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Genome Plasticity in Health and Disease
1st Edition - April 7, 2020
Editors: Diego A. Forero, George P. Patrinos
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Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the… Read more
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Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.
Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.
Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders
Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery
1. Impact of Genome Plasticity on Health and Disease
Section I. Plasticity of the Human Genome2. Overview of the Human Genome3. Methods for Epigenomic Analyses: DNA Methylation4. Genomic Databases5. Genomic Variability: Germline, Somatic and de novo Variants6. Founder Variations in Isolated Populations7. DNA Methylation8. Chromatin, Histones and Histone Modifications in Health and Diseases9. Networks of Transcription Factors10. Centromere and Telomere Dynamics in Humans
Section II. Human Genome Plasticity and Diseases11. Genome Plasticity and Cardiovascular Diseases12. Genome Plasticity and Neuropsychiatric Disorders13. Genome Plasticity and Endocrine Diseases14. Implications of Genome Plasticity for Drug Development
No. of pages: 288
Published: April 7, 2020
Imprint: Academic Press
Paperback ISBN: 9780128178195
eBook ISBN: 9780128178201
Diego A. Forero
Professor Forero is medical doctor, graduated from the National University of Colombia and did his PhD in Biomedical Sciences at the University of Antwerp (Belgium). Dr. Forero is Full Professor at the School of Medicine of the Universidad Antonio Nariño (Bogotá, Colombia), being the current leader of the Biomedical Sciences Research Group, Director of the Neuropsychiatric Genetics Laboratory and Director of the PhD Program in Health Sciences. He has led several research projects in molecular genetics of neurological and psychiatric disorders, in collaboration with national and international research groups. Dr Forero has authored publications in international scientific journals and books (cumulative impact factor of 223.267, h index: 22). He has been Associate Editor of BMC Research Notes, member of the editorial board of 3 international scientific journals and peer reviewer for 69 international scientific journals.
Affiliations and expertise
Full Professor; Director, Laboratory of Neuropsychiatric Genetics; Director, PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño,
George P. Patrinos
Dr. Patrinos is internationally renowned for his involvement in the field of pharmacogenomics research. His research includes discovery work and addresses the issue of clinical implementation of pharmacogenomics in a holistic manner, including wet- and dry-lab, as well as public health genomics approaches. Dr. Patrinos has also a keen interest in the clinical implementation of genomic medicine in resource-limited environments.
Affiliations and expertise
Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates; Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates