Handbook of Animal Models in Neurological Disorders

1st Edition - November 23, 2022
Imprint: Academic Press
Editors: Colin R. Martin, Vinood B. Patel, Victor R Preedy
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 8 3 3 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 8 8 6 - 7

Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurol… Read more

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Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Part I: Alzheimer’s disease and dementias
Chapter 1: Alzheimer’s disease preliminary screening in zebrafish integrating behavioral models and molecular markers
Abstract
Introduction
Evaluation of cognitive performance through behavioral tasks in AD
Anxiety models
Transgenic fish model
Summary points
References
Chapter 2: Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice
Abstract
Introduction
Details of the animal model
Advantages and disadvantages
Other model systems
Mini-dictionary of terms
Key facts
Summary points
References
Chapter 3: Current mouse models of Alzheimer’s disease for investigating therapeutic agents
Abstract
Introduction
Transgenic mouse models
Single transgenic models
Multiple transgenic models
Non-genetic models
Selection of the best models to improve translational predictability
Conclusion
Mini-dictionary of terms
Key facts of transgenic mouse models of AD
Summary points
References
Chapter 4: A rat model of pre-clinical Alzheimer’s disease
Abstract
Introduction
Generating the sub-clinical “at-risk” Aβ rat model of AD
Measuring synaptic plasticity: Electrophysiological experiments
Levels of Alzheimer’s disease-related proteins
Summary points
References
Chapter 5: Modeling menopause and dementia in rodents: Investigations on cognition and coordination
Abstract
Introduction
Alzheimer’s disease
Menopause animal model induced by ovariectomy
Animal behavioral test
Advances in researching using the animal model
Advantages and disadvantages of the model
Other models
Mini-dictionary of terms
Key facts of dementia
Summary points
References
Further reading
Part II: Amyotrophic lateral sclerosis
Chapter 6: Drosophila model of amyotrophic lateral sclerosis targeting FUS and ubiquilin
Abstract
Introduction
Details of Drosophila models
Study periods and age preferences
Commonly used tools to study Drosophila ALS models
Commonly used assays with Drosophila ALS models
Utilization of Drosophila ALS models targeting FUS to identify genetic interactants
Utilization of Drosophila ALS models targeting UBQLNs to examine the role of proteostasis in the pathogenesis of ALS
Advantages and disadvantages of Drosophila ALS models
Other model systems
Mini-dictionary of terms
Key facts of Drosophila ALS models targeting FUS and ubiquilin
Summary points
References
Chapter 7: The amyotrophic lateral sclerosis SOD1G93A mouse model and applications: Studies into the P2X7 receptor
Abstract
Introduction
Gene mutations found in ALS patients that are being modeled in mice
The SOD1G93A mouse model of ALS
Neuroinflammation and P2X7 receptors in ALS pathogenesis
Trial protocol to test the effects of P2X7R blockers in SOD1G93A mice
The controversial outcomes of studies on the therapeutic potential of P2X7R blockers in SOD1G93A mice
Conclusions and perspectives
Mini-dictionary of terms
Key facts of ALS
Summary points
References
Chapter 8: Modeling amyotrophic lateral sclerosis through Ataxin-2 pathology
Abstract
Introduction
Details of the animal model
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of Ataxin-2 PolyQ expansions
Summary points
References
Part III: Brain injury
Chapter 9: Drosophila melanogaster model of traumatic brain injury: Investigating the pharmacodynamics of volatile anesthetics
Abstract
Introduction
Details of the fruit fly model
Findings and advances from the fruit fly–anesthesia–TBI model
Advantages and disadvantages of the model(s)
Other model systems
Mini-dictionary of terms
Key facts of the D. melanogaster model of TBI
Summary points
References
Chapter 10: Mouse model of repetitive mild traumatic brain injury (investigating cognitive impairment)
Abstract
Acknowledgments
Introduction
A mouse model of repetitive mild traumatic brain injury
Assessment of cognitive impairment
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of controlled cortical impact injury (CCI)
Summary points
Reference
Chapter 11: Blood–brain barrier damage following mild traumatic brain injury
Abstract
Introduction
Experimental blast-induced injury
Pericytes and the BBB
