Hematology
Basic Principles and Practice
- 8th Edition - December 2, 2022
- Editors: Ronald Hoffman, Edward J. Benz, Leslie E. Silberstein, Helen Heslop, Jeffrey Weitz, Mohamed E. Salama
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 3 3 8 8 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 8 3 4 4 - 4
Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteCovers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.
Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.
Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies
Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.
Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.
Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.
Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.
Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.
Presents relevant basic science as background for clinical application in later sections.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
- Instructions for Online Access
- Cover image
- Title page
- Table of Contents
- Any screen, Any time, Anywhere
- Copyright
- Dedication
- Contributors
- Preface
- Part I: Molecular and Cellular Basis of Hematology
- Chapter 1. Anatomy and Physiology of the Gene
- Abstract
- The Genetic View of the Biosphere: The Central Dogma of Molecular Biology
- The Anatomy and Physiology of THE Gene
- Regulation of Gene Expression
- Molecular Genetic Methodologies Allowing the Isolation, Analysis, and Manipulation of Genes
- DNA- and RNA-Based Therapeutics
- Future Directions
- Suggested Readings
- Chapter 2. Epigenomics in Hematology
- Abstract
- Functional Chromatin Domains
- Dna Methylation
- Histones and Histone Variants
- Covalent Histone Modifications
- Transcription Factors
- Chromatin Remodelers
- Experimental Approaches in Epigenetics
- Mechanisms of Disease
- Epigenetic Therapies
- Future Directions
- Suggested Readings
- Chapter 3. Genomic Approaches to Hematology
- Abstract
- Introduction
- General Principles of Genomic Testing
- Next-Generation Sequencing Technology
- The Clinical Utility of Genomics in Hematologic Malignancies
- The Clinical Utility of Genomics in Benign Hematology
- Approaches to the Development of Molecular Testing
- Suggested Readings
- References
- Chapter 4. Regulation of Gene Expression in Hematology
- Abstract
- Introduction
- Regulation of Transcription
- Regulation of RNA Processing: Capping, Splicing, and Polyadenylation
- Nuclear Export of RNA
- RNA Heterogeneity
- Regulation of RNA Metabolism: Stability and Localization
- Protein Synthesis
- Protein Sorting
- Protein Folding and Posttranslational Modifications
- Protein Degradation
- Conclusions
- Suggested Readings
- References
- Chapter 5. Genome Editing
- Abstract
- Double-Stranded Dna Breaks: The Basis of Nuclease-Based Genome Editing
- Base Editing
- Other Genome Editing Systems
- Using Engineered Nucleases to Initiate the Genome Editing Process
- Genome Editing Using Only a Nuclease and Nonhomologous End-Joining Repair
- A Broad Range of Genomic Changes by Homologous Recombination–Mediated Genome Editing
- Genotoxicity Through Potential Off-Target Nuclease-Induced Double-Strand Breaks
- Genome Editing as a Research Tool
- Genome Editing as a Therapeutic Strategy
- Ex Vivo Manufacturing of Therapeutic Cells
- Therapeutic Genome Editing for Hematologic Diseases
- Opportunities for Genome Editing in Vivo
- Challenges to in Vivo Editing of Hematopoietic Stem Cells
- Heritable Genome Editing
- Suggested Readings
- References
- Chapter 6. Signaling Transduction and Metabolomics
- Abstract
- Signaling Transduction
- Metabolomics and Control of Hematopoietic Cell Metabolism
- Summary and Perspectives
- Suggested Readings
- Chapter 7. Protein Architecture: Relationship of Form and Function
- Abstract
- Amino Acids and the Peptide Bond
- Future Directions
- Suggested Readings
- References
- Chapter 8. Pharmacogenomics and Hematologic Diseases
- Abstract
- Variation in the Human Genome
- Single-Nucleotide Polymorphisms
- Single-Nucleotide Polymorphisms and Phenotypes
- Structural Genomic Variants
- Somatic Genomic Variants
- Catalogs of Genomic Variants, Genotyping Platforms, and Genome-Wide Association Studies
- Genetic Variations Influencing Drug Response: Pharmacogenetics–Pharmacogenomics–Pharmacoepigenomics
- Optimization of Drug Therapy
- Genetic Variations that Influence Drug Disposition and Effects
- Drug Transporters
- Genetic Variations Influencing Drug Targets
- Adverse Drug Effects Presenting as Hematologic Disorders
- Drug Development
- Future Directions
- Suggested Reading
- References
- Part II: Cellular Basis of Hematology
- Chapter 9. Hematopoietic Stem Cell Biology
- Abstract
- Embryonic Origin of Hematopoietic Stem Cells
- Definition and Characterization of Hematopoietic Stem Cells
- Regulation of Hematopoietic Stem Cell Fate
- Intrinsic Pathways
- Hematopoietic Stem Cell Metabolism
- Novel Growth Factors for Expanding Hematopoietic Stem Cells and Clinical Testing
- Generating Hematopoietic Stem Cells from Pluripotent Stem Cells and by Reprogramming of Somatic Cells
- Hematopoietic Stem Cell Regeneration
- Hematopoietic Stem Cells and Malignancy (See Chapters 13 and 59Chapter. 13Chapter. 59Chapters 13 and 59)
- Suggested Readings
- References
- Chapter 10. Mitochondria and Hematopoiesis
- Abstract
- Mitochondrial Structure and Function
- Mitochondrial Diseases
- Mitochondrial Regulation of Hematopoietic Stem Cell Fates
- Interaction of Mitochondrial Network with the Bone Marrow Milieu Regulates Hematopoietic Stem Cell Fates
- Mitochondrial and Bone Marrow Roles in Leukemic Stem Cells and Aged Hematopoietic Stem Cells
- Mitochondrial and Epigenome Control Reprogramming of Hematopoietic Stem Cells
- Concluding Remarks
- References
- Chapter 11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors
- Abstract
- Introduction
- Cytokines and Their Modifying Influences
- Specifics of Growth-Modulating Factors
- Colony-Stimulating Factors
- Other Growth Modulating Proteins/Factors
- Concluding Thoughts
- Suggested Readings
- References
- Chapter 12. Role of Chemokines in Leukocyte Trafficking
- Abstract
- Chemokines
- Signaling by Chemokine Receptors
- Atypical Chemokine Receptors
- Chemokine Interaction With Glycosaminoglycans
- Leukocyte Entry Into Tissues
- Leukocyte Migration Within Tissues
- Leukocyte Exit from Tissues
- Summary
- Suggested Readings
- References
- Chapter 13. Stem Cell Model of Hematologic Diseases
- Abstract
- Cell-Of-Origin Studies in Hematologic Malignancies
- Acute Myeloid Leukemia
- Myelodysplastic Syndromes
- Myeloproliferative Neoplasms
- Acute Lymphoblastic Leukemia
- Mature B-Cell Malignancies
- Chronic Lymphocytic Leukemia
- Hairy Cell Leukemia
- Diffuse Large B-Cell Lymphoma
- Follicular Lymphoma
- Conclusion
- References
- Chapter 14. Hematopoietic Microenvironment
- Abstract
- Evolution of the Niche Concept
- Hematopoietic Microenvironment During Development
- Adult Bone Marrow Microenvironment
- Extrinsic Regulation of the Hematopoietic Stem Cell Niche
- Lymphoid Niches
- Erythroid Niches
- Megakaryocytic Niches
- Human Bone Marrow Microenvironment
- Hematopoietic Microenvironment in Acute Leukemia and Myelodysplasia
- Future Directions
- References
- Chapter 15. Cell Adhesion
- Abstract
- Adhesion Molecules
- Extracellular Matrix Proteins
- Integrins
- Immunoglobulin-Like Receptors
- Other Adhesion Receptors that Mediate Protein–Protein Interactions
- Lectin Adhesion Receptors
- Ligand Binding Versus Cell Adhesion
- Regulation of Adhesion Receptors
- Regulation of Synthesis
- Regulation of Surface Expression
- Regulation of Binding Affinity
- Cell Signaling Through Adhesion Molecules
- Cooperative Interactions Between Signaling and Adhesion Molecules
- Platelet Adhesion, Aggregation, and Hemostasis
- Suggested Readings
- Chapter 16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment
- Abstract
- Introduction
- Lessons from Steady-State Homeostatic Regulation of Hematopoietic Stem and Progenitor Cells
- Medical Approaches Originating from Understanding Mechanisms that Regulate Physiological Hspc Trafficking, for the Sake of Curative Stem Cell Transplantation Protocols
- Hematopoietic Stem and Progenitor Cell Homing
