Handbook of Imaging in Multiple Sclerosis
- 1st Edition - November 29, 2024
- Imprint: Academic Press
- Editors: Dejan Jakimovski, Robert Zivadinov
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 3 9 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 4 0 - 3
Handbook of Imaging in Multiple Sclerosis provides an up-to-date introduction into multiple sclerosis disease, including new findings on the pathophysiological processes, the cl… Read more
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Request a sales quoteHandbook of Imaging in Multiple Sclerosis provides an up-to-date introduction into multiple sclerosis disease, including new findings on the pathophysiological processes, the clinical presentation, diagnosis, and treatment of the disease. This book includes in-depth chapters exploring the use of conventional and non-conventional imaging methods. These chapters cover magnetic resonance imaging (MRI) specific topics such as measurement of brain atrophy and susceptibility-weighted imaging. Additional chapters explore the use of additional imaging methods such as positron emission tomography (PET), optical coherence tomography (OCT) and high field MRI (use of 7T MRI scanners).
- Reviews all non-conventional imaging modalities currently developed in the field of multiple sclerosis
- Written by an international list of authors that are very highly regarded in the very specific field of their respective chapter
- Includes information regarding the basics of acquisition and analysis that would allow researchers set-up their own MRI research
Neurologists, Radiologists, Researchers in the field of Neurology/Radiology/Multiple Sclerosis, Radiology residents, Neurology residents, Physicists, Immunologists, Neuroscience researchers, Biomedical engineering PhD students, Physics and neuroscience students
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Chapter 1. Introduction
- Abstract
- Outline
- Introduction
- Chapter 2. The immunology and pathophysiology of multiple sclerosis
- Abstract
- Outline
- Introduction
- The immunology of multiple sclerosis
- The pathophysiology of multiple sclerosis
- Conclusion
- References
- Chapter 3. Diagnosis and clinical features of multiple sclerosis
- Abstract
- Outline
- What is multiple sclerosis
- Clinical symptoms of multiple sclerosis
- Development and mechanisms of multiple sclerosis
- Ethnic and racial disparities in multiple sclerosis
- Clinical course of multiple sclerosis and multiple sclerosis types
- Linking multiple sclerosis pathophysiology and in vivo imaging
- Multiple sclerosis diagnostic criteria
- Precursors to multiple sclerosis: clinically isolated syndrome and radiologically isolated syndrome
- Recommendations on the timing of imaging for monitoring of multiple sclerosis disease activity and progression
- Recommendations on the use of newer magnetic resonance imaging techniques for evaluation of multiple sclerosis
- Summary
- References
- Chapter 4. Cognition in multiple sclerosis
- Abstract
- Outline
- Introduction
- A historical review of cognition in multiple sclerosis
- Acute cognitive decline as a marker of active disease in multiple sclerosis
- Treatment of cognitive impairment in multiple sclerosis
- Open questions and future directions
- Conclusion
- References
- Chapter 5. Multiple sclerosis treatment
- Abstract
- Outline
- Introduction
- Escalation versus induction approach?
- Interferon beta 1-a and interferon beta 1-b
- Glatiramer acetate
- Dimethyl fumarate and diroximel fumarate (monomethyl fumarate)
- Teriflunomide
- Sphingosine 1-phosphate–receptor modulators (ozanimod, ponesimod, fingolimod, siponimod)
- B-cell depletion
- Natalizumab
- Alemtuzumab
- Conflict of interest
- References
- Chapter 6. Use of magnetic resonance imaging and quantitative imaging reports in clinical care of multiple sclerosis
- Abstract
- Outline
- Introduction
- Magnetic resonance imaging in multiple sclerosis diagnosis
- Magnetic resonance imaging in differential diagnosis of multiple sclerosis
- Magnetic resonance imaging in the prediction of disease activity
- Magnetic resonance imaging for monitoring disease activity
- Magnetic resonance imaging in drug safety surveillance
- Quantitative magnetic resonance imaging reports in clinical care
- Disclosures
- References
- Chapter 7. Magnetic resonance imaging markers in multiple sclerosis clinical trials and emerging imaging biomarkers
- Abstract
- Outline
- Introduction
