Goldman-Cecil Medicine, 2-Volume Set
- 25th Edition - April 21, 2015
- Imprint: Elsevier
- Authors: Lee Goldman, Andrew I. Schafer
- Language: English
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 3 2 2 8 5 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 3 2 2 8 6 - 7
Since 1927, Goldman-Cecil Medicine has been the world’s most influential internal medicine resource. In the ground-breaking 25th edition, your original purchase ensures you will b… Read more
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Request a sales quoteSince 1927, Goldman-Cecil Medicine has been the world’s most influential internal medicine resource. In the ground-breaking 25th edition, your original purchase ensures you will be up-to-date without the need for a subscription. Through the new, more powerful Expert Consult eBook platform, this "living text" provides continuous updates that will integrate the latest research, guidelines, and treatments into each chapter, ensuring that the content is as current as the day this edition was first published.
Goldman-Cecil Medicine
offers definitive, unbiased guidance on the evaluation and management of every medical condition, presented by a veritable "Who's Who" of modern medicine. A practical, straightforward style; templated organization; evidence-based references; and robust interactive content combine to make this dynamic resource quite simply the fastest and best place to find all of the authoritative, state-of-the-art clinical answers you need.
"The content is superb, authoritative and not surprisingly very up to date."Reviewed by: Dr Harry Brown, on behalf of Glycosmedia Date: July 2015
- Expert Consult eBook version included with print purchase:
- Access continuous updates from Editor Lee Goldman, MD, who thoroughly reviews internal medicine and specialty journals, updating online content to reflect the latest guidelines and translating that evidence into treatment.
- Interactive Q&A section features over 1,500 board-style questions and answers to aid in preparing for certification or recertification exams.
- Outstanding supplementary tools include figures, tables, videos, heart and lung sounds, treatment and management algorithms, fully integrated references, and thousands of illustrations and full-color photos.
- Search all of the text, figures, supplementary material, and references from the book on a variety of devices and at no additional cost — Expert Consult access is included with this title!
- Practical, bulleted, highly templated text with easy-to-use features including flow charts and treatment boxes.
- New chapters on global health, cancer biology and genetics, and the human microbiome in health and disease keep you on the cutting edge of medicine.
- Today's most current evidence-based medicine guidelines help you form a definitive diagnosis and create the best treatment plans possible.
- Focused coverage of the latest developments in biology includes the specifics of current diagnosis, therapy, and medication doses.
- The reference of choice for every stage of your career!
Internal Medicine, Internal Medicine Residents, Family Medicine, Primary Care
VOLUME I
SECTION I: SOCIAL AND ETHICAL ISSUES IN MEDICINE
1 Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession
2
Bioethics in the Practice of Medicine3
Care of Dying Patients and Their Families4
Cultural Context of Medicine5
Socioeconomic Issues in Medicine6
Global HealthSECTION II: PRINCIPLES OF EVALUATION AND MANAGEMENT
7
Approach to the Patient: History and Physical Examination8
Approach to the Patient with Abnormal Vital Signs9
Statistical Interpretation of Data10
