Gonadotropins: From Bench Side to Bedside

Chapter One: Mouse Models of Gonadotrope Development

• Abstract
• 1. Introduction
• 2. Signaling Pathways
• 3. Transcription Factors
• 4. CRE Mice for Targeting Gonadotropes
• 5. Concluding Remarks

Chapter Two: Mouse Models for the Study of Synthesis, Secretion, and Action of Pituitary Gonadotropins

• Abstract
• 1. Introduction
• 2. α-Glycoprotein Hormone Subunit
• 3. LHβ Subunit
• 4. FSHβ Subunit
• 5. Transforming Growth Factor-β Superfamily Members and Gonadotropins
• 6. Other Mouse Models
• 7. Conclusions and Future Directions
• Acknowledgments

Chapter Three: Clinical Applications of Gonadotropins in the Female: Assisted Reproduction and Beyond

• Abstract
• 1. Introduction
• 2. Molecular Biology of the Ovarian Response
• 3. Gonadotropins in Assisted Reproduction
• 4. Ovarian Stimulation Protocols in ART
• 5. Adverse Events in Ovarian Stimulation
• 6. Gonadotropins Beyond ART
• 7. Conclusions
• Acknowledgments

Chapter Four: Clinical Applications of Gonadotropins in the Male

• Abstract
• 1. Introduction
• 2. Structural Features of the Gonadotropins
• 3. Regulation of the Synthesis and Secretion of the Pituitary Gonadotropins
• 4. Gonadotropin Secretion
• 5. Pharmacokinetics of Gonadotropins
• 6. Gonadotropin Formulations Available for Treating Hypogonadotropic Hypogonadism and Infertility in Men
• 7. Treatment with Gonadotropins in the Male
• 8. Concluding Remarks
• Acknowledgments

Chapter Five: Beyond Reproduction: Pituitary Hormone Actions on Bone

• Abstract
• 1. Evolutionary Considerations
• 2. Epidemiology Suggests an FSH–Bone Connection
• 3. FSH Directly Affects the Skeleton
• 4. FSH Signals Through FSHRs on Bone Cells
• 5. FSH Antibody Rescues Hypogonadal Bone Loss
• 6. Oxytocin is Anabolic to Bone
• 7. Oxytocin and Skeletal Regulation During Reproduction
• 8. Prolactin and Bone

Chapter Six: Gonadotrope Tumors

• Abstract
• 1. Introduction
• 2. Gonadotropes in the Normal Pituitary
• 3. Gonadotrope Hyperplasia
• 4. Gonadotrope Tumors
• 5. Conclusions