Gluten-Related Disorders
Diagnostic Approaches, Treatment Pathways, and Future Perspectives
- 1st Edition - September 19, 2021
- Editor: Mohammad Rostami-Nejad
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 8 4 6 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 8 5 8 - 7
Gluten-related disorders are prevalent worldwide, especially in developing countries. These diseases have similar clinical manifestations. Although they are characterized by a… Read more
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Request a sales quoteGluten-related disorders are prevalent worldwide, especially in developing countries. These diseases have similar clinical manifestations. Although they are characterized by a specific pathophysiological response to ingestion of gluten, differential diagnosis of these disorders is very challenging. Failure to diagnose and treat these disorders at an early stage, can lead to irreparable health and cost damages. Gluten-Related Disorders: Diagnostic Approaches, Treatment Pathways, and Future Perspectives solves this problem by reporting up-to-date scientific findings that allow for faster, more accurate diagnosis of gluten-related disorders as well as guidance on treatment options. By identifying the distinctive features of each of the gluten-related disorders, the chapters lead readers to optimal diagnosis and treatment options as well as better research designs for future research studies on the pathogenesis of these disorders. This reference provided by experts in the field is perfect for researchers, scientists, and medical practitioners who are involved in addressing gluten-related disorders.
- Provides a comprehensive overview on all aspects of gluten-related disorders, incorporating many up-to-date scientific findings
- Highlights the differences and overlaps in clinical presentations of gluten-related disorders in order to aid differential diagnosis
- Presents the current understanding of the pathogenesis of gluten-related disorders, which can be used to inform future research endeavors
Researchers, scientist and medical practitioners, universities, research centers and analytical laboratories. Manufacturers of kits for clinical diagnostics
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Foreword
- Acknowledgments
- Chapter 1. Introduction
- Abstract
- Chapter Outline
- References
- Chapter 2. Gluten-related disorders: an evolving story
- Abstract
- Chapter Outline
- Introduction
- Early history of sprue
- The modern era of coeliac disease
- Dermatitis herpetiformis
- Non-coeliac gluten sensitivity
- Wheat allergy
- Gluten ataxia
- Conclusion
- References
- Chapter 3. Gluten and its main food sources and other components of grains that may impact on health
- Abstract
- Chapter Outline
- Introduction
- Gluten
- Foods containing gluten
- Other sources of gluten
- How is gluten damaging to human health?
- Celiac disease
- Nonceliac gluten sensitivity
- Wheat allergy
- Gluten ataxia
- Dermatitis herpetiformis
- Other components associated with Gluten Free Diets
- Improving the tolerability of wheat and gluten grains
- Exorphins
- Herbicides, fungicides, insecticides, and other grain contaminants
- Glyphosate
- Patient perspectives on dietary exclusion
- Conclusion
- References
- Chapter 4. Gluten-related disorders definition
- Abstract
- Chapter Outline
- Introduction
- Gluten-related disorders definition
- Dermatitis herpetiformis
- Gluten ataxia
- Wheat allergy
- Nonceliac gluten sensitivity
- Conclusion
- References
- Chapter 5. Epidemiology and burden of gluten-related disorders
- Abstract
- Chapter Outline
- Introduction
- Prevalence of celiac disease across the world
- Celiac disease and other disorders
- Celiac disease in children
- Economic burden
- The dilemma of screening
- References
- Further reading
- Chapter 6. Genetic and environmental factors of gluten-related disorders
- Abstract
- Chapter Outline
- Introduction
- Celiac disease
- HLA and celiac disease
- Celiac locus and the risk of disease
- Non-HLA genes and CD
- SNPs and the risk of celiac disease
- Celiac disease and environmental factors
- Infections
- Intestinal microbiota
- Viruses
- Other environmental factors
- Dermatitis herpetiformis
- Gluten ataxia
- Wheat allergy
- Nonceliac gluten sensitivity
- Conclusions
- References
- Chapter 7. Pathomechanism of gluten-related disorders
- Abstract
- Chapter Outline
- Introduction
- Celiac disease
- Nonceliac gluten sensitivity
- Wheat allergy
- Dermatitis herpetiformis
- Gluten ataxia
- Conclusion
- References
- Chapter 8. Clinical features of GRDs
- Abstract
- Chapter Outline
- Introduction
- Celiac disease presentation
- Gluten ataxia clinical presentation
- Dermatitis herpetiformis clinical presentation
- Wheat allergy clinical presentation
- Nonceliac gluten sensitivity clinical presentation
- Conclusion
- References
- Further reading
- Chapter 9. Histopathologic aspects of gluten-related disorders
- Abstract
- Chapter Outline
- Introduction
- Histopathology of celiac disease
- Small intestinal biopsy: site and number?
