Fundamentals and Future Trends of 3D Printing in Drug Delivery
- 1st Edition - November 20, 2024
- Editors: Dimitrios A. Lamprou, Dimitrios G. Fatouros
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 6 4 5 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 6 4 6 - 4
Fundamentals and Future Trends of 3D Printing in Drug Delivery provides readers with all needed information for their journey from ideation to approval of innovative drug delivery… Read more
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Request a sales quoteFundamentals and Future Trends of 3D Printing in Drug Delivery provides readers with all needed information for their journey from ideation to approval of innovative drug delivery devices produced through additive manufacturing.
This book provides an in-depth discussion on key factors affecting the printing process such as different printer technologies, materials selection, resolutions, temperatures and speeds. Dedicated chapters include specific drug delivery devices in the form of oral solid dosage, implants, catheters and vascular grafts, and microneedles. The prospects of 3D printing associated with personalized medicine are covered in a full chapter.
Fundamentals and Future Trends of 3D Printing in Drug Delivery is the perfect reference for any researcher or professional embarking on a 3D printing process for drug delivery devices. The regulatory aspects included are of particular interest to companies entering this promising market.
- Includes discussion on key parameters of the printing process like materials selection, temperatures, printing technologies, resolutions, and speeds
- 3D printed drug delivery methods covered include oral solid dosage, implants, catheters and vascular grafts, and microneedles
- Covers the potential of 3D printed drug delivery for personalized medicine
Researchers in Industry and Academia working in drug delivery and medical implants, in general, and specifically using additive manufacturing technologies. Undergraduate and Postgraduate (e.g., Masters, Ph.D.) students in Pharmacy, Pharmaceutical Sciences, and Pharmaceutical Biotechnology. Regulatory bodies. Pharmaceutical, biopharmaceutical, additive manufacturing, and biofabrication industries. The book can be used from most pharmacy, pharmaceutical sciences, and pharmaceutical technologies courses for undergraduate students and from a variety of Master courses worldwide (e.g., Additive Manufacturing, Industrial Pharmaceutics, Drug Delivery, and Biofabrication)
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1. Overview of emerging printing technologies: How 2D printing has evolved towards multidimensional printing
- Introduction
- Applications of two-dimensional (2D) printing in drug delivery
- 2D materials
- 2D printing advancements in drug delivery
- Applications of three-dimensional printing in drug delivery
- Introduction to three-dimensional printing
- Types of 3D-printed drug delivery systems
- 3D printed solid oral dosage forms
- 3D printed transdermal drug delivery systems
- 3D printed medical device drug delivery systems
- 3D printed drug eluting implants
- 4D printing technology
- Mechanism of smart materials
- Categories of external stimuli
- Temperature
- Liquid absorption
- Light
- Magnetic field
- Electric field
- pH
- 4DP hydrogels
- 4DP microneedles
- 4DP drug-eluting implants
- 5D printing technology
- 6D printing technological performance
- Future manufacturing marvels: The perception of 7D printing process
- Conclusions
- MCQs
- Chapter 2. 3D-printing technologies for pharmaceutical applications
- Introduction
- 3D-printing technologies for drug delivery
- Extrusion based 3D-printing technologies
- Fused Deposition Modeling (FDM)
- Semisolid Extrusion (SSE)
- Direct Powder Extrusion
- Micro-extrusion
- Vat Polymerization
- Stereolithography (SLA)
- Two-photon polymerization (2PP)
- Digital Light Processing (DLP)
- Continuous Liquid Interface Production (CLIP)
- Powder Bed Fusion (PBF)
- Selective Laser Sintering (SLS)
- Inkjet Printing
- Material Jetting (MJ)
- Binder Jetting (BJ)
- Conclusions
- MCQs
- Chapter 3. Polymeric biomaterials for 3D printing
- Introduction
- 3D printing techniques
- Selective laser sintering (SLS)
- Stereolithography (SLA)
- Inkjet
- Polyjet
- Fused filament fabrication (FFF)
- Bioprinting
- Synthetic polymers
- Polycaprolactone (PCL)
- Polylactic acid (PLA)
- Polycarbonate (PC)
- Polyetheretherketone (PEEK)
- Polyethylene glycol (PEG)
- Thermoplastic polyurethane (TPU)
- Polypropylene (PP)
- Polyamides
- Acrylonitrile butadiene styrene (ABS)
- Polydimethylsiloxane (PDMS)
- Polymer composites
- Bio-based polymers
- Gelatin
- Collagen
- Chitosan
- Cellulose
- Biocomposites
- Engineered living materials: Next generation of bioinks
- Conclusions
