Heart Failure in the Child and Young Adult
From Bench to Bedside
- 2nd Edition - October 27, 2025
- Latest edition
- Editors: Joseph Rossano, John Lynn Jefferies, Anthony C. Chang, Jeffrey A. Towbin, Robert E Shaddy, Shelley Miyamoto
- Language: English
Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines… Read more
Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.
This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.
- Combines cutting-edge research with current guidelines from the field
- Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation
- Includes expanded chapters on the immune system and inflammation in the development and progression of heart failure
- Reviews new randomized controlled trials in pediatric heart failure
Basic science researchers in cardiology and pediatrics, cardiologists, pediatric cardiologists, intensive care physicians, and cardiac surgeons
Section I Basic science of heart failure
1. From molecular and cellular mechanisms to models of heart failure
Raffaella Lombardi, Brisa Peña, Kristen Medo, Matthew Taylor and Luisa Mestroni
2. Cardiovascular receptors and signaling in heart failure
Daniel Bernstein and Giovanni Fajardo
3. Heart failure in the child and young adult: From bench to bedside: Inflammatory mediators in heart failure
Kory J. Lavine
4. Transcriptional regulation, epigenetic regulation, and transcriptomics of pediatric heart failure
Obed O. Nyarko and Carmen C. Sucharov
5. Mechanisms of hypertrophy in heart failure
Matthew Zinn, Shawn C. West and Bernhard Kühn
6. Hemodynamic adaptive mechanisms in heart failure
Alexander D. Hussey, Lucas Eastaugh and Robert G. Weintraub
7. Neurohormonal axis and natriuretic peptides in heart failure
Anastacia M. Garcia and Stephanie J. Nakano
8. Novel biomarkers in heart failure
Brian Madden, Kae Watanabe and Yuk Law
9. Systolic and diastolic function
Alyssa Power and Aamir Jeewa
10. Echocardiographic quantitation of ventricular function
Mark K. Friedberg
11. MRI assessment of heart failure
Michael D. Taylor
12. Assessment of heart failure by invasive methods
Michael L. O’Byrne and Jonathan J. Rome
13. The lymphatic system in heart failure
Benjamin Kelly, Vibeke E. Hjortdal and Yoav Dori
14. Endothelial dysfunction in heart failure in the child and young adult
Ankit Kushwaha, Shelley D. Miyamoto and Sushma Reddy
Section II Clinical diagnosis and management of pediatric heart failure
15. Epidemiology and economics of pediatric heart failure
Joseph W. Rossano and Christopher S. Almond
16. Clinical recognition of heart failure in children
Jonathan N. Johnson
17. Classification of pediatric heart failure
Robert D. Ross and Humera Ahmed
18. Right ventricular dysfunction
Andrew N. Redington
19. Pediatric myocarditis
Kathleen E. Simpson, Pei-Ni Jone, William B. Orr and Charles E. Canter
20. Dilated cardiomyopathy
Erika J. Mejia, Shelley D. Miyamoto, Kurt R. Schumacher and Kimberly Y. Lin
21. Clinical features of restrictive cardiomyopathy and constrictive pericarditis
Joseph A. Spinner and Susan W. Denfield
22. Hypertrophic cardiomyopathy
Steven D. Colan
23. Left ventricular noncompaction cardiomyopathy
Jason Johnson, Mario Briceno-Medina, Jeffrey A. Towbin and Karine Guerrier
24. Arrhythmogenic cardiomyopathies
Dominic J. Abrams
25. Valvular insufficiency and heart failure
Matthew C. Schwartz, Andrew C. Glatz and Matthew J. Gillespie
26. Valvular stenosis and heart failure
Alyssa Power and Anne I. Dipchand
27. Coronary artery disease in children and young adults
Rachel E. Harris, Simon Lee and Deipanjan Nandi
28. Chronic heart failure in congenital heart disease including single ventricle circulation
Sharon Chen and David N. Rosenthal
29. Heart failure in adults with congenital heart disease
Luke J. Burchill, Jonathan N. Menachem and Alexander R. Opotowsky
30. Dysrhythmias and ventricular dysfunction and heart failure
Jeffrey J. Kim and Maully Shah
31. Fetal heart failure
Suma P. Goudar, Edgar T. Jaeggi and Mary T. Donofrio
32. Heart failure in the neonate
Thomas D. Ryan, Steven J. Kindel and Matthew J. O’Connor
33. Heart failure in pediatric pulmonary diseases
Ryan D. Coleman and D Dunbar Ivy
34. Pediatric cardiorenal syndrome
Ayse Akcan-Arikan, Tara Neumayr, Naile Tufan Pekkucuksen, Natasha Afonso and Kriti Puri
35. Heart failure in pediatric oncologic disease
Neha Bansal, Shahnawaz Amdani, Jyothsna Akam-Venkata, Emma R. Lipshultz, Daniel Maywalt and Steven E. Lipshultz
36. Neuromuscular disorders
Scott R. Auerbach and Carol Wittlieb-Weber
37. Sickle cell disease
Hugo R. Martinez, Kaitlin A. Ryan, Mohammed Absi and Jeffrey A. Towbin
38. The cardiovascular system in systemic inflammatory syndromes
Monique M. Gardner, Mahsun Yuerek, Alexander Alali and Maryam Y. Naim
39. Outpatient management of pediatric heart failure
Jennifer A. Su, Priyanka Doshi and Paul F. Kantor
40. Cardiac intensive care and inpatient management of heart failure
Mohammed Absi, Jennifer Kramer and Daphne T. Hsu
41.Quality of life, neurodevelopmental and psychosocial outcomes in pediatric heart failure
Ivan Wilmot and Bradley S. Marino
42. Palliative care
Erika J. Mejia and Elizabeth D. Blume
43. Quality metrics and quality improvement in pediatric heart failure
Angela Lorts, Steven J. Kindel, Jeffrey B. Anderson and Samuel Hanke
44. Nursing aspects of heart failure
Meghan Williams and Deborah Bedard
Section III Medical treatment for pediatric heart failure
45. Diuretic and invasive fluid management strategies
Jack F. Price and Sameer Thadani
46. Inotropic agents in heart failure
Bhavikkumar D. Langanecha, Alejandro A. Floh, Emilie Jean-St-Michel and Steven M. Schwartz
47. Phosphodiesterase inhibitors
Timothy Michael Hoffman
48. Use of vasodilators in heart failure
Michael Burch, Sebastiano A.G. Lava and Timothy Thiruchelvam
49. Recognition and treatment of low cardiac output states in pediatric cardiac intensive care
Hari Tunuguntla, Mario Briceno-Medina, Jennifer Kramer, Antonio G. Cabrera and David P. Nelson
50. New therapeutic strategies for heart failure
Joseph W. Rossano, William J. Dreyer and John L. Jefferies
51. Electrophysiologic devices in heart failure
Bryan Cannon and Philip Wackel
52.Catheter device therapies for heart failure
Brian Morray and Frank Ing
Section IV Cardiac surgery and pediatric heart failure
53. Posttransplant heart failure
Philip T. Thrush, Simon Urschel and Elfriede Pahl
54. Surgical strategies for the failing single ventricle
Kevin Kulshrestha, David L.S. Morales and Katsuhide Maeda
55. Valve interventions for heart failure
Mohammad Alnoor, Aaron Kunamalla, Sahishnu Patel, Hussam Suradi, Ralf J. Holzer and Ziyad M. Hijazi
56. Principles of mechanical cardiopulmonary support
Timothy M. Maul, Angela Lorts, Peter D. Wearden and Jennifer L. Conway
57. Future of mechanical circulatory support devices in children and young adults
Mehreen S. Iqbal and Robert D.B. Jacquiss
58. Short-term mechanical cardiopulmo-nary support devices
Jason W. Greenberg, Ryan R. Davies and David L.S. Morales
59. Decision-making in ventricular assist device support in pediatric advanced heart failure patients
Caitlin Milligan, Francis Fynn-Thompson, Elizabeth D. Blume and Christina J. VanderPluym
60. Long-term ventricular assist devices in children
Iki Adachi, Junsang Cho, Antonio Amodeo, Katsuhide Maeda and Charles D. Fraser
Section V Special topics
61. Genetics and genomics
Kathryn C. Chatfield, Teresa M. Lee and Shannon N. Nees
62. Genetic testing
Leslie McCallen and Alyssa L. Rippert
63. Big data and artificial intelligence in pediatric heart failure
Tuyet Nguyen, Anthony C. Chang and Alessandra Toscano
64. Outpatient monitoring and self- care
Sharif Kayali, John Alexander, Aranyak Rawal, Deya Alkhatib and John L. Jefferies
65. Cardiac regenerative medicine for congenital heart defects
Timothy Nelson
66. Development of digital twin models for heart failure patient treatment
Howard Lei and Anthony C. Chang
67. Nutritional assessment and management in pediatric heart failure
Chitra Ravishankar
68. The role of wearable technology in improving the care of pediatric heart failure
Jonathan B. Edelson, Sarah Gao, Divya Gandla and Brendan J. Keating
1. From molecular and cellular mechanisms to models of heart failure
Raffaella Lombardi, Brisa Peña, Kristen Medo, Matthew Taylor and Luisa Mestroni
2. Cardiovascular receptors and signaling in heart failure
Daniel Bernstein and Giovanni Fajardo
3. Heart failure in the child and young adult: From bench to bedside: Inflammatory mediators in heart failure
Kory J. Lavine
4. Transcriptional regulation, epigenetic regulation, and transcriptomics of pediatric heart failure
Obed O. Nyarko and Carmen C. Sucharov
5. Mechanisms of hypertrophy in heart failure
Matthew Zinn, Shawn C. West and Bernhard Kühn
6. Hemodynamic adaptive mechanisms in heart failure
Alexander D. Hussey, Lucas Eastaugh and Robert G. Weintraub
7. Neurohormonal axis and natriuretic peptides in heart failure
Anastacia M. Garcia and Stephanie J. Nakano
8. Novel biomarkers in heart failure
Brian Madden, Kae Watanabe and Yuk Law
9. Systolic and diastolic function
Alyssa Power and Aamir Jeewa
10. Echocardiographic quantitation of ventricular function
Mark K. Friedberg
11. MRI assessment of heart failure
Michael D. Taylor
12. Assessment of heart failure by invasive methods
Michael L. O’Byrne and Jonathan J. Rome
13. The lymphatic system in heart failure
Benjamin Kelly, Vibeke E. Hjortdal and Yoav Dori
14. Endothelial dysfunction in heart failure in the child and young adult
Ankit Kushwaha, Shelley D. Miyamoto and Sushma Reddy
Section II Clinical diagnosis and management of pediatric heart failure
15. Epidemiology and economics of pediatric heart failure
Joseph W. Rossano and Christopher S. Almond
16. Clinical recognition of heart failure in children
Jonathan N. Johnson
17. Classification of pediatric heart failure
Robert D. Ross and Humera Ahmed
18. Right ventricular dysfunction
Andrew N. Redington
19. Pediatric myocarditis
Kathleen E. Simpson, Pei-Ni Jone, William B. Orr and Charles E. Canter
20. Dilated cardiomyopathy
Erika J. Mejia, Shelley D. Miyamoto, Kurt R. Schumacher and Kimberly Y. Lin
21. Clinical features of restrictive cardiomyopathy and constrictive pericarditis
Joseph A. Spinner and Susan W. Denfield
22. Hypertrophic cardiomyopathy
Steven D. Colan
23. Left ventricular noncompaction cardiomyopathy
Jason Johnson, Mario Briceno-Medina, Jeffrey A. Towbin and Karine Guerrier
24. Arrhythmogenic cardiomyopathies
Dominic J. Abrams
25. Valvular insufficiency and heart failure
Matthew C. Schwartz, Andrew C. Glatz and Matthew J. Gillespie
26. Valvular stenosis and heart failure
Alyssa Power and Anne I. Dipchand
27. Coronary artery disease in children and young adults
Rachel E. Harris, Simon Lee and Deipanjan Nandi
28. Chronic heart failure in congenital heart disease including single ventricle circulation
Sharon Chen and David N. Rosenthal
29. Heart failure in adults with congenital heart disease
Luke J. Burchill, Jonathan N. Menachem and Alexander R. Opotowsky
30. Dysrhythmias and ventricular dysfunction and heart failure
Jeffrey J. Kim and Maully Shah
31. Fetal heart failure
Suma P. Goudar, Edgar T. Jaeggi and Mary T. Donofrio
32. Heart failure in the neonate
Thomas D. Ryan, Steven J. Kindel and Matthew J. O’Connor
33. Heart failure in pediatric pulmonary diseases
Ryan D. Coleman and D Dunbar Ivy
34. Pediatric cardiorenal syndrome
Ayse Akcan-Arikan, Tara Neumayr, Naile Tufan Pekkucuksen, Natasha Afonso and Kriti Puri