- The reality of patchiness
- Definition of normal versus abnormal
- Morphologic spectrum of celiac disease
- Reporting
- Histopathology of nonceliac gluten sensitivity
- Histopathology of wheat allergy
- Histopathology of dermatitis herpetiformis
- Histopathology of gluten ataxia
- Conclusion
- References
- Chapter 10. Diagnosis of gluten-related disorders
- Abstract
- Chapter Outline
- Diagnosis of celiac disease
- Diagnosis of dermatitis herpetiformis
- Diagnosis of gluten ataxia
- Diagnosis of wheat allergy
- Diagnosis of nonceliac gluten sensitivity
- Conclusions
- References
- Chapter 11. Treatment of gluten-related disorders
- Abstract
- Chapter Outline
- Introduction
- The gluten-free diet
- Other components of management of celiac disease
- Special situations in the treatment of gluten-related disorders
- Novel alternatives to a gluten-free diet
- Approach 1: decreasing immunogenic epitopes in the gluten
- Approach 2: intraluminal sequestration of gluten immunogenic epitopes
- Approach 3: prevention of uptake of gliadin epitopes
- Approach 4: tissue transglutaminase-2 inhibition in the intestinal mucosa
- Approach 5: prevention of downstream immune activation after gluten exposure
- Other miscellaneous therapies
- Conclusion
- References
- Chapter 12. Comorbidities associated with celiac disease, dermatitis herpetiformis, and nonceliac gluten sensitivity
- Abstract
- Chapter Outline
- Introduction
- Celiac disease
- Dermatitis herpetiformis
- Comorbidities in relatives of patients with celiac disease
- Nonceliac gluten sensitivity
- Conclusion
- Abbreviation
- References
- Chapter 13. Gluten-related disorders: monitoring and follow-up
- Abstract
- Chapter Outline
- Follow-up celiac disease in childhood
- Transition from childhood to adulthood in celiac disease
- Gluten-free diet for adult-onset celiac disease
- Follow-up of adult-onset celiac disease
- Follow-up of other gluten-related disorders
- Conclusion
- References
- Chapter 14. Refractory celiac disease
- Abstract
- Chapter Outline
- Introduction
- Pathogenesis of refractory celiac disease
- Evaluation of slow responder celiac disease patients
- Classification of refractory celiac disease
- Clinical characteristics
- Diagnosis of refractory celiac disease
- Prognosis of refractory celiac disease
- Enteropathy-associated T-cell lymphoma
- Management of refractory celiac disease
- Conclusion
- References
- Chapter 15. Summary of tables and figures
- Chapter Outline
- Gluten-related disorders: an evolving story
- Gluten and its main food sources and other components of grains that may impact on health
- Gluten-related disorders definition
- Epidemiology of gluten-related disorders
- Genetic and environmental factors of gluten-related disorders
- Pathomechanism of gluten-related disorders
- Clinical features of gluten-related disorders
- Histopathologic aspects of gluten-related disorders
- Diagnosis of gluten-related disorders
- Treatment of gluten-related disorders
- Comorbidities associated with celiac disease, dermatitis herpetiformis and nonceliac gluten sensitivity
- Gluten-related disorders: monitoring and follow-up
- Refractory celiac disease
- Chapter 16. Conclusion and insights
- Abstract
- Chapter Outline
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Gluten ataxia
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Nonceliac gluten sensitivity
- Celiac disease
- Dermatitis herpetiformis
- Wheat allergy
- Nonceliac gluten sensitivity
- References
- Index
- No. of pages: 300
- Language: English
- Edition: 1
- Published: September 19, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128218464
- eBook ISBN: 9780128218587
MR
Mohammad Rostami-Nejad
Mohammad Rostami-Nejad, PhD is the head of the Celiac Disease Department in the Research Institute for Gastroenterology and Liver Diseases (RIGLD) at the Shahid Beheshti University of Medical Sciences. His major areas of research include clinical immunology, especially for celiac disease and other gluten-related disorders. He has collaborated with various national and international centers and universities. Additionally, he has taken part in more than 60 projects as well as published 200 scientific papers, books, and book chapters on celiac disease (H-index=27). He initiated the first celiac diseases website in Persian (www.celiac.ir) and is the Deputy Editor of the Gastroenterology and Hepatology From Bed to Bench (GHFBB) journal.
Affiliations and expertise
Department of Celiac disease, Research Institute for Gastroenterology and Liver Diseases (RIGLD), Shahid Beheshti University of Medical Sciences, IranRead Gluten-Related Disorders on ScienceDirect