Goldman-Cecil Medicine, 2-Volume Set

VOLUME I

SECTION I: SOCIAL AND ETHICAL ISSUES IN MEDICINE

1 Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession

2

Bioethics in the Practice of Medicine

3

Care of Dying Patients and Their Families

4

Cultural Context of Medicine

5

Socioeconomic Issues in Medicine

6

Global Health

SECTION II: PRINCIPLES OF EVALUATION AND MANAGEMENT

7

Approach to the Patient: History and Physical Examination

8

Approach to the Patient with Abnormal Vital Signs

9

Statistical Interpretation of Data

10

Using Data for Clinical Decisions

11

Measuring Health and Health Care

12

Quality of Care and Patient Safety

13

Comprehensive Chronic Disease Management

SECTION III: PREVENTIVE AND ENVIRONMENTAL ISSUES

14

Counseling for Behavior Change

15

The Periodic Health Examination

16

Physical Activity

17

Adolescent Medicine

18

Immunization

19

Principles of Occupational and Environmental Medicine

20

Radiation Injury

21

Bioterrorism

22

Chronic Poisoning: Trace Metals and Others

SECTION IV: AGING AND GERIATRIC MEDICINE

23

Epidemiology of Aging: Implications of an Aging Society

24

Geriatric Assessment

25

Common Clinical Sequelae of Aging

26

Incontinence

27

Neuropsychiatric Aspects of Aging

28

Delirium or Acute Mental Status Change in the Older Patient

SECTION V: CLINICAL PHARMACOLOGY

29

Principles of Drug Therapy

30

Pain

31

Biology of Addiction

32

Nicotine and Tobacco

33

Alcohol Use Disorders

34

Drugs of Abuse

35

Immunosuppressing Drugs Including Corticosteroids

36

Biologic Agents and Signaling Inhibitors

37

Prostanoids, Aspirin, and Related Compounds

38

Antithrombotic Therapy

39

Complementary and Alternative Medicine

SECTION VI: GENETICS

40

Principles of Genetics

41

Gene, Genomic, and Chromosomal Disorders

42

The Inherited Basis of Common Diseases

43

Application of Molecular Technologies to Clinical Medicine

44

Regenerative Medicine, Cell, and Gene Therapies

SECTION VII: PRINCIPLES OF IMMUNOLOGY AND INFLAMMATION

45

The Innate Immune System

46

The Adaptive Immune System

47

Mechanisms of Immune-Mediated Tissue Injury

48

Mechanisms of Inflammation and Tissue Repair

49

Transplantation Immunology

50

Complement System in Disease

SECTION VIII: CARDIOVASCULAR DISEASE

51

Approach to the Patient with Possible Cardiovascular Disease

52

Epidemiology of Cardiovascular Disease

53

Cardiac Function and Circulatory Control

54

Electrocardiography

55

Echocardiography

56

Noninvasive Cardiac Imaging

57

Catheterization and Angiography

58

Heart Failure: Pathophysiology and Diagnosis

59

Heart Failure: Management and Prognosis

60

Diseases of the Myocardium and Endocardium

61

Principles of Electrophysiology

62

Approach to the Patient with Suspected Arrhythmia

63

Approach to Cardiac Arrest and Life-Threatening Arrhythmias

64

Cardiac Arrhythmias with Supraventricular Origin

65

Ventricular Arrhythmias

66

Electrophysiologic Interventional Procedures and Surgery

67

Arterial Hypertension

68

Pulmonary Hypertension

69

Congenital Heart Disease in Adults

70

Atherosclerosis, Thrombosis, and Vascular Biology

71

Angina Pectoris and Stable Ischemic Heart Disease

72

Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction

73

ST Segment Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction

74

Interventional and Surgical Treatment of Coronary Artery Disease

75

Valvular Heart Disease

76

Infective Endocarditis

77

Pericardial Diseases

78

Diseases of the Aorta

79

Atherosclerotic Peripheral Arterial Disease

80

Other Peripheral Arterial Diseases

81

Peripheral Venous Disease

82

Cardiac Transplantation

SECTION IX: RESPIRATORY DISEASES

83

Approach to the Patient with Respiratory Disease

84

Imaging in Pulmonary Disease

85

Respiratory Function: Mechanisms and Testing

86

Disorders of Ventilatory Control

87