- Hematopoietic Stem and Progenitor Cell Mobilization: A Dynamic Multi-Facet Process
- Concluding Remarks
- Acknowledgments
- References
- Chapter 17. Control of Cell Division
- Abstract
- The Cell Division Cycle
- Signaling
- Cyclins and Cyclin-Dependent Kinases
- Cyclin-Dependent Kinase Inhibitors
- Transcriptional Regulation: MYC, RB-E2F, and Dream/Muvb
- Ubiquitination
- Deoxyribonucleic Acid Replication
- Mitosis
- Cell Cycle Checkpoints
- Special Hematology Cell Cycle Features
- References
- Chapter 18. Cell Death
- Abstract
- Core Apoptosis Pathways
- The Intrinsic Apoptotic Pathway
- Nonapoptotic Roles of Bcl-2 Family Proteins
- The Death Receptor (Extrinsic) Pathway of Apoptosis
- Nonapoptotic Forms of Cell Death
- Cell Survival and Cell Death Pathways and Adaptive Responses to Stress
- Clinical Applications
- Preclinical Activity of Bcl2 Antisense and Bh3-Mimetics in Myeloid Malignancies
- Clinical Development of Bh3-Mimetics for Myeloid Malignancies
- Rationale for Use of Bh-3 Mimetics in Chronic Lymphocytic Leukemia
- Clinical Development of Venetoclax for Chronic Lymphocytic Leukemia
- Mechanisms of Resistance to Venetoclax in Chronic Lymphocytic Leukemia
- Summary
- Suggested Readings
- References
- Chapter 19. Aging and Hematopoiesis
- Abstract
- Aging
- Hematopoietic Stem Cell Potential Declines With Aging
- Clinical Manifestations
- Clonal Hematopoiesis, Clonal Hematopoiesis of Indeterminate Potential, and Age-Related Clonal Hematopoiesis
- Mechanisms of Hematopoietic Stem Cell Aging
- Intrinsic Factors
- Extrinsic Factors
- Future Perspectives
- References
- Part III: Immunologic Basis of Hematology
- Chapter 20. Dendritic Cell Biology
- Abstract
- Dendritic Cell Subsets and Development
- Dendritic Cell Maturation
- Antigen Processing and Presentation
- Dendritic Cell-Mediated Immune Responses
- Dendritic Cells in Disease
- Dendritic Cells and Cancers
- Immunotherapeutic Strategies and Clinical Trials
- Future Directions
- Suggested Readings
- References
- Chapter 21. Natural Killer Cell Immunity AND THERAPY
- Abstract
- Natural Killer Cell Fundamental Biology
- Natural Killer Cell Development
- Natural Killer Cell Receptors
- Adaptive Immune Properties Of Natural Killer Cells
- The Role Of Natural Killer Cells In Human Disease
- The Therapeutic Potential Of Natural Killer Cells
- Future Directions
- Suggested Readings
- References
- Chapter 22. B-Cell Development
- Abstract
- Stages of B-Cell Development
- B Lineage Specification and Commitment
- Immunoglobulin Gene Rearrangement
- The Pro-B- and Pre-B-Cell Checkpoints
- The Hematopoietic Microenvironment
- Fetal B-Cell Development
- Secondary Lymphoid Tissues
- Effects of Aging on B-Cell Development and Function
- References
- Chapter 23. Complement And Immunoglobulin Biology Leading To Clinical Translation
- Abstract
- The Complement System: An Overview
- Immunoglobulins
- Therapeutic Use Of Immunoglobulin
- Drugs Targeting The Complement System
- References
- Suggested Readings
- Chapter 24. T-Cell Immunity
- Abstract
- T-Cell Activation
- T-Cell Development
- T-Cell Function
- Maturation Of T-Cell-Mediated Immunity
- Inhibition Of T Cell-Mediated Immunity
- Therapeutic Manipulation Of T-Cell-Mediated Immunity
- Suggested Readings
- References
- Chapter 25. Unmodified Ex Vivo Expanded T Cells
- Abstract
- Adoptive Immunotherapy of Viral Infections with Virus-Specific T Cells
- Adoptive Immunotherapy Of Cancer
- Future Directions
- Suggested Readings
- References
- Chapter 26. Treatment of Hematologic Malignancies With Genetically Modified T Cells
- Abstract
- Types of Cellular Immunotherapy
- Genetic Modification of T Cells
- Future Applications and Implementation of Cell Therapies for Cancer
- Acknowledgment
- References
- Part IV: Disorders of Hematopoietic Cell Development
- Chapter 27. Biology Of Erythropoiesis, Erythroid Differentiation, And Maturation
- Abstract
- Erythroid Cell Compartments
- The Morphologically Recognizable Erythroid Precursor Cell Compartment
- Intrinsic Control of Erythropoiesis
- Cellular Dynamics in Erythropoiesis: Steady State and Stress Erythropoiesis
- Ontogeny of Erythropoiesis
- Suggested Readings
- References
- Chapter 28. Granulocytopoiesis and Monocytopoiesis
- Abstract
- Granulocytopoiesis
- Control of Granulopoiesis
- Role of Developmentally Important Neutrophil-Specific Genes In Disease
- Eosinophil Production
- Basophil and Mast Cell Production
- Monocytopoiesis
- Suggested Readings
- References
- Chapter 29. Thrombocytopoiesis
- Abstract
- Megakaryocyte Biology
- Unique Features Of Megakaryocytes
- Cytokine Regulation Of Thrombocytopoiesis
- Transcriptional Control Of Megakaryocytopoiesis
- Micro Rnas In Megakaryocytopoiesis
- Future Directions
- Suggested References
- References
- Chapter 30. Inherited Bone Marrow Failure Syndromes
- Abstract
- Introduction
- Inherited Bone Marrow Failure Syndrome With Multi-Lineage Cytopenias
- Inherited Bone Marrow Failure Syndromes Predominantly with Anemia
- Inherited Bone Marrow Failure Syndromes with Predominantly Neutropenia
- Inherited Bone Marrow Failure Syndromes With Predominantly Thrombocytopenia
- Suggested Readings
- Chapter 31. Aplastic Anemia
- Abstract
- History
- Classification
- Epidemiology
- Etiology And Pathogenesis
- Pathophysiologic Pathways Leading To Aplastic Anemia
- Typical And Atypical Presentations
- Clinical Associations
- Laboratory Evaluation
- Diagnosis Of Aplastic Anemia
- Bone Marrow
- Differential Diagnosis Of Pancytopenia
- Treatment
- Prognosis
- Suggested Readings
- References
- Chapter 32. Paroxysmal Nocturnal Hemoglobinuria
- Abstract
- Introduction and History
- Epidemiology And Classification
- Clinical Manifestations
- Pathophysiology
- Diagnosis And Differential Diagnosis
- Evaluation OF Newly Diagnosed Patients
- Treatment
- Suggested Readings
- References
- Chapter 33. Acquired Disorders of Red Cell, White Cell, and Platelet Production
- Abstract
- Etiology and Classification
- Pathogenesis
- Primary Pure Red Cell Aplasia
- Secondary Forms of Pure Red Cell Aplasia
- Laboratory Evaluation
- Medical
- Hematopoietic Stem Cell Transplantation
- Secondary Forms of Neutropenias
- Laboratory Evaluation
- Nutritional Deficiencies
- Suggested Readings
- References
- Part V: Red Blood Cells
- Chapter 34. Pathobiology of the Human Erythrocyte and Its Hemoglobins
- Abstract
- Essential Features of Red Blood Cell Homeostasis
- Major Features of the Red Blood Cell Membrane
- Enzymes of Red Blood Cell Intermediary Metabolism
- Red Blood Cell Senescence and Destruction
- Hemoglobin Synthesis, Structure, and Function
- Nosology of Hemoglobinopathies
- Suggested Readings
- Chapter 35. Approach to Anemia in the Adult and Child
- Abstract
- Overview of Erythropoiesis
- Definition, PhysioloGic Consequences and Symptoms of Anemia
- Mechanisms of Anemia
- Comparison of Etiologies of Anemia in Adults and Children
- Future Directions
- References
- Chapter 36. Iron Homeostasis and Its Disorders
- Abstract
- Regulation of Cellular and Systemic Iron Homeostasis
- Use of Iron for Erythropoiesis
- Recycling of Erythrocyte Iron by Macrophages
- Liver Regulation of Systemic Iron Homeostasis and Iron Storage
- Intestinal Iron Absorption
- Future Directions
- References
- Chapter 37. Disorders of Iron Homeostasis: Iron Deficiency and Overload
- Abstract
- Iron Deficiency
- Iron Overload
- References
- Cases From Real Life
- References
- Chapter 38. Anemia of Chronic Inflammation
- Abstract
- Clinical Overview of Anemia of Chronic Inflammation
- Etiology and Pathophysiology of Anemia of Chronic Inflammation
- Pathophysiology of Iron Sequestration
- Conclusion
- References
- Chapter 39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
- Abstract
- Heme Biosynthesis
- Porphyrias
- Sideroblastic Anemias
- Sideroblastic Anemia and Porphyrinuria Caused By Drugs
- Presentations Associated with Sideroblastic Anemia or Porphyrinuria
- References
- Suggested Readings
- Chapter 40. Megaloblastic Anemias
- Abstract
- Cobalamin
- Folates
- Intracellular One-Carbon Metabolism And Cobalamin–Folate Relationships
- Morphologic Expression Of Megaloblastosis
- Neurologic Dysfunction With Cobalamin Deficiency
- Other Effects Of Cobalamin And Folate Deficiency
- Spectrum Of Clinical Presentations With Cobalamin Deficiency
- Biochemical Indicators Of Evolving Deficiency
- Biochemical Evaluation Of Cobalamin And Folate Deficiencies
- Pathogenesis Of Cobalamin Deficiency
- Pathogenesis Of Folate Deficiency
- Megaloblastic Anemia Not Caused By Folate Or Cobalamin Deficiency
- Therapy
- Routine Supplementation Of Cobalamin And Folate
- Future Directions
- Suggested Readings
- References
- Chapter 41. Thalassemia Syndromes
- Abstract
- Definitions And Nomenclature
- Epidemiology
- Pathophysiology: General Principles
- BETA-Thalassemia Syndromes
- ALPHA-Thalassemia Syndromes
- Thalassemic Structural Variants
- Extraordinarily Unstable Hemoglobins
- References
- Suggested Readings
- Chapter 42. Pathobiology of Sickle Cell Disease
- Abstract
- Early Years of Sickle Cell Disease Research
- Genetic Considerations
- Abnormal Molecular Behaviors of Sickle Hemoglobin
- Abnormalities of Sickle Red Blood Cells
- Disease Pathogenesis
- The Unique Systems Biology of Sickle Cell Anemia
- Inflammation
- References
- Chapter 43. Clinical Aspects of Sickle Cell Disease
- Abstract
- Genetic Epidemiology of the Sickle Gene
- Variant Sickle Cell Syndromes
- Prevalence
- Clinical Laboratory Features and Diagnosis
- Clinical Presentation and Management
- Suggested Readings
- References
- Chapter 44. Hemoglobin Variants Associated With Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
- Abstract
- Unstable Hemoglobins
- Hemoglobins With Increased Oxygen Affinity
- Hemoglobins with Decreased Oxygen Affinity
- Suggested Readings
- Chapter 45. Red Blood Cell Enzymopathies
- Abstract
- Metabolic Pathways
- Enzymopathies Associated with Hemolytic Anemia
- Other Enzymopathies of the Glutathione Pathway
- Other Enzymopathies of the Glycolytic Pathway
- Other Enzymopathies
- Enzymopathies Associated with Erythrocytosis
- Enzymopathies Associated with Methemoglobinemia
- Suggested Readings
- Chapter 46. Red Blood Cell Membrane Disorders
- Abstract
- Vertical and Horizontal Interactions of Membrane Proteins and Disorders of Red Blood Cell Shape
- Differential Diagnosis
- Therapy and Prognosis
- Hereditary Elliptocytosis and Related Disorders
- Red Blood Cell Membrane Disorders Manifested by Target Cell Formation
- Red Cell Membrane Variants and Infectious Disease
- Suggested Readings
- Chapter 47. Autoimmune Hemolytic Anemia
- Abstract
- History
- Epidemiology
- Pathobiology
- Etiology and Pathophysiology
- Symptoms, Clinical Findings, and Risks
- Laboratory Diagnosis of Autoimmune Hemolytic Anemia
- Immunologic Phenomena Associated with Autoimmune Hemolytic Anemia
- Differential Diagnosis
- Treatment
- Future Directions
- Acknowledgments
- Suggested Readings
- References
- Chapter 48. Extrinsic Nonimmune Hemolytic Anemias
- Abstract
- Fragmentation Hemolysis: Microangiopathy
- Other Forms of Mechanical Damage to Red Blood Cells
- Drug-Induced Oxidative Hemolysis
- Miscellaneous, Poorly Characterized Causes of Extrinsic Hemolytic Anemias
- References
- Part VI: Non-Malignant Leukocytes
- Chapter 49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia
- Abstract
- Neutrophilic Leukocytosis (Neutrophilia)
- Neutropenia (and Agranulocytosis)
- Monocytosis
- Monocytopenia
- References
- Chapter 50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
- Abstract
- Quantitative Disorders of Lymphocytes
- Quantitative Disorders of Immunoglobulins
- References
- Chapter 51. Disorders of Phagocyte Function
- Abstract
- Approach to Diagnosis of Phagocyte Function Disorders
- Disorders of the Respiratory Burst Pathway
- Disorders of Phagocyte Adhesion and Chemotaxis
- Defects in the Structure and Function of Lysosomal Granules
- Miscellaneous Inherited and Acquired Disorders of Phagocyte Function
- References
- Chapter 52. Congenital Disorders of Lymphocyte Function
- Abstract
- Defects of Thymus Organogenesis
- Severe Combined Immune Deficiency Due to Early Defects in T-Lymphocyte Development
- Other Combined Immunodeficiencies
- Combined Immunodeficiencies With Osseous Dysplasia
- Other Combined Immunodeficiencies
- Disorders With T-Cell-Mediated Immune Dysregulation
- Defects of Cell-Mediated Cytotoxicity
- Defects of B-Cell Development and Function
- B-Cell–Intrinsic Defects of Class-Switch Recombination
- Suggested Readings
- References
- Chapter 53. Pediatric and Adult Histiocytic Disorders
- Abstract
- Langerhans Cell Histiocytosis
- Juvenile Xanthogranulomatous Disease
- Erdheim-Chester Disease
- Rosai-Dorfman-Destombes Disease (or Sinus Histiocytosis with Massive Lymphadenopathy)
- Hemophagocytic Lymphohistiocytosis
- Distinctive Clinical Contexts
- Hemophagocytic Lymphohistiocytosis Associated with Malignancies
- Hemophagocytic Lymphohistiocytosis in the Context of a Rheumatologic Disease (R-HLH)
- Hemophagocytic Lymphohistiocytosis in the Context of Immune-Activating Therapies (Rx-HLH)
- Hemophagocytic Lymphohistiocytosis in the Context of Immune Compromise (IC-HLH)
- Suggested Readings
- References
- Chapter 54. Lysosomal Storage Diseases, Focusing On Gaucher Disease: Perspectives And Principles
- Abstract
- Lysosomal Storage Diseases
- Lysosomal Protein Biosynthesis and Sorting
- Genetics of Lysosomal Storage Diseases
- Diagnosis of Lysosomal Storage Diseases
- Screening Programs
- Laboratory Diagnosis
- Baseline and Sequential Assessment
- Specific Treatment
- Cellular Therapy, Including Gene Therapy
- Small Molecule Therapy
- General Aspects of Treatment
- Hematologic Aspects of Individual Lysosomal Storage Disorders
- Splenomegaly
- Excessive Bruising/Bleeding
- Thrombosis
- Abnormal Morphologic Appearances: Bone Marrow and Peripheral Blood
- Gaucher Disease
- Genetics and Biochemistry
- Epidemiology
- Clinical Manifestations
- Laboratory Findings
- Imaging Findings
- Differential Diagnosis
- Substrate Reduction Therapy
- Associated Diseases: Parkinson and Malignancies
- Prognosis
- New Therapeutic Modalities, Including Gene Therapy
- Conclusions and Future Directions
- References
- Chapter 55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions
- Abstract
- Biology of Epstein-Barr Virus
- Primary Epstein-Barr Virus Infection
- Latent Epstein-Barr Virus Infection
- Immune Response to Epstein-Barr Virus
- Epstein-Barr Virus Vaccine Development
- Infectious Mononucleosis
- Inherited Immunodeficiency Disorders and Predisposition to Epstein-Barr Virus–Associated Neoplasms
- Other Inherited Immunodeficiency Disorders Associated with Epstein-Barr Virus Disease
- Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
- Acquired Immunodeficiency and Epstein-Barr Virus–Associated Neoplasms
- Immunotherapy for Epstein-Barr Virus–Associated Neoplasms
- Other Epstein-Barr Virus–Associated Diseases
- Future Directions
- Suggested Readings
- References
- Part VII: Hematologic Malignancies
- Chapter 56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
- Abstract
- Progress in the Diagnosis and Classification of Myeloid Neoplasms
- Evolving Concepts in Classification of Lymphoid Neoplasms
- Dendritic Cell and Histiocytic Neoplasms
- References
- Chapter 57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies
- Abstract
- Methods
- Myelodysplastic Syndromes
- Acute Myeloid Leukemia
- Acute Lymphoblastic Leukemia
- Chronic B-Cell Lymphocytic Leukemia (Chapter 76)
- Multiple Myeloma
- Lymphoma
- Hairy Cell Leukemia (Chapter 77)
- Allogeneic Hematopoietic Stem Cell Transplantation
- Future Directions
- References
- Chapter 58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
- Abstract
- Tumor Cell Heterogeneity of Hematologic Malignancies
- Development of Chemotherapeutic Agents
- Traditional Cytotoxic Antineoplastic Agents Targeting the Cell Cycle and DNA
- Pharmacology of Traditional Chemotherapeutic Agents
- Pharmacology of Targeted Antineoplastic Agents
- Drug Resistance to Chemotherapeutic Agents or Multidrug Resistance
- Future Directions
- SUGGESTED READINGS
- Reference
- Chapter 59. Pathobiology of Acute Myeloid Leukemia
- Abstract
- Phenotype of Acute Myeloid Leukemia
- Etiology of Acute Myeloid Leukemia
- Genetic and Epigenetic Alterations in Acute Myeloid Leukemia
- Biology of Acute Myeloid Leukemia
- Future Directions
