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Gastrointestinal and Liver Pathology
A Volume in the Series: Foundations in Diagnostic Pathology
- 3rd Edition - December 30, 2022
- Authors: Amitabh Srivastava, Daniela S. Allende
- Editor: John R. Goldblum
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 5 2 7 9 4 - 1
Now fully revised to include recent advances in the field, the third edition of Gastrointestinal and Liver Pathology Pathology, a volume in the Foundations in Diagnostic Pathology… Read more
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Request a sales quoteNow fully revised to include recent advances in the field, the third edition of Gastrointestinal and Liver Pathology Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what’s new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.
Key features of this practical text include:
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A consistent, user-friendly format that explores each entity's clinical features, gross and microscopic findings, ancillary studies, differential diagnoses, and prognostic and therapeutic considerations.
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A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses.
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Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis.
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Nearly 1,000 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
What’s NEW in this edition:
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Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine.
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New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
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The latest TNM staging and WHO classification systems.
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New co-editors Drs. Amitabh Srivastava and Daniela S. Allende lead a team of expert, internationally recognized pathologists who keep you up to date with the latest information in the field.
- Cover image
- Title page
- Table of Contents
- Any screen, Any time, Anywhere
- Copyright
- Dedication
- Contributors
- Foreword
- Preface
- Acknowledgments
- 1. Non-Neoplastic Disorders of the Esophagus
- Abstract
- Esophagitis
- Eosinophilic Esophagitis
- Lymphocytic Esophagitis
- Lichen Planus and Lichenoid Esophagitis
- Crohn’s Disease
- Graft-Versus-Host Disease
- IgG4-Related Esophageal Disease
- Therapy or Toxin-Related Injur
- Radiation or Chemotherapy Esophagitis
- Pill Esophagitis
- Esophagitis Dissecans Superficialis or Sloughing Esophagitis
- Caustic Esophageal Injury
- Miscellaneous Lesions
- Inlet Patch
- Heterotopic Sebaceous Glands
- Glycogenic Acanthosis
- Esophageal Hyperkeratosis and Epidermoid Metaplasia
- Inflammation and Intestinal Metaplasia of the Gastroesophageal Junction
- Structural Abnormalities
- Acquired (Diverticula, Webs, and Rings)
- Motility Disorders
- Systemic Sclerosis
- Esophageal Varices, Perforations, and Tears
- References
- 2. Tumors of the Esophagus
- Abstract
- Squamous Papillomas
- Atypical Lipomatous Tumor (“Giant Fibrovascular Polyp” of the Esophagus)
- Ancillary Studies
- Barrett’s Esophagus
- Risk Factors for Esophageal Carcinoma
- Dysplasia in Barrett’s Esophagus
- Intramucosal Adenocarcinoma
- Adenocarcinoma
- Squamous Dysplasia and Squamous Cell Carcinoma
- Undifferentiated Carcinoma
- Pathologic Findings
- Microscopic Findings
- Ancillary Studies
- Salivary Gland Type Tumors
- Pathologic Features
- Ancillary Studies
- Differential Diagnosis
- Neuroendocrine Neoplasms
- Pathologic Features
- Ancillary Studies
- Secondary Tumors of the Esophagus
- Suggested Readings
- 3. Non-Neoplastic Disorders of the Stomach
- Abstract
- Acute Erosive/Hemorrhagic Gastritis (“Stress” Gastritis)
- Clinical Features
- Reactive (Chemical) Gastropathy
- Clinical Features
- Helicobacter pylori Gastritis
- Clinical Features
- Gastric Peptic Ulcer Disease
- Clinical Features
- Autoimmune Gastritis
- Clinical Features
- Granulomatous Gastritis
- Gastric Crohn’s Disease
- Gastric Sarcoidosis
- Lymphocytic Gastritis
- Clinical Features
- Infectious Gastritis
- Eosinophilic Gastritis
- Clinical Features
- Collagenous Gastritis
- Clinical Features
- Gastric Mucosal Calcinosis
- Clinical Features
- Doxycycline Gastritis
- Clinical Features
- Ménétrier’s Disease
- Clinical Features
- Zollinger-Ellison Syndrome
- Clinical Features
- Gastric Amyloidosis
- Clinical Features
- Gastric Antral Vascular Ectasia (“Watermelon Stomach”)
- Clinical Features
- Portal Hypertensive Gastropathy
- Clinical Features
- Dieulafoy’s Lesion (Caliber Persistent Artery)
- Clinical Features
- Suggested Readings
- 4. Epithelial Polyps and Neoplasms of the Stomach
- Abstract
- Gastric Polyps
- Fundic Gland Polyps
- Gastric Hyperplastic Polyps
- Gastritis Cystica Polyposa
- Pancreatic Heterotopia
- Gastric Mucosal Xanthoma
- Gastric Carcinomas, Neuroendocrine Tumors, and their Precursor Lesions
- Gastric Epithelial Dysplasia and Gastric Adenomas
- Pyloric Gland Adenoma
- Oxyntic Gland Adenoma
- Gastric Adenocarcinoma
- Neuroendocrine Neoplasms
- Suggested Readings
- 5. Non-Neoplastic and Inflammatory Disorders of the Small Bowel
- Abstract
- Patterns of Small Bowel Disorders
- Malabsorption Disorders
- Celiac Disease
- Pathogenesis
- Nonresponsive or Refractory Celiac Disease
- Collagenous Sprue
- Tropical Sprue
- Peptic Duodenal Disease
- Small Intestinal Bacterial Overgrowth
- Nonsteroidal Antiinflammatory Drug–Associated Injury
- Olmesartan-Associated Sprue-Like Enteropathy
- Common Variable Immunodeficiency
- Autoimmune Enteropathy
- Microvillus Inclusion Disease
- Congenital Tufting Enteropathy (Intestinal Dysplasia)
- Enteroendocrine Cell Dysgenesis
- Abetalipoproteinemia
- Small Intestinal Inflammatory Bowel Disease
- Crohn’s Disease
- Pathologic Features
- Graft-Versus-Host Disease
- Pathologic Features
- Eosinophilic Gastroenteritis
- Pathologic Features
- Ischemic or Hemorrhagic Enteritis
- Infectious Enteritis
- Primary Lymphangiectasia
- Incidental Pigmentation
- References
- Suggested Readings
- 6. Neoplasms of the Small Intestine
- Abstract
- Brunner’s Gland Hyperplasia and Hamartoma
- Gastric Heterotopia
- Pancreatic Heterotopia
- Pyloric Gland Adenoma
- Conventional Adenoma, Serrated Polyps, and Adenocarcinoma of the Small Intestine
- Adenoma and Adenocarcinoma of the Ampulla of Vater
- Neuroendocrine Tumors of the Small Intestine
- Gangliocytic Paraganglioma
- Neuroendocrine Carcinoma of the Small Intestine and Ampulla
- Secondary Tumors
- Suggested Readings
- 7. Gastrointestinal Mesenchymal Tumors
- Abstract
- Gastrointestinal Stromal Tumor
- Smooth Muscle Tumors of the Gastrointestinal Tract
- Granular Cell Tumor
- Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract/Malignant Gastrointestinal Neuroectodermal Tumor
- Inflammatory Fibroid Polyp
- Plexiform Fibromyxoma
- Calcifying Fibrous Tumor
- Schwannoma of the Gastrointestinal Tract
- Mucosal Perineurioma (“Benign Fibroblastic Polyp”)
- Mucosal Schwann Cell Hamartoma
- Ganglioneuroma
- Gangliocytic Paraganglioma
- Glomus Tumor
- Intraabdominal Desmoid Fibromatosis
- Sclerosing Mesenteritis
- Inflammatory Myofibroblastic Tumor
- Lymphangioma
- PEComa
- Suggested Readings
- 8. Non-Neoplastic and Neoplastic Disorders of the Appendix
- Abstract
- Congenital and Acquired Anatomic Anomalies of the Appendix
- Fibrous Obliteration of the Appendiceal Lumen (Neural Hyperplasia)
- Acute Appendicitis
- Periappendicitis
- Ulcerative Colitis Involving the Appendix
- Crohn’s Disease Involving the Appendix
- Granulomatous Appendicitis
- Cystic Fibrosis
- Infectious Causes of Acute Appendicitis
- Endometriosis, Deciduosis, Gliomatosis
- Epithelial Neoplasms of the Appendix (Nonendocrine)
- Adenoma
- Serrated Polyps
- Clinical Features
- Low-And High-Grade Appendiceal Mucinous Neoplasms
- Clinical Features
- Clinical Features
- Neuroendocrine Tumors of the Appendix
- Clinical Features
- Goblet Cell Adenocarcinoma
- Clinical Features
- Suggested Readings
- 9. Infectious Diseases of the Gastrointestinal Tract
- Abstract
- Viral Infections
- Cytomegalovirus
- Clinical Features
- Herpesvirus
- Adenovirus
- Clinical Features
- Human Immunodeficiency Virus–Associated Ulcerative Esophagitis
- Aids Enterocolopathy
- Bacterial Infections
- Sarcina Ventriculi and Related Organisms
- Tropheryma Whipplei (Whipple Disease)
- Clinical Features
- Bacterial Enterocolitis
- Escherichia Coli
- Enterohemorrhagic Escherichia Coli
- Clinical Features
- Salmonellosis
- Clinical Features
- Shigellosis
- Clinical Features
- CampylobacterSPP.
- Clinical Features
- Yersiniosis
- Clinical Features
- Vibrio Cholerae and Related Organisms
- Clinical Features
- AeromonasSpp.
- Clinical Features
- Clostridial Infections of the Gut
- Clinical Features
- Klebsiella Oxytoca
- Mycobacterial Infections of the Gut
- Clinical Features
- Syphilis (Treponema Pallidum)
- Clinical Features
- Chlamydia Trachomatis
- Neisseria Gonorrheae
- Intestinal Spirochetosis
- Clinical Features
- Actinomycosis
- Fungal Infections
- Prognosis and Therapy
- CANDIDASPP.
- AspergillusSpp.
- Mucormycosis and Related Infections
- Clinical Features
- Basidiobolus Ranarum
- Clinical Features
- Histoplasmosis
- Penicillium Marneffei
- CryptococcusSpp.
- Parasitic Infections Of The Gastrointestinal Tract
- Clinical Features
- Trypanosoma Cruzi (Chagas Disease)
- Flagellates
- Clinical Features
- Visceral Leishmaniasis (Kala-Azar) Caused By Leishmania Donovani and Related Species
- Clinical Features
- Coccidians and Related Organisms
- Clinical Features
- Helminths (Nematodes, Trematodes, and Cestodes)
- Nematodes
- Clinical Features
- Ascaris Lumbricoides (Roundworm), Ancylostoma Duodenale (Hookworm), and Trichuris Trichiura (Whipworm)
- Clinical Features
- Strongyloides Stercoralis
- Clinical Features
- Anisakis Simplex (Anisakiasis) and Related Species
- Clinical Features
- Trematodes
- Clinical Features
- Acknowledgement
- Suggested Readings
- 10. Non-neoplastic Disorders of the Colon
- Abstract
- Idiopathic Inflammatory Bowel Disease
- Ulcerative Colitis
- Clinical Features
- Dysplasia In Ulcerative Colitis
- Crohn’s Disease
- Clinical Features
- Ileal Pouch Enteritis (Pouchitis)
- Collagenous Colitis
- Clinical Features
- Lymphocytic Colitis
- Ischemic Colitis
- Radiation Colitis
- Diversion Colitis
- Diverticular Disease–Associated Colitis
- Mucosal Prolapse Or Solitary Rectal Ulcer Syndrome
- Eosinophilic Proctocolitis
- Systemic Mastocytosis
- Mycophenolate Mofetil Colitis
- Immune Checkpoint Receptor Inhibitor–Associated Colitis
- Cord Colitis Syndrome
- Nonsteroidal Antiinflammatory Drug Colitis
- Chemotherapy Effect or Mucositis
- Selected Readings
- 11. Gastrointestinal Polyposis Syndromes
- Abstract
- Adenomatous Polyposis Syndromes
- Serrated Polyposis Syndrome
- Peutz-Jeghers Syndrome
- Juvenile Polyposis Syndrome
- Cowden’s Syndrome
- Cronkhite-Canada Syndrome
- Hereditary Mixed Polyposis Syndrome
- Miscellaneous Syndromes With Associated Gastrointestinal Polyposis
- Suggested Readings
- 12. Epithelial Neoplasms of the Colorectum
- Colorectal Polyps
- Adenomatous Polyps
- Neuroendocrine Proliferation In Adenomatous Polyps
- Intramucosal Adenocarcinoma And “Carcinoma In Situ”
- Molecular Features Of Adenomatous Polyps
- Malignant Polyps
- Invasive Adenocarcinoma Versus Misplaced Epithelium (Pseudoinvasion)
- Serrated Polyps
- Hyperplastic Polyps
- Sessile Serrated Polyp/Adenoma
- Traditional Serrated Adenomas
- Molecular Alterations
- Serrated Polyposis Syndrome
- Colorectal Adenocarcinoma
- Molecular Pathways For Colorectal Carcinogenesis
- Lynch Syndrome
- Uncommon Variants Of Colorectal Carcinomas
- Morphologic Features Associated With Microsatellite Instability
- Neuroendocrine Neoplasms
- Suggested Readings