Asthma

88

Chronic Obstructive Pulmonary Disease

89

Cystic Fibrosis

90

Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders

91

Alveolar Filling Disorders

92

Interstitial Lung Disease

93

Occupational Lung Disease

94

Physical and Chemical Injuries of the Lung

95

Sarcoidosis

96

Acute Bronchitis and Tracheitis

97

Overview of Pneumonia

98

Pulmonary Embolism

99

Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum

100

Obstructive Sleep Apnea

101

Interventional and Surgical Approaches to Lung Disease

SECTION X: CRITICAL CARE MEDICINE

102

Approach to the Patient in a Critical Care Setting

103

Respiratory Monitoring in Critical Care

104

Acute Respiratory Failure

105

Mechanical Ventilation

106

Approach to the Patient with Shock

107

Cardiogenic Shock

108

Shock Syndromes Related to Sepsis

109

Disorders Due to Heat and Cold

110

Acute Poisoning

111

Medical Aspects of Injuries and Burns

112

Envenomation

113

Rhabdomyolysis

SECTION XI: RENAL AND GENITOURINARY DISEASES

114

Approach to the Patient with Renal Disease

115

Structure and Function of the Kidneys

116

Disorders of Sodium and Water Homeostasis

117

Potassium Disorders

118

Acid-Base Disorders

119

Disorders of Magnesium and Phosphorus

120

Acute Kidney Injury

121

Glomerular Disorders and Nephrotic Syndromes

122

Tubulointerstitial Nephritis

123

Obstructive Uropathy

124

Diabetes and the Kidney

125

Vascular Disorders of the Kidney

126

Nephrolithiasis

127

Cystic Kidney Diseases

128

Hereditary Nephropathies and Developmental Abnormalities of the Urinary Tract

129

Benign Prostatic Hyperplasia and Prostatitis

130

Chronic Kidney Disease

131

Treatment of Irreversible Renal Failure

SECTION XII: GASTROINTESTINAL DISEASES

132

Approach to the Patient with Gastrointestinal Disease

133

Diagnostic Imaging Procedures in Gastroenterology

134

Gastrointestinal Endoscopy

135

Gastrointestinal Hemorrhage

136

Disorders of Gastrointestinal Motility

137

Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, Chest Pain of Presumed Esophageal Origin, and Heartburn

138

Diseases of the Esophagus

139

Acid Peptic Disease

140

Approach to the Patient with Diarrhea and Malabsorption

141

Inflammatory Bowel Disease

142

Inflammatory and Anatomic Diseases of the Intestine, Peritoneum, Mesentery, and Omentum

143

Vascular Diseases of the Gastrointestinal Tract

144

Pancreatitis

145

Diseases of the Rectum and Anus

SECTION XIII: DISEASES OF THE LIVER, GALLBLADDER, AND BILE DUCTS

146

Approach to the Patient with Liver Disease

147

Approach to the Patient with Jaundice or Abnormal Liver Tests

148

Acute Viral Hepatitis

149

Chronic Viral and Autoimmune Hepatitis

150

Toxin- and Drug-Induced Liver Disease

151

Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases

152

Alcoholic and Nonalcoholic Steatohepatitis

153

Cirrhosis and Its Sequelae

154

Hepatic Failure and Liver Transplantation

155

Diseases of the Gallbladder and Bile Ducts

SECTION XIV: HEMATOLOGIC DISEASES

156

Hematopoiesis and Hematopoietic Growth Factors

157

The Peripheral Blood Smear

158

Approach to the Anemias

159

Microcytic and Hypochromic Anemias

160

Autoimmune and Intravascular Hemolytic Anemias

161

Hemolytic Anemias: Red Blood Cell Membrane and Metabolic Defects

162

The Thalassemias

163

Sickle Cell Disease and Other Hemoglobinopathies

164

Megaloblastic Anemias

165

Aplastic Anemia and Related Bone Marrow Failure States

166

Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofi brosis

167

Leukocytosis and Leukopenia

168

Approach to the Patient with Lymphadenopathy and Splenomegaly

169

Disorders of Phagocyte Function

170

Eosinophilic Syndromes

171

Approach to the Patient with Bleeding and Thrombosis

172

Thrombocytopenia

173

Von Willebrand Disease and Hemorrhagic Abnormalities of Platelet and Vascular Function

