Glycolysis

Tissue-Specific Metabolic Regulation in Physio-pathological Conditions

1st Edition - October 13, 2023
Imprint: Academic Press
Editors: Rita Ferreira, Pedro Fontes Oliveira, Rita Nogueira-Ferreira
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 7 0 4 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 5 6 6 - 6

Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-… Read more

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Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research.

Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Part I: Introduction
Chapter 1. Glycolysis: breaking paradigms since Meyerhof’s contribution
Abstract
1.1 Introduction
1.2 Pyruvate or lactate: what is the end product of glycolysis?
1.3 Glycolytic enzymes work together to maximize their activity
1.4 Control of metabolic damage in glycolysis
1.5 Glycolytic enzymes: more than metabolic players
1.6 Conclusions
References
Part II: Glycolysis and physiological processes
Chapter 2. Development and glycolysis dependence
Abstract
2.1 Metabolism and embryonic development: general considerations
2.2 Temporal control and metabolic switches during embryonic development
2.3 Signaling metabolism interactions during embryonic development
2.4 Metabolism, gene expression regulation, and epigenetic control in embryonic development
2.5 Metabolism, glycolysis, and embryonic development: conclusions and future perspectives
References
Chapter 3. Neuro–glia communication and glycolysis
Abstract
3.1 Introduction
3.2 Brain glucose metabolism: at a glance
3.3 Better together: the important metabolic crosstalk between neurons and glia
3.4 Neuro–glia signaling in neurodegenerative disorders: the case of Alzheimer’s disease
3.5 Final remarks
Acknowledgments
References
Chapter 4. Glycolysis and skeletal muscle plasticity: lactate as a key signaling molecule
Abstract
4.1 Introduction
4.2 Skeletal muscle fibers and their reliance on glycolysis
4.3 Feeder pathways for glycolysis
4.4 Lactate and muscle fiber fatigue
4.5 The role of lactate on mitochondrial biogenesis and functionality
4.6 Conclusions
Acknowledgments
References
Chapter 5. Glucose utilization by the trained heart: the molecular mechanisms behind fuel choice
Abstract
5.1 Introduction
5.2 Revisiting glucose metabolism in the healthy heart
5.3 The contribution of glycolysis to the metabolic remodeling of the trained heart
5.4 Conclusions
Acknowledgments
References
Chapter 6. Bone glycolysis and the regulation of energy balance
Abstract
6.1 Introduction
6.2 Bone as an endocrine organ. Who would have thought it?
6.3 Evidence of bone as a regulator of energy homeostasis
6.4 Final remarks
Acknowledgments
References
Chapter 7. Glycolysis in adipose tissue-dependent thermogenesis
Abstract
7.1 Adipose tissue
7.2 Types of adipose tissue
7.3 BAT nonshivering thermogenesis
7.4 UCP1-independent thermogenesis in adipocytes
7.5 Glycolysis in BAT nonshivering thermogenesis
7.6 Nonshivering thermogenesis in the context of metabolic diseases: obesity and type 2 diabetes
7.7 Conclusion
Acknowledgments
References
Chapter 8. Liver metabolism: the pathways underlying glucose utilization and production
Abstract
8.1 Introduction
8.2 Overview of the metabolic networks involving glucose use and production in hepatocytes
8.3 Hormonal regulation of glucose metabolism in hepatocytes
8.4 Liver-centered organ–organ interplay
8.5 Conclusions
Acknowledgments
References
Chapter 9. The Warburg-like effect in male reproductive events
Abstract
9.1 Introduction
9.2 Metabolic cooperation in the testis is established as a Warburg-like effect
9.3 Relevance Warburg-like effect in male reproductive potential: from germ cells to fertilization
9.4 Endogenous and exogenous factors that control the Warburg-like effect in testis
9.5 Conclusion
References
Chapter 10. Pancreatic β cells: the metabolic network underlying body’s glucostat
Abstract
10.1 Introduction
10.2 Coupling glucose metabolism with insulin secretion in β cells
10.3 Metabolic amplifiers of insulin secretion
10.4 Other physiologic “potentiators” of insulin secretion
10.5 Conclusions
Acknowledgments
References
Part III: Glycolysis and pathological events
Chapter 11. Exploring glycolytic adaptations in cancer cells
Abstract
11.1 Introduction
11.2 Warburg effect: who is responsible?
11.3 Warburg effect: how does it contribute to cancer progression?
11.4 Therapeutic applications
11.5 Conclusions and future challenges
Acknowledgments
References
Chapter 12. The glycolytic pathway to heart failure
Abstract
12.1 Glycolysis
12.2 Glycolysis contributions to heart metabolism
12.3 Glycolysis in the ischemic heart
12.4 Glycolysis in ischemic heart disease
12.5 Glycolysis alterations in the heart during development, differentiation, and postnatal maturation
12.6 Glycolysis in the exercised heart
12.7 Glycolysis in the hypertrophied heart
12.8 Glycolysis in heart failure
12.9 Metabolically-driven heart failure therapeutic approaches
References
Chapter 13. Glycolysis in pulmonary arterial hypertension and metabolic reprogramming
Abstract
13.1 Introduction
13.2 Metabolic pathways and molecular concepts
13.3 Metabolic dysregulation in the right ventricle
13.4 Diagnostics for metabolic reprogramming in PAH
13.5 Therapeutic development of metabolic drugs in PAH
13.6 Mutations associated with PAH and metabolic abnormalities
13.7 Summary
Acknowledgments
References
Chapter 14. Glycolysis and diabetes mellitus
Abstract
14.1 Type 2 diabetes mellitus pathophysiology
14.2 Alterations of glycolysis in diabetes and their relation with oxidative stress and diabetic complications
14.3 Conclusion
References
Chapter 15. Inborn glycolytic pathway defects
Abstract
15.1 Introduction
15.2 Inborn errors of the glycolytic pathway
15.3 Pathophysiology
15.4 Diagnosis
15.5 Treatment approaches
15.6 Deficiency of metabolite repair enzymes
15.7 Conclusions
References
Chapter 16. Glucose, glycolysis, and neurodegenerative disorders
Abstract
16.1 Introduction
16.2 Role of brain cell interactions in glucose metabolism
16.3 Age-dependent changes in glucose metabolism
16.4 Mitochondria and brain glucose metabolism
16.5 Dysfunctional glucose metabolism: impact on neurodegenerative disorders
16.6 Conclusion
References
Chapter 17. Viral infections and glycolysis
Abstract
17.1 Introduction to viruses
17.2 Why do viruses manipulate glycolysis?
17.3 Viruses that trigger the Warburg effect
17.4 Viruses that alter glycolysis
17.5 Controlling viral infection and disease by targeting glycolysis
17.6 Takeaway
References
Part IV: Supplemental information
Chapter 18. Useful bioinformatics approaches for studying pathological conditions characterized by the dysregulation of glucose metabolism
Abstract
18.1 Introduction
18.2 Materials
18.3 Methods
18.4 Notes
Acknowledgments
Appendix
References
Chapter 19. Determination of glycolysis flux by extracellular flux measurements
Abstract
19.1 Summary
19.2 Introduction
19.3 Materials, equipment, and reagents
19.4 Protocols
19.5 Analysis and statistics
19.6 Related techniques
19.7 Advantages and disadvantages
19.8 Alternative methods and procedures
19.9 Troubleshooting and optimization
References
Index