Astrocytes and the BBB
Microglial contributions to the BBB
TBI and the endothelial glycocalyx
Tight junction-associated proteins after TBI
Efflux transporters on the brain endothelial cells
Ramifications of BBB breakdown in TBI
Conclusion
Mini-dictionary of terms
Key facts of animal models of traumatic brain injury
Summary points
References
Chapter 12: Rodent modeling of neonatal hypoxic–ischemic brain injury
Abstract
Introduction
Details of the animal models
Findings and advances
Mini-dictionary of terms
Key facts for neonatal hypoxic–ischemic brain injury
Key facts for Rice–Vannucci model
Summary points
References
Chapter 13: Modeling brain injury: Neonatal intraventricular hemorrhage
Abstract
Introduction: (The neuroscience of the problem)
Details of the animal model
Advantages and disadvantages of the model
Other model systems
Large animal models
Mini-dictionary of terms
Key facts about intraventricular hemorrhage
Summary points
References
Chapter 14: Penetrating traumatic brain injury model in rats: Applications to studying duraplasty following decompressive craniectomy
Abstract
Introduction
Details of the animal model(s)
A subtitle or series of subtitles relating to how the model (s) has been used to generate findings and advances
Advantages and disadvantages of the model (s)
Other model systems
Mini-dictionary of terms
Key facts of experimental penetrated traumatic brain injury
Summary points
References
Part IV: Cerebral palsy
Chapter 15: The spa transgenic mouse model of hypertonia and use for studying cerebral palsy
Abstract
Introduction
Details of the animal model
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts
Summary points
References
Chapter 16: Transient occlusion of uterine arteries and intra-amniotic injection of lipopolysaccharide in rats as a model of cerebral palsy
Abstract
Introduction
Details of the animal model
Findings and advances
Advantages and disadvantages
Other animal models
Mini-dictionary of terms
Key facts of cerebral palsy
Summary points
References
Chapter 17: Experimental cerebral palsy in animals and developmental plasticity
Abstract
Acknowledgments
Introduction
Cerebral palsy
Details of the animal model
Other models system
Conclusion
Mini-dictionary of terms
Key facts in perinatal diseases
Summary points
References
Part V: Epilepsy and seizures
Chapter 18: Second-hit pentylenetetrazole-induced seizure model in zebrafish
Abstract
Introduction
Epilepsy-induced comorbidity
Current treatment for epilepsy
In vivo seizure models
Applications of the zebrafish seizure model
Pilocarpine in zebrafish larvae
Pilocarpine in adult zebrafish
Benefits and limitations of the pilocarpine-induced seizure model
Mini-dictionary of terms
Key facts of second-hit pentylenetetrazole-induced seizure model with pilocarpine in zebrafish
Summary points
References
Chapter 19: The zebrafish model of Tuberous sclerosis complex to study epilepsy
Abstract
Introduction
Details of the animal model
Advantages and disadvantages
Other model systems
Mini-dictionary of terms
Key facts on zebrafish
Summary points
References
Further reading
Chapter 20: The Brd2+/− mouse model of juvenile myoclonic epilepsy (JME)
Abstract
Introduction
Genetics involved in the JME
BRD2 role in JME susceptibility
Model creation
Model validation
Model mechanisms beyond genetic deficits
Behavioral findings in the model
Developmental findings in the model
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of juvenile myoclonic epilepsy (JME)
Key facts of Brd2+/− mouse model of JME
Summary points
References
Chapter 21: Modeling the link between traumatic brain injury and epileptiform activity in rats
Abstract
Clinical relevance of studying epileptiform activity after TBI
Translational research and animal models of TBI
Lateral fluid percussion brain injury (LFPBI)
Periods of TBI: Opportunities for staging
Immediate seizures
Types of electrophysiological recordings and electrode planning
Surgical techniques
Bullet questions
Tissue preparation
Analysis of electrographic recordings
Usage of standardized terminology
Epileptiform activity and seizures in early period of TBI
Epileptiform activity and seizures in late period of TBI
Spike wave discharges and TBI
High-frequency oscillations and DC-potentials
Limitations of the model
Mini-dictionary of terms
Key facts of traumatic brain injury
Key facts of posttraumatic epilepsy
Summary points
References
Chapter 22: Animal models of infantile spasms: Focus on new treatments
Abstract
Introduction
The rationale for the animal model of IS
Prenatal betamethasone-postnatal NMDA model
Validation of the model
Screening for potential novel pharmacological agents for treatment of IS
Investigating the underlying mechanisms of IS using our model
Effects of the prenatal betamethasone/stress priming
Effects of the postnatal spasms
Studying the mechanism of action of IS treatments using our model
Advantages and disadvantages of the prenatal betamethasone-postnatal NMDA IS model
Other model systems to test IS
Genetic IS models
IS models by acquired lesions
Mini-dictionary of terms
Key facts of IS
Key facts of modeling IS
Summary points
References
Part VI: Headaches, migraines and pain
Chapter 23: Light flash in rats as a model for the triggering of migraine headache
Abstract
Why we developed the model
Question 1. Does light REALLY trigger migraine headache?
Question 2. What are the features of light that might lend themselves to induce headache?
Question 3. Where is the pathway by which TLM becomes transformed into migraine headache?
The models
Philosophy of the most elaborated experiments
Details of the animal model
How the model has been used to generate findings
Summary points
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of migraine
Summary points
References
Chapter 24: Inhibition of diacylglycerol lipase alpha (DAGLα) as a model for episodic headache in rats: Features and applications
Abstract
Introduction
Details of animal model
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts
Summary points
References
Chapter 25: Animal models of headache
Abstract
Introduction
Animal migraine models
Mini-dictionary of terms
Key facts of CSD
Key facts of GTN
Summary points
References
Chapter 26: Animal models of orofacial pain comorbidity in mice
Abstract
Introduction
Animal models of migraine
Animal models of TMD-like pain
Animal models for comorbidity of TMD with migraine or other diseases
Mini-dictionary of terms
Key facts
Summary points
References
Part VII: Meningitis
Chapter 27: Experimental meningitis by Streptococcus pneumoniae and Neisseria meningitidis in rodents
Abstract
Acknowledgments
Introduction
Details of the animal models
How the models have been used to generate findings and advances
Advantages and disadvantages of the models
Other model systems
Mini-dictionary of terms
Key facts of BM
Summary points
References
Chapter 28: The rabbit model: Pathological manifestations of tuberculous meningitis
Abstract
Introduction
Pathogenesis of TBM in humans
Rabbit model of TBM
Establishment of a rabbit model TBM
Rabbit model of TBM for drug discovery
Evaluation of anti-inflammatory drugs as an adjunct therapy for TBM in the rabbit model
Limitations of the rabbit model TBM
Conclusion
Mini-dictionary of terms
Key facts of tuberculous meningitis
Summary points
References
Chapter 29: Novel Streptococcus suis meningitis model in pigs: Longitudinal assessment of oxygen values, neutrophil function, and DNase activity in the central nervous system
Abstract
Introduction
Goal of this book chapter
Details of the animal model
Sources and suppliers
Design
Preferences for age and gender
Housing and enrichment
Feeding regimens
Scoring of animals
Description of i.v. infection
Determination of CSF and blood parameters during onset of meningitis using a final long-term anesthesia
In vivo oxygen measurement
Sampling procedure post mortem
Neutrophil extracellular trap (NET) formation at onset of meningitis
Advantages and disadvantages of the i.v. S. suis infection in piglets with long-term anesthesia
Other model systems
Mini-dictionary of terms
Key facts of S. suis meningitis
Summary points
References
Part VIII: Multiple sclerosis
Chapter 30: R-Ras1−/− and R-Ras2−/− mice as models for investigating multiple sclerosis
Abstract
Acknowledgments
Multiple sclerosis neurodegenerative disease
Details of the R-Ras1−/− and/or R-Ras2−/− mouse models
Contribution of new R-Ras1−/− and/or R-Ras2−/− models to the understanding of MS pathogenesis
Advantages and disadvantages of R-Ras1−/− and R-Ras2−/− models
Other model systems for MS research
Conclusion
Mini-dictionary of terms
Key facts
Summary points
References
Chapter 31: Animal models of multiple sclerosis and the lower urinary tract
Abstract
Introduction
Clinical pathology of MS: The classic characteristics
Pathophysiology of MS-associated LUTS/D: The known and the unknown
Animal models relevant to MS-associated LUTS/D
Urinary pathophysiology of animal models of MS: What is known?
Future translational potential/strategies: The light on the horizon
Mini-dictionary of terms
Key facts of MS-LUTS/D
Summary points
References
Further reading
Part IX: Neuroinflammation
Chapter 32: The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis
Abstract
Introduction
Details of the animal model
Immunofluorescence staining of the tissue sections
Periods of study
Characterization of the model
Advantages and disadvantages of the EAE model
Other models of optic neuritis
Mini-dictionary of terms
Key facts of the EAE model
Summary points
Funding
References
Chapter 33: Modeling neurotoxin-induced neuroinflammation with chemotherapy
Abstract
Introduction
Animal models
Mini-dictionary of terms
Key facts of chemotherapy induced dementia-neuroinflammation
Summary points
Author contribution
References
Chapter 34: Modeling and investigating neuroinflammation in cardiopulmonary resuscitation in pigs
Abstract
Rationale for the cardiac arrest studies
Neuroinflammation after cardiac arrest
Hypoxic ischemic brain injury-related regions of interest
Anatomical features of regions of interest
Model details: The porcine resuscitation model
Technical aspects
Histopathological evaluation of HIBI
Histopathological evaluation of further neuroinflammation
Conclusions and perspectives
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of cardiopulmonary resuscitation
Summary points
References
Chapter 35: Investigating neuroinflammation in lateral fluid percussion injury
Abstract
Introduction
Lateral fluid percussion injury model
lFPI-induced neuroinflammation
lFPI compared to other TBI models
Conclusion
Mini-dictionary of terms
Key facts of neuroinflammation
Summary points
References
Part X: Neurotoxins
Chapter 36: Use of zebrafish embryos to study molecular and cellular neurotoxic effects of drugs: A focus on signaling and ketamine
Abstract
Introduction
Zebrafish embryo model
Ketamine-induced neurotoxicity in zebrafish embryos
Ketamine-induced changes in gene expression in zebrafish embryos
Ketamine, calcium, and the ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) pathway
Advantages and disadvantages of the zebrafish embryo model
Other model systems
Mini-dictionary of terms
Key facts of ketamine-induced neurotoxicity
Summary points
References
Chapter 37: Rodent models of anesthesia-induced developmental neurotoxicity☆
Abstract
Introduction
Overview of the animal model
Advantages of the rodent model
Conclusion
Mini-dictionary of terms
Key facts of hypoxia-induced neural injury
Summary points
References
Part XI: Parkinson’s disease
Chapter 38: Modeling of Parkinson’s disease in Drosophila based on DJ-1 deficiency
Abstract
Introduction
Details of the animal model
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of Parkinson’s disease
Summary points
References
Chapter 39: Drosophila model of Parkinson’s disease using rotenone
Abstract
Introduction
Drosophila model to study behavior and motor function related to PD
Genetic modifiers available in drosophila model of Parkinson’s disease
Environmental toxins contribute toward Parkinson’s disease
Rotenone induced model of Parkinson’s disease
Drosophila model for rotenone induced oxidative stress as a key factor in PD
Rotenone and genetic variables influencing mitochondrial dysfunction in PD
Advantage and disadvantage of PD model of drosophila
Mini-dictionary of terms
Key facts of Parkinson’s disease
Key facts of rotenone model of Parkinson’s disease
Summary points
References
Chapter 40: 6-Hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease: Investigating neural control of cardiorespiratory function
Abstract
Historical 6-hydroxydopamine (6-OHDA) drug evidence for the development of a Parkinson’s disease model
Details of the 6-OHDA animal model
The mechanisms of 6-OHDA as model of PD
The location of central injections of 6-OHDA as a model of PD
Cardiorespiratory impairment in the 6-OHDA model of PD
Other model systems and its advantages
Conclusions
Mini-dictionary of terms
Key facts of cardiorespiratory function in 6-OHDA PD model
Summary points
References
Chapter 41: The use of the proteasome inhibitor lactacystin for modeling Parkinson’s disease: Early neurophysiological biomarkers and candidates for intranigral and extranigral neuroprotection
Abstract
Acknowledgment
Introduction
UPS
Dysregulation of UPS in PD
Proteasome inhibitor LC
Lactacystin-induced model of PD in rodents
Unilateral nigral injection of LC
Bilateral nigral injections of LC
Intranasal administration of LC
LC model for the search of early neurophysiological markers of PD
LC model to test new agents for the treatment of PD
Advantages and disadvantages of the LC model
Other model systems
Mini-dictionary of terms
Key facts about Parkinson’s disease models
Summary points
References
Part XII: Peripheral neuropathy
Chapter 42: Zebrafish as a model for studying peripheral neuropathy
Abstract
Introduction
Details of the animal model
How the model has been used to generate findings and advances
Advantages and disadvantages
Mini-dictionary of terms
Key facts
Summary points
References
Part XIII: Prenatal related injury and neurodevelopmental disorders
Chapter 43: Prenatal systemic hypoxia-ischemia: A rat model of neurodevelopmental disorders related to prematurity
Abstract
Introduction
Animal models of PSHI
Main results after prenatal systemic hypoxia-ischemia
Advantages/disadvantages
Key facts?
Summary points
References
Chapter 44: Modeling prenatal stress in rats: Impact on the hippocampus
Abstract
Introduction
The prenatal chronic unpredictable mild stress model
Findings emerging from the prenatal stress model
Advantages and disadvantages of the prenatal CUMS model
Other model systems of prenatal stress in rats
Mini-dictionary of terms
Key facts of prenatal stress
Summary points
References
Chapter 45: The use of oxcarbazepine during gestation has adverse effects in rats
Abstract
Introduction
Details of the animal model
Conclusion
Advancement for science with this animal model
Advantages and disadvantages of the model
Mini-dictionary of terms
Key facts of epilepsy
Summary points
References
Chapter 46: Modeling the effect of anesthesia in pregnancy and impact on the fetal brain: Studies in rabbits
Abstract
Introduction
General methodology
Specific research questions
Advantages and disadvantages of the model
Other model systems
Mini-dictionary of terms
Key facts of “Modeling the effect of anesthesia in pregnancy and impact on the fetal brain: Studies in rabbits”
Summary points
References
Part XIV: Stroke
Chapter 47: Murine subarachnoid hemorrhage: Delayed injury
Abstract
Introduction
Details of the model
Advantages and disadvantages of the model
Other models
Mini-dictionary of terms
Key facts of murine subarachnoid hemorrhage: Delayed injury
Summary points
References
Chapter 48: Intraluminal filament induced middle cerebral artery occlusion model of transient focal cerebral ischemia in rats
Abstract
Introduction
Middle cerebral artery occlusion (MCAo) model
Intraluminal filament induced MCAo model of transient focal cerebral ischemia in rats
Mini-dictionary of terms
Key facts of MCAo model of focal cerebral ischemia
Summary points
References
Chapter 49: Modeling subarachnoid hemorrhage in rabbits: Investigating drugs
Abstract
Introduction
Details of the animal model
Puncturing middle cerebral artery and superior sagittal sinus
Morphometric characteristics of rabbits
Anesthesia and perioperative care
Mortality
Methods for sacrificing the animals
Outcome measures
Conclusion
Mini-dictionary of terms
Key facts of rabbit subarachnoid hemorrhage model
Summary points
References
Chapter 50: Non-human primates models of stroke: Imaging studies in cerebral ischemia in Macaca fascicularis
Abstract
Introduction
Details of the NHP endovascular AIS model
Evaluation of AIS with clinical read-outs and advanced imaging biomarkers
Advantages and disadvantages of the NHP endovascular AIS model
Other model systems
Mini-dictionary of terms
Key facts of the role of imaging in recent advances in medical treatment of ischemic stroke
Key facts of endovascular ischemic stroke models with imaging read-outs
Summary points
References
Part XV: Resources
Chapter 51: Recommended resources and online material for investigating neurological disorders and the use of animal models
Abstract
Introduction
Resources
Other resources
Summary points
Acknowledgements (in alphabetical order)
References
Index

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Affiliations and expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Vinood B. Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and expertise

Reader in Clinical Biochemistry, University of Westminster, London, UK

Victor R Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Affiliations and expertise

Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK

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Handbook of Animal Models in Neurological Disorders

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