- Suggested Readings
- Chapter 60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia
- Abstract
- Epidemiology
- Clinical and Laboratory Manifestations
- Diagnosis and Classification
- Prognosis
- Therapeutic Considerations at Initial Presentation
- Acute Promyelocytic Leukemia
- Blastic Plasmacytoid Dendritic Cell Neoplasm (Chapter 64)
- Extramedullary Acute Myeloid Leukemia
- Future Directions
- Suggested Readings
- Chapter 61. Myelodysplastic Syndromes
- Abstract
- History
- Classification
- Epidemiology
- Pathobiology
- Germline Predisposition
- Clinical Manifestations
- Laboratory Manifestations
- Differential Diagnosis
- Prognosis
- Treatment of Patients with Myelodysplastic Syndromes
- Future Directions
- Suggested Readings
- References
- Chapter 62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
- Abstract
- Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
- Transplantation for Myelodysplastic Syndrome
- Future Directions
- References
- Suggested Readings
- Chapter 63. Acute Myeloid Leukemia in Children
- Abstract
- Epidemiology
- Pathobiology
- Conclusion
- Suggested Reading
- References
- Chapter 64. Blastic Plasmacytoid Dendritic Cell Neoplasm
- Abstract
- Epidemiology
- Pathobiology
- Clinical Manifestations and Recommended Diagnostic Evaluation
- Histopathology
- Differential Diagnosis
- Prognosis
- Therapy
- Future Directions
- Suggested Readings
- References
- Chapter 65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children
- Abstract
- Myelodysplastic Syndromes
- Myeloproliferative Neoplasms
- Chronic Myeloid Leukemia
- Other Myeloproliferative Neoplasms
- Future Directions
- Suggested Readings
- References
- Chapter 66. Pathobiology of Acute Lymphoblastic Leukemia
- Abstract
- Introduction
- Lineage-Specific Features of Leukemic Lymphoblasts
- Genetic Basis of Acute Lymphoblastic Leukemia
- Germline Predisposition in Acute Lymphoblastic Leukemia
- Chemotherapy Resistance Mechanisms and Novel Therapeutic Targets
- Future Directions
- Suggested Readings
- Chapter 67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia
- Abstract
- Epidemiology
- Pathobiology
- Genomics of Acute Lymphoblastic Leukemia
- Clinical Manifestations
- Differential Diagnosis
- Prognosis
- Therapy, Including Stem Cell Transplantation
- Acute Lymphoblastic Leukemia Relapse
- Immunotherapeutic Options for Acute Lymphoblastic Leukemia
- Supportive Care
- Drug Interactions
- Late Effects of Treatment
- Future Directions
- Update
- Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia
- Update
- Apixaban versus no anticoagulation for the prevention of venous thromboembolism in children with newly diagnosed acute lymphoblastic leukaemia or lymphoma
- References
- Chapter 68. Acute Lymphoblastic Leukemia in Adults
- Abstract
- Epidemiology
- Etiology
- Clinical Manifestations
- Clinical and Laboratory Evaluation
- Approach to Diagnosis
- Morphology
- Cytochemistry
- Immunophenotype
- Cytogenetics and Molecular Genetics
- Differential Diagnosis
- Prognosis
- Minimal Residual Disease
- Treatment of Acute Lymphoblastic Leukemia
- Remission Induction
- Postremission Therapy
- Central Nervous System Disease: Prophylaxis and Treatment
- Maintenance Therapy
- Allogeneic Stem Cell Transplant In First Complete Remission
- Therapy for Specific Disease Subsets
- Burkitt Lymphoma/Leukemia
- Adolescents and Young Adults With Acute Lymphoblastic Leukemia: The Intersection Between Pediatric And Adult Care
- Differences in Treatment for B- Versus T-Cell Acute Lymphoblastic Leukemia
- Older Adults With Acute Lymphoblastic Leukemia
- Relapsed Acute Lymphoblastic Leukemia
- Novel Therapies
- Survivorship
- Future Directions
- Suggested Readings
- Epidemiology, Classification, and Prognosis
- References
- Chapter 69. Chronic Myeloid Leukemia
- Abstract
- Introduction and Historical Perspective
- Epidemiology
- Molecular Biology
- Cellular Biology
- Transformation to Accelerated and Blast Phase
- Molecular Basis of Tyrosine Kinase Inhibitor Resistance
- Diagnosis and Initial Workup
- Risk Stratification
- Differential Diagnosis
- Monitoring Response to Therapy
- Therapy
- Approach to the Newly Diagnosed Chronic Phase Patient
- Approach to the Patient with Tyrosine Kinase Inhibitor Resistance
- Treatment-Free Remission
- Future Directions
- Acknowledgments
- Suggested Readings
- References
- Chapter 70. The Polycythemias
- Abstract
- Erythropoiesis
- Erythropoietin, Oxygen Sensing, and Hypoxia-Inducible Factor
- The Erythropoietin Receptor
- The Renin–Angiotensin System and Hematopoiesis
- Definition and Classification of Polycythemia
- Relative Polycythemia
- Absolute Polycythemias
- Secondary Polycythemias
- Polycythemia Vera
- Clinical Manifestations
- Laboratory Manifestations
- Cytogenomic Abnormalities
- Differential Diagnosis
- Prognosis
- Therapy
- Future Directions
- Update
- Rusfertide, a Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera
- Suggested Readings
- References
- Chapter 71. Essential Thrombocythemia
- Abstract
- Epidemiology
- Pathobiology
- Clinical Manifestations
- Laboratory Manifestations
- Differential Diagnosis
- Prognosis
- Therapy
- Future Directions
- References
- Chapter 72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia
- Abstract
- Phylogeny of the Nomenclature: Primary Myelofibrosis
- Epidemiology
- Pathobiology of Primary Myelofibrosis
- Driver mutations
- The role of epigenetic mutations in the molecular landscape of primary myelofibrosis
- Extramedullary hematopoiesis in primary myelofibrosis
- Bone marrow fibrosis in primary myelofibrosis
- Clonal Evolution of Primary Myelofibrosis
- Clinical Manifestations
- Laboratory Manifestations
- Differential Diagnosis
- Prognosis
- Evolution of Prognostic Models in Primary Myelofibrosis
- Management of PRIMARY MYELOFIBROSIS
- Treatment of the anemic patient
- Treatment of spleen-related and systemic symptoms
- Allogeneic hematopoietic stem cell transplantation
- Investigational therapeutic options
- Future Directions
- Chronic Neutrophilic Leukemia
- Molecular pathogenesis of chronic neutrophilic leukemia
- Clonal evolution
- Clinical and laboratory features of chronic neutrophilic leukemia
- Diagnosis
- Differential diagnosis
- Prognosis
- Management of chronic neutrophilic leukemia
- Future directions
- References
- Chapter 73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes
- Abstract
- Epidemiology
- Diagnostic Evaluation and Criteria
- Pathogenesis and Molecular Characterization
- Risk Stratification and Prognosis
- Treatment Approaches
- Future Directions
- Conclusion
- References
- Chapter 74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes
- Abstract
- Epidemiology
- Morphology and Phenotype of Eosinophils
- Origin, Differentiation, Recruitment, and Activation of Eosinophils
- Monitoring of Eosinophil Numbers and Activity in Health and Disease
- Etiology and Pathobiology of Hypereosinophilia
- Definition and Classification of Hypereosinophilia and Hypereosinophilic Syndrome
- Clinical Manifestations of Hypereosinophilic Syndrome in Various Organ Systems and Differential Diagnosis
- Treatment Algorithm, Treatment Options, and Prognosis
- Summary and Future Perspectives
- References
- Chapter 75. Mast Cells and Mastocytosis
- Abstract
- Origin and Development of Mast Cells
- Mast Cell Activation and Function
- Tools to Study Human Mast Cells
- Epidemiology and Classification of Mastocytosis
- Treatment
- Future Directions
- Suggested Readings
- References
- Chapter 76. Chronic Lymphocytic Leukemia
- Epidemiology
- Familial Chronic Lymphocytic Leukemia
- Pathobiology
- B-Cell Receptor Pathway and Its Role in Pathogenesis
- Clinical Manifestations
- Diagnosis and Laboratory Manifestations
- Monoclonal B-Cell Lymphocytosis
- Laboratory Manifestations
- Prognosis
- Treatment
- Targeted Therapy
- Bruton Tyrosine Kinase Inhibitors
- Treatment of Patients With Relapsed Chronic Lymphocytic Leukemia
- Special Clinical Scenarios in Chronic Lymphocytic Leukemia
- Infections in Patients With Chronic Lymphocytic Leukemia
- Autoimmune Complications of Chronic Lymphocytic Leukemia
- SARS-COV-2 and Chronic Lymphocytic Leukemia
- Future Directions
- Update
- Pirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia
- Update
- Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease
- Suggested Readings
- Chapter 77. Hairy Cell Leukemia
- Abstract
- Epidemiology
- Etiology and Cell of Origin
- Clinical Presentation and Diagnosis
- Differential Diagnosis
- Treatment
- Future Directions
- References
- Chapter 78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
- Abstract
- Introduction and Historical Background
- Mature B-Cell Neoplasms
- T-CELL and Natural Killer-Cell Lymphomas
- Suggested Readings
- References
- Chapter 79. Origin of Hodgkin Lymphoma and Therapeutic Targets
- Abstract
- CHARACTERISTICS AND ORIGIN OF HODGKIN LYMPHOMA
- Therapeutic Targets
- Conclusions and Future Directions
- References
- Chapter 80. Hodgkin Lymphoma
- Abstract
- Epidemiology and Etiology Incidence and Age of Onset
- Pathobiology of Hodgkin Lymphoma
- Diagnosis and Staging
- Clinical Features
- Prognostic Factors, Risk Stratification, and Treatment Groups
- Treatment of Early-Stage Hodgkin Lymphoma
- Treatment of Advanced-Stage Hodgkin Lymphoma
- Relapsed and Refractory Hodgkin Lymphoma
- Special Considerations
- Long-Term Complications of Treatment in Hodgkin Lymphoma
- Suggested Readings
- References
- Chapter81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets
- Abstract
- Overview of B-Cell Lymphomas
- Diffuse Large B-Cell Lymphoma
- Gene Expression Profiles Define Diffuse Large B-Cell Lymphoma Subtypes
- Burkitt Lymphoma
- Follicular Lymphoma
- Mantle Cell Lymphoma
- Other Non-Hodgkin Lymphomas
- Future Directions
- Suggested Readings
- Chapter 82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
- Abstract
- Epidemiology
- Pathogenesis
- Clinical Presentation
- Diagnosis of Follicular Lymphoma
- Staging
- Natural History
- Treatment of Follicular Lymphoma
- When to Institute Therapy
- Treatment Approaches
- Treatment of Relapsed Follicular Lymphoma
- Suggested Readings
- References
- Chapter 83. Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)
- Abstract
- Initial Evaluation of Marginal Zone Lymphoma
- Staging of Marginal Zone Lymphoma
- Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Type
- Splenic Marginal Zone Lymphoma
- Nodal Marginal Zone Lymphoma
- Suggested Readings
- References
- Chapter 84. Diffuse Large B-Cell Lymphoma of the Central Nervous System
- Epidemiology
- Pathogenesis
- Clinical Presentation
- Neuroimaging
- Neuroimaging and Differential Diagnosis Prior to Biopsy
- Tissue Diagnosis
- Cerebrospinal Fluid Assessment for Diagnosis
- Ophthalmology Exam and Vitreoretinal Specimen Testing for Diagnosis
- Histology Characterization
- Biomarkers for Diagnosis
- Staging
- Frontline Therapy and Response Assessment
- Induction Therapy
- Consolidation
- Primary Central Nervous System Lymphoma in Older Adults
- Induction in Older Adults—Should it Be REDUCED?
- AUTOLOGOUS Hematopoietic Stem Cell Transplantation in Older Adults as Consolidation Therapy
- Maintenance Therapy—Emerging Concept
- Treatment of Primary Vitreoretinal Lymphoma - A Subset of Primary Central Nervous System Lymphoma
- Real-World Treatment Patterns and Outcomes—Data from Population-Based Studies
- Primary Central Nervous System Lymphoma in the Immunocompromised Host
- Post-Transplant Lymphoproliferative Disease–Related Primary Central Nervous System Lymphoma
- Autoimmune Disease–Related Primary Central Nervous System Lymphoma
- Experimental Therapeutics in Primary Central Nervous System Lymphoma
- NGR-Human Tumor Necrosis Factor With R-CHOP
- Front-line Treatment Challenges and Controversies
- Prognostic and Predictive Markers
- Additional Prognostic and Predictive Markers
- Relapsed and Refractory Disease
- Non-Chemotherapeutic Targets and Agents
- Prevention of Cns Relapse for Aggressive Systemic Lymphomas and Controversies
- Perspective and Future Directions
- Acknowledgments
- Suggested Readings
- References
- Chapter 85. High-Grade B-Cell Lymphomas
- Abstract
- Diffuse Large B-Cell Lymphoma
- Primary Central Nervous System Lymphoma
- Burkitt Lymphoma
- Salvage Therapy
- Future Directions
- References
- Chapter 86. Mantle Cell Lymphoma
- Abstract
- Epidemiology
- Pathobiology
- Clinical Manifestations
- Laboratory Manifestations
- Diagnosis
- Therapy
- Prognosis
- Future Directions
- References
- Chapter 87. Virus-Associated Lymphoma
- Abstract
- Epstein-Barr Virus
- Kaposi Sarcoma–Associated Herpesvirus
- Human T-Lymphotropic Virus-1
- Human Immunodeficiency Virus-Associated Lymphomas
- Hepatitis C Virus
- Future Directions
- Suggested Readings
- References
- Chapter 88. Malignant Lymphomas in Childhood
- Abstract
- Non-Hodgkin Lymphoma
- Hodgkin Lymphoma
- Rare Subtypes of Lymphoma
- Future Directions
- Suggested Reading
- References
- Chapter 89. T-Cell Lymphomas
- Abstract
- Classification and Cell of Origin
- Chronic T-Cell Leukemias
- Cutaneous T-Cell Lymphomas
- References
- Suggested Readings
- Chapter 90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
- Abstract
- Monoclonal Gammopathy of Undetermined Significance
- Variants of Monoclonal Gammopathy of Undetermined Significance
- Smoldering Multiple Myeloma
- Risk Stratification
- Future Directions
- References
- Chapter 91. Multiple Myeloma
- Abstract
- Screening, Epidemiology, and Risk Factors
- Pathogenesis
- Clinical Implications of Clonal Heterogeneity and Evolution
- Immune and Bone Marrow Microenvironment
- Clinical Manifestations
- Genomic Biomarkers
- Differential Diagnosis
- Indications for Treatment
- Treatment of Newly Diagnosed Myeloma
- Relapsed Disease
- Future Directions
- Update
- Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
- Update
- Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma
- Update
- Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma
- Suggested Readings
- References
- Chapter 92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma
- Abstract
- Epidemiology
- Pathogenesis
- Mutation in MYD88
- CXCR4 Whim Mutations
- Impact of WM Genomics on Clinical Presentation
- Marrow Microenvironment
- Clinical Features
- Morbidity Mediated by the Effects of Immunoglobulin M
- Laboratory Findings
- Marrow Findings
- Immunologic Abnormalities
- Serum Viscosity
- Imaging
- Lymph Node Biopsy
- Treatment
- Future Directions
- Suggested Readings
- References
- Chapter 93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
- Abstract
- Epidemiology
- Pathobiology of the Disease
- Clinical Manifestations
- Laboratory Manifestations
- Differential Diagnosis
- Prognosis
- Mayo Clinic Treatment Approach in Newly Diagnosed Amyloid Light-Chain Amyloidosis
- Conclusions
- Future Directions
- References
- Suggested Readings
- Part VIII: Comprehensive Care of Patients with Hematologic Malignancies
- Chapter 94. Key Considerations for Managing Infections in the Compromised Host
- Abstract
- Hematologic Conditions Predisposing To Infection
- Infection Management In The Hematopoietic Stem Cell Transplant Recipient: A Model Of Severe Immune Deficiency
- Suggested Readings
- References
- Chapter 95. Principles of Radiation Therapy for Hematologic Disease
- Abstract
- History and Background
- Modern Radiation Planning and Treatment Techniques
- Radiation Therapy by Diagnosis
- Dose Constraints and Tolerances
- Summary of Guidelines
- Future Directions
- Suggested Readings
- References
- Chapter 96. Grading and Toxicity Management after Immune Effector Therapy
- Abstract
- Cytokine Release Syndrome
- Grading of Cytokine Release Syndrome
- Management of Cytokine Release Syndrome
- Immune Effector Cell–Associated Neurotoxicity Syndrome
- Grading of Immune Effector Cell–Associated Neurotoxicity Syndrome
- Management of Immune Effector Cell–Associated Neurotoxicity Syndrome
- Other Toxicities from Immune Effector Therapy
- Conclusions
- References
- Chapter 97. Identification and Management of Checkpoint Inhibition Toxicity
- Abstract
- Immunotherapy-Related Fatigue and Systemic Toxicities
- Dermatologic/Mucosal Toxicity
- Diarrhea/Colitis
- Hepatitis
- Pneumonitis
- Endocrinopathies
- Patients with Autoimmune Disease
- Conclusions
- References
- Chapter 98. Psychosocial Aspects Of Hematologic Disorders
- Abstract
- Clinical Course of Hematologic Malignancies
- Hematopoietic Stem Cell Transplantation
