Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Methods
- 2nd Edition, Volume 2 - June 1, 2024
- Imprint: Elsevier
- Editor: Bimal Banik
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 6 1 6 4 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 6 1 6 5 - 0
Green Approaches in Medicinal Chemistry for Sustainable Drug Design: Methods, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. Af… Read more
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Request a sales quoteGreen Approaches in Medicinal Chemistry for Sustainable Drug Design: Methods, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context on the growth of green chemistry in relation to drug discovery, the book identifies a range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure, and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global experts, the book encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists, and more.
This volume covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources, including plants and agricultural materials.
- Highlights the need for the adoption of sustainable and green chemistry pathways in drug development
- Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these factors
- Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
Medicinal chemists, pharmaceutical, biotechnologists, green chemists and environmental chemists working in both academia and industry; postgraduate students in related fields. Scientists working in Government Research Agencies; industrial scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface
- Acknowledgment
- Section 1: Nanotechnology
- Chapter 1. Nanocatalyzed organic transformations for synthesis of drug-like small molecules with medicinally privileged heterocycles
- Abstract
- Graphical abstract
- 1.1 Introduction
- 1.2 Functionalized five- and fused five-membered heterocycles
- 1.3 Functionalized six- and fused six-membered heterocycles
- 1.4 Functionalized seven-membered heterocycles
- 1.5 Conclusion
- References
- Chapter 2. Nano-based drug delivery of anticancer agents
- Abstract
- 2.1 Introduction
- 2.2 Several polysaccharides used in drug delivery systems
- 2.3 Synthesis of nanoparticles
- 2.4 Formulation of nanoparticles
- 2.5 Characterization of nanoparticles
- 2.6 Nano-based drug delivery system of anticancer agents
- 2.7 Advantages of nanoparticles
- 2.8 Limitations of nanoparticles
- 2.9 Conclusion
- List of abbreviations
- References
- Chapter 3. Green synthesis of silver nanoparticles for antibacterial properties
- Abstract
- 3.1 Introduction
- References
- Further reading
- Chapter 4. Green synthesis of nanoparticles and nanocomposites: medical aspect
- Abstract
- 4.1 Nanoparticles
- 4.2 Nanocomposites
- 4.3 Conclusion
- References
- Chapter 5. Nanomaterial-mediated synthesis of β-lactams and exploration of their enhanced biological activities: recent advances
- Abstract
- 5.1 Introduction
- 5.2 Nanocatalyst-abetted concoction of β-lactams
- 5.3 Coalescence and biological estimation of nano-functionalized β-lactams
- 5.4 Conclusion
- Acknowledgments
- References
- Section 2: Combinatorial chemistry
- Chapter 6. Green combinatorial chemistry in medicinal science
- Abstract
- 6.1 Introduction
- 6.2 Libraries of medicinal drugs via combinatorial methods
- 6.3 Conclusion
- References
- Chapter 7. Combinatorial chemistry in cancer drug discovery
- Abstract
- 7.1 Drug discovery process
- 7.2 Combinatorial chemistry
- 7.3 Milestones in combinatorial chemistry
- 7.4 Principle of combinatorial chemistry
- 7.5 Advantages of combinatorial chemistry
- 7.6 Limitation of combinatorial chemistry
- 7.7 Types of combinatorial synthesis
- 7.8 Solid-phase synthesis
- 7.9 Solid support used in solid-phase synthesis
- 7.10 Types of solid phase used in solid-phase synthesis
- 7.11 Linkers and anchors used in solid-phase synthesis
- 7.12 Protecting groups used in solid-phase synthesis
- 7.13 For amines
- 7.14 For carboxylic acids
- 7.15 Solid-phase synthesis of organic compounds
- 7.16 Advantages of solid-phase synthesis
- 7.17 Limitations of solid-phase synthesis
