Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Applications
- 2nd Edition, Volume 1 - May 30, 2024
- Editor: Bimal Banik
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 6 1 6 6 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 6 1 6 7 - 4
Sustainable and Green Approaches in Medicinal Chemistry: Applications, Second Edition reveals essential context on the growth of green chemistry in relation to drug discovery,… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteSustainable and Green Approaches in Medicinal Chemistry: Applications, Second Edition reveals essential context on the growth of green chemistry in relation to drug discovery, identifying a broad range of practical techniques and useful insights and revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure, and increase the environmental benignity of the entire drug discovery process. The book encourages the growth of green medicinal chemistry and supports medicinal chemists, drug discovery researchers, pharmacologists, and all those in related fields across both academia and industry in integrating these approaches into their own work.
This volume includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods.
- Highlights the need for adoption of sustainable and green chemistry pathways in drug development
- Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these
- Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
Medicinal chemists, pharmaceutical, biotechnologists, green chemists and environmental chemists working in both academia and industry; postgraduate students in related fields. Scientists working in Government Research Agencies; industrial scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface
- Acknowledgment
- Section 1: Chemical catalysis
- Chapter 1. Green metal catalyzed reactions under sustainable conditions toward medicinally potent biomolecules
- Abstract
- 1.1 Introduction
- 1.2 C–C coupling reactions
- 1.3 Conclusion
- References
- Further reading
- Chapter 2. Graphene oxide and modified graphene oxide-mediated synthesis of medicinally active compounds
- Abstract
- 2.1 Introduction
- 2.2 One-pot multistep synthesis
- 2.3 Dehydrogenative coupling reactions
- 2.4 Oxidation and hydration reactions
- 2.5 Ring-opening reactions
- 2.6 Direct amidation of carboxylic acids with amines
- 2.7 Conclusions
- Acknowledgments
- References
- Chapter 3. Organocatalytic cycloaddition reaction: a gateway for molecular complexity
- Abstract
- 3.1 Introduction
- 3.2 [4+2] Cycloaddition reaction
- 3.3 [4+2] Cycloaddition via iminium ion activation
- 3.4 [4+2] Cycloaddition via enamine activation
- 3.5 Conclusions
- Acknowledgments
- References
- Section 2: Biocatalysis
- Chapter 4. Baker’s yeast-induced synthesis of medicinally important compounds
- Abstract
- 4.1 Introduction
- 4.2 Future perspectives
- 4.3 Conclusions
- List of abbreviations
- References
- Chapter 5. New methods for the manufacturing of pharmaceuticals and their intermediates using lipase
- Abstract
- 5.1 Introduction
- 5.2 Methods based on hydrolysis
- 5.3 Method based on esterification
- References
- Section 3: Green solvents
- Chapter 6. Green synthesis of biologically active pyrroles and related substrates via C–H bond functionalization
- Abstract
- 6.1 Introduction
- 6.2 Ring-closing metathesis for the preparation of heterocycles
- 6.3 Synthesis and biological activities of benzimidazoles-pyrroles
- 6.4 Synthesis and biological activities of coupling products derived from pyrroles and carbonyl compounds
- 6.5 Synthesis of functionalized pyrroles via domino and multicomponent reactions
- 6.6 One-pot synthesis
- 6.7 Synthesis of oxadiazoles
- 6.8 Conclusions
- Acknowledgments
- References
- Chapter 7. Ionic liquids in pharmaceutics and bioanalytics
- Abstract
- 7.1 Introduction
- 7.2 Molecular interaction in ionic liquids
- 7.3 Industrial applications of smart ionic liquids
- 7.4 Biological applications of smart ionic liquids
- 7.5 Crystallization in ionic liquids