Rita Ferreira

Rita Ferreira has a degree and a PhD in Biochemistry. RF is Assistant Professor at University of Aveiro where she has been teaching courses related to biochemistry and biomedicine to both undergraduate and graduate students. RF develops research work in the field of muscle plasticity in pathophysiological conditions, including the evaluation of the impact of exercise training in cancer-induced muscle wasting using Omics approaches. She is particularly interested in the study of the preventive and therapeutic effect of physical activity in the setting of wasting conditions.

Affiliations and expertise

Assistant Professor, Department of Chemistry, University of Aveiro, Aveiro, Portugal

Pedro Fontes Oliveira

Dr. Pedro Fontes Oliveira, in 2004, earned his PhD degree in Biomedical Sciences, at the University of Porto, Portugal. In 2005, Pedro F. Oliveira started his post-doctoral fellowship at the University of Porto and began working on a new line of research now focused on reproductive biology, specifically in Sertoli cells ionic regulation. In 2009, Dr. Oliveira was selected to apply for the “Ciência 2008 Program” through the Health Science Research Center, University of Beira Interior (CICS-UBI) and was hired as an Assistant Researcher. Currently Dr. Oliveira's research interests include hormonal control and metabolic modulation of spermatogenesis, with emphasis on Sertoli cells hormonal modulation, ionic water transport, and mechanisms by which endocrine disorders and pathologies, namely Diabetes Mellitus, result in subfertility and infertility.

Affiliations and expertise

Assistant Professor, Department of Chemistry, University of Aveiro, Aveiro, Portugal

Rita Nogueira-Ferreira

Rita Nogueira Ferreira has a graduation in Biochemistry (2010), a master's degree in Biochemistry – specialization in Clinical Biochemistry (2012), and a PhD in Biochemistry (2017), obtained at the University of Aveiro (Portugal). She has been developing research work in the study of the molecular and cellular mechanisms associated with different pathological conditions (pulmonary arterial hypertension, heart failure, cancer, obesity) and related to the effect of pharmacological and non-pharmacological approaches (exercise training) in the prevention or treatment of these conditions, using proteomic approaches. Currently, she works as Junior Researcher at UnIC@RISE, Department of Surgery and Physiology from the Faculty of Medicine of the University of Porto, Portugal. She was awarded in the FCT Individual Call to Scientific Employment Stimulus (CEECIND) 2021 to proceed in the study of sexual dimorphism in cardiovascular pathophysiology. In particular, she is interested in exploring the sex differences in heart failure, as well as the adaptations to exercise training, aiming to improve heart failure management.

Affiliations and expertise

UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal

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Glycolysis

Tissue-Specific Metabolic Regulation in Physio-pathological Conditions

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Rita Ferreira

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Rita Nogueira-Ferreira

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