- 7.18 Solution-phase synthesis
- 7.19 Advantages of solution-phase synthesis
- 7.20 Disadvantages of solution-phase synthesis
- 7.21 Mixed combinatorial synthesis
- 7.22 Synthetic methods used in combinatorial chemistry
- 7.23 Split and mix or split and pool synthesis
- 7.24 Advantages of split-mix synthesis
- 7.25 Disadvantages of split-mix synthesis
- 7.26 Parallel synthesis
- 7.27 Advantages of parallel synthesis
- 7.28 Disadvantage of parallel synthesis
- 7.29 Methods for parallel synthesis
- 7.30 Role of combinatorial chemistry in cancer drug discovery
- 7.31 Conclusion
- References
- Section 3: Energy
- Chapter 8. The use of ultrasound in drug synthesis: a sustainable method
- Abstract
- Abbreviations
- 8.1 Introduction
- 8.2 Development in ultrasound assisted synthesis
- 8.3 Ultrasound in synthetic chemistry
- 8.4 Ultrasound-assisted synthesis of benzoic acid
- 8.5 Synthesis of δ-chloro esters
- 8.6 Ultrasound-assisted named reactions
- 8.7 Important named reactions
- 8.8 Ultrasound assisted synthesis of steroid derivatives using Clemmensen-type reduction
- 8.9 Ultrasound-assisted synthesis of aza Michael reaction
- 8.10 UR assisted synthesis of cyclopalladated ferrocenyl imines using Suzuki reaction
- 8.11 Ultrasound assisted synthesized drugs
- 8.12 Ultrasound-assisted extraction and conventional methods
- 8.13 Conclusion
- References
- Chapter 9. Solar-powered chemistry: new catalytic solutions for a greener planet
- Abstract
- 9.1 Introduction
- 9.2 Application of solar energy
- 9.3 Future prospects
- 9.4 Conclusion
- References
- Chapter 10. Photocatalytic reactions for the synthesis and derivatization of pharmaceutically significant heterocycles
- Abstract
- Graphical abstract
- 10.1 Introduction
- 10.2 Photocatalytic access to heterocyclic compounds
- 10.3 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Chapter 11. Visible light-induced dye degradation potential of green synthesized nanoparticles: an approach toward polluted water treatment
- Abstract
- 11.1 Introduction
- 11.2 Materials and methods
- 11.3 Experimental details
- 11.4 Results and discussion
- 11.5 Conclusion
- References
- Chapter 12. Green synthetic approach for biologically relevant heterocyclic compounds by using ball mill
- Abstract
- 12.1 Introduction of heterocyclic compounds
- 12.2 Importance of ball mill in the synthesis of compounds
- 12.3 Synthetic methods for heterocyclic compounds by using ball mill
- 12.4 Conclusion
- Acknowledgments
- References
- Chapter 13. Synthesis of natural products by photochemistry
- Abstract
- 13.1 Introduction
- 13.2 Biyouyanagin A
- 13.3 Brasoside and littoralisone
- 13.4 Punctaporonin C
- 13.5 Phytoalexins
- 13.6 Humulanolides
- 13.7 Solanoeclepin A
- 13.8 Cyclobutenes
- 13.9 Gliocladin C
- 13.10 Pseudotabersonine, pseudovincadifformine, and coronaridine
- 13.11 Rocaglate derivatives
- 13.12 Hamigerans
- 13.13 Xanthanolides
- 13.14 Conclusions
- Acknowledgments
- References
- Chapter 14. Recent magneto/electrochemical/biosensors and analytical approaches to detect β-lactam antibiotics in food and environment
- Abstract
- Abbreviations
- 14.1 Introduction
- 14.2 Biosensors
- 14.3 Magneto/chromatography methods
- 14.4 Conclusion
- Acknowledgments
- References
- Section 4: Methods and synthesis
- Chapter 15. Use of sustainable organic transformations in the construction of heterocyclic scaffolds
- Abstract
- 15.1 Introduction
- 15.2 Organic transformations in deep eutectic solvents
- 15.3 Conclusion
- References
- Chapter 16. Diverse synthesis of medicinally active steroids
- Abstract
- 16.1 Background on steroids
- 16.2 Classification based upon medicinal activities
- 16.3 Different classical synthetic methods
- 16.4 Conclusions
- Acknowledgments
- References
- Further reading
- Chapter 17. Solvent-less reactions: green and sustainable approaches in medicinal chemistry
- Abstract
- 17.1 Introduction
- 17.2 Conclusion
- Acknowledgments
- Abbreviations
- References
- Chapter 18. Versatile thiosugars in medicinal chemistry
- Abstract
- 18.1 Introduction