- 13. Molecular Testing of Gastrointestinal Neoplasms
- Assessment Of Mismatch Repair Function
- HER-2 in colorectal carcinoma
- HER2 Testing in Upper Gastrointestinal Tract (Esophageal, Gastric, and Gastroesophageal Junction) Adenocarcinoma
- Suggested Readings
- 14. Pathology of the Anal Canal
- Abstract
- Anal Anatomic and Histologic Landmarks
- Inflammatory And Non-Neoplastic
- Crohn’s Disease
- Clinical Features
- Hemorrhoids And Anal Tags
- Clinical Features
- Anal Tags
- Anal And Perianal Squamous Neoplasia Terminology
- Tumors And Precursor Lesions Of The Anal Canal
- Anal Canal Squamous Intraepithelial Lesion
- Ancillary Studies
- Squamous Cell Carcinoma
- Ancillary Studies
- Molecular Pathology
- Adenocarcinoma
- Clinical Features
- Ancillary Studies
- Melanoma
- Ancillary Studies
- Molecular Pathology
- Tumors And Precursor Lesions Of The Perianal Skin
- Clinical Features
- Condyloma Acuminatum
- Clinical Features
- Molecular Pathology
- Perianal High-Grade Squamous Intraepithelial Lesion (Bowen’s Disease)
- Clinical Features
- Bowenoid Papulosis
- Squamous Cell Carcinoma Of The Perianal Skin
- Verrucous Carcinoma
- Clinical Features
- Molecular Pathology
- Paget’s Disease
- Clinical Features
- Ancillary Studies
- Immunohistochemistry
- Suggested Readings
- 15. Pathology of the Gallbladder and Extrahepatic Bile Ducts
- Abstract
- Gallbladder
- Dysplasia And Early Gallbladder Carcinoma
- Advanced Gallbladder Carcinoma
- Extrahepatic Bile Ducts
- Carcinoma Of Extrahepatic Bile Ducts
- Other Lesions Of The Gallbladder And Extrahepatic Bile Ducts
- Suggested Readings
- 16. Non-Neoplastic and Neoplastic Pathology of the Pancreas
- Abstract
- Non-Neoplastic Diseases
- Pancreatitis
- Neoplastic Diseases
- Neuroendocrine Tumors
- Tumors With Acinar Differentiation
- Frozen Section Evaluation and Diagnosis
- Suggested Readings
- 17. Non-Neoplastic Disorders of the Liver
- Major Histologic Patterns of Injury
- Acute Hepatitis Pattern of Injury
- Acute Viral (Hepatotropic) Hepatitis
- Clinical Features
- Nonhepatotropic Viral Infections
- Clinical Features
- Chronic Hepatitis Pattern of Injury
- Chronic Viral Hepatitis
- Autoimmune Hepatitis
- Fatty Liver Disease or Steatohepatitis Pattern of Injury
- Nonalcoholic Fatty Liver Disease
- Alcoholic Liver Disease
- Disorders of the Bile Ducts
- Large Duct Obstruction
- Primary Biliary Cholangitis
- Primary Sclerosing Cholangitis
- Laboratory Findings
- Overlap Syndromes (Autoimmune Hepatitis, Primary Biliary Cholangitis, And Primary Sclerosing Cholangitis)
- Vascular Pattern Of Injury
- Budd-Chiari Syndrome
- Clinical Features
- Congestive (Cardiac) Hepatopathy
- Clinical Features
- Sinusoidal Obstruction Syndrome
- Clinical Features
- Portal Vein Thrombosis or Obstruction
- Nodular Regenerative Hyperplasia
- Clinical Features
- Hepatoportal Sclerosis
- Clinical Features
- Peliosis Hepatis
- Clinical Features
- Drug-Induced Liver Injury
- Clinical Features
- Miscellaneous Patterns of Injury
- “Almost Normal” Biopsy or Nonspecific Findings
- Hepatic Granulomas
- Necrosis
- Metabolic Diseases
- Iron Overload
- Hereditary Hemochromatosis
- Clinical Features
- Secondary Iron Overload
- Copper Accumulation Disorder
