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Elsevier

Gastrointestinal Endocrinology

Receptors and Post-Receptor Mechanisms

  • 1st Edition - June 28, 1990
  • Latest edition
  • Editor: James Thompson
  • Language: English

Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms provides information pertinent to the fundamental aspects of receptors and post-receptor mechanisms. This… Read more

Description

Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms provides information pertinent to the fundamental aspects of receptors and post-receptor mechanisms. This book discusses a variety of topics, including normal and neoplastic growth, molecular biology and genetics, and actions of gut hormones and their clinical importance. Organized into 37 chapters, this book begins with an overview of the initial step in the interaction of a gastrointestinal peptide with its target cell. This text then examines the concept that the receptor proteins are a major control mechanism by which a cell engineers the effects of a hormone. Other chapters consider the epidermal growth factor (EGF), which is a heat-stable polypeptide that exerts both short- and long-term regulatory effects on various cellular processes. This book discusses as well the developments in the ability to measure the concentration of ionized calcium in cells. The final chapter deals with the hormonal mechanisms in gallbladder motility. This book is a valuable resource for biochemists.

Table of contents


Contributors

Preface

Acknowledgments

Abbreviations


1. Role of Receptors in Expression of Gastrointestinal Hormone Function


2. Gastrointestinal Hormone Receptors and Receptor-Regulation


3. Multifunctional Role of the Epidermal Growth Factor Receptor in the Regulation of Cell Growth


4. Regulation of Intracellular Calcium Release and Calcium Uptake by Inositol 1,4,5-trisphosphate in Exocrine Glands


5. Cellular Calcium and Phospholipid Metabolism Mediate Pancreatic Enzyme Secretion


6. Heterogeneity of Receptors and Signal Transduction Pathways in Smooth Muscle Cells of the Gut


7. Biochemical Characterization of Receptors for the Cholecystokinin Family of Hormones


8. Cholecystokinin Receptor Antagonists: Ability to Distinguish Various Classes of Cholecystokinin Receptors


9. Cholecystokinin Gene Expression


10. Human and Mouse Amylase Genes in Transgenic Mice


11. Studies on Gastrin Posttranslational Processing


12. Cell-Specific Expression and Processing of Procholecystokinin and Progastrin


13. Pancreatic Polypeptide, Peptide YY, and Secretin Gene Expression


14. Modern Imaging at the Cellular Level


15. Gastrointestinal Peptides and Autocrine Growth Effects


16. Primary Cultures of Pancreatic Acinar Cells


17. Trophic Effects of Cholecystokinin on the Exocrine Pancreas


18. Involvement of Somatostatin in Pancreatic Growth


19. Pancreatic Adaptation Involves Regulation of Gene Expression by Cholecystokinin


20. Growth of Normal and Malignant Gastrointestinal Cells in Culture: Differential Responses to Peptides


21. Effect of Gastrointestinal Hormones on Neoplastic Growth


22. Gastrin is a Hormonal Stimulant of the Intestinal, Gastric and Cephalic Phases of Acid Secretion in Dogs


23. Pancreatic Enzymes in Feedback Regulation of Cholecystokinin Release


24. Bile Salts in Cholecystokinin Feedback


25. Neuronal Actions of Cholecystokinin


26. The Role of Pancreatic Polypeptide in Glucose Metabolism


27. Immunologie and Biologic Properties of Glucagon-Like Peptide-1 (GLP-1)


28. Peptide YY Release and Actions


29. Receptor Mediated Biologic Actions of Cholecystokinin


30. The Cell Biology of Acute Pancreatitis


31. Somatostatin: Treatment of Gut Endocrinopathies and a Mechanism of Action


32. Cytoprotective Effects of Somatostatin on Experimental Diabetes


33. Actions of Parathyroid Hormone on the Gut


34. Inhibitory Mechanisms of the Exocrine Pancreas


35. Autocrine/Paracrine Growth Factors of Human Malignancies


36. Clinical Syndromes of Gut Hormones


37. Hormonal Mechanisms in Gallbladder Motility

Index

Product details

  • Edition: 1
  • Latest edition
  • Published: November 12, 2012
  • Language: English

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