
Growth Factors in Development
- 1st Edition, Volume 97 - November 7, 2011
- Imprint: Academic Press
- Editor: Carman Birchmeier
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 8 5 9 7 5 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 8 5 9 7 6 - 1
This new volume of the renowned serial Current Topics in Developmental Biology covers the important features of growth factors in development. With an international board of… Read more
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- Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area
- This volume provides an up-to-date and timely perspective
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Contributors
Preface
Chapter one: New Insights into Signaling During Myelination in Zebrafish
1. Introduction
2. Schwann Cell Development
Forward Genetic Screens
Reverse Genetics: Morpholinos, TILLING, and Zinc Fingers
Small Molecules
In vivo imaging
3. Neuregulin1/ErbB Signaling
4. Gpr126
5. New Roles for Schwann Cells
6. Oligodendrocytes
7. Conclusions and Future Directions
Chapter two: Wnt Signaling
1. Overview of Wnt Signal Transduction Cascades
2. Wnt Proteins: Different Branches of Signaling
3. Regulation of Wnt Signaling Above the Receptor Level
4. Regulation of Wnt Signaling Pathways at the Receptor Level
5. Conclusions and Perspective
Chapter three: Notch-Independent Functions of CSL
1. Introduction
2. CSL as a Repressor
3. CSL as a Notch-Independent Transcriptional Activator
4. Role of cis-Regulatory Modules in Determining Target Gene Transcription
5. Role of Competition Between CSL-Containing Complexes—Is CSL a Limiting Factor?
6. Concluding Remarks
Chapter four: Sonic Hedgehog Signaling in the Developing CNS
1. Prologue: Identification of Shh
2. Setting the Stage: Shh Signaling During Nervous System Regionalization
3. I Am Dying to Hear from You: The Range of Shh Signaling in the CNS
4. Character Creation: Production and Secretion of Shh Protein
5. Won't You Take My Hand: Shh-Binding Proteins and Diffusion
6. Character Development: Transduction of Shh Signal in Receiving Cells
7. Cutting in on the Dance: The Interplay Between Ptc and Smo
8. Taking It to the Extreme: The Central Role of the Primary Cilium in Shh Signaling
9. Stepping into the Dark: How Does Smo Control Gli Phosphorylation?
10. Are You Going to Use That Thing? Smo as a G-Protein-Coupled Receptor
11. Being in the Right Place at the Right Time: Shh–Gli Signaling and Patterning in the Ventral Neural Tube
12. Walking Down the Runway: A Model for Shh–Gli Control of Early Progenitor Patterning
13. What’s It Gonna Be, Boy? GliA Versus GliR-Regulated Genes
14. New Game: Distinct Mechanisms for GliA-and GliR-Mediated Transcription
15. Summary and Further Questions
Chapter five: Activity-Mediated Synapse Formation
1. Introduction
2. Wnts and Their Receptors
3. The Role of Wnt Signaling in Synapse Formation
4. Role of Neuronal Activity in Wnt-Mediated Dendrite Morphogenesis
5. Role of Neuronal Activity in Wnt-Mediated Synapse Formation
6. Concluding Remarks
Chapter six: Signaling Pathways and Axis Formation in the Lower Metazoa
1. Introduction
2. Animal Relationships and the Origin of the Basal Metazoa
3. Wnt Signaling
4. TGF-β and BMP Signaling
5. Negative Regulators of BMP and Wnt Signaling
6. Axis Formation and Regeneration in Basal Metazoans
7. Conclusions and Outlook
Chapter seven: FGF and ROR2 Receptor Tyrosine Kinase Signaling in Human Skeletal Development
1. Introduction
2. FGF Signaling: Craniosynostosis, Digit Abnormalities, and Short Stature
3. The Atypical Receptor TK ROR2 and WNT Signaling
Subject index
Contents of previous volume
- Edition: 1
- Volume: 97
- Published: November 7, 2011
- Imprint: Academic Press
- Language: English