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Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease
From Basic Science to Clinical Application
- 1st Edition - August 6, 2024
- Author: Asim K. Duttaroy
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 0 0 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 0 1 - 4
Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease: From Basic Science to Clinical Application presents the latest information on the contributions of differ… Read more
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Request a sales quoteFatty Acid-Binding Proteins and Their Roles in Human Health and Disease: From Basic Science to Clinical Application presents the latest information on the contributions of different FABPs in physiology and pathophysiology, along with their importance in clinical outcomes. The book is divided into six main sections that cover FABP biology and their role in inflammation and diseases, such as cardiovascular, neurological, and liver diseases, to FABPs and their clinical applications.
Each chapter thoroughly reviews current literature, primary research data and clinical cases, providing readers with an overview of the latest information in the expanded field of FABPs. This is an invaluable resource for both researchers and clinicians familiar with and those new to the exciting and everchanging world of fatty acid-binding proteins and clinical disorders.
- Compiles the most recent and comprehensive findings on fatty acid-binding proteins (FABPs)
- Describes the pathophysiology of FABPs in various diseases and as therapeutic targets
- Highlights opportunities for improving diagnosis and treatment by encompassing all pathological conditions involving FABPs
Researchers, clinicians and students of life science and medicine. Graduate students of cell biology, biochemistry, lipid biochemistry, and molecular biology. Pharma industries
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Section 1: Overview of FABP biology
- Chapter 1 Introduction to fatty acid-binding protein family, tissue expression, and ligand specificity
- Abstract
- Introduction
- FABP types
- FABPs and their ligands
- Tissue distribution of FABPs
- Conclusions
- References
- Chapter 2 FABP gene family: Expression and regulation
- Abstract
- Introduction
- FABP1 gene
- FABP2 gene
- FABP3 gene
- FABP4 gene
- FABP5 gene
- FABP6 gene
- FABP7 gene
- FABP8 gene
- FABP9 gene
- FABP12 gene
- Conclusions
- References
- Chapter 3 Structure and functions of sterol carrier protein-2 and α-synuclein
- Abstract
- Introduction
- SCP-2 and its lipid binding activities and functions
- SCP-2 structure
- Tissue distribution of SCP-2
- α-Synuclein
- Binding activity of α-synuclein
- Expression and localization of α-synuclein
- Function of α-synuclein
- Conclusions
- References
- Chapter 4 Involvement of FABPs in cell signaling, gene expression, and angiogenesis
- Abstract
- Introduction
- Cell signaling of fatty acids and involvement of FABPs
- FABPs and their interactions with nuclear receptors
- Mechanism of FABP import into the nucleus
- FABPs and their roles in angiogenesis
- Conclusions
- References
- Chapter 5 Fatty acid-binding proteins in cardiac remodeling
- Abstract
- Introduction
- Fatty acid metabolism in the heart
- FABPs in the heart
- FABP3 and cardiac remodeling
- FABP4 and cardiac remodeling
- FABP5 in cardiac remodeling
- Conclusions
- References
- Chapter 6 Impacts of fatty acids on cell growth and proliferation: Roles of fatty acid-binding proteins
- Abstract
- Introduction
- Fatty acid metabolism
- Roles of FABP1 and FABP2 in absorption and metabolism of dietary lipids
- FABP4 and its roles in lipid metabolism
- FABPs and their impacts on cell growth and proliferation
- Conclusions
- References
- Chapter 7 Roles of FABPs on endocannabinoid transport and metabolism
- Abstract
- Introduction
- Cannabinoids: Their receptors and metabolism
- FABPs and intracellular transport of cannabinoids
- Conclusions
- References
- Section 2: FABPs and inflammation
- Chapter 8 Fatty acid-binding proteins in inflammatory diseases
- Abstract
- Introduction
- Inflammation: Roles of adipocyte
- Fatty acid-binding proteins and their roles in inflammation
- Lipid metabolism and FABPs are involved in inflammation-induced endothelial dysfunction
- Conclusions
- References
- Chapter 9 Fatty acid-binding proteins and immune functions
- Abstract
- Introduction
- Fatty acids and immune functions
- Fatty acid-binding proteins (FABPs) and their roles in inflammation
- Conclusions
- References
- Chapter 10 Roles of fatty acid-binding proteins in brain inflammation
- Abstract
- Introduction
- Fatty acids and their roles in the structure and function of the brain
- FABPs and brain function
- FABPs and neuroinflammation
- FABP4
- Conclusions
- References
- Chapter 11 Fatty acid-binding proteins in adipose tissue inflammation
- Abstract
- Introduction
- Adipose tissue and fatty acid-binding protein 4: Roles in the development of cardiovascular diseases
- FABP4 and its roles in inflammation
- Conclusions
- References
- Section 3: FABPs in metabolic disorders and obesity
- Chapter 12 Roles of fatty acid-binding proteins in the development of insulin resistance and type 2 diabetes mellitus
- Abstract
- Introduction
- FABP4
- Interactions between FABP4 and PPARγ
- FABP4 and GDM
- Relationship between FABP4 and T2DM and its complications
- Conclusions
- References
- Chapter 13 Fatty acid-binding proteins in the development and progression of cardiovascular diseases
