Gametogenesis

Series Page

Contributors

Preface

Chapter One. Cohesin in Gametogenesis

1 Introduction

2 Meiosis I

3 Meiosis II

4 Cohesin Loading and Associated Factors

5 Role of Cohesin in Checkpoint Mechanisms

6 Centromeres, Kinetochores, and Centrioles

7 Errors and Age Effects in Oocytes

8 Perspective/Questions

References

Chapter Two. Genomic Imprinting Is a Parental Effect Established in Mammalian Germ Cells

1 Introduction

2 Discovery of Genomic Imprinting

3 Expression of Imprinted Genes

4 Coregulation of the Imprinted Genes in Clusters

5 DNA Methylation

6 DNA Demethylation

7 Cycle of DMR Methylation

8 Establishment of the DNA Methylation Imprint

9 Maintenance of the DNA Methylation Imprint

10 Imprinting Control Mechanisms

11 Igf2–H19 Imprinted Region

12 Igf2r Imprinted Region

13 Dlk1–Gtl2 Imprinted Region

14 Snrpn Imprinted Region

15 Imprinting-Related Human Diseases

16 Macro ncRNA in Imprinting Control

17 Imprinting in Pluripotent Stem Cells

18 Evolution of Imprinting

19 Conclusions

References

Chapter Three. The Identity and Fate Decision Control of Spermatogonial Stem Cells

1 Introduction

2 Heterogeneity of Isolated Type A Spermatogonia and the SSC Population Size in the Mouse Testis

3 Cell-Surface and Intracellular SSC Markers

4 Balance Between Self-Renewal and Commitment

5 The Point of No Return: When and How Does SSC Commitment Start and End?

6 Concluding Remarks

References

Chapter Four. Germline Stem Cells

1 Spermatogonial Stem Cells

2 Female Germline Stem Cells

References

Chapter Five. LINCing the Nuclear Envelope to Gametogenesis

1 Introduction

2 LINC Complexes Are Versatile Connectors

3 General Features of the Nucleocytoplasmic Intersection in Germ Cells

4 SUN–KASH Bridges Drive Meiosis

5 LINCs in Sperm Head Formation

6 Concluding Remarks

References

Chapter Six. Small RNAs in Germline Development

1 Introduction: Germline Development and Small Regulatory RNAs

2 Small RNAs in Germ Cells

3 Small RNAs in Germ Cell Tumor Formation

4 Conclusion

References

Chapter Seven. The Control of Meiotic Maturation in Mammalian Oocytes

1 Introduction

2 Control of GV Arrest

3 Control of Meiosis I

4 Concluding Remarks

References

Chapter Eight. Signaling Modalities During Oogenesis in Mammals

1 Introduction

2 Framing and Qualifying the Complexity of Oogenesis

3 Cell Contact-Mediated Signaling

4 Receptor–Ligand Interactions

5 Autocrine–Paracrine Signaling Pathways

6 Heterocellular Contact via TZPs

7 RTKs and Cortical Maturation

8 Summary and Conclusions

References

Chapter Nine. Biogenesis of the Mouse Egg’s Extracellular Coat, the Zona Pellucida

1 Introduction to the Mammalian Egg’s Zona Pellucida

2 Appearance of the Mouse Egg’s ZP During Oogenesis

3 Nature of Mouse ZP Glycoproteins

4 Genes Encoding Mouse ZP Glycoproteins

5 Synthesis of ZP Glycoproteins by Mouse Oocytes

6 Molecular Aspects of Synthesis of Mouse ZP Glycoproteins

7 Elimination of Synthesis of Mouse ZP Glycoproteins

8 Secretion and Assembly of Mouse ZP Glycoproteins

References

Chapter Ten. Molecular Changes During Egg Activation

1 Introduction

2 Ion Levels

3 Changes in Proteome Composition

4 mRNA Degradation

5 Summary

References

Chapter Eleven. The Role of the Double Bromodomain-Containing BET Genes During Mammalian Spermatogenesis

1 Introduction

2 Mammalian BET Gene Expression During Spermatogenesis

3 BRDT Is Required for Proper Spermatogenesis and Male Fertility

4 BRDT and Regulation of Transcription and Posttranscriptional Processing During Spermatogenesis

5 BRDT and Later Stages of Spermiogenesis

6 BET Inhibition as a Possible Contraceptive

7 Conclusions

References

Chapter Twelve. DMRT Genes in Vertebrate Gametogenesis

1 Background

2 DMRT1 in the Mammalian Fetal Gonad

3 DMRT1 in Human Testicular Germ Cell Cancer

4 DMRT1 in the Postnatal Mammalian Gonad

5 DMRT1 in Supporting Cells of the Mammalian Testis

6 DMRT1 in the Mammalian Ovary

7 DMRT7 and Sex Chromatin

8 DMRT1 in Other Vertebrates

9 Conclusions

References

Chapter Thirteen. RanBPM, a Scaffolding Protein for Gametogenesis

1 Introduction

2 Protein Structure

3 Function Outside the Reproductive System

4 Phenotype of RanBPM-Deficient Mice

5 Expression in the Reproductive System

6 RanBPM Is Dispensable for Primordial Germ Cell Migration

7 Function of RanBPM During Postnatal Testis Development

8 Meiotic Arrest in Mice Deficient for RanBPM

9 Role of RanBPM in the Adult Gonad

10 Cell-Autonomous Function of RanBPM

11 Conclusion

References

Further reading

Chapter Fourteen. K+ and Cl− Channels and Transporters in Sperm Function

1 Introduction

2 Epididymal Maturation

3 Capacitation

4 Acrosome Reaction

5 Final Remarks

References

Index