Glucosinolates

Chapter One. General Introduction to Glucosinolates

• 1. Introduction
• 2. Biosynthesis
• 3. Localization of the Biosynthesis
• 4. Storage
• 5. Pathway Engineering
• 6. Transport Processes
• 7. Conclusions

Chapter Two. Complex Environments Interact With Plant Development to Shape Glucosinolate Profiles

• 1. Introduction
• 2. All Classes of Glucosinolates Can Change in Response to Pathogens and Herbivores
• 3. Changes in Abiotic Environmental Factors Modulate Glucosinolate Responses
• 4. Plants Integrate External and Internal Signals to Optimize Their Metabolism
• 5. Concluding Remarks

Chapter Three. Nonlinear Selection and a Blend of Convergent, Divergent and Parallel Evolution Shapes Natural Variation in Glucosinolates

• 1. Introduction
• 2. Loci
• 3. Evolutionary Implications
• 4. Future Perspectives for Understanding Glucosinolate Variation

Chapter Four. Glucosinolate Regulation in a Complex Relationship – MYC and MYB – No One Can Act Without Each Other

• 1. Introduction
• 2. Subgroup 12 R2R3-MYB Transcription Factors in Glucosinolate Regulation
• 3. Subgroup IIIe bHLH Transcription Factors in Glucosinolate Regulation
• 4. The MYC-bHLH Interact With the GSL-MYBs and Are Thereby Crucial Regulators of IG and AG
• 5. HIG-MYB-Dependent Effects on IG-Related Indolic Compounds
• 6. Glucosinolate-Feedback Mechanism
• 7. HIG-HAG Crosstalk – Possible Reasons for the Reciprocal Regulation of Aliphatic and Indolic Glucosinolates
• 8. Further Regulatory Proteins in Glucosinolate Regulation
• 9. Summary and Future Perspectives

Chapter Five. Glucosinolate Synthesis in the Context of Plant Metabolism

• 1. Introduction
• 2. Connection of Glucosinolates With Sulphur Metabolism
• 3. Redox Regulation
• 4. Transporters in Glucosinolate Synthesis
• 5. Conclusions

Chapter Six. Glucosinolate Breakdown

• 1. Introduction
• 2. Myrosinases
• 3. Specifier Proteins
• 4. Compartmentation
• 5. Structural Diversity of Breakdown Products Formed Upon Tissue Disruption and Their Impact on Plant Defence
• 6. Breakdown Inside Herbivores
• 7. Breakdown in Nondisrupted Tissue
• 8. Conclusions and Perspectives

Chapter Seven. The Function of Glucosinolates and Related Metabolites in Plant Innate Immunity

• 1. Introduction
• 2. Aliphatic Glucosinolates in Plant Immunity
• 3. Pathogen-Triggered Indole Glucosinolate Metabolism
• 4. Functional and Biosynthetic Relationships Between Indole Glucosinolates and Brassicaceae Phytoalexins
• 5. Mode of Action of Glucosinolate-Derived Products
• 6. Concluding Remarks

Chapter Eight. Insect Detoxification of Glucosinolates and Their Hydrolysis Products

• 1. Introduction: Glucosinolate Hydrolysis and Its Effects on Insect Herbivores
• 2. General Detoxification Strategies
• 3. Specialized Detoxification Strategies
• 4. Conclusion

Chapter Nine. Health Benefits of Glucosinolates

• 1. Glucosinolate Structure and Metabolism
• 2. Metabolic Fate in Humans
• 3. Evidence for Health Benefits From Epidemiology
• 4. Diet–Gene Interactions and the Role of Glutathione-S-Transferase Genotypes
• 5. Evidence for Health Benefits From Human Interventional Studies
• 6. Mechanisms of Bioactivity From Animal and Cell Models
• 7. Conclusion

Chapter Ten. Glucosinolates – The Agricultural Story

• 1. Introduction
• 2. Oilseed Rape – From Industrial to Food Plant
• 3. Consequences of an Abrupt Switch of Oilseed Rape Varieties in Agricultural Production
• 4. Knockout of Double Low Oilseed Rape Varieties by Severe Sulphur Deficiency
• 5. Genetic Changes in Glucosinolate Metabolism Modify Sulphur Utilisation, Natural Plant Health and Wildlife Interactions
• 6. Epilogue
• Supplementary Data