- Clinical Features
- Clinical Features
- Glycogen Storage Diseases
- Clinical Features
- Clinical Features
- Glycogenic Hepatopathy
- Porphyrias
- Suggested Readings
- 18. Liver Neoplasms
- Epithelial Tumors Hepatocellular Tumors Focal Nodular Hyperplasia
- Clinical Features
- Hepatic Adenoma
- Macroregenerative and Dysplastic Nodules
- Hepatocellular Carcinoma
- Fibrolamellar Carcinoma
- Hepatoblastoma
- Biliary TumorsBile Duct Hamartoma
- Bile Duct Adenoma
- Solitary Biliary Cyst
- Polycystic Liver Disease
- Mucinous Cystic Neoplasm
- Cholangiocarcinoma
- Combined Hepatocellular–Cholangiocarcinoma
- Mesenchymal Tumors Benign Hemangioma
- Infantile Hemangioma
- Mesenchymal Hamartoma
- Angiomyolipoma
- Malignant Angiosarcoma
- Epithelioid Hemangioendothelioma
- Embryonal Sarcoma of the Liver
- Primary Hepatic Lymphoma
- Metastases
- Suggested Readings
- 19. Gastrointestinal Lymphoma
- Extranodal Marginal Zone B-cell Lymphoma of Mucosa Associated Lymphoid Tissue (MALT LYMPHOMA)
- Immunoproliferative Small Intestinal Disease (a Heavy Chain Disease)
- Follicular Lymphoma (Including Primary Duodenal-Type Follicular Lymphoma)
- ■ Mantle Cell Lymphoma
- Large Cell and Aggressive B-Cell Lymphomas
- ■Diffuse Large B-Cell Lymphoma
- ■High-Grade B-Cell Lymphoma
- Epstein-Barr Virus–Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified
- Plasmablastic Lymphoma
- ■Burkitt Lymphoma
- Epstein-Barr Virus–Positive Mucocutaneous Ulcer
- Mature T- and Natural Killer Cell Neoplasms
- Enteropathy-Associated T-Cell Lymphoma
- Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
- Hepatosplenic T-Cell Lymphoma
- Indolent T- and Natural Killer Cell Lymphoproliferative Disorders
- Summary
- Suggested Readings
- 20. Pathology of Liver, Small Bowel, and Pancreas Transplantation
- Liver Transplantation
- Pretransplant Donor Evaluation
- Preservation or Ischemia-Reperfusion Injury
- Laboratory Findings
- Antibody-Mediated Rejection
- Ancillary Studies
- (Acute) T Cell–Mediated Rejection
- Chronic (Ductopenic) Rejection
- Complications of Transplantation
- Portal Hyperperfusion Injury or Small-for-Size Graft Syndrome
- Hepatic Venous Outflow Obstruction or Congestive Hepatopathy
- Biliary Complications
- Recurrent Disease
- Small Bowel Transplantation
- Acute Cellular Rejection
- Antibody-Mediated Rejection
- Chronic Rejection
- Pancreas Transplantation
- Evaluating Posttransplant Needle Core Biopsies
- Cell-Mediated Rejection
- Chronic Rejection and Graft Fibrosis
- Chronic Graft Fibrosis
- Other Complications
- Recurrence of Primary Disease
- Suggested Readings
- Index
- Confidence is ClinicalKey
- No. of pages: 784
- Language: English
- Edition: 3
- Published: December 30, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323527941
JG
John R. Goldblum
Affiliations and expertise
Chairman of Pathology, Cleveland Clinic; Professor of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OhioAS
Amitabh Srivastava
Affiliations and expertise
Assistant Professor, Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NHDA
Daniela S. Allende
Affiliations and expertise
Department of Pathology, Cleveland Clinic, Cleveland, OhioRead Gastrointestinal and Liver Pathology on ScienceDirect