G Protein-Coupled Receptors - Part A
- 1st Edition, Volume 193 - November 8, 2022
- Imprint: Academic Press
- Editor: Arun K. Shukla
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 3 1 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 3 2 - 3
G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupl… Read more
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Request a sales quoteG Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes.
- Covers a broad range of topics related to GPCR activation and signaling
- Covers several receptor systems with an emphasis on emerging paradigms
- Covers different processes and model systems with a focus on GPCRs
Scientists interested in learning about the latest developments in the field of GPCR biology and drug discovery
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Computational and experimental approaches to probe GPCR activation and signaling
- Abstract
- 1: Introduction
- 2: Experimental methods to study GPCR activation and signal transduction
- 3: Computational methods to study GPCR activation
- 4: Computational methods to study GPCR signal transduction
- 5: Viral Hijacking of GPCR Signaling
- References
- Chapter Two: Adrenergic receptors in breast cancer
- Abstract
- 1: Breast cancer
- 2: Stress
- 3: Adrenergic receptors
- 4: β2-Adrenergic receptors in the normal breast and breast cancer
- 5: Beta-blockers
- 6: α2-Adrenergic receptors in breast cancer
- 7: Conclusions
- References
- Chapter Three: Tools for adapting to a complex habitat: G-protein coupled receptors in Trichoderma
- Abstract
- 1: Introduction
- 2: Activation of GPCRs
- 3: Downstream targets of GPCR receptors
- 4: Regulation mechanisms of GPCRs
- 5: GPCRs in Trichoderma
- References
- Chapter Four: Targeting G protein coupled receptors for alleviating neuropathic pain
- Abstract
- 1: Introduction
- 2: General etiology of neuropathic pain
- 3: Opioid receptors in neuropathic pain
- 4: Modulation of mesolimbic circuitry by opioids
- 5: Cannabinoid receptors
- 6: Chemokines receptors
- 7: Adenosine receptors
- 8: Conclusion and future prospective
- References
- Chapter Five: Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans
- Abstract
- 1: Introduction
- 2: Neuron-glial interactions through neurotransmitter GPCRs
- 3: Conclusion
- Acknowledgments
- References
- Chapter Six: Cardiovascular GPCR regulation by regulator of G protein signaling proteins
- Abstract
- 1: Introduction
- 2: Cardiac GPCRs and RGS proteins
- 3: Vascular cardiac GPCRs and RGS proteins
- 4: Platelet/other cardiovascular GPCRs and RGS proteins
- 5: Conclusions and future perspectives
- References
- Chapter Seven: The interaction, mechanism and function of GPR158-RGS7 cross-talk
- Abstract
- References
- Chapter Eight: Taste GPCRs and their ligands
- Abstract
- 1: Introduction
- 2: Currently known ligands
- 3: Functional cell-based assays for discovery of taste GPCR ligands
- 4: Facilitating ligands discovery through computational methods
- 5: Future directions
- 6: Concluding remarks
- Acknowledgments
- References
- Chapter Nine: Palmitoylation and G-protein coupled receptors
- Abstract
- 1: Introduction
- 2: S-palmitoylation
- 3: Conclusion
- References
- Index
- Edition: 1
- Volume: 193
- Published: November 8, 2022
- No. of pages (Hardback): 230
- No. of pages (eBook): 230
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323994316
- eBook ISBN: 9780323994323
AS
Arun K. Shukla
Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.
Affiliations and expertise
Indian Institute of Technology, Kanpur, IndiaRead G Protein-Coupled Receptors - Part A on ScienceDirect