Using Data for Clinical Decisions11
Measuring Health and Health Care12
Quality of Care and Patient Safety13
Comprehensive Chronic Disease ManagementSECTION III: PREVENTIVE AND ENVIRONMENTAL ISSUES
14
Counseling for Behavior Change15
The Periodic Health Examination16
Physical Activity17
Adolescent Medicine18
Immunization19
Principles of Occupational and Environmental Medicine20
Radiation Injury21
Bioterrorism22
Chronic Poisoning: Trace Metals and OthersSECTION IV: AGING AND GERIATRIC MEDICINE
23
Epidemiology of Aging: Implications of an Aging Society24
Geriatric Assessment25
Common Clinical Sequelae of Aging26
Incontinence27
Neuropsychiatric Aspects of Aging28
Delirium or Acute Mental Status Change in the Older PatientSECTION V: CLINICAL PHARMACOLOGY
29
Principles of Drug Therapy30
Pain31
Biology of Addiction32
Nicotine and Tobacco33
Alcohol Use Disorders34
Drugs of Abuse35
Immunosuppressing Drugs Including Corticosteroids36
Biologic Agents and Signaling Inhibitors37
Prostanoids, Aspirin, and Related Compounds38
Antithrombotic Therapy39
Complementary and Alternative MedicineSECTION VI: GENETICS
40
Principles of Genetics41
Gene, Genomic, and Chromosomal Disorders42
The Inherited Basis of Common Diseases43
Application of Molecular Technologies to Clinical Medicine44
Regenerative Medicine, Cell, and Gene TherapiesSECTION VII: PRINCIPLES OF IMMUNOLOGY AND INFLAMMATION
45
The Innate Immune System46
The Adaptive Immune System47
Mechanisms of Immune-Mediated Tissue Injury48
Mechanisms of Inflammation and Tissue Repair49
Transplantation Immunology50
Complement System in DiseaseSECTION VIII: CARDIOVASCULAR DISEASE
51
Approach to the Patient with Possible Cardiovascular Disease52
Epidemiology of Cardiovascular Disease53
Cardiac Function and Circulatory Control54
Electrocardiography55
Echocardiography56
Noninvasive Cardiac Imaging57
Catheterization and Angiography58
Heart Failure: Pathophysiology and Diagnosis59
Heart Failure: Management and Prognosis60
Diseases of the Myocardium and Endocardium61
Principles of Electrophysiology62
Approach to the Patient with Suspected Arrhythmia63
Approach to Cardiac Arrest and Life-Threatening Arrhythmias64
Cardiac Arrhythmias with Supraventricular Origin65
Ventricular Arrhythmias66
Electrophysiologic Interventional Procedures and Surgery67
Arterial Hypertension68
Pulmonary Hypertension69
Congenital Heart Disease in Adults70
Atherosclerosis, Thrombosis, and Vascular Biology71
Angina Pectoris and Stable Ischemic Heart Disease72
Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction73
ST Segment Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction74
Interventional and Surgical Treatment of Coronary Artery Disease75
Valvular Heart Disease76
Infective Endocarditis77
Pericardial Diseases78
Diseases of the Aorta79
Atherosclerotic Peripheral Arterial Disease80
Other Peripheral Arterial Diseases81
Peripheral Venous Disease82
Cardiac TransplantationSECTION IX: RESPIRATORY DISEASES
83
Approach to the Patient with Respiratory Disease84
Imaging in Pulmonary Disease85
Respiratory Function: Mechanisms and Testing86
Disorders of Ventilatory Control87
Asthma88
Chronic Obstructive Pulmonary Disease89
Cystic Fibrosis90
Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders91
Alveolar Filling Disorders92
Interstitial Lung Disease93
Occupational Lung Disease94
Physical and Chemical Injuries of the Lung95
Sarcoidosis96
Acute Bronchitis and Tracheitis97
Overview of Pneumonia98
Pulmonary Embolism99
Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum100
Obstructive Sleep Apnea101
Interventional and Surgical Approaches to Lung DiseaseSECTION X: CRITICAL CARE MEDICINE
102
Approach to the Patient in a Critical Care Setting103
Respiratory Monitoring in Critical Care104
Acute Respiratory Failure105
Mechanical Ventilation106
Approach to the Patient with Shock107
Cardiogenic Shock108
Shock Syndromes Related to Sepsis109
Disorders Due to Heat and Cold110
Acute Poisoning111
Medical Aspects of Injuries and Burns112
Envenomation113
RhabdomyolysisSECTION XI: RENAL AND GENITOURINARY DISEASES
114
Approach to the Patient with Renal Disease115
Structure and Function of the Kidneys116
Disorders of Sodium and Water Homeostasis117
Potassium Disorders118
Acid-Base Disorders119
Disorders of Magnesium and Phosphorus120
Acute Kidney Injury121
Glomerular Disorders and Nephrotic Syndromes122
Tubulointerstitial Nephritis123
Obstructive Uropathy124
Diabetes and the Kidney125
Vascular Disorders of the Kidney126
Nephrolithiasis127
Cystic Kidney Diseases128
Hereditary Nephropathies and Developmental Abnormalities of the Urinary Tract129
Benign Prostatic Hyperplasia and Prostatitis130
Chronic Kidney Disease131
Treatment of Irreversible Renal FailureSECTION XII: GASTROINTESTINAL DISEASES
132
Approach to the Patient with Gastrointestinal Disease133
Diagnostic Imaging Procedures in Gastroenterology134
Gastrointestinal Endoscopy135
Gastrointestinal Hemorrhage136
Disorders of Gastrointestinal Motility137
Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, Chest Pain of Presumed Esophageal Origin, and Heartburn138
Diseases of the Esophagus139
Acid Peptic Disease140
Approach to the Patient with Diarrhea and Malabsorption141
Inflammatory Bowel Disease142
Inflammatory and Anatomic Diseases of the Intestine, Peritoneum, Mesentery, and Omentum143
Vascular Diseases of the Gastrointestinal Tract144
Pancreatitis145
Diseases of the Rectum and AnusSECTION XIII: DISEASES OF THE LIVER, GALLBLADDER, AND BILE DUCTS
146
Approach to the Patient with Liver Disease147
Approach to the Patient with Jaundice or Abnormal Liver Tests148
Acute Viral Hepatitis149
Chronic Viral and Autoimmune Hepatitis150
Toxin- and Drug-Induced Liver Disease151
Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases152
Alcoholic and Nonalcoholic Steatohepatitis153
Cirrhosis and Its Sequelae154
Hepatic Failure and Liver Transplantation155
Diseases of the Gallbladder and Bile DuctsSECTION XIV: HEMATOLOGIC DISEASES
156
Hematopoiesis and Hematopoietic Growth Factors157
The Peripheral Blood Smear158
Approach to the Anemias159
Microcytic and Hypochromic Anemias160
Autoimmune and Intravascular Hemolytic Anemias161
Hemolytic Anemias: Red Blood Cell Membrane and Metabolic Defects162
The Thalassemias163
Sickle Cell Disease and Other Hemoglobinopathies164
Megaloblastic Anemias165
Aplastic Anemia and Related Bone Marrow Failure States166
Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofi brosis167
Leukocytosis and Leukopenia168
Approach to the Patient with Lymphadenopathy and Splenomegaly169
Disorders of Phagocyte Function170
Eosinophilic Syndromes171
Approach to the Patient with Bleeding and Thrombosis172
Thrombocytopenia173
Von Willebrand Disease and Hemorrhagic Abnormalities of Platelet and Vascular Function174
Hemorrhagic Disorders: Coagulation Factor Defi ciencies175
Hemorrhagic Disorders: Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Defi ciency176
Thrombotic Disorders: Hypercoagulable States177
Transfusion Medicine178
Hematopoietic Stem Cell TransplantationSECTION XV: ONCOLOGY
179
Approach to the Patient with Cancer180
Epidemiology of Cancer181
Cancer Biology and Genetics182
Myelodysplastic Syndromes183
The Acute Leukemias184
The Chronic Leukemias185
Non-Hodgkin Lymphomas186
Hodgkin Lymphoma187
Plasma Cell Disorders188
Amyloidosis189
Tumors of the Central Nervous System190
Head and Neck Cancer191
Lung Cancer and Other Pulmonary Neoplasms192
Neoplasms of the Esophagus and Stomach193
Neoplasms of the Small and Large Intestine194
Pancreatic Cancer195
Pancreatic Neuroendocrine Tumors196
Liver and Biliary Tract Cancers197
Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis198
Breast Cancer and Benign Breast Disorders199
Gynecologic Cancers200
Testicular Cancer201
Prostate Cancer202
Malignant Tumors of Bone, Sarcomas, and Other Soft Tissue Neoplasms203
Melanoma and Nonmelanoma Skin Cancers204
Cancer of Unknown Primary OriginVOLUME II
SECTION XVI: METABOLIC DISEASES
205
Approach to Inborn Errors of Metabolism206
Disorders of Lipid Metabolism207
Glycogen Storage Diseases208
Lysosomal Storage Diseases209
Homocystinuria and Hyperhomocysteinemia210
The Porphyrias211
Wilson Disease212
Iron Overload (Hemochromatosis)SECTION XVII: NUTRITIONAL DISEASES
213
Nutrition’s Interface with Health and Disease214
Nutritional Assessment215
Protein-Energy Malnutrition216
Enteral Nutrition217
Malnutrition, Nutritional Assessment, and Nutritional Support in Adult Hospitalized Patients218
Vitamins, Trace Minerals, and Other Micronutrients219
Eating Disorders220
ObesitySECTION XVIII: ENDOCRINE DISEASES
221
Approach to the Patient with Endocrine Disease222
Principles of Endocrinology223
Neuroendocrinology and the Neuroendocrine System224
Anterior Pituitary225
Posterior Pituitary226
Thyroid227
Adrenal Cortex228
Adrenal Medulla, Catecholamines, and Pheochromocytoma229
Diabetes Mellitus230
Hypoglycemia and Pancreatic Islet Cell Disorders231
Polyglandular Disorders232
Neuroendocrine Tumors and the Carcinoid Syndrome233
Disorders of Sexual Development234
The Testis and Male Hypogonadism, Infertility, and Sexual Dysfunction235
Ovaries and Pubertal Development236
Reproductive Endocrinology and InfertilitySECTION XIX: WOMEN’S HEALTH
237
Approach to Women’s Health238
Contraception239
Common Medical Problems in Pregnancy240
Menopause241
Intimate Partner ViolenceSECTION XX: DISEASES OF BONE AND MINERAL METABOLISM
242
Approach to the Patient with Metabolic Bone Disease243
Osteoporosis244
Osteomalacia and Rickets245
The Parathyroid Glands, Hypercalcemia and Hypocalcemia246
Medullary Thyroid Carcinoma247
Paget Disease of Bone248
Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Disorders of BoneSECTION XXI: DISEASES OF ALLERGY AND CLINICAL IMMUNOLOGY
249
Approach to the Patient with Allergic or Immunologic Disease250
Primary Immunodeficiency Diseases251
Allergic Rhinitis and Chronic Sinusitis252
Urticaria and Angioedema253
Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy254
Drug Allergy255
MastocytosisSECTION XXII: RHEUMATIC DISEASES
256
Approach to the Patient with Rheumatic Disease257
Laboratory Testing in the Rheumatic Diseases258
Imaging Studies in the Rheumatic Diseases259
Connective Tissue Structure and Function260
Inherited Diseases of Connective Tissue261
The Systemic Autoinflammatory Diseases262
Osteoarthritis263
Bursitis, Tendinitis, and Other Periarticular Disorders and Sports Medicine264
Rheumatoid Arthritis265
The Spondyloarthropathies266
Systemic Lupus Erythematosus267
Systemic Sclerosis (Scleroderma)268
Sjögren Syndrome269
Inflammatory Myopathies270
The Systemic Vasculitides271
Polymyalgia Rheumatica and Temporal Arteritis272
Infections of Bursae, Joints, and Bones273
Crystal Deposition Diseases274
Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain275
Systemic Diseases in Which Arthritis Is a Feature276
Surgical Treatment of Joint DiseasesSECTION XXIII: INFECTIOUS DISEASES
