Fibroblast Growth Factors
- 2nd Edition - November 16, 2023
- Imprint: Academic Press
- Author: Xiaokun Li
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 7 9 3 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 7 9 4 - 3
Fibroblast Growth Factors, Second Edition systematically introduces readers to FGF in the fields of injury repair and regeneration, endocrinology and metabolism, structure and mo… Read more
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Request a sales quoteFibroblast Growth Factors, Second Edition systematically introduces readers to FGF in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering and new drug development. Fibroblast growth factors (FGFs) are secreted protein ligands that act in a paracrine or endocrine fashion to carry out their pleiotropic functions in development, tissue homeostasis and metabolism. This book covers the work from Li’s team from 2013 to 2018 and will be a primer for scientists, particularly young students entering the FGFs field with an eye on basic research and application.
- Contains approximately 90% new material on topics covered
- Includes information on “breakthrough” discoveries which have been made since the publication of the first edition
- Introduces detailed research methods and technologies of FGFs so the book can be used as a “toolbox” by the user
- Includes comprehensive and systematic research and industry application
Scientists who are working in Fibroblast Growth Factors (FGFs) basic research and engineering field. Clinical practitioners who are working in wound healing, surgery, emergency, and diabetes. Postgraduate students whose major is pharmacology, biopharmacology. Scientists who are engaged in new drug development in biopharmacological companies. Biopharmacology course for postgraduate students. Doctors and clinical researcher who are interesting in FGF
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Preface
- Preface for first edition
- Preface for first edition
- The FGF metabolic axis
- 1 Introduction
- 2 The mitogenic FGF axis
- 3 The metabolic FGF axis
- 4 FGF19 metabolic axis
- 5 FGF21 metabolic axis
- 6 FGF23 metabolic axis
- 7 Conclusion and future perspective
- References
- Chapter 1 Growth factors reviews
- Fibroblast growth factors, old kids on the new block
- Pharmacological application of growth factors: Basic and clinical
- Cytokines and diabetes research
- Small molecule inhibition of fibroblast growth factor receptors in cancer
- Research advances in tissue engineering materials for sustained release of growth factors
- Minireview: Roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases
- Physiological and pharmacological roles of FGF21 in cardiovascular diseases
- Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
- Delivery of growth factor-based therapeutics in vascular diseases: Challenges and strategies
- Fibroblast growth factor 10 in pancreas development and pancreatic cancer
- Chapter 2 Injury repair and regeneration
- TAT-mediated acidic fibroblast growth factor delivery to the dermis improves wound healing of deep skin tissue in rats
- Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protection in a rat model of spinal cord injury
- The antiscar effects of basic fibroblast growth factor on wound repair in vitro and in vivo
- Exogenous basic fibroblast growth factor inhibits ER stress-induced apoptosis and improves recovery from spinal cord injury
- FGF10 protects against renal ischemia/reperfusion injury by regulating autophagy and inflammatory signaling
- Reduction of cellular stress is essential for fibroblast growth factor 1 treatment for diabetic nephropathy
- Chapter 3 Endocrinology and metabolism
- Fibroblast growth factor 21 (FGF21) therapy attenuates left ventricular dysfunction and metabolic disturbance by improving FGF21 sensitivity, cardiac mitochondrial redox homoeostasis, and structural changes in prediabetic rats
- NMR-based metabolomics reveal a recovery from metabolic changes in the striatum of 6-OHDA-induced rats treated with basic fibroblast growth factor
- FGF21 mediates alcohol-induced adipose tissue lipolysis by activating systemic release of catecholamine in mice
- Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice
- Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
- FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
- Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice
- Attenuation of hyperlipidemia and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration of fibroblast growth factor-21 is associated with suppression of renal inflammation
- The prevention of diabetic cardiomyopathy by nonmitogenic acidic fibroblast growth factor is probably mediated by the suppression of oxidative stress and damage
- Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner
- Chapter 4 Structure and modification
- α-Klotho is a nonenzymatic molecular scaffold for FGF23 hormone signaling
- Comparative study of heparin-poloxamer hydrogel modified bFGF and aFGF for in vivo wound healing efficiency
- Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats
- Two FGF receptor kinase molecules act in concert to recruit and transphosphorylate phospholipase Cγ
- A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog
- One-step production of bioactive proteins through simultaneous PEGylation and refolding
- Structural mimicry of A-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation
- Dual delivery of bFGF- and NGF-binding coacervate confers neuroprotection by promoting neuronal proliferation
- Design and evaluation of lyophilized fibroblast growth factor 21 and its protection against ischemia cerebral injury
- Chapter 5 Signaling pathway and pharmacology
- Fibroblast growth factor-1 released from a heparin coacervate improves cardiac function in a mouse myocardial infarction model
- Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways
- Regulation of caveolin-1 and junction proteins by bFGF contributes to the integrity of blood-spinal cord barrier and functional recovery
- The role of bFGF in the excessive activation of astrocytes is related to the inhibition of TLR4/NFκB signals
- bFGF promotes the migration of human dermal fibroblasts under diabetic conditions through reactive oxygen species production via the PI3K/Akt-Rac1-JNK pathways
- Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signaling pathway
