Limited Offer
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Handbook of the Behavioral Neurobiology of Serotonin
- 1st Edition, Volume 21 - December 2, 2009
- Editors: Christian P. Muller, Barry Jacobs
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 7 4 6 3 4 - 4
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 8 7 8 1 7 - 1
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteSerotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.
- The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
- Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
- The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community
- Of great value not only for researchers and experts, but also for students and clinicians as a background reference
neuroscientists, pharmacologists, psychiatrists, neurologists and psychologists in academia, medical institutions, pharmaceutical industry.
Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).
Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).
Section 1: Functional anatomy of the serotonergic system
- Evolution of serotonin: sunlight to suicide
- Genetic organisation of the serotonergic system
- The neuronatomy of the serotonergic system
- Ultrastructure of the serotonin innervation in mammalian central nervous system
- Classification and signaling characteristics of 5-HT receptors
- Distribution of 5-HT receptors in the central nervous system
- Measuring serotonin activity in vivo in the brains of animals and humans
Efrain C. Azmitia
Ursula M. D’Souza and Ian W. Craig
Jean-Pierre Hornung
Laurent Descarries Mustapha Riad and Martin Parent
Joël Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin
Guadalupe Mengod, Roser Cortés, M. Teresa Vilaró and Daniel Hoyer
Charles A Marsden
Section 2: The neurophysiology of serotonin
2.1 Activity of brain serotonergic neurons in relation to physiology and behavior
Barry L. Jacobs and Casimir A. Fornal
2.2 Electrophysiology of serotonin receptors
Gerard J. Marek
2.3 Tryptophane hydroxylase and serotonin synthesis regulation
Hiroyuki Hasegawa and Kazuhiro Nakamura
2.4 The degradation of serotonin: role of MAO
Marco Bortolato, Kevin Chen and Jean C Shih
2.5 Cellular effects of serotonin in the CNS
Rodrigo Andrade and Sheryl G. Beck
2.6 Serotonergic feedback control
Trevor Sharp
2.7 Tryptophan depletion and serotonin release - a critical reappraisal
Matthijs G.P. Feenstra and Geoffrey van der Plasse
2.8 Serotonin interaction with other transmitter systems
Albert Adell, Analía Bortolozzi, Llorenç Díaz-Mataix, Noemí Santana, Pau Celada, and Francesc Artigas
2.9 Serotonergic regulation of rhythmical activity of the brain, concentrating on the hippocampus
Robert P. Vertes
2.10 5-HT neurons and central CO2 chemoreception
Carolin I. Dohle and George B. Richerson
Section 3: Serotonin and behavioural control
3.1 Serotonin and development
Patricia M. Whitaker-Azmitia
3.2 Serotonin and basal sensory: motor control
Robert J. Carey
3.3 Role of the serotonergic system in appetite and ingestion control
Michelle D. Lee and Peter G. Clifton
3.4 Serotonin and sexual behavior
Lynda Uphouse and Jutatip Guptarak
3.5 Serotonin in mood and emotion
Julie G. Hensler
3.6 Serotonin and the neurobiology of anxious states
Christopher A. Lowry and Matthew W. Hale
3.7 Role of Serotonin in Brain Reward and Regulation of Alcohol Drinking Behavior
W. J. McBride
3.8 Role of central serotonin in impulsivity and compulsivity: Comparative studies in experimental animals and humans
TW Robbins & MJ Crockett
3.9 Experimental studies on the role(s) of serotonin in learning and memory functions
Jean-Christophe Cassel
3.10 Social behavior and serotonin
Elif Aysimi Duman and Turhan Canli
3.11 Serotonin in pain and pain control
Claudia Sommer
Section 4: Serotonin in disease conditions
4.1 The Impact of Stress on Serotonergic Neurotransmission
Astrid C.E. Linthorst and Johannes M.H.M. Reul
4.2 Role for serotonin in depression
Gregory V. Carr and Irwin Lucki
4.3 The role of serotonin in drug addiction
Christian P. Müller, Martin E. Pum, Gunter Schumann and Joseph P. Huston
4.4 The serotonergic system in obsessive compulsive disorders
Addy van Dijk, Andre Klompmakers, and Damiaan Denys
4.5 The role of serotonin in attention-deficit hyperactivity disorder (ADHD)
Robert D. Oades
4.6 Serotonin and schizophrenia
Boris B. Quednow, Mark A. Geyer, and Adam L. Halberstadt
4.7 Serotonin and serotonin receptors in hallucinogen action
Adam L. Halberstadt and David E. Nichols
4.8 The role of serotonin in cortical development: implications for Autism Spectrum Disorder [ASD]
Christine F. Hohmann and Mary E. Blue
4.9 Serotonin in panic and anxiety disorders
Francisco Silveira Guimarães, Hélio Zangrossi Jr., Cristina Marta Del Ben and Frederico Guilherme Graeff
4.10 Serotonin and agression
Isabel M. Quadros, Aki Takahashi and Klaus A. Miczek
4.11 Altered serotonin function in anorexia and bulimia nervosa
Vikas Duvvuri, Ursula F Bailer and Walter H Kaye
4.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions
Eva Friedel & Andreas Heinz
4.13 The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression
Olivia F. O’Leary and John F. Cryan
4.14 Functional pharmacogenetics of serotonin receptors in psychiatric drug action
Olga O. Yevtushenko, Gavin P. Reynolds
- No. of pages: 836
- Language: English
- Edition: 1
- Volume: 21
- Published: December 2, 2009
- Imprint: Academic Press
- Hardback ISBN: 9780123746344
- eBook ISBN: 9780080878171
CM
Christian P. Muller
Dr. Müller is Professor of Addiction Medicine at the Friedrich-Alexander-University Erlangen-Nuremberg, Germany. He obtained his PhD in Psychology from the University of Düsseldorf. He did PostDocs at the University of Syracuse (USA), University of Düsseldorf, and University of Brasilia (Brazil) before becoming a Senior Lecturer at the Institute of Psychiatry, King’s College London, UK. In 2010 he joined the Friedrich-Alexander-University of Erlangen-Nuremberg, Germany. He serves on several journal editorial boards and guest edited special issues of Behavioral Brain Research and Brain Research Bulletin. Dr. Müller has published more than 120 scientific papers and book chapters.
Affiliations and expertise
Professor, Department of Psychiatry and Psychotherapy Friedrich-Alexander-University Erlangen-Nuremberg, GermanyRead Handbook of the Behavioral Neurobiology of Serotonin on ScienceDirect