277
Introduction to Microbial Disease: Host-Pathogen Interactions278
The Human Microbiome279
Principles of Anti-Infective Therapy280
Approach to Fever or Suspected Infection in the Normal Host281
Approach to Fever and Suspected Infection in the Compromised Host282
Prevention and Control of Health Care–Associated Infections283
Approach to the Patient with Suspected Enteric Infection284
Approach to the Patient with Urinary Tract Infection285
Approach to the Patient with a Sexually Transmitted Infection286
Approach to the Patient before and after Travel287
Antibacterial Chemotherapy288
Staphylococcal Infections289
Streptococcus Pneumoniae Infections290
Nonpneumococcal Streptococcal Infections and Rheumatic Fever291
Enterococcal Infections292
Diphtheria and Other Corynebacterium Infections293
Listeriosis294
Anthrax295
Erysipelothrix Infections296
Clostridial Infections297
Diseases Caused by Non–Spore-Forming Anaerobic Bacteria298
Neisseria Meningitidis Infections299
Neisseria Gonorrhoeae Infections300
Haemophilus and Moraxella Infections301
Chancroid302
Cholera and Other Vibrio Infections303
Campylobacter Infections304
Escherichia Coli Enteric Infections305
Infections Due to Other Members of the Enterobacteriaceae, Including Management of Multidrug-Resistant Strains306
Pseudomonas and Related Gram-Negative Bacillary Infections307
Diseases Caused by Acinetobacter and Stenotrophomonas Species308
Salmonella Infections (Including Enteric Fever)309
Shigellosis310
Brucellosis311
Tularemia and Other Francisella Infections312
Plague and Other Yersinia Infections313
Whooping Cough and Other Bordetella Infections314
Legionella Infections315
Bartonella Infections316
Granuloma Inguinale (Donovanosis)317
Mycoplasma Infections318
Diseases Caused by Chlamydiae319
Syphilis320
Nonsyphilitic Treponematoses321
Lyme Disease322
Relapsing Fever and Other Borrelia Infections323
Leptospirosis324
Tuberculosis325
The Nontuberculous Mycobacteria326
Leprosy (Hansen Disease)327
Rickettsial Infections328
Zoonoses329
Actinomycosis330
Nocardiosis331
Systemic Antifungal Agents332
Histoplasmosis333
Coccidioidomycosis334
Blastomycosis335
Paracoccidioidomycosis336
Cryptococcosis337
Sporotrichosis338
Candidiasis339
Aspergillosis340
Mucormycosis341
Pneumocystis Pneumonia342
Mycetoma343
Dematiaceous Fungal Infections344
Antiparasitic Therapy345
Malaria346
African Sleeping Sickness347
Chagas Disease348
Leishmaniasis349
Toxoplasmosis350
Cryptosporidiosis351
Giardiasis352
Amebiasis353
Babesiosis and Other Protozoan Diseases354
Cestodes355
Schistosomiasis (Bilharziasis)356
Liver, Intestinal, and Lung Fluke Infections357
Intestinal Nematode Infections358
Tissue Nematode Infections359
Arthropods and Leeches360
Antiviral Therapy (Non-HIV)361
The Common Cold362
Respiratory Syncytial Virus363
Parainfluenza Viral Disease364
Influenza365
Adenovirus Diseases366
Coronaviruses367
Measles368
Rubella (German Measles)369
Mumps370
Cytomegalovirus, Epstein-Barr Virus, and Slow Virus Infections of the Central Nervous System371
Parvovirus372
Smallpox, Monkeypox, and Other Poxvirus Infections373
Papillomavirus374
Herpes Simplex Virus Infections375
Varicella-Zoster Virus (Chickenpox, Shingles)376
Cytomegalovirus377
Epstein-Barr Virus Infection378
Retroviruses Other Than Human Immunodeficiency Virus379
Enteroviruses380
Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses381
Viral Hemorrhagic Fevers382
Arboviruses Causing Fever and Rash Syndromes383
Arboviruses Aff ecting the Central Nervous SystemSECTION XXIV: HIV AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME
384
Epidemiology and Diagnosis of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome385
Immunopathogenesis of Human Immunodeficiency Virus Infection386
Biology of Human Immunodeficiency Viruses387
Prevention of Human Immunodeficiency Virus Infection388
Antiretroviral Therapy of HIV/AIDS389
Infectious and Metabolic Complications of HIV and AIDS390
Gastrointestinal Manifestations of HIV and AIDS391
Pulmonary Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome392
Skin Manifestations in Patients with Human Immunodeficiency Virus Infection393
Hematology and Oncology in Patients with Human Immunodeficiency Virus Infection394
Neurologic Complications of Human Immunodeficiency Virus Infection395
Immune Reconstitution Inflammatory Syndrome in HIV/AIDSSECTION XXV: NEUROLOGY
396
Approach to the Patient with Neurologic Disease397
Psychiatric Disorders in Medical Practice398
Headaches and Other Head Pain399
Traumatic Brain Injury and Spinal Cord Injury400
Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord401
Regional Cerebral Dysfunction: Higher Mental Functions402
Alzheimer Disease and Other Dementias403
The Epilepsies404
Coma, Vegetative State, and Brain Death405
Disorders of Sleep406
Approach to Cerebrovascular Diseases407
Ischemic Cerebrovascular Disease408
Hemorrhagic Cerebrovascular Disease409
Parkinsonism410
Other Movement Disorders411
Multiple Sclerosis and Demyelinating Conditions of the Central Nervous System412
Meningitis: Bacterial, Viral, and Other413
Brain Abscess and Parameningeal Infections414
Acute Viral Encephalitis415
Prion Diseases416
Nutritional and Alcohol-Related Neurologic Disorders417
Congenital, Developmental, and Neurocutaneous Disorders418
Autonomic Disorders and Their Management419
Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases420
Peripheral Neuropathies421
Muscle Diseases422
Disorders of Neuromuscular TransmissionXXVI: EYE, EAR, NOSE, AND THROAT DISEASES
423
Diseases of the Visual System424
Neuro-Ophthalmology425
Diseases of the Mouth and Salivary Glands426
Approach to the Patient with Nose, Sinus, and Ear Disorders427
Smell and Taste428
Hearing and Equilibrium429
Throat DisordersSECTION XXVII: MEDICAL CONSULTATION
430
Principles of Medical Consultation431
Preoperative Evaluation432
Overview of Anesthesia433
Postoperative Care and Complications434
Medical Consultation in PsychiatrySECTION XXVIII: SKIN DISEASES
435
Structure and Function of the Skin436
Examination of the Skin and an Approach to Diagnosing Skin Diseases437
Principles of Therapy of Skin Diseases438
Eczemas, Photodermatoses, Papulosquamous (Including Fungal) Diseases, and Figurate Erythemas439
Macular, Papular, Vesiculobullous, and Pustular Diseases440
Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases441
Infections, Hyperpigmentation and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin442
Diseases of Hair and NailsAPPENDIX-LABORATORY REFERENCE INTERVALS AND VALUES
Reference Intervals and Laboratory Values
- Edition: 25
- Published: April 21, 2015
- Imprint: Elsevier
- No. of pages: 2100
- Language: English
- eBook ISBN: 9780323322850
- eBook ISBN: 9780323322867
LG
Lee Goldman
Professor of Medicine and Epidemiology
Dean Emeritus of the Faculties of Health Sciences and Medicine
Columbia University Medical Center, New York
Affiliations and expertise
Professor of Medicine and Epidemiology Dean Emeritus of the Faculties of Health Sciences and Medicine Columbia University Medical Center, New YorkAS
Andrew I. Schafer
Affiliations and expertise
Professor of Medicine, Director, Richard T. Silver Center for Myeloproliferative Neoplasms, Weill Cornell Medical College, New York, New York