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Fundamental Neuroscience
- 2nd Edition - November 13, 2002
- Editors: Larry Squire, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh, Larry R. Squire, Nicholas C. Spitzer, Susan K. McConnell, James L. Roberts, Michael J. Zigmond
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 6 6 0 3 0 3 - 3
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 2 1 8 0 - 0
With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of… Read more
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Request a sales quoteWith over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates.
The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.
The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.
Key Features
* Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters
* Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts
* Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM
* Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters
* Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts
* Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM
Graduate students and researchers in neuroscience, as well as medical students.
Neuroscience
Cellular and Molecular Neuroscience
Nervous System Development
Sensory Systems
Motor Systems
Regulatory Systems
Behavioral and Cognitive Neuroscience
Cellular and Molecular Neuroscience
Nervous System Development
Sensory Systems
Motor Systems
Regulatory Systems
Behavioral and Cognitive Neuroscience
- No. of pages: 1426
- Language: English
- Edition: 2
- Published: November 13, 2002
- Imprint: Academic Press
- Hardback ISBN: 9780126603033
- eBook ISBN: 9780080521800
LS
Larry Squire
Affiliations and expertise
University of California, San Diego, La Jolla, CA, USADB
Darwin Berg
Affiliations and expertise
University of California, San Diego, La Jolla, CA, USAFB
Floyd E. Bloom
Affiliations and expertise
Scripps Research Institute, La Jolla, CA, USASd
Sascha du Lac
Affiliations and expertise
The Salk Institute, La Jolla, CA, USAAG
Anirvan Ghosh
Affiliations and expertise
University of California, San Diego, La Jolla, CA, USALS
Larry R. Squire
Larry R. Squire is Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego. He is also a Research Career Scientist at the Veterans Affairs Medical Center in San Diego. Squire is a member of the National Academy of Sciences and a past president of the Society for Neuroscience.
Affiliations and expertise
Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego; Research Career Scientist at the Veterans Affairs Medical Center in San Diego; member of the National Academy of Sciences and a past president of the Society for Neuroscience.NS
Nicholas C. Spitzer
Affiliations and expertise
University of California, San Diego, La Jolla, CA, USASM
Susan K. McConnell
Affiliations and expertise
Stanford University, Palo Alto, California, U.S.A.JR
James L. Roberts
Affiliations and expertise
Trinity University, San Antonio, TX, USAMZ
Michael J. Zigmond
Affiliation: Professor of Neurology, Department of Neurology, University of Pittsburg, USA
Over the past year, Dr. Zigmond and his research team have continued their studies of cellular and animal models to examine Parkinson's disease (PD), which they believe is a multi-factorial disorder. A major focus of the lab is the role of intracellular signaling cascades in determining the viability of dopamine (DA) neurons. They hypothesize, for example, that trophic factors such as GDNF and oxidative stress can both stimulate intracellular survival cascades, including those involving MAP kinases. They further believe that endogenous trophic factor expression can be enhanced by exercise which in turn can be neuroprotective. And they have evidence that protection also can derive from acute exposure to low levels of a neurotoxin, a form of preconditioning. Last year their work included studies of the impact of oxidative stress induced by 6-hydroxydopamine (6-OHDA), a DA analogue that is concentrated in DA cells and rapidly breaks down to form reactive oxygen species. Results from these and other studies suggest that DA neurons react to stress by initiating a set of protective responses. Learning more about these responses may provide insights into new treatment modalities for PD.
In the coming year, Dr. Zigmond will continue to focus on understanding the strategies DA neurons use to reduce their vulnerability to intracellular stress. For example, studies are underway to determine if inhibition of trophic actor action or of kinase activation will block neuroprotection seen with exercise or GDNF or increase 6-OHDA toxicity. Some of these studies involve the preparation of molecular biological tools that maintain kinases in a constitutively or dominant negative state and/or localize a kinase to the cytoplasm or the nucleus. In addition, histochemical methods are being developed to quantify kinase levels in different cellular compartments of identified cells.
Affiliations and expertise
Professor of Neurology, Department of Neurology, University of Pittsburgh, Pennsylvania, U.S.A.