY DISORDERS

54. The Pathology of Primary Immunodeficiencies

55. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder

Part VII: SITE-SPECIFIC ISSUES in the DIAGNOSIS of LYMPHOMA and LEUKEMIA

56. Bone Marrow Evaluation for Lymphoma

57. Evaluation of the Bone Marrow After Therapy

58. Non-Hematopoietic Neoplasms of the Bone Marrow

59. Nonlymphoid Lesions of the Lymph Nodes

60. Spleen: Normal Architecture and Neoplastic and Nonneoplastic Lesions

61. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

Elaine Sarkin Jaffe

Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard.

Affiliations and expertise

Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland

Daniel A. Arber

Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen.

Affiliations and expertise

Professor and Chair of Pathology, University of Chicago School of Medicine, USA

Elias Campo

the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium.

Affiliations and expertise

Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain

Leticia Quintanilla-Fend

Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks.

Affiliations and expertise

Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, Germany

Attilio Orazi

Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.

Affiliations and expertise

Chair, Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas

Lisa M. Rimsza

Affiliations and expertise

Department of Pathology Mayo Clinic

Steven H. Swerdlow

Affiliations and expertise

Professor of Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA