Growth Factors in Development

Series Page

Contributors

Preface

Chapter one: New Insights into Signaling During Myelination in Zebrafish

1. Introduction

2. Schwann Cell Development

Forward Genetic Screens

Reverse Genetics: Morpholinos, TILLING, and Zinc Fingers

Small Molecules

In vivo imaging

3. Neuregulin1/ErbB Signaling

4. Gpr126

5. New Roles for Schwann Cells

6. Oligodendrocytes

7. Conclusions and Future Directions

Chapter two: Wnt Signaling

1. Overview of Wnt Signal Transduction Cascades

2. Wnt Proteins: Different Branches of Signaling

3. Regulation of Wnt Signaling Above the Receptor Level

4. Regulation of Wnt Signaling Pathways at the Receptor Level

5. Conclusions and Perspective

Chapter three: Notch-Independent Functions of CSL

1. Introduction

2. CSL as a Repressor

3. CSL as a Notch-Independent Transcriptional Activator

4. Role of cis-Regulatory Modules in Determining Target Gene Transcription

5. Role of Competition Between CSL-Containing Complexes—Is CSL a Limiting Factor?

6. Concluding Remarks

Chapter four: Sonic Hedgehog Signaling in the Developing CNS

1. Prologue: Identification of Shh

2. Setting the Stage: Shh Signaling During Nervous System Regionalization

3. I Am Dying to Hear from You: The Range of Shh Signaling in the CNS

4. Character Creation: Production and Secretion of Shh Protein

5. Won't You Take My Hand: Shh-Binding Proteins and Diffusion

6. Character Development: Transduction of Shh Signal in Receiving Cells

7. Cutting in on the Dance: The Interplay Between Ptc and Smo

8. Taking It to the Extreme: The Central Role of the Primary Cilium in Shh Signaling

9. Stepping into the Dark: How Does Smo Control Gli Phosphorylation?

10. Are You Going to Use That Thing? Smo as a G-Protein-Coupled Receptor

11. Being in the Right Place at the Right Time: Shh–Gli Signaling and Patterning in the Ventral Neural Tube

12. Walking Down the Runway: A Model for Shh–Gli Control of Early Progenitor Patterning

13. What’s It Gonna Be, Boy? GliA Versus GliR-Regulated Genes

14. New Game: Distinct Mechanisms for GliA-and GliR-Mediated Transcription

15. Summary and Further Questions

Chapter five: Activity-Mediated Synapse Formation

1. Introduction

2. Wnts and Their Receptors

3. The Role of Wnt Signaling in Synapse Formation

4. Role of Neuronal Activity in Wnt-Mediated Dendrite Morphogenesis

5. Role of Neuronal Activity in Wnt-Mediated Synapse Formation

6. Concluding Remarks

Chapter six: Signaling Pathways and Axis Formation in the Lower Metazoa

1. Introduction

2. Animal Relationships and the Origin of the Basal Metazoa

3. Wnt Signaling

4. TGF-β and BMP Signaling

5. Negative Regulators of BMP and Wnt Signaling

6. Axis Formation and Regeneration in Basal Metazoans

7. Conclusions and Outlook

Chapter seven: FGF and ROR2 Receptor Tyrosine Kinase Signaling in Human Skeletal Development

1. Introduction

2. FGF Signaling: Craniosynostosis, Digit Abnormalities, and Short Stature

3. The Atypical Receptor TK ROR2 and WNT Signaling

Subject index

Contents of previous volume