- Factors that Influence Psychosocial Adjustment
- Differentiating Psychiatric Complications from Expected Psychologic Response
- Screening for Psychologic Distress
- Screening for Positive Psychological Wellbeing
- Management of Psychosocial Problems
- Future Directions
- Suggested Readings
- References
- Chapter 99. Pain Management and Antiemetic Therapy in Hematologic Disorders
- Abstract
- Taxonomy of Pain
- Evaluation of the Pain Complaint
- Therapy Directed at the Underlying Etiology
- Nonpharmacologic Methods of Pain Management
- Pharmacotherapy
- Specific Clinical Problems
- Pathophysiology of Nausea and Vomiting
- Patient Assessment
- Therapy
- Conclusion
- Acknowledgments
- Suggested Readings
- References
- Chapter 100. Palliative Care
- Abstract
- Communication
- Relief of Suffering
- Management Concerns During the Last Days of Life
- Hospice Programs
- Bereavement
- Conclusion and Future Directions
- References
- Chapter 101. Therapy-Related Late Effects of Hematologic Malignancies
- Abstract
- Cardiovascular Disease
- Pulmonary Effects
- Endocrinologic Effects
- Musculoskeletal Effects
- Cognitive Impairment
- Other Toxicities
- Potential Late Effects By Diagnosis
- Providing Clinical Care to Survivors
- Future Directions
- Suggested Readings
- References
- Part IX: Transplantation and Other Cell-Based Therapies
- Chapter 102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization
- Stem Cell Donor
- Stem Cell Collection
- Collection Peripheral Blood Stem Cells
- Combination Regimen
- Collection of Peripheral Blood Stem Cells by Apheresis
- Hematopoietic Stem Cell Product Quality
- References
- Chapter 103. Graft Engineering and Cell Processing
- Abstract
- Regulatory Issues With Cell Processing
- Professional Standards
- Manipulation of Hematopoietic Stem Cell Transplantation Products
- Evaluation of Manipulated Allogeneic Grafts
- Cellular Therapy Products
- Future Directions
- References
- Chapter 104. Principles of Cell-Based Genetic Therapies
- Abstract
- Hematologic Diseases, Cellular Targets, and the Basis for Genetic Therapies
- Vector Systems
- Experience in Hematologic Clinical Trials to Date
- Chronic Granulomatous Disease
- Insertional Mutagenesis
- Recent Modifications of Vector Systems Based on Clinical Experience
- Future Directions
- Acknowledgments
- Suggested Readings
- References
- Chapter 105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
- Abstract
- Background
- Patient Population
- Conditioning Regimens
- Graft Sources
- Impact of Measurable Residual Disease
- Prevention of Relapse after Allogeneic Transplantation
- Long-Term Survival after Allogeneic Transplantation
- Disease-Specific Indications for Allogeneic Transplantation
- Suggested Readings
- References
- Chapter 106. Unrelated Donor Hematopoietic Cell Transplantation
- Abstract
- The Human Leukocyte Antigen and Killer-Cell Immunoglobulin-LIKE Receptor Genetic Systems
- Human Leukocyte Antigen Typing Methods
- Genetics of the Killer-CellImmunoglobulin-Like Receptors System
- Killer-Cell Immunoglobulin-Like Receptors Typing Methods
- Donor Identification and Likelihood of Transplantation
- Human Leukocyte Antigen Criteria
- Human Leukocyte Antigen Vector of Mismatching
- Human Leukocyte Antigen Haplotypes
- Donor Killer-Cell Immunoglobulin-LIKE Receptor Criteria
- Clinical Significance of Human Leukocyte Antigen and Killer-Cell Immunoglobulin-LIKE Receptor in Transplantation
- Summary
- Suggested Readings
- References
- Chapter 107. Haploidentical Hematopoietic Stem Cell Transplantation
- Abstract
- Introduction
- Historical Perspective
- Immunological Considerations of Major Human Leukocyte Antigen Mismatched Grafts
- Modern approaches to haploidentical transplantation (Fig. 107.3)
- Comparative Outcomes Between Haploidentical and Other Donor Grafts
- Potential Complications After Haploidentical Transplantation
- Donor Selection for Haploidentical Transplantation (Table 107.4)
- Conclusions and Future Directions
- References
- Suggested Readings
- Chapter 108. Cord Blood Transplantation
- Cord Blood as a Stem Cell Source
- Cord Blood Unit Selection
- Donor-Specific Antibodies
- Conditioning Regimens in Cord Blood Transplantation
- Graft-Versus-Host Disease in Cord Blood Transplantation
- Outcomes of Cord Blood Transplantation
- Other Diseases
- Outcomes of Cord Blood Relative to Other Donor Types
- Strategies to Improve Cord Blood Transplantation Outcomes
- Supportive Care in Cord Blood Transplantation
- Summary
- Suggested Readings
- References
- Chapter 109. Graft-Versus-Host Disease and Graft-Versus-Leukemia Responses
- Abstract
- Graft-Versus-Host Disease: Clinical and Pathologic Aspects
- Pathophysiology of Acute Graft-Versus-Host Disease
- Biomarkers of Graft-Versus-Host Disease
- Chronic Graft-Versus-Host Disease
- Chronic Graft-Versus-Host Disease: Pathophysiology
- Therapy for Chronic Graft-Versus-Host Disease
- Syngeneic Graft-Versus-Host Disease
- Graft-Versus-Leukemia Responses
- Donor Leukocyte Infusions
- Future Directions
- Update
- Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis
- References
- Chapter 110. Supportive Care for the Transplant Patient
- Abstract
- Infections
- Early Non-Infectious Complications
- Late Non-Infectious Complications
- Graft-Versus-Host Disease
- Future Directions
- Suggested Readings
- References
- Part X: Transfusion Medicine
- Chapter 111. Human Blood Group Antigens and Antibodies
- Abstract
- Erythrocyte Blood Group Antigens
- References
- Chapter 112. Principles of Red Blood Cell Transfusion
- Abstract
- Red Blood Cell Components
- Appropriate Transfusion Practice in Various Clinical Settings
- Red Blood Cell Preservation and Storage
- Biochemical Changes Associated with Red Blood Cell Storage
- Red Cell Alloimmunization
- Alternatives to Allogeneic Red Cell Transfusions
- Blood Substitutes
- Red Blood Cell Substitutes
- Suggested Reading
- Chapter 113. Clinical Considerations in Platelet Transfusion Therapy
- Abstract
- Platelet Collection and Manufacturing
- Prophylactic Platelet Transfusion
- Adverse Effects of Platelet Transfusion
- Platelet Refractoriness
- References
- Chapter 114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems
- The Genetics, Structure, and Function of Human Leukocyte Antigen Molecules
- Organization of the Human Leukocyte Antigen Genes
- Inheritance and Linkage Disequilibrium
- Structure of the Human Leukocyte Antigen Class I and II
- Expression of Human Leukocyte Antigen Molecules
- Human Leukocyte Antigen Polymorphism and Its Clinical Significance
- Nonclassic Major Histocompatibility Complex and Major Histocompatibility Complex Class I Chain-Related Molecules
- Non-Human Leukocyte Antigen Polymorphism and Its Clinical Significance
- Human Leukocyte Antigen Nomenclature
- Immunologically Defined Human Leukocyte Antigen Nomenclature
- Sequence-Defined Allelic Nomenclature
- Human Leukocyte Antigen Typing in Clinical Hematology and Determination of Compatibility Human Leukocyte Antigen Typing
- Testing for Allosensitization and Determination of Compatible Donor-RECIPIENT Pairs
- The Human Leukocyte Antigen Molecules as Antigens and Human Leukocyte Antigen Alloimmunization
- Human Leukocyte Antigen as a Functional Mediator of Graft-Versus-Host Disease and/or Graft-Versus-Neoplasia Effect
- Graft-Versus-Host Disease
- Graft-Versus-Neoplasia Effect
- Human Leukocyte Antigen and T-Cell-Directed Immunization
- Monitoring Immune Responses With Tetrameric Human Leukocyte Antigen-Peptide Complexes
- Human Leukocyte Antigen Summary
- Human Neutrophil Antigens and Their Clinical Significance
- The HNA-1 Antigen System
- The HNA-2 Antigen System
- The HNA-3 Antigen System
- HNA-4 and HNA-5 Antigen Systems
- Clinical Significance of Antibodies to Neutrophil Antigens
- Autoimmune Neutropenia of Childhood
- Transfusion Reactions
- Neutrophil Antigens Summary
- Suggested Readings
- References
- Chapter 115. Principles Of Plasma And Plasma Derivatives
- Abstract
- Plasma
- Cryoprecipitate
- Plasma Derivatives
- Albumin
- Human Immunoglobulin
- Hyperimmune Immunoglobulin Products
- Coagulation Factor Concentrates
- References
- Suggested Readings
- Chapter 116. Hemapheresis
- Abstract
- Principles of Apheresis