- Chapter 4. Design optimization and finite element analysis of 3D printed drug delivery systems
- Introduction
- Design optimization in 3D printed drug delivery systems
- Introduction to design principles
- Considerations for designing drug delivery systems
- Geometry
- Material selection
- Drug release mechanisms
- Dosage control
- Importance of optimization
- Enhancing drug delivery efficiency
- Precise dosage control
- Reduction of side effects
- Improving patient adherence
- Finite element analysis (FEA) in 3D printed drug delivery systems
- Introduction to FEA
- Benefits of FEA
- Stress analysis
- Deformation analysis
- Fluid dynamics and drug dispersion
- Thermal analysis
- Case studies
- A novel 3D printing approach for creating drug-filled capsules: A case study
- Fabrication and finite element analysis of stereolithographic 3D printed microneedles for transdermal drug delivery: A case study
- Conclusion
- Chapter 5. 3D printing in personalized medicine
- Taking advantage of 3D printed personalized medicines
- Tailored dosage and release profiles
- Enhanced patient compliance
- Reduced healthcare costs
- Major challenges overcome by 3D printing techniques compared to conventional technologies
- Implementation of 3D printed personalized medicines in clinical practice
- Safety and quality assessment of 3D printed medicines for implementation into clinical practice
- Healthcare professionals and patient acceptability of 3D printed personalized medicines
- Physicians' acceptability
- Pharmacists' acceptability
- Patient's acceptability
- Challenges and barriers to 3D printed medicine implementation
- Regulatory issues
- Technological limitations
- Cost and accessibility
- Unlocking the potential of 3D printed personalized medicines in clinical practice
- Integration with other technologies
- Expanding the range of printable materials and drug combinations
- Developing new business models
- Education and training of healthcare professionals
- Future perspectives and conclusions
- Chapter 6. 3D printed bespoke solid dosage forms for oral drug delivery
- Solid oral dosage forms (SODFs)
- 3D-printing basics
- Advantages of 3D-Printing
- 3D-printing in pharmaceutics: Characteristics of 3D-Printed SODFs
- 3D-printing methods in SODFs manufacturing
- Vat polymerization
- Extrusion based technic
- Powder based technic
- Inkjet based technic
- SODF 3D-Printing materials
- Examples of 3D-Printed SODFs
- Tablets
- Gastro-retentive tablets
- Immediate release tablets
- Modified release tablets
- Orodispersible tablets (ODTs)
- Polypills
- Capsules
- Oral films
- Sweet-like SODFs
- Future of SODF 3D-Printing
- Conclusion
- Chapter 7. Development of 3D printed drug-loaded catheters and vascular grafts
- Introduction
- What are vascular grafts?
- Physiology of blood vessels
- Design requirement of vascular grafts
- What are catheters?
- Drugs used in catheters and vascular grafts
- General overview of 3D printing techniques
- Different mechanisms for drug loading
- Fabrication of 3D printed vascular grafts
- Fabrication of 3D printed catheter
- Future directions and conclusions
- Multiple choice questions
- Chapter 8. 3D printed microneedle patches for painless drug delivery
- Introduction
- Microneedle (MN) system
- Classification and characteristics of microneedles
- Solid microneedles
- Coated microneedles
- Hollow microneedles
- Dissolving microneedles
- Hydrogel microneedles
- Porous microneedles
- Materials used in the production of microneedles
- Manufacturing of MNs
- Lithography
- Laser ablation
- Moulding
- 3D-printing techniques applied in microneedle manufacturing
- Stereolithography (SLA)
- Digital light processing (DLP)
- Fused deposition modeling (FDM)
- Continuous liquid interface production (CLIP)
- Two-photon polymerization (TPP)
- Potential applications of 3DP MNs as drug delivery systems
- Diabetes and glucose control
- Skin tumours
- Contraceptives
- Bacterial infections
- Vaccination
- Wrinkles
- Combining 3DP with other techniques to obtain MNs for drug delivery
- Summary
- MCQ
- Answers
- Chapter 9. 3D printed therapeutic scaffolds for wound healing applications
- Introduction
- Cells in 3D printing technology
- Fibroblasts cells
- Epithelial cells
- Immune cells
- Wounds and inflammation
- The immune response to the inserted material
- Immunomodulation—3D immunomodulatory microenvironment
- Conclusions
- Chapter 10. 3D-printed implants targeting gynaecological disease
- Introduction
- Biological and clinical background
- The vaginal microbiome
- Gynaecological diseases
- Antiviral and antibiotic treatment for gynaecological diseases
- 3D-printing for gynaecological applications
- Types of 3D-printing
- Intra-vaginal drug delivery via 3D-printed implants
- Engineering considerations
- 3D-printing design parameters