35. Heart failure in pediatric oncologic disease
Neha Bansal, Shahnawaz Amdani, Jyothsna Akam-Venkata, Emma R. Lipshultz, Daniel Maywalt and Steven E. Lipshultz
36. Neuromuscular disorders
Scott R. Auerbach and Carol Wittlieb-Weber
37. Sickle cell disease
Hugo R. Martinez, Kaitlin A. Ryan, Mohammed Absi and Jeffrey A. Towbin
38. The cardiovascular system in systemic inflammatory syndromes
Monique M. Gardner, Mahsun Yuerek, Alexander Alali and Maryam Y. Naim
39. Outpatient management of pediatric heart failure
Jennifer A. Su, Priyanka Doshi and Paul F. Kantor
40. Cardiac intensive care and inpatient management of heart failure
Mohammed Absi, Jennifer Kramer and Daphne T. Hsu
41.Quality of life, neurodevelopmental and psychosocial outcomes in pediatric heart failure
Ivan Wilmot and Bradley S. Marino
42. Palliative care
Erika J. Mejia and Elizabeth D. Blume
43. Quality metrics and quality improvement in pediatric heart failure
Angela Lorts, Steven J. Kindel, Jeffrey B. Anderson and Samuel Hanke
44. Nursing aspects of heart failure
Meghan Williams and Deborah Bedard
Section III Medical treatment for pediatric heart failure
45. Diuretic and invasive fluid management strategies
Jack F. Price and Sameer Thadani
46. Inotropic agents in heart failure
Bhavikkumar D. Langanecha, Alejandro A. Floh, Emilie Jean-St-Michel and Steven M. Schwartz
47. Phosphodiesterase inhibitors
Timothy Michael Hoffman
48. Use of vasodilators in heart failure
Michael Burch, Sebastiano A.G. Lava and Timothy Thiruchelvam
49. Recognition and treatment of low cardiac output states in pediatric cardiac intensive care
Hari Tunuguntla, Mario Briceno-Medina, Jennifer Kramer, Antonio G. Cabrera and David P. Nelson
50. New therapeutic strategies for heart failure
Joseph W. Rossano, William J. Dreyer and John L. Jefferies
51. Electrophysiologic devices in heart failure
Bryan Cannon and Philip Wackel
52.Catheter device therapies for heart failure
Brian Morray and Frank Ing
Section IV Cardiac surgery and pediatric heart failure
53. Posttransplant heart failure
Philip T. Thrush, Simon Urschel and Elfriede Pahl
54. Surgical strategies for the failing single ventricle
Kevin Kulshrestha, David L.S. Morales and Katsuhide Maeda
55. Valve interventions for heart failure
Mohammad Alnoor, Aaron Kunamalla, Sahishnu Patel, Hussam Suradi, Ralf J. Holzer and Ziyad M. Hijazi
56. Principles of mechanical cardiopulmonary support
Timothy M. Maul, Angela Lorts, Peter D. Wearden and Jennifer L. Conway
57. Future of mechanical circulatory support devices in children and young adults
Mehreen S. Iqbal and Robert D.B. Jacquiss
58. Short-term mechanical cardiopulmo-nary support devices
Jason W. Greenberg, Ryan R. Davies and David L.S. Morales
59. Decision-making in ventricular assist device support in pediatric advanced heart failure patients
Caitlin Milligan, Francis Fynn-Thompson, Elizabeth D. Blume and Christina J. VanderPluym
60. Long-term ventricular assist devices in children
Iki Adachi, Junsang Cho, Antonio Amodeo, Katsuhide Maeda and Charles D. Fraser
Section V Special topics
61. Genetics and genomics
Kathryn C. Chatfield, Teresa M. Lee and Shannon N. Nees
62. Genetic testing
Leslie McCallen and Alyssa L. Rippert
63. Big data and artificial intelligence in pediatric heart failure
Tuyet Nguyen, Anthony C. Chang and Alessandra Toscano
64. Outpatient monitoring and self- care
Sharif Kayali, John Alexander, Aranyak Rawal, Deya Alkhatib and John L. Jefferies
65. Cardiac regenerative medicine for congenital heart defects
Timothy Nelson
66. Development of digital twin models for heart failure patient treatment
Howard Lei and Anthony C. Chang
67. Nutritional assessment and management in pediatric heart failure
Chitra Ravishankar
68. The role of wearable technology in improving the care of pediatric heart failure
Jonathan B. Edelson, Sarah Gao, Divya Gandla and Brendan J. Keating