- Technology and Techniques
- Therapeutic Plasma Exchange (Plasmapheresis)
- Replacement Fluids for Plasma Exchange
- Mononuclear Cell Collection for Cellular Immunotherapies
- Pediatric Hemapheresis
- Complications of Therapeutic Apheresis
- Conclusions and Future Directions
- References
- Chapter 117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products
- Abstract
- Hemolytic Transfusion Reactions
- Acute Intravascular Hemolytic Transfusion Reactions
- Acute Extravascular Hemolytic Transfusion Reactions
- Delayed Hemolytic Reactions
- Febrile Nonhemolytic Transfusion Reactions
- Allergic Transfusion Reactions
- Transfusion-Related Acute Lung Injury
- Transfusion-Associated Circulatory Overload
- Hypotensive Transfusion Reaction
- References
- Chapter 118. Transfusion-Transmitted Diseases
- Abstract
- Hepatitis Viruses
- Retroviral Infections
- Human Herpesvirus Infections
- Epstein-Barr Virus (HHV-4)
- Parvovirus
- West Nile Virus
- Dengue Viruses
- Chikungunya Virus
- Zika Virus
- SARS-CoV-2 (COVID-19)
- Pandemic Influenza A
- Bacterial Infections
- Spirochete Infections
- Parasitic Infections
- Transmissible Spongiform Encephalopathies
- Future Directions
- Suggested Readings
- References
- Chapter 119. Pediatric Transfusion Medicine
- Abstract
- Pediatric Blood Banking
- Technical Considerations/Mechanical Devices
- Transfusion Medicine: General Indications and Dosing
- Transfusion Medicine: Indications in Unique Pediatric Populations
- References
- Chapter 120. Transfusion and Apheresis Support for Sickle Cell Disease Patients
- Abstract
- Hemodynamic Considerations
- Clinical Considerations for Transfusion
- Acute Anemia
- Transfusion for Complications of Sickle Cell Disease
- Apheresis Supported Red Cell Exchange
- PREPARATIVE TRANSFUSION for Stem Cell Transplantation
- Selection of Red Cell Components for Transfusion
- Red Cell Antigen Matching
- Complications of Transfusion Therapy
- Iron Overload
- References
- Part XI: Hemostasis and Thrombosis
- Chapter 121. Overview of Hemostasis and Thrombosis
- Abstract
- Introduction
- Hemostatic System
- Disorders of Hemostasis or Thrombosis
- Treatment of Disorders of Hemostasis and Thrombosis
- References
- Chapter 122. Blood Vessels
- Abstract
- Hemostatic, Hematopoietic, and Vascular Systems as a Functional Continuum
- Structure and Function of the Vessel Wall
- Endothelial Structure, Function, and Heterogeneity
- Physiologic Functions of the Endothelium
- Interaction of Blood Cells with the Vessel Wall
- Endothelial Cell Activation and Dysfunction
- Molecular Regulators of Vascular Growth Responses
- Pleiotropic Regulators of Vascular Growth
- Endogenous Inhibitors of Vascular Growth
- Cellular and Molecular Programs Involved in Blood Vessel Growth and Homeostasis
- Mechanisms Triggering Blood Vessel Growth
- Therapeutic Implications of Endothelial and Angiogenic Responses to Disease
- Tumor Angiogenesis and Antiangiogenesis
- Angiogenesis and Antiangiogenesis in Hematopoietic Malignancies
- Hematologic Complications Associated With Blood Vessel-Directed Agents
- Relationship Between the Vasculature and Hematopoiesis
- Summary
- Suggested Readings
- References
- Chapter 123. Megakaryocyte And Platelet Structure
- Abstract
- Megakaryocyte Development
- Regulation of Megakaryocyte Development
- Platelet Formation
- Platelets
- References
- Chapter 124. Molecular Basis of Platelet Function
- Abstract
- Molecular Basis of Platelet Adhesion
- Molecular Basis of Platelet Activation
- Molecular Basis of Platelet Aggregation
- Molecular Basis of Inherited Platelet Disorders
- Suggested Readings
- References
- Chapter 125. Molecular Basis of Blood Coagulation
- Abstract
- Inventory: Procoagulant, Anticoagulant, and Fibrinolytic Proteins, Inhibitors and Receptors
- Connectivity and Dynamics in Hemostasis
- Summary
- Acknowledgments
- Suggested Readings
- References
- Chapter 126. Evaluation of the Patient With Suspected Bleeding Disorders
- Abstract
- BLEEDING HISTORY EVALUATION
- Bleeding Score
- The Physical Examination
- Epidemiology and Genetics
- Laboratory Manifestations
- Prognosis
- Therapy
- Summary
- Suggested Readings
- References
- Chapter 127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders
- Abstract
- Laboratory Evaluation of Coagulation Proteins
- Screening for Coagulation Protein Defects: Activated Partial Thromboplastin Time, Prothrombin Time, and Thrombin Clotting Time
- Evaluation of Specific Coagulation Protein Defects
- Practical Approach to Laboratory Testing of Coagulation Proteins
- Laboratory Evaluation of Platelets and Von Willebrand Factor
- Laboratory Evaluation of Fibrinolysis
- Other Activities for Hemostasis Laboratories
- References
- Chapter 128. Acquired Disorders of Platelet Function
- Abstract
- Drugs, Foods, and Additives that Affect Platelet Function
- Antiplatelet Drugs
- Other Drugs that Adversely Affect Platelet Function
- Clonal Disorders
- Systemic Metabolic Disorders
- Platelet Dysfunction Related with Extracorporeal Circuits
- Infectious Diseases
- Suggested Readings
- References
- Chapter 129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
- Abstract
- Immune Thrombocytopenia
- Clinical Features
- Fostamatinib
- Immune Suppressant Medications
- Neonatal Alloimmune Thrombocytopenia
- Posttransfusion Purpura
- Suggested Readings
- References
- Chapter 130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution
- Abstract
- Approach to Patients with Thrombocytopenia
- Anatomy and Physiology
- Pathologic Platelet Sequestration: Hypersplenism
- Drug-Induced Thrombocytopenic Syndromes
- Drug-Induced Immune Thrombocytopenia
- Drug-Induced Immune Thrombocytopenia of Rapid Onset
- Thrombocytopenia Caused By Glycoprotein Iib/Iiia Receptor Antagonists
- Hemodilution and Platelet Consumption After Surgery
- Suggested Readings
- References
- Chapter 131. Heparin-Induced Thrombocytopenia
- Abstract
- Epidemiology
- Pathobiology
- Clinical and Laboratory Manifestations
- Autoimmune Hit
- Differential Diagnosis
- Clinical Scoring Systems
- Laboratory Diagnosis
- Prognosis
- Therapy
- Platelet Count Monitoring for Heparin-Induced Thrombocytopenia
- Anticoagulation and Previous Heparin-Induced Thrombocytopenia
- Suggested Readings
- References
- Chapter 132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
- Abstract
- Differential Diagnosis
- Treatment of Thrombotic Thrombocytopenic Purpura
- Infection-Associated Hemolytic Uremic Syndrome
- Atypical Hemolytic Uremic Syndrome
- Genetics
- Other Thrombotic Microangiopathic Disorders
- Suggested Readings
- References
- Chapter 133. Structure, Biology, and Genetics of von Willebrand Factor
- Abstract
- Functions of Von Willebrand Factor
- Basal Von Willebrand Factor Levels
- Von Willebrand Factor Gene
- Domain Structure
- Biosynthesis
- Storage and Secretion
- ADAMTS13
- Clearance
- ABO Blood Groups
- Areas of Ongoing Investigation
- Von Willebrand Disease
- Suggested Readings
- References
- Chapter 134. Hemophilia A and B
- Abstract
- Epidemiology
- Factor VIII Biology: Genetics, Structure, Function, and Pathophysiology
- Pathophysiology of Hemophilia A
- Factor Ix Biology: Genetics, Structure, Function, and Pathophysiology
- Clinical Features of Hemophilia
- Clinical Management of Hemophilia
- Inhibitors in Hemophilia B
- Management of Inhibitors in Hemophilia B
- Gene Therapy for Hemophilia
- Hemophilia in the World—Economic Considerations
- Acknowledgment
- Update
- Hematology: Basic Principles and Practice, 8e
- Update
- Hematology: Basic Principles and Practice, 8e
- Suggested Readings
- References
- Chapter 135. Rare Coagulation Factor Deficiencies
- Abstract
- Inherited Fibrinogen Deficiency (OMIM 202400)
- Inherited Dysfibrinogenemia (Omim 134820 Aa Chain, 134830 Bb Chain, 134850 g Chain)
- Inherited Prothrombin Deficiency (Omim 176930)
- Inherited Factor V Deficiency (Omim 227400)
- Inherited Factor Vii Deficiency (Omim 227500)
- Inherited Factor X Deficiency (OMIM 227600)
- Inherited Factor Xi Deficiency (Omim 264900)
- Deficiencies of Factor Xii, Prekallikrein or High Molecular Weight Kininogen
- Inherited Factor Xiii Deficiency (Omim 134570 [A Subunit] and 134580 [B Subunit]
- Inherited Deficiencies Involving Multiple Coagulation Factors