- Biomaterials in gynaecological applications and their incorporation with 3D-printing
- Mechanical properties of 3D-printed implants
- 3D-printed implants to deliver alternative treatments
- Summary
- Chapter 11. 3D printing in preclinical evaluation
- Introduction
- Characterization of feedstock materials and 3D-printed drug products
- Physical appearance, mass, and content uniformity
- Disintegration and dissolution
- Mechanical properties
- Solid-state properties
- Physical, chemical, and microbiological stability
- Non-destructive quality control
- Concluding remarks
- Chapter 12. 4D printed therapeutic systems
- Introduction
- Progression from 3D to 4D: Evolution of bioprinting
- Shape memory polymers
- Stimuli-responsive hydrogels
- Thermo-responsive hydrogels
- Photo-responsive hydrogels
- pH-responsive hydrogels
- Swelling-based shape transformation of hydrogels
- Magneto-responsive hydrogels
- Applications of 4D bioprinted therapeutic systems
- 4D printing for tissue engineering
- 4D printed drug delivery systems
- Conclusion
- Chapter 13. Additive Manufacturing (AM) and AI
- Introduction
- Goal and direction of this chapter
- Content overview
- 3D printing classifications
- 3D printing and AM enabling technologies
- Inkjet 3D printing
- Powder deposition
- Spray drying
- Bio printing
- 4D, 5D, 6D printing
- Industry 5.0 and mass customization
- Integration of processes
- Production lifecycle—AI-related processes
- Logistics processes in general and logistics trends
- Process logistics and lean techniques
- Logistic trends, AI and AM
- Resources problem and AI and AM
- AM in the context of resources
- AI in the context of resources
- The knowledge context as a resource problem
- Future research program: System dynamics integration as a future trend and epistemology of science
- Summary and outlook
- Chapter 14. Regulatory aspects of 3D printing systems in healthcare
- Introduction
- 3D-printed products
- Medicinal products
- Medical devices
- 3D-printing in healthcare settings
- 3D printing at point-of-care
- 3D printing integrated with medical device software
- Summary
- Index
- No. of pages: 400
- Language: English
- Edition: 1
- Published: November 20, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443236457
- eBook ISBN: 9780443236464
DL
Dimitrios A. Lamprou
Dr. Lamprou is Full Professor, Chair of Biofabrication and Advanced Manufacturing, and Director at MSc Industrial Pharmaceutics at Queen's University Belfast. He is also the Chair at United Kingdom and Ireland Controlled Release Society (UKICRS) and the Chair of the Academy of Pharmaceutical Sciences (APS) Emerging Technologies Focus Group. Dimitrios, is the author of over 140 peer-reviewed publications (including 3 books in 3D Printing area), has over 350 conference abstracts, has given over 150 Invited Talks in institutions and conferences across the world, and has secure Funding more than £3M. Dimitrios, has been recognized as world leader in 3D Printing with PubMed-based algorithms placed him in the top 0.088% of scholars in the world writing about 3D Printing in the last 10 years. Dimitrios has also been named in the Stanford University's list 2021 & 2022 of World's Top 2% Scientists, for his research in Pharmaceutics and Biomedical Engineering.
Affiliations and expertise
Professor, School of Pharmacy, Material and Advanced Technologies for Healthcare, Queen’s University Belfast, Northern Ireland, UKDF
Dimitrios G. Fatouros
Dimitris Fatouros is Professor in Pharmaceutics at Aristotle University of Thessaloniki School of Pharmacy. He holds a PhD in Pharmaceutical Technology from the School of Pharmacy at the University of Patras in Greece. He subsequently held posts as a Post-Doctoral fellow at Leiden/Amsterdam Centre of Drug Delivery (LA/CDR), Research Assistant Professor at Danish University of Pharmaceutical Sciences and Senior Lecturer at School of Pharmacy and Biomedical Portsmouth University. His areas of research expertise cover additive manufacturing, mucosal delivery, nanomedicine and poorly soluble drugs. He has contributed over 180 publications in refereed journals and books. He has filled three national (granted) and five international patents. He has been Theme Editor in Advanced Drug Delivery Reviews “Personalized nanomedicine” (Editors, Vizirianakis and Fatouros, ADDR 2012 64 :1359-62) and “Additive Manufacturing in Pharmaceutical Product Design” (Editors, Rantanen and Fatouros 2021 178:113991). He is Associate Editor in Journal of Drug Delivery Science and Technology (Elsevier), Associate Editor in Frontiers and Bioengineering and Biotechnology and member of the Editorial Board of Pharmaceutics.
Affiliations and expertise
Professor, Department of Pharmacy, Aristotle University of Thessaloniki, GreeceRead Fundamentals and Future Trends of 3D Printing in Drug Delivery on ScienceDirect