- 18.2 Thiosugars–sulfur as a ring heteroatom: synthesis and medicinal activity
- 18.3 Thiosugars—sulfur outside the ring: synthesis and medicinal activity
- 18.4 Naturally occurring thiosugars: medicinal activity
- 18.5 Conclusions
- Acknowledgment
- References
- Section 5: Microwave-induced chemistry
- Chapter 19. Microwave-assisted synthesis of antitubercular agents: a novel approach
- Abstract
- 19.1 Introduction
- 19.2 Structure-activity relationship study of benzodiazepines scaffolds
- 19.3 Structure-activity relationship study of benzimidazole analogs
- 19.4 Conclusion
- Abbreviation
- References
- Chapter 20. Microwave-induced synthesis as a part of green chemistry approach for novel antiinflammatory agents
- Abstract
- 20.1 Inflammation
- 20.2 Importance of antiinflammatory drugs
- 20.3 Introduction to the microwave technique
- 20.4 Conclusion
- Abbreviation
- References
- Section 6: Computers in drug discovery
- Chapter 21. Dipole moment studies on beta lactams
- Abstract
- 21.1 Introduction
- 21.2 Dipole moment of imines
- 21.3 α-Hydroxy-β-lactam derivatives
- 21.4 Penicillin isomers and related antibiotics
- 21.5 Dipole moments of anticancer β-lactams
- 21.6 Conclusions
- Acknowledgments
- References
- Chapter 22. Computational approaches for development of anti-COVID-19 agents
- Abstract
- 22.1 Introduction
- 22.2 Pathogenesis of COVID-19
- 22.3 The life cycle of COVID-19
- 22.4 Transmission of coronavirus
- 22.5 Clinical features of COVID-19 infection
- 22.6 Computational approaches in drug development
- 22.7 Computational studies for the development of anti-COVID-19 agents
- 22.8 Computational approaches in vaccines development
- 22.9 Computational approaches in diagnosis of COVID-19
- 22.10 Conclusion
- List of Abbreviations
- References
- Chapter 23. Dipole moment in medicinal research: green and sustainable approach
- Abstract
- 23.1 Background on dipole moment
- 23.2 2-Pyrrolidone
- 23.3 Cholestanone
- 23.4 Purines, pyrimidines and azines
- 23.5 Thiophene and carboxamides
- 23.6 Dipole moment and anticancer activity
- 23.7 Dipole moment and antifungal activity
- 23.8 Dipole moment and antibacterial activity
- 23.9 Dipole moment and various other medical disorders (antimicrobial, antimalarial, and antileishmanial)
- 23.10 Conclusions
- Acknowledgments
- References
- Chapter 24. Computational methods and tools for sustainable and green approaches in drug discovery
- Abstract
- 24.1 Introduction
- 24.2 Quantitative structure-activity relationship, 3-D QSAR, and ligand-based drug design
- 24.3 Structure-based drug design and virtual screening strategy
- 24.4 Drugability
- References
- Index
- Edition: 2
- Volume: 2
- Published: June 1, 2024
- No. of pages (Paperback): 656
- No. of pages (eBook): 600
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780443161643
- eBook ISBN: 9780443161650
BB
Bimal Banik
Bimal Krishna Banik is a full professor of the Deanship of Research Development at the Prince Mohammad Bin Fahd University in the Kingdom of Saudi Arabia. He was a tenured full professor and first president’s endowed professor at the University of Texas for many years. He also served as the vice president of the Research & Education Development of the Community Health System of Texas. Professor Banik was awarded $7.25 million in grants from the US NIH and US NCI. Importantly, he published more than 600 peer-reviewed papers and 500 presentation abstracts. Notably, he authored and edited 20 books published by Springer, Springer Nature, Nova, Elsevier, De Gruyter, and CRC. He mentored approximately 300 students, 20 postdoctoral fellows, and 7 PhD research scientists. He advised 28 university faculties and 2 students’ organizations that have 1400 students. He chaired 20 symposiums at the American Chemical Society National Meetings and 1 conference at the Nobel Prize Celebration. He served as the editor of 12 journals. He received more than two dozens of national and international awards for teaching, mentoring, advising, public service, overall recognitions, and research.
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