Fluorine Chemistry V3
- 1st Edition - December 2, 2012
- Editor: J.H. Simons
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 3 5 8 1 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 5 8 9 5 - 4
Fluorine Chemistry, Volume III: Biological Effects of Organic Fluorides focuses on the biological threats of fluorine-containing compounds. The book first looks at the toxicity of… Read more
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Request a sales quoteFluorine Chemistry, Volume III: Biological Effects of Organic Fluorides focuses on the biological threats of fluorine-containing compounds. The book first looks at the toxicity of fluoroacetate. Acute human poisoning, chemical factors, cause of death, pharmacological properties, evidence of fluorocitrate, and sites of inhibition are discussed. The text notes the biological effects of phosphofluoridates. Toxicity of DFP and derivatives, DFP metabolism, studies on DFP32 metabolism, and enzymes hydrolyzing DFP are described. The book also looks at the effects of acute doses of fluorine-containing organic compounds. The effects of organic fluorine compounds on enzyme systems; metabolic effects of tyrosine analogs; local anesthetics; effects of organofluorine compounds on microorganisms; and miscellaneous pharmacological effects of organic fluorides are discussed. The text underscores the acute effects of organofluorine compounds in experimental animals. Tabulated representations that show the effects of fluorine-containing compounds on humans and animals are presented. The book is a valuable source of information for readers wanting to study the biological effects of fluorine-containing compounds.
Preface
Acknowledgments
Fluoroacetate
Acute Human Poisoning
Species Variations
Occurrence in Nature
Chemical Factors
Cause of Death
Pharmacological Properties
Essential Biochemical Lesions
Citrate Concentration Increase
Nature of the Inhibitor
Evidence for Fluorocitrate
The Sites of Inhibition
Aconitase
Condensing Enzyme
Acetoacetate Formation
Amine Acetylation
Thiol Esters
Transacetylases
Phosphotransacetylase
F-Sensitive System
Pigeon Liver Preparation
Other Sources
Metabolic Mechanisms: Summary
Structure-Toxicity Relations
Phosphofluoridates
Toxicity of DFP and Derivatives
DFP Metabolism
Studies of DFP32 Metabolism
Enzymes Hydrolyzing DFP (DFPases)
Acute Effects of Organofluorine Compounds in Experimental Animals
Plan of Review
Inhalation Toxicity
Effects of Acute Doses of Fluorine-Containing Organic Compounds
Anesthetic Effects
Local Anesthetics
Mephenesin Analogs
Sympathomimetic Amines
Metabolic Effects of Tyrosine Analogs
9α-Fluorocorticosteroids
Effects of Organic Fluorine Compounds on Enzyme Systems
Anti-Tumor Action
Effects of Organofluorine Compounds on Microorganisms
Antimalarials
Fungistats
Viruses
Miscellaneous Pharmacological Effects of Organic Fluorides
Rodent Repellency
Organic Fluorine Compounds Useful as Insecticides
Chronic Experimental Intoxication
Miscellaneous
Tables
Table I. Acute Fatal Intoxication Caused by Sodium Fluoroacetate
Table II. Acute, Nonfatal Intoxications Caused by Sodium Fluoroacetate
Table III. Lethal Doses of Sodium Fluoroacetate in Various Species
Table IV. Mean Lethal Dose (LD50) of Sodium Fluoroacetate in Various Species
Table V. Mean Lethal Dose (LD50) of Methyl Fluoroacetate in Various Species
Table VI. Mean Lethal Dose (LD50) of Organic Compounds Containing the C-F Link
Table VII. Metabolic Interference in Systems Utilizing Pyruvate and Acetate
Table VIII. Increase in Citrate Concentration Due to FAc
Table IX. Inhibition of Citrate Oxidation
Table X. Citric Acid Content of Rat Tissues in Vivo following Injection of Fluoroacetate
Table XI. The Toxicity of and Citrate Accumulation Caused by Representative Even and Odd ω-Fluoro Compounds Administered to Mice
Table XII. Comparative Toxicities of DFP, Sarin, and Tabun in the Mouse
Table XIII. Mean Lethal Dose (LD50) of Diisopropyl Phosphofluoridate in Various Species
Table XIV. Mean Lethal Dose (LD50) of Organic Fluorophosphate Compounds
Table XV. Hydrolysis of Diisopropyl Phosphofluoridate by Tissue Extracts
Table XVI. Acute Doses of Fluorine-Containing Organic Compounds in Various Species
Table XVII. Approximate Lethal Concentration of Fire Extinguisher Compounds in Order of Increasing Toxicity
Table XVIII. Toxic Effects of Fluorocarbons by Inhalation
Table XIX. Miscellaneous Effects of Fluorine-Containing Organic Compounds
Table XX. Fluorine-Containing Organic Compounds Tested for Anesthetic Properties
Table XXI. Glucocorticoid and Mineralocorticoid Activities of Fluorocorticosteroids
Table XXII. Effects of Fluorine-Containing Compounds on Enzyme Systems
Table XXIII. Fluorine-Containing Organic Compounds Tested as Tumor Inhibitors in the Mouse
Table XXIV. Effects of Fluorine-Containing Organic Compounds upon Microorganisms
Table XXV. Fluorine-Containing Compounds Tested as Antimalarial Agents
Table XXVI. Additional Fluorine-Containing Compounds Tested as Antimalarials
Table XXVII. Effects of Fluorine-Containing Organic Compounds upon Fungi
Table XXVIII. Breaking Strength of Cotton Thread Treated with Fungicides and Exposed 14 Days to Mycothecium verrucario
Table XXIX. Repellency Index for Rats of Fluorine-Containing Organic Compounds
Table XXX. Activity of Difluorodiphenyltrichloroethane (DFDT) against Pests
Table XXXI. Activity of Miscellaneous Fluorine-Containing Organic Compounds against Pests
Table XXXII. Fluorine-Containing Organic Compounds Tested as Plant Growth Regulators
Table XXXIII. Experimental Chronic Intoxication in the Rat Produced by Fluorine-Containing Organic Compounds
Table XXXIV. Organ Systems of the Rat Affected in Chronic Intoxication Produced by Fluorine-Containing Organic Compounds
References
Bibliographical Supplement (1959-1961)
Subject Index
- No. of pages: 252
- Language: English
- Edition: 1
- Published: December 2, 2012
- Imprint: Academic Press
- Paperback ISBN: 9780124335813
- eBook ISBN: 9780323158954
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