Heart Failure in the Child and Young Adult

From Bench to Bedside

2nd Edition - December 1, 2024
Editors: Joseph Rossano, John Lynn Jefferies, Anthony C Chang, Jeffrey A. Towbin, Robert E Shaddy, Shelley Miyamoto
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 2 7 9 - 7
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 2 7 8 - 0

Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines… Read more

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Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.

This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.

Section I: Basic Science of Heart Failure

1. Molecular and Cellular Mechanisms in Heart Failure including Models of Heart Failure

2. Cardiovascular Receptors and Signaling in Heart Failure

3. Inflammatory Mediators in Heart Failure

4. Epigenetics and Transcriptomics

5. Mechanisms of Hypertrophy in Heart Failure

6. Hemodynamic Adaptive Mechanisms in Heart Failure

7. Neurohormonal Axis and Natriuretic Peptides in Heart Failure

8. Biomarkers in Heart Failure

9. Mechanisms of systolic and diastolic dysfunction

10. Echocardiographic Quantitation of Ventricular Function

11. Magnetic Resonance Imaging Assessment of Heart Failure

12. Assessment of Heart Failure by Invasive Methods

13. Lymphatic System in Heart Failure

14. Endothelial Dysfunction

Section II: Clinical Diagnosis and Management of Pediatric Heart Failure

15. Epidemiology and Economic Aspects of Pediatric Heart Failure

16. Clinical Recognition of Heart Failure in Children

17. Classification of Heart Failure

18. Right Ventricular Dysfunction

19. Pediatric Myocarditis

20. Dilated Cardiomyopathy

21. Clinical Features of Restrictive Cardiomyopathy and Constrictive Pericarditis

22. Hypertrophic Cardiomyopathy

23. Left Ventricular Noncompaction

24. Arrhythmogenic Cardiomyopathies

25. Valvular Insufficiency and Heart Failure

26. Valvular Stenosis and Heart Failure

27. Coronary Artery Disease in Children and Young Adults

28. Heart Failure in Congenital Heart Disease Including Single Ventricle Circulation

29. Heart Failure in Adults with Congenital Heart Disease

30. Dysrhythmias and Ventricular Dysfunction and Heart Failure

31. Heart Failure in the Fetus

32. Heart Failure in the Neonate

33. Heart Failure in Pediatric Pulmonary Diseases

34. Cardiorenal Syndrome

35. Heart Failure in Pediatric Oncologic Disease

36. Neuromuscular Diseases

37. Sickle Cell Disease

38. The Cardiovascular System in Systemic Inflammatory Syndromes

39. Outpatient Management

40. Cardiac Intensive Care and Inpatient Management

41. Quality of Life and Psychosocial Care

42. Palliative Care

43. Quality Improvement and Learning Collaboratives

44. Nursing Aspects of Heart Failure

Section III: Medical Treatment for Pediatric Heart Failure

45. Diuretics and Invasive Fluid Management Strategies

46. Inotropic Agents in Heart Failure

47. Phosphodiesterase Inhibitors

48. Inhibition of the Renin-Angiotensin-Aldosterone System and Other Vasodilators

49. Beta-adrenergic Receptor Blockade

50. Low Cardiac Output Syndrome in the Intensive Care Setting

51. New Therapeutic Strategies in Heart Failure

52. Electrophysiologic Devices in Heart Failure

53. Catheter Device Therapy for Heart Failure

Section IV: Cardiac Surgery and Pediatric Heart Failure

54. Post-Transplant Heart Failure

55. Surgical Strategies for the Failing Systemic Ventricle

56. Valve Intervention for Valve Failure

57. General Principles of Mechanical Cardiopulmonary Support

58. Short-Term Mechanical Cardiopulmonary Support Devices

59. Decision Making in Ventricular Assist Device Support in Pediatric Patients

60. Long-Term Ventricular Assist Devices and Destination Therapy

61. Future of Mechanical Support Devices in Children and Young Adults

Section V: Special Topics

62. Genetics and Genomics

63. Genetic Testing

64. Data Management and Analytics

65. Self-Management and Outpatient Monitoring

66. Regenerative Medicine

67. Nanomedicine

68. Digital Twin and Innovation in Research Design

69. Nutritional Assessment and Management in Pediatric Heart Failure

Joseph Rossano

Dr. Rossano is the medical director of Pediatric Heart Transplant and Heart Failure. He is also an attending physician in the Cardiac Center and the Cardiac Intensive Care Unit (CICU) and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Rossano is principal investigator or co-investigator on several ongoing research studies of the use of ventricular assist devices and artificial hearts in children, studying the effectiveness of post-transplant treatments for children who have received heart transplants, an observational study of children with heart failure, and building a registry of pediatric heart transplant patients that aims to further the knowledge of pediatric heart disease and transplantation.

Affiliations and expertise

Executive Director, The Cardiac Center, Medical Director, Heart Failure and Transplantation, Associate Professor of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, USA

John Lynn Jefferies

Dr. Jefferies is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.

Affiliations and expertise

Cincinnati Children’s Hospital, OH, USA

Anthony C Chang

Dr. Chang is the founder and medical director of the Medical Intelligence and Innovation Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to the introduction and implementation of artificial intelligence in medicine and was the first institute of its kind in a hospital. Dr. Chang intends to build a clinician-computer scientist interface with a nascent society (the Medical Intelligence Society) and is the editor-in-chief of Intelligence-based Medicine, the accompanying journal for his book, Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. He is the organizing chair for Artificial Intelligence in Medicine (AIMed) meetings around the world, the largest and most comprehensive clinician-led meetings that focus on applications of artificial intelligence in medicine and the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM). He is also the founding president of the Medical Intelligence Society (MIS).

Affiliations and expertise

Sharon Disney Lund Medical Intelligence, Information, Investigation, and Innovation Institute (Mi4), Children’s Health of Orange County, Orange, CA, USA; Heart Failure Program, Heart Institute, Children’s Health of Orange County, Orange, CA, USA; Chapman University, Orange, CA, USA

Jeffrey A. Towbin

Dr. Towbin is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.

Affiliations and expertise

Cincinnati Children’s Hospital, OH, USA

Robert E Shaddy

Dr. Shaddy is Chief of the Division of Cardiology at The Children’s Hospital of Philadelphia and holds the Jennifer Terker Endowed Chair in Pediatric Cardiology. He is Professor of Pediatrics and Vice Chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Shaddy brings more than 25 years of experience as a cardiologist caring for children with heart failure to his role as one of the leaders of the transplant program.

Affiliations and expertise

Chief of the Division of Cardiology, Jennifer Terker Endowed Chair in Pediatric Cardiology at CHOP

Shelley Miyamoto

Dr. Miyamoto is the Director of the Cardiomyopathy Program and Professor of Pediatrics at Children’s Hospital Colorado and the University of Colorado. She is a nationally and internationally recognized authority on pediatric cardiac transplantation and cardiomyopathy, much of her groundbreaking work focuses on the failing heart of children with cardiomyopathies and congenital heart disease.

Affiliations and expertise

Director, Cardiomyopathy Program, University of Colorado Anschutz Medical Campus, USA