- Abstract
- Introduction
- FABP3 and CVD
- FABP4 and CVD
- Plasma levels of FABP4 and cardiovascular disease
- FABP5 and CVD
- Conclusions
- References
- Chapter 14 Fatty acid-binding proteins and metabolic syndrome
- Abstract
- Introduction
- FABPs in metabolic diseases
- Conclusions
- References
- Chapter 15 Role of fatty acid-binding proteins in obesity and obesity-mediated diseases
- Abstract
- Introduction
- Obesity and fatty acid metabolism
- FABP4 and its function in obesity
- Roles of FABP1 and obesity
- Obesity and cancers: Roles of FABP4
- Conclusions
- References
- Section 4: FABPs and human diseases
- Chapter 16 Fatty acid-binding proteins and their dysregulation in human diseases
- Abstract
- Introduction
- FABPs and their expression and binding properties
- FABPs in metabolic diseases, CVD, and atherosclerosis
- FABPs in various cancers
- Conclusions
- References
- Chapter 17 Fatty acid-binding proteins and brain diseases
- Abstract
- Introduction
- Brain structure and function: Roles of long-chain polyunsaturated fatty acids
- LCPUFAs and brain disorders
- ARA, and brain function
- FABPs in the brain function and dysfunction
- Conclusions
- References
- Chapter 18 Fatty acid-binding proteins and liver diseases
- Abstract
- Introduction
- FABP1 and liver function
- FABP1 and liver diseases
- FABP4 and liver disease
- Conclusions
- References
- Chapter 19 Fatty acid-binding proteins: Impacts of injury on cardiac, renal, and intestine tissues
- Abstract
- Introduction
- Cardiac injury and FABPs
- Plasma levels of FABPs and kidney injury
- FABPs and intestine injury
- Measurement of FABPs in the plasma
- Conclusions
- References
- Chapter 20 Fatty acid-binding proteins in celiac diseases
- Abstract
- Introduction
- Roles of liver fatty acid-binding protein (FABP1) and FABP2 in CD
- Conclusions
- References
- Chapter 21 Dysregulation of fatty acid-binding proteins in cancers
- Abstract
- Introduction
- FABPs and cancers
- Liver fatty acid-binding protein
- Intestinal fatty acid-binding protein
- Heart-type fatty acid-binding protein
- Adipocyte fatty acid-binding protein
- Epidermal fatty acid-binding protein
- Ileal bile acid-binding protein
- Brain fatty acid-binding protein
- Myelin fatty acid-binding protein
- Testis fatty acid-binding protein
- Fatty acid-binding protein 11
- Drugs that modulate FABPs in cancer
- Conclusions
- References
- Section 5: FABPs and cancers
- Chapter 22 Fatty acid-binding proteins in prostate cancer
- Abstract
- Introduction
- Fatty acid-binding protein 4
- Fatty acid-binding protein 5 and prostate cancer
- The rationale for targeting FABP5 in prostate cancer
- Inhibition of FABP5 in prostate cancer
- Conclusions
- References
- Chapter 23 Fatty acid-binding proteins in psoriasis
- Abstract
- Introduction
- Fatty acid-binding protein 3 and psoriasis
- Fatty acid-binding protein 4 and involvement of psoriasis
- Fatty acid-binding protein 5 and psoriasis
- Fatty acid-binding protein 6 and possible relation in psoriasis
- Fatty acid-binding protein 7
- Conclusions
- References
- Chapter 24 Fatty acid-binding proteins and breast cancer
- Abstract
- Introduction
- Fatty acids and breast cancer
- Fatty acid-binding protein 4 (FABP4) and its impacts on breast cancer
- FABP5 and breast cancer
- FABP7 and its roles in breast cancer
- Conclusions
- References
- Chapter 25 Plasma fatty acid-binding proteins as biomarkers of diseases
- Abstract
- Introduction
- Circulating levels of FABP1 and diseases
- Circulating FABP2 levels and human diseases
- Circulating FABP3 levels and human diseases
- Circulating FABP4 and diseases
- Circulatory FABP and tissue damage
- Conclusions
- References
- Section 6: FABPs in clinical applications
- Chapter 26 Clinical usefulness of urinary fatty acid-binding proteins in assessing several diseases
- Abstract
- Introduction
- Urinary FABP1 and diseases
- Urinary FABP4
- Conclusion
- References
- Chapter 27 Fatty acid-binding proteins as therapeutic targets in different diseases
- Abstract
- Introduction
- FABP2 and diseases
- FABP3 and brain diseases
- FABP4 and several diseases
- FABP5 and diseases
- Conclusions
- References
- Index
- No. of pages: 424
- Language: English
- Edition: 1
- Published: August 6, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780323957007
- eBook ISBN: 9780323957014
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Asim K. Duttaroy
Dr. Asim K. Duttaroy is a professor at the Faculty of Medicine, University of Oslo, Oslo, Norway. His research programs focus on the roles of food components on growth and development, as well as in the prevention of diseases such as diabetes and cardiovascular disease. He is also investigating the roles of the antiplatelet and antihypertensive properties of fruits and vegetables. His discoveries of antithrombotic factors in tomatoes and kiwifruits are patented internationally, and three companies (Provexis Limited in the United Kingdom, IDIA AS in Norway, and Genimen Pharmacon in India) are working to commercialize these discoveries. He has published over 265 original contributions and reviews, 6 books, and several book chapters and editorials, and he is the Editor-in-Chief of the journal Food & Nutrition Research, as well as a guest editor of several journals such as Nutrients and Frontiers in Physiology.
Affiliations and expertise
Faculty of Medicine, University of Oslo, Oslo, NorwayRead Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease on ScienceDirect