Haschek and Rousseaux's Handbook of Toxicologic Pathology
- 2nd Edition - October 16, 2001
- Editors: Wanda M Haschek, Brad Bolon, Wanda M Haschek, Ricardo Ochoa, Colin G. Rousseaux, Matthew A. Wallig
- Language: English
A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs… Read more
A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology.
This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.
This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.
Key Features
* Easy to find, up-to-date reference information
* Graphic and photographic plates
* Current hot topics and anticipated changes in toxicologic pathology
* Standardized chapter format
* Topics that are addressed in both a broad and deep manner, resulting in a stand alone text
* Added coverage of important environmental toxicants
* Chapters authored by internationally recognized experts and peer-reviewed
* Easy to find, up-to-date reference information
* Graphic and photographic plates
* Current hot topics and anticipated changes in toxicologic pathology
* Standardized chapter format
* Topics that are addressed in both a broad and deep manner, resulting in a stand alone text
* Added coverage of important environmental toxicants
* Chapters authored by internationally recognized experts and peer-reviewed
Researchers in the area of toxicology and pathology, veterinary scientists, veterinary diagnostic and medical forensic laboratories, and pharmaceutical and chemical companies.
Volume 1: General Toxicologic Pathology
Preface.
Contributors.
Part A: Basics of Toxicologic Pathology
Toxicologic Pathology: An Introduction.
Biochemical Basis of Toxicity.
Morphologic Manifestation of Toxic Cell Injury.
Organelle Biochemistry and Regulation of Cell Death.
Carcinogenesis.
Applied Clinical Pathology in Preclinical Toxicology Testing.
Nomenclature.
Part B: The Practice of Toxicologic Pathology
Basic Techniques.
Managing Pitfalls in Toxicologic Pathology.
Special Techniques in Toxicologic Pathology.
Application of New Technologies to Toxicologic Pathology.
Issues in Laboratory Animal Science for the Toxicologic Pathologist.
New Animal Models in Toxicology.
Pathology Issues in the Design of Toxicology Studies.
Use and Misuse of Statistics in the Design and Interpretation of Studies.
Preparation of the Report for a Toxicology/Pathology Study.
Part C: Selected Topics in Toxicologic Pathology
Risk Assessment: The Changing Paradigm.
Principles of Risk Communication: Building Trust and Credibility with the Public.
Biomedical Devices and Biomaterials.
Biotechnology and Its Products.
Endocrine Disruptors.
Radiation and Heat.
Nutritional Toxicologic Pathology.
Phycotoxins.
Mycotoxins.
Heavy Metals.
Volume 2: Organ Specific Toxicologic Pathology
Organ-Specific Toxicologic Pathology: An Introduction.
Respiratory System.
Skin and Oral Mucosa.
Gastrointestinal Tract.
Liver.
Pancreas.
Kidney.
Lower Urinary Tract.
Cardiovascular and Skeletal Muscle Systems.
Bones and Joints.
Nervous System.
The Eye.
Immune System.
Hematopoietic System.
Endocrine System.
Male Reproduction.
Female Reproduction.
Embryo and Fetus.
Index.
Preface.
Contributors.
Part A: Basics of Toxicologic Pathology
Toxicologic Pathology: An Introduction.
Biochemical Basis of Toxicity.
Morphologic Manifestation of Toxic Cell Injury.
Organelle Biochemistry and Regulation of Cell Death.
Carcinogenesis.
Applied Clinical Pathology in Preclinical Toxicology Testing.
Nomenclature.
Part B: The Practice of Toxicologic Pathology
Basic Techniques.
Managing Pitfalls in Toxicologic Pathology.
Special Techniques in Toxicologic Pathology.
Application of New Technologies to Toxicologic Pathology.
Issues in Laboratory Animal Science for the Toxicologic Pathologist.
New Animal Models in Toxicology.
Pathology Issues in the Design of Toxicology Studies.
Use and Misuse of Statistics in the Design and Interpretation of Studies.
Preparation of the Report for a Toxicology/Pathology Study.
Part C: Selected Topics in Toxicologic Pathology
Risk Assessment: The Changing Paradigm.
Principles of Risk Communication: Building Trust and Credibility with the Public.
Biomedical Devices and Biomaterials.
Biotechnology and Its Products.
Endocrine Disruptors.
Radiation and Heat.
Nutritional Toxicologic Pathology.
Phycotoxins.
Mycotoxins.
Heavy Metals.
Volume 2: Organ Specific Toxicologic Pathology
Organ-Specific Toxicologic Pathology: An Introduction.
Respiratory System.
Skin and Oral Mucosa.
Gastrointestinal Tract.
Liver.
Pancreas.
Kidney.
Lower Urinary Tract.
Cardiovascular and Skeletal Muscle Systems.
Bones and Joints.
Nervous System.
The Eye.
Immune System.
Hematopoietic System.
Endocrine System.
Male Reproduction.
Female Reproduction.
Embryo and Fetus.
Index.
"The 2 volumes are excellent companions that complement each other as a "1,2"punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."—VETERINARY AND HUMAN TOXICOLOGY (October 2002)
"...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."—Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY NEWSLETTER (Spring 2002)
"...very readable, well-referenced, and current...an excellent book for research training."—DOODY'S
"[W]ell illustrated with good quality diagrams, colour and black and white photographs…. [A]n excellent, eminently readable book to have as a study or reference book, covering the essential basics and providing a good overview for any toxicological pathologist, toxicologist or research scientist with an interest in the pathological changes seen in toxicological studies."—British Toxicology Society Newsletter
- Edition: 2
- Published: October 16, 2001
- Language: English
WM
Wanda M Haschek
Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.
Affiliations and expertise
Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USABB
Brad Bolon
Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Affiliations and expertise
President and Pathologist, GEMpath, Inc., Longmont, Colorado, USAWM
Wanda M Haschek
Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.
Affiliations and expertise
Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USARO
Ricardo Ochoa
Affiliations and expertise
Pre-Clinical Safety Inc.CR
Colin G. Rousseaux
Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Affiliations and expertise
Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa Principal, Colin Rousseaux and Associates, CanadaMW
Matthew A. Wallig
Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Affiliations and expertise
Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USARead Haschek and Rousseaux's Handbook of Toxicologic Pathology on ScienceDirect