- Edition: 2
- Latest edition
- Published: October 27, 2025
- Language: English
JR
Joseph Rossano
Dr. Rossano is the medical director of Pediatric Heart Transplant and Heart Failure. He is also an attending physician in the Cardiac Center and the Cardiac Intensive Care Unit (CICU) and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Rossano is principal investigator or co-investigator on several ongoing research studies of the use of ventricular assist devices and artificial hearts in children, studying the effectiveness of post-transplant treatments for children who have received heart transplants, an observational study of children with heart failure, and building a registry of pediatric heart transplant patients that aims to further the knowledge of pediatric heart disease and transplantation.
Affiliations and expertise
Executive Director, The Cardiac Center, Medical Director, Heart Failure and Transplantation, Associate Professor of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, USAJJ
John Lynn Jefferies
Dr. Jefferies is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.
Affiliations and expertise
Cincinnati Children’s Hospital, OH, USAAC
Anthony C. Chang
Dr. Chang is the founder and medical director of the Medical Intelligence, Information, Investigation, and Innovation Institute (Mi4) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to the introduction and implementation of artificial intelligence in medicine and was the first institute of its kind in a hospital. Dr. Chang intends to build a clinician-computer scientist interface with a nascent society (the Medical Intelligence Society) and is the editor-in-chief of Intelligence-based Medicine, the accompanying journal for his book, Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. He is the organizing chair for Artificial Intelligence in Medicine (AIMed) meetings around the world, the largest and most comprehensive clinician-led meetings that focus on applications of artificial intelligence in medicine and the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM). He is also the founding president of the Medical Intelligence Society (MIS).
Affiliations and expertise
Sharon Disney Lund Medical Intelligence, Information, Investigation, and Innovation Institute (Mi4), Children’s Hospital of Orange County, a part of Rady Children’s Health, Orange, CA, USA; Heart Failure Program, Heart Institute, Children’s Health of Orange County, Orange, CA, USA; Chapman University, Orange, CA, USAJT
Jeffrey A. Towbin
Dr. Towbin is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.
Affiliations and expertise
Cincinnati Children’s Hospital, OH, USARS
Robert E Shaddy
Dr. Shaddy is Chief of the Division of Cardiology at The Children’s Hospital of Philadelphia and holds the Jennifer Terker Endowed Chair in Pediatric Cardiology. He is Professor of Pediatrics and Vice Chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Shaddy brings more than 25 years of experience as a cardiologist caring for children with heart failure to his role as one of the leaders of the transplant program.
Affiliations and expertise
Chief of the Division of Cardiology, Jennifer Terker Endowed Chair in Pediatric Cardiology at CHOPSM
Shelley Miyamoto
Dr. Miyamoto is the Director of the Cardiomyopathy Program and Professor of Pediatrics at Children’s Hospital Colorado and the University of Colorado. She is a nationally and internationally recognized authority on pediatric cardiac transplantation and cardiomyopathy, much of her groundbreaking work focuses on the failing heart of children with cardiomyopathies and congenital heart disease.
Affiliations and expertise
Director, Cardiomyopathy Program, University of Colorado Anschutz Medical Campus, USARead Heart Failure in the Child and Young Adult on ScienceDirect