- Pharmacokinetics of topically applied recombinant human keratinocyte growth factor-2 in alkali-burned and intact rabbit eye
- Fibroblast growth factors stimulate hair growth through β-catenin and shh expression in C57BL/6 mice
- High-efficiency expression of TAT-bFGF fusion protein in Escherichia coli and the effect on hypertrophic scar tissue
- bFGF protects against blood-brain barrier damage through junction protein regulation via PI3K-Akt-Rac1 pathway following traumatic brain injury
- bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway
- Selection of a novel FGF23-binding peptide antagonizing the inhibitory effect of FGF23 on phosphate uptake
- Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo
- ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress
- Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial and endoplasmic reticulum stress-dependent pathways in the mouse model
- Fibroblast growth factor 2 protects against renal ischemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signaling
- Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration
- Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways
- Chapter 6 Pharmaceutics and new material
- Prevent diabetic cardiomyopathy in diabetic rats by combined therapy of aFGF-loaded nanoparticles and ultrasound-targeted microbubble destruction technique
- Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction
- Gelatin nanostructured lipid carriers-mediated intranasal delivery of basic fibroblast growth factor enhances functional recovery in hemiparkinsonian rats
- Heparin-based coacervate of FGF2 improves dermal regeneration by asserting a synergistic role with cell proliferation and endogenous facilitated VEGF for cutaneous wound healing
- A thermosensitive heparin-poloxamer hydrogel bridges aFGF to treat spinal cord injury
- Dual delivery of NGF and bFGF coacervate ameliorates diabetic peripheral neuropathy via inhibiting Schwann cells apoptosis
- Chapter 7 Bioreactor and engineering
- Increased production of human fibroblast growth factor 17 in Escherichia coli and proliferative activity in NIH3T3 cells
- Application of oleosin-flanked keratinocyte growth factor-2 expressed from Arabidopsis thaliana promotes hair follicle growth in mice
- Expression of functional recombinant human fibroblast growth factor 8b and its protective effects on MPP+-lesioned PC12 cells
- High production in E. coli of biologically active recombinant human fibroblast growth factor 20 and its neuroprotective effects
- Expression of bioactive recombinant human fibroblast growth factor 10 in Carthamus tinctorius L. seeds
- Expression of bioactive recombinant human fibroblast growth factor 9 in oil bodies of Arabidopsis thaliana
- Expression of biologically recombinant human acidic fibroblast growth factor in Arabidopsis thaliana seeds via oleosin fusion technology
- Highly efficient expression of functional recombinant human keratinocyte growth factor 1 and its protective effects on hepatocytes
- High-efficiency production of bioactive recombinant human fibroblast growth factor 18 in Escherichia coli and its effects on hair follicle growth
- Oil body-bound oleosin-rhFGF9 fusion protein expressed in safflower (Carthamus tinctorius L.) stimulates hair growth and wound healing in mice
- Two-hundred-liter scale fermentation, purification of recombinant human fibroblast growth factor-21, and its antidiabetic effects on ob/ob mice
- Chapter 8 FGFR and inhibitors
- Influenza virus infects epithelial stem/progenitor cells of the distal lung: Impact on Fgfr2b-driven epithelial repair
- Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage
- Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair
- The therapeutic potential of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor on gastric cancer
- Discovery and anticancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in nonsmall cell lung cancer
- DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors
- A novel FGF2 antagonist peptide P8 with potent antiproliferation activity
- Discovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential in nonsmall cell lung cancer
- FGFR4 and TGF-β1 expression in hepatocellular carcinoma: Correlation with clinicopathological features and prognosis
- Transient inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development
- Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis
- Chapter 9 Others
- Nonmitogenic form of acidic fibroblast growth factor protects against graft-versus-host disease without accelerating leukemia
- Topical application of a new monoclonal antibody against fibroblast growth factor 10 (FGF 10) mitigates propranolol-induced psoriasis-like lesions in guinea pigs
- A short peptide derived from the gN helix domain of FGF8b suppresses the growth of human prostate cancer cells
- Screening a phage display library for a novel FGF8b-binding peptide with antitumor effect on prostate cancer
- FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function, and cell apoptosis in obese, insulin-resistant male rats
- Cerebrospinal fluid FGF23 levels correlate with a measure of impulsivity
- bFGF protects against oxygen glucose deprivation/reoxygenation-induced endothelial monolayer permeability via S1PR1-dependent mechanisms
- Index
- Edition: 2
- Published: November 16, 2023
- No. of pages (Paperback): 1032
- No. of pages (eBook): 880
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443157936
- eBook ISBN: 9780443157943
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Xiaokun Li
Xiaokun Li is Professor at Wenzhou Medical University, and has been vice director and associate professor at the Bioengineering Institute at Jinan University, China. He was among the first to study FGFs in China, and leads the largest dedicated research group in the world on the subject. In the past 20 years he has had new drugs and products approved by China SFDA. He has published 183 papers in leading international journals, and is the chair of the International Chinese FGF Association. He holds a PhD from Sun-Yat sen Medical University, and a degree in medical science from Norman Bethune Medical University in China.
Affiliations and expertise
Professor, Wenzhou Medical University and formerly Vice Director and Associate Professor, Bioengineering Institute, Jinan University, ChinaRead Fibroblast Growth Factors on ScienceDirect