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Gene-Environment Interactions in Birth Defects and Developmental Disorders
1st Edition - January 25, 2023
Editors: Robert J. Lipinski, Robert S. Krauss
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 1 5 7 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 1 6 3 - 3
Gene-Environment Interactions in Birth Defects and Developmental Disorders, Volume 152, covers the multifactorial etiology of a variety of developmental disorders, including… Read more
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Gene-Environment Interactions in Birth Defects and Developmental Disorders, Volume 152, covers the multifactorial etiology of a variety of developmental disorders, including orofacial clefts, fetal alcohol spectrum disorders, autism, and others. The causes of individual cases of most common birth defects are unknown but likely involve a combination of genetic predisposition and environmental exposures. How these risk factors interact in the genesis of these conditions is still largely unknown and readers will find the latest information and ideas on these disorders, along with discussion of the challenges and opportunities for furthering knowledge in this area.
- Presents latest information on gene-environment interactions in birth defects and developmental disorders
- Covers multiple animal model systems and human conditions
- Includes discussion of the opportunities for discovery in a challenging area of biomedical research
Researchers and students
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Gene-environment interactions in birth defect etiology: Challenges and opportunities
- Abstract
- 1: Introduction
- 2: Defining the genetic landscape of birth defect etiology
- 3: Elucidating the environmental landscape of birth defect etiology
- 4: Gene-environment interactions
- 5: Model systems for the study of gene-environment interactions in birth defects
- 6: Future directions: Potential mechanisms of gene-environment interaction
- 7: Concluding remarks
- Acknowledgments
- References
- Chapter Two: Transgenerational inheritance and its modulation by environmental cues
- Abstract
- 1: Introduction
- 2: Epigenetic mechanisms of inheritance
- 3: Substrates for epigenetic inheritance
- 4: Evidence for environmentally-induced epigenetic inheritance in mammals
- 5: Harnessing in vitro models for gene-environment interaction studies
- 6: Conclusion and future challenges
- References
- Chapter Three: Gene-alcohol interactions in birth defects
- Abstract
- 1: Introduction
- 2: FASD background and prevalence
- 3: What are multifactorial interactions in birth defects?
- 4: Evidence for gene-alcohol interactions
- 5: Concluding remarks
- Acknowledgment
- References
- Chapter Four: The role of genes and environment in the etiology of congenital diaphragmatic hernias
- Abstract
- 1: Introduction
- 2: Diaphragm development
- 3: Congenital diaphragmatic hernia (CDH)
- 4: Development of CDH
- 5: Genetic etiology of CDH
- 6: Environmental factors contributing to CDH
- 7: Vitamin A in CDH development
- 8: Gene–environment interactions in etiology of CDH
- 9: Concluding remarks
- Acknowledgments
- References
- Chapter Five: Gene–environment interactions in the pathogenesis of common craniofacial anomalies
- Abstract
- 1: Introduction
- 2: Overview of craniofacial morphogenesis
- 3: Developmental basis of common craniofacial anomalies
- 4: Common risk factors and gene–environment interaction in craniofacial anomalies
- 5: Conclusion
- Acknowledgments
- References
- Chapter Six: Gene × environment associations in orofacial clefting
- Abstract
- 1: Introduction
- 2: Genetic architecture of nonsyndromic OFCs
- 3: Maternal exposures and behaviors during pregnancy influence OFC risk
- 4: Gene × environment associations in OFC
- 5: Summary and conclusions
- References
- Chapter Seven: Gene–environment interactions underlying the etiology of neural tube defects
- Abstract
- 1: Introduction
- 2: Neural tube defects phenotypes
- 3: Embryonic origin of neural tube defects
- 4: Genetic risk factors for neural tube defects
- 5: Environmental factors contributing to the etiology of neural tube defects
- 6: Organoid model systems to study neural tube defects
- 7: Folate deficiencies and neural tube defects
- 8: Conclusions
- References
- Chapter Eight: Gene × environment interactions in autism spectrum disorders
- Abstract
- 1: Introduction
- 2: Environmental chemicals identified as putative autism risk factors
- 3: Mechanisms by which gene × environment interactions influence autism risk
- 4: PCBs as putative autism risk factors
- 5: Evolving areas of research
- 6: Concluding remarks
- Acknowledgments
- References
- No. of pages: 296
- Language: English
- Published: January 25, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128201572
- eBook ISBN: 9780128201633
RL
Robert J. Lipinski
Robert J. Lipinski is an Associate Professor and Associate Chair of Comparative Biosciences and Associate Director of the Molecular and Environmental Toxicology program at the University of Wisconsin. He is also an Associate Editor for the American Journal of Medical Genetics and serves on the organizing committee for the David W. Smith Workshop on Malformations and Morphogenesis. His research program is focused on environmentally sensitive developmental mechanisms that regulate craniofacial morphogenesis. His research team has developed in vivo and advanced in vitro models that recapitulate molecular, cellular, and morphological aspects of human embryogenesis to identify genetic and environmental risk factors and investigate their interaction in causing birth defects.
Affiliations and expertise
School of Veterinary Medicine, University of Wisconsin, WI, USARK
Robert S. Krauss
Robert S. Krauss is Mount Sinai Chair in Cell Biology; Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai; and a member of The Black Family Stem Cell Institute and Mindich Child Health and Development Institute. His work focuses on the mechanisms of early embryonic development and adult tissue regeneration. His laboratory uses a wide combination of approaches to gain insight into how genes and the environment interact in the causation of common birth defects, and how adult stem cells are called into action to repair injury to tissues. His lab has constructed accurate animal models for holoprosencephaly, a common and often devastating birth defect, leading to identification of genetic and environmental risk factors. In other work, his lab has identified factors critical to regulation of adult stem cells and muscle regeneration.
Affiliations and expertise
Icahn School of Medicine at Mount Sinai, New York, USA