174

Hemorrhagic Disorders: Coagulation Factor Defi ciencies

175

Hemorrhagic Disorders: Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Defi ciency

176

Thrombotic Disorders: Hypercoagulable States

177

Transfusion Medicine

178

Hematopoietic Stem Cell Transplantation

SECTION XV: ONCOLOGY

179

Approach to the Patient with Cancer

180

Epidemiology of Cancer

181

Cancer Biology and Genetics

182

Myelodysplastic Syndromes

183

The Acute Leukemias

184

The Chronic Leukemias

185

Non-Hodgkin Lymphomas

186

Hodgkin Lymphoma

187

Plasma Cell Disorders

188

Amyloidosis

189

Tumors of the Central Nervous System

190

Head and Neck Cancer

191

Lung Cancer and Other Pulmonary Neoplasms

192

Neoplasms of the Esophagus and Stomach

193

Neoplasms of the Small and Large Intestine

194

Pancreatic Cancer

195

Pancreatic Neuroendocrine Tumors

196

Liver and Biliary Tract Cancers

197

Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis

198

Breast Cancer and Benign Breast Disorders

199

Gynecologic Cancers

200

Testicular Cancer

201

Prostate Cancer

202

Malignant Tumors of Bone, Sarcomas, and Other Soft Tissue Neoplasms

203

Melanoma and Nonmelanoma Skin Cancers

204

Cancer of Unknown Primary Origin

VOLUME II

SECTION XVI: METABOLIC DISEASES

205

Approach to Inborn Errors of Metabolism

206

Disorders of Lipid Metabolism

207

Glycogen Storage Diseases

208

Lysosomal Storage Diseases

209

Homocystinuria and Hyperhomocysteinemia

210

The Porphyrias

211

Wilson Disease

212

Iron Overload (Hemochromatosis)

SECTION XVII: NUTRITIONAL DISEASES

213

Nutrition’s Interface with Health and Disease

214

Nutritional Assessment

215

Protein-Energy Malnutrition

216

Enteral Nutrition

217

Malnutrition, Nutritional Assessment, and Nutritional Support in Adult Hospitalized Patients

218

Vitamins, Trace Minerals, and Other Micronutrients

219

Eating Disorders

220

Obesity

SECTION XVIII: ENDOCRINE DISEASES

221

Approach to the Patient with Endocrine Disease

222

Principles of Endocrinology

223

Neuroendocrinology and the Neuroendocrine System

224

Anterior Pituitary

225

Posterior Pituitary

226

Thyroid

227

Adrenal Cortex

228

Adrenal Medulla, Catecholamines, and Pheochromocytoma

229

Diabetes Mellitus

230

Hypoglycemia and Pancreatic Islet Cell Disorders

231

Polyglandular Disorders

232

Neuroendocrine Tumors and the Carcinoid Syndrome

233

Disorders of Sexual Development

234

The Testis and Male Hypogonadism, Infertility, and Sexual Dysfunction

235

Ovaries and Pubertal Development

236

Reproductive Endocrinology and Infertility

SECTION XIX: WOMEN’S HEALTH

237

Approach to Women’s Health

238

Contraception

239

Common Medical Problems in Pregnancy

240

Menopause

241

Intimate Partner Violence

SECTION XX: DISEASES OF BONE AND MINERAL METABOLISM

242

Approach to the Patient with Metabolic Bone Disease

243

Osteoporosis

244

Osteomalacia and Rickets

245

The Parathyroid Glands, Hypercalcemia and Hypocalcemia

246

Medullary Thyroid Carcinoma

247

Paget Disease of Bone

248

Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Disorders of Bone

SECTION XXI: DISEASES OF ALLERGY AND CLINICAL IMMUNOLOGY

249

Approach to the Patient with Allergic or Immunologic Disease

250

Primary Immunodeficiency Diseases

251

Allergic Rhinitis and Chronic Sinusitis

252

Urticaria and Angioedema

253

Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy

254

Drug Allergy

255

Mastocytosis

SECTION XXII: RHEUMATIC DISEASES

256

Approach to the Patient with Rheumatic Disease

257

Laboratory Testing in the Rheumatic Diseases

258

Imaging Studies in the Rheumatic Diseases

259

Connective Tissue Structure and Function

260

Inherited Diseases of Connective Tissue

261

The Systemic Autoinflammatory Diseases

262

Osteoarthritis

263

Bursitis, Tendinitis, and Other Periarticular Disorders and Sports Medicine

264

Rheumatoid Arthritis

265

The Spondyloarthropathies

266

Systemic Lupus Erythematosus

267

Systemic Sclerosis (Scleroderma)