- Conventional magnetic resonance imaging markers in multiple sclerosis
- Emerging imaging biomarkers
- Conclusions
- References
- Section I: Imaging of multiple sclerosis
- Part 1: Conventional MRI use in multiple sclerosis
- Chapter 8. Magnetic resonance imaging physics and image acquisition
- Abstract
- Outline
- Introduction
- Magnetic resonance imaging image formation
- Relationship between magnetic resonance imaging signal and tissue properties
- Summary
- References
- Chapter 9. Magnetic resonance imaging of the multiple sclerosis lesions
- Abstract
- Outline
- Introduction
- White matter lesions
- Black holes
- Contrast-enhancing lesions
- Chronic active lesions
- Cortical lesions
- Conclusions
- References
- Chapter 10. Spinal cord imaging in multiple sclerosis
- Abstract
- Outline
- Introduction
- Characteristics of spinal cord lesions in multiple sclerosis: multiple sclerosis diagnosis and differential diagnosis
- Practical considerations in spinal cord clinical imaging
- Spinal cord magnetic resonance imaging assessment for patient’s prognosis and disease monitoring
- Future directions
- Conclusions
- References
- Part 2: Non-conventional MRI use in multiple sclerosis
- Chapter 11. Magnetization transfer imaging in multiple sclerosis
- Abstract
- Outline
- Introduction
- Clinical use of magnetization transfer contrast
- Quantifying the magnetization transfer effect
- Validation of magnetization transfer–derived parameters as myelin markers
- Magnetization transfer ratio in multiple sclerosis
- Quantitative magnetization transfer in multiple sclerosis
- Magnetization transfer saturation in multiple sclerosis
- Inhomogeneous magnetization transfer in multiple sclerosis
- Magnetization transfer in spinal cord and optic nerve
- Conclusions
- References
- Chapter 12. Susceptibility weighted imaging in multiple sclerosis
- Abstract
- Outline
- Introduction
- Imaging biomarkers in multiple sclerosis
- SWI-FLAIR or FLAIR*
- Quantitative susceptibility mapping
- Introduction to STrategically Acquired Gradient Echo Imaging
- Water content as a new biomarker for multiple sclerosis lesions
- Microvascular in vivo contrast revealed origins
- Conclusion
- References
- Chapter 13. Quantitative susceptibility mapping in multiple sclerosis
- Abstract
- Outline
- Introduction
- Fundamentals of quantitative susceptibility mapping
- Nonheme iron concentrations in the deep gray matter
- Regional content of nonheme iron in the deep gray matter
- Subvoxel distribution of iron in the deep gray matter
- Gadolinium retention in the deep gray matter
- Confounding effects of myelin in the deep gray matter
- Normal appearing white matter
- Focal white matter damage
- Other applications of quantitative susceptibility mapping in multiple sclerosis
- Summary and outlook
- Acknowledgments
- References
- Chapter 14. Functional magnetic resonance imaging in multiple sclerosis
- Abstract
- Outline
- Introduction
- Functional reorganization: task-based functional magnetic resonance imaging
- Functional connectivity: resting-state functional magnetic resonance imaging
- Functional brain changes over time
- Dynamic functional connectivity
- The network collapse
- Advanced network analyses: network efficiency
- Conclusion
- References
- Chapter 15. Perfusion-weighted imaging in multiple sclerosis
- Abstract
- Outline
- Magnetic resonance imaging techniques for estimating cerebral perfusion
- Magnetic resonance imaging perfusion studies in multiple sclerosis
- Conclusions
- References
- Chapter 16. Magnetic resonance spectroscopy and myelin water fraction in multiple sclerosis
- Abstract
- Outline
- Magnetic resonance spectroscopy
- Metabolites of interest for multiple sclerosis studies
- Magnetic resonance spectroscopy data acquisition
- Magnetic resonance spectroscopy data analysis
- Factors affecting reproducibility of magnetic resonance spectroscopy and consensus protcols
- Magnetic resonance spectroscopy findings in multiple sclerosis lesions
- Magnetic resonance spectroscopy findings in multiple sclerosis normal-appearing white matter and gray matter
- Magnetic resonance spectroscopy and multiple sclerosis cognitive impairment
- Magnetic resonance spectroscopy in multiple sclerosis clinical trials and disease modifying therapy evaluation
- Limitations of magnetic resonance spectroscopy studies in multiple sclerosis
- Future directions in magnetic resonance spectroscopy for multiple sclerosis research and clinical care
- Myelin water fraction
- What is myelin water?
- Measurement of myelin water fraction
- Myelin water fraction validation
- Myelin water fraction in different multiple sclerosis tissues
- Myelin water fraction in multiple sclerosis subtypes
- Myelin water fraction correlations with clinical measures
- Myelin water fraction and disease modifying treatments
- Limitations
- Future directions
- Summary
- References
- Chapter 17. High-field imaging in multiple sclerosis
- Abstract
- Outline
- Introduction
- Multiple sclerosis–induced disease under the microscope of high-field imaging
- Clinical application of high-field imaging
- Technical challenges associated with the use of high-field imaging
- Summary and conclusions
- Acknowledgments
- Conflict of interest
- References
- Part 3: Use of other imaging acquisition and analysis modalities in multiple sclerosis
- Chapter 18. Positron emission tomography imaging in multiple sclerosis
- Abstract
- Outline
- Introduction
- Positron emission tomography imaging
- Microglial activation and translocator protein–positron emission tomography
- Translocator protein–positron emission tomography ligands
- Translocator protein–positron emission tomography and gray matter pathology in multiple sclerosis
- Translocator protein–positron emission tomography and white matter
- Translocator protein–positron emission tomography and symptom pathogenesis
- Translocator protein–positron emission tomography and prognostication in multiple sclerosis
- Translocator protein–positron emission tomography and treatment effects
- Beyond translocator protein–positron emission tomography: other glial imaging targets and PET ligands
- Beyond translocator protein–positron emission tomography: PET imaging of nonimmune mechanisms in MS
- Future directions and conclusion
- References
- Chapter 19. Optical coherence tomography in multiple sclerosis
- Abstract
- Outline
- Introduction
- Technical principles of optical coherence tomography
- Retina as a window to the brain
- Optical coherence tomography in optic neuritis
- Optical coherence tomography is a marker of multiple sclerosis–associated neuroaxonal damage
- Optical coherence tomography in treatment monitoring
- Practical issues and limitations affecting clinical application of optical coherence tomography in multiple sclerosis
- Conclusion
- References
- Chapter 20. Imaging of multiple sclerosis in resource-poor settings
- Abstract
- Outline
- Optimization strategies
- Conclusion
- References
- Chapter 21. Use of artificial intelligence in multiple sclerosis imaging
- Abstract
- Outline
- Introduction
- Basics of AI in medical imaging
- AI in MS neuroimaging: survey of current applications
- AI pitfalls and ethical concerns
- Future directions
- Conclusions
- References
- Index
- Edition: 1
- Published: November 29, 2024
- Imprint: Academic Press
- No. of pages: 454
- Language: English
- Paperback ISBN: 9780323957397
- eBook ISBN: 9780323957403
DJ
Dejan Jakimovski
Dejan Jakimovski, MD, Ph.D., is a Research Assistant Professor at the Department of Neurology, University at Buffalo, the State University of New York and Clinical Research Unit Director at Buffalo Neuroimaging Analysis Center. In 2015, Dr. Jakimovski received his medical degree at Ss. Cyril and Methodius University, Skopje, Macedonia and in 2020 he also received Neuroscience Ph.D. degree at University at Buffalo. He performed research spanning from cardiovascular, environmental and genetic risk factors in multiple sclerosis (MS) and use of quantitative multimodal imaging techniques in predicting disease outcomes in MS and other neurodegenerative diseases. Furthermore, his focus included clinical, neuropsychological and optical coherence tomography (OCT) characterization of both adult and aging MS populations.
Affiliations and expertise
Research Assistant Professor at the Department of Neurology, University at Buffalo, the State University of New York and Clinical Research Unit Director at Buffalo Neuroimaging Analysis Center.RZ
Robert Zivadinov
Robert Zivadinov, MD, Ph.D., has served as Director of the Buffalo Neuroimaging Analysis Center (BNAC) since 2003. The Center is part of the Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York, where he is Professor of Neurology. He also is Director of the University’s Center for Biomedical Imaging at the Clinical Translational Science Institute.Having published more than 450 articles and 750 abstracts in leading peer-reviewed journals, Dr. Zivadinov’s work is widely cited with H-index of 80.He is Honorary Professor of Neurology at the University of Sidney, Australia. Dr. Zivadinov was a founding member of the International Society for Neurovascular Disease and currently serves on its Executive Committee.
Affiliations and expertise
University at Buffalo, State University of New York, Buffalo, NY, USARead Handbook of Imaging in Multiple Sclerosis on ScienceDirect