Health and Environmental Applications of Biosensing Technologies

Clinical and Allied Health Science Perspective

1st Edition - October 13, 2023
Editors: Murugan Veerapandian, James Joseph, Mohana Marimuthu
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 3 9 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 4 0 - 7

With emerging biological threats from pathogenic microorganisms and increasing environmental pollutants, it is essential to ensure the safety needs of individuals and the ec… Read more

Health and Environmental Applications of Biosensing Technologies

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With emerging biological threats from pathogenic microorganisms and increasing environmental pollutants, it is essential to ensure the safety needs of individuals and the ecosystem are met. Modern materials science and engineering has evolved over the years to better develop devices to test abnormalities. Affordability, accessibility, and reliability of any analytical system is the prime necessity for a modern diagnostic application.

Health and Environmental Applications of Biosensing Technologies: Clinical and Allied Health Science Perspective presents a detailed overview on biosensor design systems and optimal fabrication technologies to create a greater impact on various industries and help organizations break existing performance tradeoffs to deploy biosensor technologies across inter/transdisciplinary businesses. The book presents novel and emerging trends in biosensor design and healthcare applications focused on API detection, communicable/non-communicable disease diagnosis, food quality monitoring, agro-environmental analysis, bio-defense, and industrial pollutant sensing. In addition, wearable biosensors, commercial products, and safety regulations for biosensing technologies are summarized.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Fundamentals of a biosensor system
Abstract
1.1 Introduction
1.2 Electrochemical biosensors
1.3 Evolution in electrochemical biosensors
1.4 Electroanalytical techniques as a tool for monitoring the biosensor platform
1.5 Artificial intelligence-based signal processing
1.6 Basic parameters involved in electrochemical biosensors
1.7 Categories of electrochemical biosensors
1.8 Strategies for the construction of an electrochemical biosensor system
1.9 Challenges and opportunities in electrochemical biosensor research
References
Chapter 2. Processes in biosensor design, development, and validation parameters
Abstract
2.1 Introduction
2.2 Working principle of biosensors
2.3 Biosensor design
2.4 Consideration for biosensor design
2.5 Development of biosensors
2.6 Validation parameters
2.7 Summary and future perspectives
References
Chapter 3. Types of optoelectrochemical active materials for biosensor design
Abstract
3.1 Introduction
3.2 Optoelectrochemical active materials
3.3 Salient perspectives of optoelectrochemical active materials
3.4 Optoelectrochemical materials and biosensor interactions
3.5 Limitations of material interactions with biosensors
3.6 Outlooks
Acknowledgment
References
Chapter 4. Bioreceptors and immobilization techniques for transducing communicable diseases
Abstract
4.1 Communicable diseases
4.2 Biosensors
4.3 Immobilization techniques
4.4 Practical challenges in biosensor construction
4.5 Summary and future perspectives
References
Chapter 5. Emerging biomarkers for early diagnosis of noncommunicable diseases
Abstract
5.1 Introduction
5.2 Major noncommunicable diseases
5.3 Biomarkers
5.4 Advantages of employing multivariate biomarkers
5.5 Sensing platforms for point-of-care diagnostics
5.6 Conclusion and future prospects
Abbreviation
References
Chapter 6. Biosensors in industrial waste management as sensing approaches for personal and societal healthcare
Abstract
6.1 Introduction
6.2 Conclusion and future prospects
Acknowledgment
References
Chapter 7. Biosensor platform for testing active pharmaceutical ingredients
Abstract
7.1 Introduction
7.2 Electrochemical biosensing of active pharmaceutical ingredients
7.3 Conclusion and future prospective
Acknowledgment
References
Chapter 8. Microfluidics-integrated biosensor platform for modern clinical analysis
Abstract
8.1 Introduction
8.2 Microfluidic biosensor for pathogen detection
8.3 Organ-on-a-chip biosensing platforms
8.4 Outlook and future perspectives
Acknowledgments
References
Chapter 9. Implantable biosensor platforms for animal model bioassays
Abstract
9.1 Introduction
9.2 Animal models for bioassays
9.3 Implication of implantable biosensors in diseases
9.4 Future perspectives
References
Chapter 10. Wearable biosensor platform: design and healthcare commercial values
Abstract
10.1 Introduction
10.2 Sweat as a biofluid
10.3 Interstitial fluid as a biofluid
10.4 Saliva as a biofluid
10.5 Tear as a biofluid
10.6 Challenges and future prospects
10.7 Conclusions
Acknowledgments
References
Chapter 11. Sensor platform for food quality monitoring: healthcare perspective
Abstract
11.1 Introduction
11.2 Electrochemical sensors
11.3 Immunoassay-based sensors
11.4 Colorimetric sensors
11.5 Nonconventional strategies
11.6 Conclusion
Acknowledgment
References
Chapter 12. Sensing technologies for agroenvironment toward sustainable human healthcare
Abstract
12.1 Introduction
12.2 Methods for determination of pesticides in agro and environmental samples
12.3 Summary and future perspectives
Acknowledgement
References
Chapter 13. Biosensor for biothreat detection and defense application
Abstract
13.1 Introduction
Reference
Chapter 14. Sweat-based screening of biomarkers using an enzymatic bioelectrocatalytic approach
Abstract
14.1 Introduction
14.2 Sweat analytes: an ideal alternative source for healthcare monitoring
14.3 Advantages of enzyme-related factors at the electrode interface
14.4 Optimal electrode design for facile electron transfer reaction
14.5 Analysis of enzyme–electrode interface using electrochemical techniques
14.6 Wearable electrodes and self-powered implantable devices
14.7 Conclusions and future perspectives
Acknowledgment
References
Chapter 15. Organic electrochemical transistor-based advanced biosensor for clinical diagnosis
Abstract
15.1 Introduction
15.2 Device physics of OECTs
15.3 OECTs in biosensing application
15.4 Conclusion
References
Chapter 16. Role of miRNAs as biomarkers for early diagnosis of cancer
Abstract
16.1 miRNA: background
16.2 miRNA biogenesis
16.3 miRNAs as a biomarker
16.4 miRNAs as biomarkers of early cancer development
16.5 miRNA expression associated with the emergence of breast cancer
16.6 miRNA expression associated with the emergence of cervical cancer
16.7 miRNA expression associated with the emergence of prostate cancer
16.8 Conclusion
References
Chapter 17. Surface-enhanced Raman scattering in biosensing technologies
Abstract
17.1 Introduction
17.2 Surface-enhanced Raman scattering
17.3 Surface-enhanced Raman scattering-based biosensors
17.4 Current technology challenges and future potentials
17.5 Summary
References
Chapter 18. Emerging (bio)sensor technologies for monitoring vital markers of military, mining, and defense healthcare
Abstract
18.1 Introduction
18.2 Biological warfare agents
18.3 Chemical warfare agents
18.4 Sensors for soldier health monitoring
18.5 Conclusion
Acknowledgment
References
Chapter 19. R&D players in biosensor research: key products and applications
Abstract
19.1 Introduction
19.2 Why printed electrodes are a hot topic?
19.3 Microfluidics-integrated sensor platform
19.4 Outlook
Acknowledgments
References
Chapter 20. Commercialization and safety aspects of biosensing technologies
Abstract
20.1 Introduction
20.2 Biocompatibility of biosensors
20.3 Immune response
20.4 Emerging biosensing technologies
20.5 Internet of Things in healthcare
20.6 Machine learning in healthcare
20.7 Opportunities in machine learning technology for the electrochemical (bio)sensor
20.8 Clinical data and its implementation in device development
20.9 Summary
References
Index

