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Genome Plasticity in Health and Disease
- 1st Edition - April 7, 2020
- Editors: Diego A. Forero, George P. Patrinos
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 7 8 1 9 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 7 8 2 0 - 1
Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the fi… Read more
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Request a sales quoteGenome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.
Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.
- Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders
- Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery
Active researchers, basic and translational scientists, clinicians, postgraduates, and students in the areas of genetics, human genomics, pathology, cellular biology, organismal biology, molecular biology, biochemistry, and bioinformatics
1. Impact of Genome Plasticity on Health and Disease
Section I. Plasticity of the Human Genome2. Overview of the Human Genome3. Methods for Epigenomic Analyses: DNA Methylation4. Genomic Databases5. Genomic Variability: Germline, Somatic and de novo Variants6. Founder Variations in Isolated Populations7. DNA Methylation8. Chromatin, Histones and Histone Modifications in Health and Diseases9. Networks of Transcription Factors10. Centromere and Telomere Dynamics in Humans
Section II. Human Genome Plasticity and Diseases11. Genome Plasticity and Cardiovascular Diseases12. Genome Plasticity and Neuropsychiatric Disorders13. Genome Plasticity and Endocrine Diseases14. Implications of Genome Plasticity for Drug Development
- No. of pages: 288
- Language: English
- Edition: 1
- Published: April 7, 2020
- Imprint: Academic Press
- Paperback ISBN: 9780128178195
- eBook ISBN: 9780128178201
DF
Diego A. Forero
Professor Forero is medical doctor, graduated from the National University of Colombia and did his PhD in Biomedical Sciences at the University of Antwerp (Belgium). Dr. Forero is Full Professor at the School of Medicine of the Universidad Antonio Nariño (Bogotá, Colombia), being the current leader of the Biomedical Sciences Research Group, Director of the Neuropsychiatric Genetics Laboratory and Director of the PhD Program in Health Sciences. He has led several research projects in molecular genetics of neurological and psychiatric disorders, in collaboration with national and international research groups. Dr Forero has authored publications in international scientific journals and books (cumulative impact factor of 223.267, h index: 22). He has been Associate Editor of BMC Research Notes, member of the editorial board of 3 international scientific journals and peer reviewer for 69 international scientific journals.
Affiliations and expertise
Full Professor; Director, Laboratory of Neuropsychiatric Genetics; Director, PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño,
Bogotá, ColombiaGP
George P. Patrinos
George P. Patrinos is a Professor of Pharmacogenomics and Pharmaceutical Biotechnology in the University of Patras (Greece), Department of Pharmacy, and Head of Division of Pharmacology and Biosciences of the same department and holds adjunct Full Professorships at Erasmus MC, Faculty of Medicine, and Health Sciences, Rotterdam (the Netherlands), and the United Arab Emirates University, College of Medicine, Department of Genetics and Genomics, Al-Ain (UAE). Also, from 2018 until the end of 2024, he was Chair of the Global Genomic Medicine Collaborative (G2MC). He served 12.5 years as a full member and Greece’s National representative in the CHMP Pharmacogenomics Working Party of the European Medicines Agency (EMA). George has more than 340 publications in peer-reviewed scientific journals, some of them in leading scientific journals, such as The Lancet, Nature Genetics, Nature Reviews Genetic, Nucleic Acids Research, Genes & Development. He has also coauthored and coedited more than 15 textbooks, among which the renowned textbook Molecular Diagnostics, published by Academic Press, now in its 3rd edition, while he is the editor of Translational and Applied Genomics book series, published by Elsevier. Furthermore, he serves as the Editor-In-Chief of the prestigious Pharmacogenomics Journal (TPJ), published by Nature Publishing Group, Associate Editor, and member of the editorial board of several scientific journals, and advisory and evaluation committees. Apart from that, George is the main coorganizer of the Golden Helix Conferences, an international meeting series on Pharmacogenomics and Genomic Medicine with more than 50 conferences organized in more than 25 countries worldwide.
Affiliations and expertise
Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates; Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab EmiratesRead Genome Plasticity in Health and Disease on ScienceDirect