- 7.6 Conclusion
- Acknowledgments
- References
- Chapter 8. Synthesis of bioactive heterocyclic compounds using green solvents
- Abstract
- 8.1 Introduction
- 8.2 Development in green chemistry synthesis
- 8.3 Green solvents
- 8.4 Water as a green solvent
- 8.5 Hydrothermal synthesis
- 8.6 Aqueous-phase catalysis
- 8.7 Microwaves in aqueous media
- 8.8 Reactions in water
- 8.9 Polyethylene glycol as a green solvent
- 8.10 Ethanol as a green solvent
- 8.11 Carbon dioxide (CO2) as a green solvent
- 8.12 Synthetic drugs developed by using green synthesis
- 8.13 Natural drugs developed by green synthesis
- 8.14 Green synthesis of bioactive compounds
- 8.15 Conclusion
- References
- Chapter 9. Reactions in water: synthesis of biologically active compounds
- Abstract
- 9.1 Introduction
- 9.2 Concluding remarks and future prospective
- Abbreviation
- References
- Section 4: Green chemistry
- Chapter 10. Sustainable green technologies for synthesis of potential drugs targeted toward tropical diseases
- Abstract
- 10.1 Introduction
- 10.2 Conclusion
- References
- Chapter 11. Clay-mediated synthesis of biologically active molecules: green and sustainable approaches
- Abstract
- 11.1 Introduction
- 11.2 Clay-mediated synthesis of biologically active molecules
- 11.3 Conclusions
- References
- Chapter 12. The role of ionic liquid in medicinal chemistry
- Abstract
- 12.1 Introduction
- 12.2 Ionic liquids in the detection of pharmaceutically active compounds
- 12.3 Ionic liquids for pharmaceutical crystallization
- 12.4 Ionic liquids in pharmaceutical purification and separation
- 12.5 Continuous pharmaceutical manufacturing using ionic liquids
- 12.6 Chromatographic purifications using ionic liquids
- 12.7 Biological activities of ionic liquids
- 12.8 Antimicrobial activities of ionic liquids
- 12.9 Antibiofilm activities of ionic liquids
- 12.10 Antiproliferative profile of ionic liquids
- 12.11 Ionic liquids as active pharmaceutical ingredients
- 12.12 Stoichiometric to nonstoichiometric active pharmaceutical ingredient-ionic liquids with protic ions
- 12.13 Prodrug methodology
- 12.14 Conclusion
- References
- Section 5: Medicinal chemistry
- Chapter 13. Green chemistry for the synthesis of sulfur-containing compounds with medicinal properties
- Abstract
- 13.1 Introduction
- 13.2 Synthesis of sulfur-containing compounds using green chemistry
- 13.3 Conclusion
- Acknowledgments
- References
- Chapter 14. Green synthesis of bioactive flavonoids as cardioprotective and anticancer drug agents
- Abstract
- 14.1 Introduction
- 14.2 Flavones
- 14.3 Flavanones
- 14.4 Flavonols
- 14.5 Isoflavonoids
- 14.6 Flavanols
- 14.7 Benefits of green approaches synthesis of flavonoids
- 14.8 Cardioprotective effects
- 14.9 Anticancer activity
- 14.10 Drugs development and synthesis
- 14.11 Synthesis of benzochromenes
- 14.12 Anticancer activity of coumarins
- 14.13 Synthesis of benzocoumarins
- 14.14 Anticancer and cardioprotective activity of styrylchromones
- 14.15 Synthesis of styrylchromones
- 14.16 Synthesis of anticancer and cardioprotective effects of other flavonoids
- 14.17 Concluding remarks
- References
- Chapter 15. Polysaccharide-derived hydroge ls: an approach toward cancer
- Abstract
- 15.1 Introduction
- 15.2 Types of hydrogels based on crosslinking type
- 15.3 Properties
- 15.4 Methods of preparation
- 15.5 Polysaccharides
- 15.6 Drug delivery in the treatment of cancer
- 15.7 Conclusions and looking forward
- References
- Chapter 16. Environmental-benign pathways for the synthesis of medicinally relevant heterocycles
- Abstract
- 16.1 Introduction
- 16.2 Environmental-benign pathways
- 16.3 Conclusion
- Acknowledgments
- References
- Chapter 17. Utilization of medicinally important plants as antidiabetic medicines in a sustainable manner
- Abstract
- 17.1 Introduction
- 17.2 Plants used as antidiabetic medicines in a sustainable way
- 17.3 Phytochemicals as antidiabetic medicines in a sustainable manner
- References