268

Sjögren Syndrome

269

Inflammatory Myopathies

270

The Systemic Vasculitides

271

Polymyalgia Rheumatica and Temporal Arteritis

272

Infections of Bursae, Joints, and Bones

273

Crystal Deposition Diseases

274

Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain

275

Systemic Diseases in Which Arthritis Is a Feature

276

Surgical Treatment of Joint Diseases

SECTION XXIII: INFECTIOUS DISEASES

277

Introduction to Microbial Disease: Host-Pathogen Interactions

278

The Human Microbiome

279

Principles of Anti-Infective Therapy

280

Approach to Fever or Suspected Infection in the Normal Host

281

Approach to Fever and Suspected Infection in the Compromised Host

282

Prevention and Control of Health Care–Associated Infections

283

Approach to the Patient with Suspected Enteric Infection

284

Approach to the Patient with Urinary Tract Infection

285

Approach to the Patient with a Sexually Transmitted Infection

286

Approach to the Patient before and after Travel

287

Antibacterial Chemotherapy

288

Staphylococcal Infections

289

Streptococcus Pneumoniae Infections

290

Nonpneumococcal Streptococcal Infections and Rheumatic Fever

291

Enterococcal Infections

292

Diphtheria and Other Corynebacterium Infections

293

Listeriosis

294

Anthrax

295

Erysipelothrix Infections

296

Clostridial Infections

297

Diseases Caused by Non–Spore-Forming Anaerobic Bacteria

298

Neisseria Meningitidis Infections

299

Neisseria Gonorrhoeae Infections

300

Haemophilus and Moraxella Infections

301

Chancroid

302

Cholera and Other Vibrio Infections

303

Campylobacter Infections

304

Escherichia Coli Enteric Infections

305

Infections Due to Other Members of the Enterobacteriaceae, Including Management of Multidrug-Resistant Strains

306

Pseudomonas and Related Gram-Negative Bacillary Infections

307

Diseases Caused by Acinetobacter and Stenotrophomonas Species

308

Salmonella Infections (Including Enteric Fever)

309

Shigellosis

310

Brucellosis

311

Tularemia and Other Francisella Infections

312

Plague and Other Yersinia Infections

313

Whooping Cough and Other Bordetella Infections

314

Legionella Infections

315

Bartonella Infections

316

Granuloma Inguinale (Donovanosis)

317

Mycoplasma Infections

318

Diseases Caused by Chlamydiae

319

Syphilis

320

Nonsyphilitic Treponematoses

321

Lyme Disease

322

Relapsing Fever and Other Borrelia Infections

323

Leptospirosis

324

Tuberculosis

325

The Nontuberculous Mycobacteria

326

Leprosy (Hansen Disease)

327

Rickettsial Infections

328

Zoonoses

329

Actinomycosis

330

Nocardiosis

331

Systemic Antifungal Agents

332

Histoplasmosis

333

Coccidioidomycosis

334

Blastomycosis

335

Paracoccidioidomycosis

336

Cryptococcosis

337

Sporotrichosis

338

Candidiasis

339

Aspergillosis

340

Mucormycosis

341

Pneumocystis Pneumonia

342

Mycetoma

343

Dematiaceous Fungal Infections

344

Antiparasitic Therapy

345

Malaria

346

African Sleeping Sickness

347

Chagas Disease

348

Leishmaniasis

349

Toxoplasmosis

350

Cryptosporidiosis

351

Giardiasis

352

Amebiasis

353

Babesiosis and Other Protozoan Diseases

354

Cestodes

355

Schistosomiasis (Bilharziasis)

356

Liver, Intestinal, and Lung Fluke Infections

357

Intestinal Nematode Infections

358

Tissue Nematode Infections

359

Arthropods and Leeches

360

Antiviral Therapy (Non-HIV)

