From Current to Future Trends in Pharmaceutical Technology

1st Edition - November 30, 2023
Editors: Natassa Pippa, Costas Demetzos, Maria Chountoulesi
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 1 1 1 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 4 3 9 - 0

From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on… Read more

Purchase options

Institutional subscription on ScienceDirect

Request a sales quote

From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on pharmaceutics, pharmaceutical engineering, pre-formulation protocols, techniques, innovative excipients, bio-printing techniques, scale-up based on formulas on-a-chip, and regulatory aspects based on new scientific achievements. Modified dosage forms, new aspects on the compatibility of drug excipients interactions, and drug release by various dosage forms are included. Physical pharmacy (physical and biological stability of dosage forms), innovative excipients, patents on innovative formulations and regulatory issues related to the approval process of medicines are also discussed.

The book is a valuable resource for a wide audience of academics, industrial researchers and professionals working in this field as the development of efficient and safe medicines is critical to future needs.

Cover image
Title page
Table of Contents
Copyright
Contributors
Editors biography
Preface
Chapter 1 Fundamentals of 3D printing of pharmaceuticals
Abstract
Acknowledgments
1 Introduction
2 The basic principles of 3D printing
3 Extrusion-based 3D printing
4 Inkjet (IJ) 3D printing
5 VAT photopolymerization
6 Selective laser sintering
7 Selection of suitable 3D printing technique for pharmaceutical application
8 Benefits of application of 3D printing
9 Regulatory consideration
10 Conclusion and future perspective
References
Chapter 2 In silico, in situ, in vitro, and in vivo predictive methods for modeling formulation performance
Abstract
1 Introduction
2 In silico design
3 In vitro methods
4 Animal models (in situ and in vivo)
5 In vitro–in vivo modeling
6 New paradigms in formulation development
References
Chapter 3 Impact of co-processing on functional attributes of innovative pharmaceutical excipients
Abstract
1 Introduction
2 Co-processing—process principles and CPEs manufacturing methods
3 Morphological attributes of raw materials and co-processed products
4 Added values provided by the co-processing technology
5 The role of co-processing in designing new functional API-excipient entities
6 Summary
References
Chapter 4 Insights from molecular dynamics simulations for the design of lyophilized protein formulations
Abstract
1 Advantages of freeze drying for protein pharmaceuticals
2 The freezing and drying phases may be harmful to protein stability
3 A judicious choice of excipients can mitigate protein denaturation
4 Emerging technologies for the selection of protein formulations: Role of molecular dynamics
5 Basics of MD
6 What MD can tell us: Protein-excipient interactions and conformational transitions
7 A focus on protein-interface interactions
8 Conclusions and future perspectives
References
Chapter 5 3D printing technologies for skin wound healing applications
Abstract
1 Introduction
2 Wounds and healing processes
3 Modern and classical wound dressing types
4 3D printing and wound healing
5 Conclusions
References
Chapter 6 Artificial intelligence in drug discovery and clinical practice
Abstract
1 Artificial intelligence
2 Applications in drug discovery
3 Applications in clinical practice
4 Regulatory framework
5 Challenges and future perspectives
6 Conclusions
References
Chapter 7 Drug and formulation development processes
Abstract
1 Introduction
2 Drug discovery and development
3 Formulation and process development
4 Stability
5 Summary
References
Chapter 8 Current update and challenges of implementing 3D printing technologies in pharmaceutical manufacturing
Abstract
1 Introduction
2 Pharmaceutical 3D printing technologies
3 Excipients
4 Challenges of implementing 3D printing in pharmaceuticals manufacturing
5 Quality defects in 3D printed pharmaceuticals
6 Application of 3D printing in drug delivery systems
7 Summary
References
Chapter 9 Modified-release drug delivery systems with emphasis on oral dosage forms
Abstract
1 Introduction
2 Modified-release strategies
3 Advantages and disadvantages of modified-release dosage forms (Murugesan et al., 2020; Prajapat et al., 2022; Rao et al., 2015):
4 Categories of modified release systems
5 Applications of modified-release drug delivery systems
6 Conclusions
References
Chapter 10 Additive manufacturing methods for pharmaceutical and medical applications
Abstract
1 Introduction
2 Main methods of 3D printing
3 Medical applications for 3D printing
4 3D-printed dosage forms and drug delivery systems
5 Benefits of 3D printing for medical applications
6 Limitations and future work
7 Conclusion
References
Chapter 11 Parameters affecting the APIs release profile from polymersomes
Abstract
Declaration of competing interest
1 Introduction
2 Methods/methodology of literature review
3 The release properties of polymersomes
4 Preparation protocols and characterization techniques
5 Active pharmaceutical ingredient
6 Conclusions
References
Index

Natassa Pippa

Dr. Natassa Pippa is an Assistant Professor in the Department of Pharmaceutical Technology at the National and Kapodistrian University of Athens, Greece. Her research focuses on pharmaceutical technology, specifically the design and development of nanoparticles, such as liposomes, micelles, and hydrogels, for drug delivery and targeting. She completed her master's degree in "Industrial Pharmacy" in 2012 and her PhD thesis in 2015 at the Department of Pharmacy, University of Athens.

Dr. Pippa has been awarded three scholarships for postdoctoral research in Greece and France. She has collaborated with the pharmaceutical industry in the development of drugs, cosmetics, and nutritional supplements.

Affiliations and expertise

Assistant Professor, National and Kapodistrian University of Athens, Greece

Costas Demetzos

Costas Demetzos is Professor, Pharmaceutical Nanotechnology and Director in the Laboratory of Pharmaceutical Technology, Department of Pharmacy at the National and Kapodistrian University of Athens, Greece. His research focuses in the area of pharmaceutical nanotechnology.

Affiliations and expertise

Professor, Pharmaceutical Nanotechnology and Director, Laboratory of Pharmaceutical Technology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece

Maria Chountoulesi

Maria Chountoulesi is a PhD Student at the Laboratory of Pharmaceutical Nanotechnology, Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Greece. Her research interests in pharmaceutical nanotechnology include the design and development of drug delivery nanosystems; preparation of lyotropic liquid crystalline nanoparticles liposomes and mixed/chimeric nanosystems, and drug loading and release studies.

Affiliations and expertise

PhD Student, Laboratory of Pharmaceutical Nanotechnology, Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Nationa and Kapodistrian University of Athens, Athens, Greece

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

From Current to Future Trends in Pharmaceutical Technology

Purchase options

Institutional subscription on ScienceDirect

Natassa Pippa

Costas Demetzos

Maria Chountoulesi