- Chapter 18. One-pot synthesis of biologically active oxazole, isoxazole, and pyranopyrazoles—an overview
- Abstract
- Abbreviations
- 18.1 Introduction
- 18.2 Oxazoles
- 18.3 Isoxazoles
- 18.4 Pyranopyrazoles
- 18.5 Conclusion
- References
- Chapter 19. Green synthesis of organometallic compounds and their medicinal aspects
- Abstract
- 19.1 Introduction
- 19.2 Green organometallic reactions
- 19.3 Medicinal aspects of organometallic compounds
- 19.4 Conclusions
- Acknowledgment
- References
- Chapter 20. Therapeutic role of biologically active macrocycles in medicine
- Abstract
- 20.1 Introduction
- 20.2 Macrocyclic drugs approved by the Food and Drug Administration
- 20.3 Green methodologies to synthesize macrocycles
- 20.4 Conclusion
- Acknowledgment
- Abbreviations
- References
- Chapter 21. Green synthesis and biological evaluation of anticancer drugs
- Abstract
- 21.1 Introduction
- 21.2 Conclusion
- Acknowledgments
- Abbreviation
- References
- Chapter 22. Green chemistry and synthetic approaches in the development of antidepressant and antipsychotic agents
- Abstract
- 22.1 Introduction
- 22.2 Green techniques for synthesis of antidepressant and antipsychotic agents
- 22.3 SAR study of quinazoline derivatives
- 22.4 Conclusion
- References
- Chapter 23. Organocatalyzed multicomponent synthesis of densely functionalized bioactive pyridines
- Abstract
- 23.1 Introduction
- 23.2 Synthesis of tetra-substituted pyridines
- 23.3 Synthesis of fully functionalized pyridines
- 23.4 Bioactivity of densely functionalized pyridine derivatives
- 23.5 Conclusions
- Acknowledgments
- References
- Chapter 24. Multicomponent reaction strategy to heterocyclic compounds in anticancer drug design
- Abstract
- 24.1 Introduction
- 24.2 Heterocyclic compounds for anticancer evaluation
- 24.3 Conclusion
- Acknowledgment
- Conflict of Interest
- References
- Chapter 25. Recent advances in asymmetric synthesis of β-lactams
- Abstract
- 25.1 Introduction
- 25.2 Mode of action of Penicillin
- 25.3 Biological activity of penicillin
- 25.4 Biological activity of cephalosporin
- 25.5 β-Lactamase inhibitors
- 25.6 Methods for the constructing of the β-lactam ring
- 25.7 Formation of the amide N-1-C-2 bond
- 25.8 Formation of C-2-C-3 bond
- 25.9 Formation of the C-3-C-4 bond
- 25.10 Formation of the C-4-N-1 bond
- 25.11 Multiple bond forming reactions
- 25.12 Carbohydrate-derived chiral imines
- 25.13 Chiral ketenes
- 25.14 Double stereodifferentiation
- 25.15 Catalytic asymmetric Staudinger reaction
- 25.16 Conclusions
- References
- Index
- No. of pages: 698
- Language: English
- Edition: 2
- Volume: 1
- Published: May 30, 2024
- Imprint: Elsevier
- Paperback ISBN: 9780443161667
- eBook ISBN: 9780443161674
BB
Bimal Banik
Bimal Krishna Banik is a full professor of the Deanship of Research Development at the Prince Mohammad Bin Fahd University in the Kingdom of Saudi Arabia. He was a tenured full professor and first president’s endowed professor at the University of Texas for many years. He also served as the vice president of the Research & Education Development of the Community Health System of Texas. Professor Banik was awarded $7.25 million in grants from the US NIH and US NCI. Importantly, he published more than 600 peer-reviewed papers and 500 presentation abstracts. Notably, he authored and edited 20 books published by Springer, Springer Nature, Nova, Elsevier, De Gruyter, and CRC. He mentored approximately 300 students, 20 postdoctoral fellows, and 7 PhD research scientists. He advised 28 university faculties and 2 students’ organizations that have 1400 students. He chaired 20 symposiums at the American Chemical Society National Meetings and 1 conference at the Nobel Prize Celebration. He served as the editor of 12 journals. He received more than two dozens of national and international awards for teaching, mentoring, advising, public service, overall recognitions, and research.
Read Green Approaches in Medicinal Chemistry for Sustainable Drug Design on ScienceDirect