- References
- Chapter 136. Transfusion Therapy for Coagulation Factor Deficiencies
- Abstract
- Hemophilia A and B
- Transfusion Therapy for Hemophilia A and B
- Treatment of Hemophilia
- Inhibitors of Factor VIII and Factor IX
- Von Willebrand Disease
- Acquired Factor VIII and Von Willebrand Factor Deficiency
- Other Coagulation Protein Deficiencies
- Other Plasma-Derived Protein Concentrates
- Future Directions
- Suggested Readings
- References
- Chapter 137. Disseminated Intravascular Coagulation
- Abstract
- Epidemiology
- Pathobiology
- Clinical Manifestations
- Laboratory Manifestations
- Differential Diagnosis
- Therapy
- References
- Chapter 138. Hypercoagulable States
- Abstract
- Inherited Hypercoagulable States
- Acquired Hypercoagulable States
- Combined Inherited and Acquired Hypercoagulable States
- Clinical Evaluation of Patients with Hypercoagulable States
- Thrombophilia Screening
- Laboratory Evaluation of Thrombophilia
- Management of Thrombosis in Patients with Hypercoagulable States
- Conclusions and Future Directions
- References
- Chapter 139. Antiphospholipid Syndrome
- Abstract
- Definition of Antiphospholipid Syndrome
- Antigenic Specificities of Antiphospholipid Antibodies
- Pathogenic Effects of Antiphospholipid Antibodies
- Antiphospholipid Assays
- Clinical Manifestations of the Antiphospholipid Syndrome
- Criteria Manifestations of Antiphospholipid Syndrome
- Reproductive Manifestations
- Non-Criteria Manifestations of Antiphospholipid Syndrome
- Hematological Abnormalities
- Catastrophic Antiphospholipid Syndrome
- Treatment of Antiphospholipid Syndrome
- Other Treatments for Antiphospholipid Syndrome
- Suggested Readings
- Chapter 140. Venous Thromboembolism
- Abstract
- Epidemiology
- Pathogenesis of Venous Thromboembolism
- Clinical Manifestations of Venous Thromboembolism
- Diagnosis of Venous Thromboembolism
- Evaluation for Underlying Malignancy
- Treatment of Venous Thromboembolism
- Venous Thromboembolism Management in Specific Populations
- Psychosocial Considerations
- Prevention of Venous Thromboembolism
- Attributions
- Suggested Readings
- References
- Chapter 141. Prevention and Treatment of Venous Thromboembolism in Pregnancy
- Abstract
- Epidemiology
- Pathophysiology
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Manifestations
- Prognosis
- Therapy
- Covid-19 and Pregnancy
- Future Directions
- References
- Chapter 142. Atherothrombosis
- Abstract
- Pathobiology
- Central Role of Lipoproteins in Atherogenesis
- Foam Cell Formation and the Fatty Streak
- Lesion Evolution: Remodeling and the Vulnerable Plaque
- Plaque Rupture and Acute Arterial Thrombosis
- Hyperlipidemia, Atherosclerosis, and a Systemic Prothrombotic State
- Cross Talk Between Coagulation and Inflammation Systems Impact Atherogenesis
- Plaque Regression
- Additional Future Directions
- References
- Chapter 143. Antithrombotic Drugs
- Abstract
- Antiplatelet Drugs
- Anticoagulants
- Oral Anticoagulants
- Fibrinolytic Drugs
- Conclusions and Future Directions
- References
- Chapter 144. Stroke
- Abstract
- Definition
- Epidemiology
- Pathobiology
- Clinical Manifestations
- Investigations
- Therapy
- Prognosis
- Future Directions
- LIST OF TRIAL ACRONYMS
- Update
- Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke
- Suggested Readings
- Chapter 145. Acute Coronary Syndromes
- Abstract
- Classification
- Pathophysiology
- Antithrombotic Management
- Reperfusion Therapy For St-Segment Elevation Myocardial Infarction
- Antiplatelet Therapy
- Anticoagulant Therapy
- Conclusions and Future Directions
- Update
- Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia
- Suggested Readings
- References
- Chapter 146. Peripheral Artery Disease
- Abstract
- Epidemiology
- Pathobiology
- Clinical Manifestations
- Diagnosis
- Prognosis
- Therapy
- Future Directions
- Suggested Readings
- References
- Chapter 147. Atrial Fibrillation
- Abstract
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Prevention of Stroke and Thromboembolism
- Anticoagulant-Related Bleeding
- Future Directions
- Update
- Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation
- References
- Chapter 148. Bleeding And Clotting Disorders In Pediatrics
- Abstract
- Developmental Hemostasis
- Bleeding Disorders In Pediatrics
- Clotting Disorders In Pediatrics
- Suggested Readings
- References
- Part XII: Consultative Hematology
- Chapter 149. Hematologic Changes in Pregnancy
- Abstract
- Anemia in Pregnancy
- Hemoglobinopathies and Pregnancy
- Other Hemolytic Anemias
- Thrombocytopenia
- Leukemia and Lymphoma
- Bleeding Disorders
- Hemophilia A AND B
- Venous Thromboembolism
- Prophylactic Anticoagulation During Pregnancy
- Thrombophilias and Pregnancy
- Future Directions
- References
- Chapter 150. Hematologic Manifestations of End-Organ Failure
- Abstract
- Hematologic Manifestations of Liver Disease
- Red Blood Cell Abnormalities
- White Blood Cell Abnormalities
- Platelet Abnormalities
- Coagulation and Liver Disease
- Treatment of Liver Disease–Related Bleeding
- Hypercoagulability and Thrombosis in Patients with Liver Disease
- Hematologic Manifestations of Renal Disease
- Anemia
- Bleeding Risk
- Thrombosis
- Thrombotic Microangiopathies
- Hematologic Manifestations of Other End-Organ Diseases
- Respiratory Disease
- Heart Failure
- Endocrinopathies
- References
- Suggested Readings
- Chapter 151. Hematologic Manifestations of Solid Tumors
- Abstract
- Erythrocytes
- Platelets
- Leukocytes
- Thrombosis and Cancer
- Future Directions
- Suggested Readings
- References
- Chapter 152. Hematologic Manifestations of HIV/AIDS
- Abstract
- Introduction to Human Immunodeficiency Virus
- Summary
- Suggested Readings
- References
- Chapter 153. Hematologic Findings And Consequences Of Novel Coronavirus (SARS-COV-2) Infection
- Abstract
- Thrombosis in Covid-19
- Covid-19 Associated Coagulopathy
- Inflammatory Markers and Cytokine Storm
- Characteristics of the Complete Blood Count and White Blood Cell Differential in Covid-19
- Vaccination
- Monoclonal Antibodies
- References
- Chapter 154. Hematologic Aspects of Parasitic Diseases
- Abstract
- Malaria
- Visceral Leishmaniasis
- African Trypanosomiasis
- American Trypanosomiasis
- Babesiosis
- Eosinophilia
- Other Parasitic Diseases
- Future Directions
- Suggested Readings
- References
- Chapter 155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
- Abstract
- preoperative evaluation of hemostatic risk
- Hemostatic Agents
- Management of Patients With Hemostatic Abnormalities
- Intraoperative and Postoperative Bleeding
- Perioperative Anticoagulation Management
- Summary
- Suggested Readings
- References
- Chapter 156. The Spleen and Its Disorders
- Abstract
- Normal Splenic Anatomy And Function
- Examination Of The Spleen
- Imaging Of The Spleen
- Tests Of Splenic Function
- Asplenia And Hyposplenia
- Acquired Hyposplenism
- Splenomegaly And Hypersplenism
- Splenic Irradiation
- Splenectomy
- Conclusions And Future Directions
- References
- Chapter 157. Aging and Hematologic Disorders
- Abstract
- Anemia
- General Principles in Older Adults with Hematologic Malignancies
- Lymphoma in Older Adults
- Myelodysplastic Syndromes
- Acute Myeloid Leukemia
- Multiple Myeloma in Older Adults
- Hematopoietic Stem Cell Transplantation and Cellular Therapy in Older Adults
- Conclusion
- Acknowledgments
- Suggested Readings
- References
- Chapter 158. Onco-Cardiology: Focus on Cardiac Complications of Hematologic Treatments
- Abstract
- Cardiotoxicity From Chemotherapy Used In Hematological Malignancies (Table 158.1)
- Cardiotoxicity From Immunotherapy Used In Hematological Malignancies
- Cardiotoxicity of Radiation Treatment
- Cardiac Considerations During Hematopoietic Stem Cell Transplantation
- Conclusion
- References
- Suggested Readings
- Chapter 159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations
- Abstract
- Appendix Contents
- Index
- Confidence is ClinicalKey
- No. of pages: 2512
- Language: English
- Edition: 8
- Published: December 2, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323733885
- eBook ISBN: 9780443283444
RH
Ronald Hoffman
EB
Edward J. Benz
LS
Leslie E. Silberstein
HH
Helen Heslop
JW