Murugan Veerapandian

Dr. Murugan received his B. Pharmacy degree from The Tamil Nadu Dr. M.G.R Medical University, INDIA. He did his M.S., and Ph.D., research work in the field of Bionanotechnology and obtained degree in Biomedical Engineering (Bionanotechnology) from Gachon University, South Korea. In S. Korea, Murugan worked on biofunctionalized metal, metalloid and carbon-polymer nanomaterials for anti-microbial and electrochemical biosensor application. Dr. Murugan was a GRSTB Postdoctoral Fellow at Université de Montréal, QC, where he worked on bio-functionalized metalloid-polymer and graphene oxide nanostructures for non-enzymatic and enzymatic bioassay of cancer marker.

Affiliations and expertise

Senior Scientist, CSIR-Central Electrochemical Research Institute, Karaikudi, Tamil Nadu, India

James Joseph

Dr. James is the Chief Scientist & Head of EEC Division and holding Adjunct Professorship in Chemical Science in AcSIR, Ghaziabad. His research is focused on the fundamental aspects of chemically modified electrodes, basic & developmental aspects of chemical sensors, synthesis of new (nano)materials for electrocatalysis, sensor construction and energy related applications. As a project coordinator/team leader he has contributed several sponsored projects from Government of India as well as private R&D organizations. Dr. James is the author of numerous research paper (>70) in peer-reviewed journals; theme coordinator for skill development course on “Electroanalytical Techniques for (Bio)Sensing and (Electro)catalytic Applications” funded by Science &Technology Division of CSIR-CECRI; and chairman of CSIR-CECRI safety committee.

Affiliations and expertise

Chief Scientist, CSIR-Central Electrochemical Research Institute, India

Mohana Marimuthu

Dr. Mohana completed her B. Pharmacy from The Tamil Nadu Dr. M.G.R Medical University. She was a Clinical Research Coordinator working on Phase III Clinical Trial program (2007-2008) at the department of Pulmonology in Sri Ramakrishna Multi-speciality Hospital Coimbatore, Tamil Nadu. She accomplished M.S., and Ph.D., at the College of BioNanotechnology, Gachon University, South Korea, with a Major in Biomedical Engineering. Her postgraduate and Ph.D., studies involve development of Microfluidic platform for polymer microfiber synthesis, tissue engineering, 3D co-culture of Cells, CMOS System for Immunoassay and ECIS for Cell-Drug Assays.

Affiliations and expertise

Associate Professor, Centre for Research, Dhanalakshmi Srinivasan University, Samayapuram, Tamil Nadu, India