361

The Common Cold

362

Respiratory Syncytial Virus

363

Parainfluenza Viral Disease

364

Influenza

365

Adenovirus Diseases

366

Coronaviruses

367

Measles

368

Rubella (German Measles)

369

Mumps

370

Cytomegalovirus, Epstein-Barr Virus, and Slow Virus Infections of the Central Nervous System

371

Parvovirus

372

Smallpox, Monkeypox, and Other Poxvirus Infections

373

Papillomavirus

374

Herpes Simplex Virus Infections

375

Varicella-Zoster Virus (Chickenpox, Shingles)

376

Cytomegalovirus

377

Epstein-Barr Virus Infection

378

Retroviruses Other Than Human Immunodeficiency Virus

379

Enteroviruses

380

Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses

381

Viral Hemorrhagic Fevers

382

Arboviruses Causing Fever and Rash Syndromes

383

Arboviruses Aff ecting the Central Nervous System

SECTION XXIV: HIV AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME

384

Epidemiology and Diagnosis of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome

385

Immunopathogenesis of Human Immunodeficiency Virus Infection

386

Biology of Human Immunodeficiency Viruses

387

Prevention of Human Immunodeficiency Virus Infection

388

Antiretroviral Therapy of HIV/AIDS

389

Infectious and Metabolic Complications of HIV and AIDS

390

Gastrointestinal Manifestations of HIV and AIDS

391

Pulmonary Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome

392

Skin Manifestations in Patients with Human Immunodeficiency Virus Infection

393

Hematology and Oncology in Patients with Human Immunodeficiency Virus Infection

394

Neurologic Complications of Human Immunodeficiency Virus Infection

395

Immune Reconstitution Inflammatory Syndrome in HIV/AIDS

SECTION XXV: NEUROLOGY

396

Approach to the Patient with Neurologic Disease

397

Psychiatric Disorders in Medical Practice

398

Headaches and Other Head Pain

399

Traumatic Brain Injury and Spinal Cord Injury

400

Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord

401

Regional Cerebral Dysfunction: Higher Mental Functions

402

Alzheimer Disease and Other Dementias

403

The Epilepsies

404

Coma, Vegetative State, and Brain Death

405

Disorders of Sleep

406

Approach to Cerebrovascular Diseases

407

Ischemic Cerebrovascular Disease

408

Hemorrhagic Cerebrovascular Disease

409

Parkinsonism

410

Other Movement Disorders

411

Multiple Sclerosis and Demyelinating Conditions of the Central Nervous System

412

Meningitis: Bacterial, Viral, and Other

413

Brain Abscess and Parameningeal Infections

414

Acute Viral Encephalitis

415

Prion Diseases

416

Nutritional and Alcohol-Related Neurologic Disorders

417

Congenital, Developmental, and Neurocutaneous Disorders

418

Autonomic Disorders and Their Management

419

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

420

Peripheral Neuropathies

421

Muscle Diseases

422

Disorders of Neuromuscular Transmission

XXVI: EYE, EAR, NOSE, AND THROAT DISEASES

423

Diseases of the Visual System

424

Neuro-Ophthalmology

425

Diseases of the Mouth and Salivary Glands

426

Approach to the Patient with Nose, Sinus, and Ear Disorders

427

Smell and Taste

428

Hearing and Equilibrium

429

Throat Disorders

SECTION XXVII: MEDICAL CONSULTATION

430

Principles of Medical Consultation

431

Preoperative Evaluation

432

Overview of Anesthesia

433

Postoperative Care and Complications

434

Medical Consultation in Psychiatry

SECTION XXVIII: SKIN DISEASES

435

Structure and Function of the Skin

436

Examination of the Skin and an Approach to Diagnosing Skin Diseases

437

Principles of Therapy of Skin Diseases

438

Eczemas, Photodermatoses, Papulosquamous (Including Fungal) Diseases, and Figurate Erythemas

439

Macular, Papular, Vesiculobullous, and Pustular Diseases

440

Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases

441

Infections, Hyperpigmentation and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin

442

Diseases of Hair and Nails

APPENDIX-LABORATORY REFERENCE INTERVALS AND VALUES

Reference Intervals and Laboratory Values