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Factors Affecting Neurological Aging

Genetics, Neurology, Behavior, and Diet

1st Edition - June 1, 2021

Editors: Colin R Martin, Victor R Preedy, Rajkumar Rajendram

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 1 7 9 9 0 - 1

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 1 7 9 9 1 - 8

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological… Read more

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Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.

Part IGenetics, Molecular and Cellular Biology

1. Genetics of frontotemporal dementiaEbru Erzurumluoglu Gokalp, Demet Adapinar and Sevilhan Artan

2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphismTing Shen, Yuyi You, Vivek K. Gupta and Stuart L. Graham

3. Aging, demented patients, and polymorphisms in cytokine genesVanêssa Gomes Fraga, Paulo Caramelli and Karina Braga Gomes

4. RNA fragments and brain agingLingyu Guan and Andrey Grigoriev

5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in agingHeide Schatten

6. Brain aging and microarray analysisCristina Sanfilippo and Michelino Di Rosa

7. Human nuclear tau and agingConcetta Federico, Francesca Bruno, Valentina Sturiale, Agata Grazia D’Amico, Grazia Maugeri, Velia D’Agata, Laura Gil and Salvatore Saccone

8. Lipoxidation: features, neurological tissues and agingReinald Pamplona, Mariona Jové, Irene Pradas, Natalia Mota-Martorell and Isidro Ferrer

9. Aging modifies concentration and metabolism of amino acids and associated receptor functionality in the brain Mitsuhiro Furuse

10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementiaMichy Kelly

11. The prohibitin complex in aging and neurodegenerationAndrea González-Morales, Mercedes Lachén-Montes, Karina Ausin, Paz Cartas-Cejudo, Naroa Mendizuri, Joaquín Fernández-Irigoyen and Enrique Santamaría

12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging processRoberto Villa and Federica Ferrari

Part IINeurological and Imaging Features

13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance ImagingYu-Chien Wu

14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiographyRuikang K. Wang and Yuandong Li

15. Potential involvement of perineuronal nets in brain aging: an anatomical point of viewJun Yamada and Shozo Jinno

16. Grey-matter networks in agingMarisa Koini

17. Changes in brain synapse-related molecules with ageKiyohito Mizutani and Yoshimi Takai

18. Macroautophagy and chaperone-mediated autophagy in agingTando Maduna, Andre du Toit and Ben Loos

19. Neuronal L-type calcium channels in agingJoanne Koh, Sheeja Navakkode, Jing Zhai and Tuck Wah Soong

20. The impact of aged microglia on D-serine-regulated glutamatergic transmissionSebastián Beltrán-Castillo, Rommy von Bernhardi and Jaime Eugenín

21. Ion channels and the aging brainFederico Sesti and Alessandro Bortolami

22. Dendritic spine remodeling and agingBenjamin D. Boros and Jeremy H. Herskowitz

23. High-density lipoprotein-cholesterol and neuroaging: memory and gyrification of the insular and frontal opercular cortexRyuta Kinno and Kenjiro Ono

24. Astrocyte and microglial aging: morphology and modelingTiffany A. Peterson and Andrew G. MacLean

25. Cerebellum - aging of the neuronal machinePavel Filip and Martin Bare

26. Lipids, beta-secretase 1, and Alzheimer diseaseJ. Villamil-Ortiz, B.J.L. Eggen and G.P. Cardona-Go´mez

27. Aging, myelination and the optic nerveAhmed Abdellatif and Hamdino Attia

28. Linking proteostasis, aging, and brain ischemiaWei Yang, Ran Li, Xuan Li and Dennis A. Turner

29. Luteinizing hormone and the aging nervous systemMegan Mey and Gemma Casadesus

30. Insights into aging using transcranial magnetic stimulationJennifer I. Lissemore, Lauren Wengle, Zafiris J. Daskalakis and Daniel M. Blumberger

31. Alpha rhythms: what they are and how they alter with agingMaria Knyazeva

32. Nicotine and its derivatives in healthy brain agingAlireza Majdi and Saeed Sadigh-Eteghad

Part IIIPhysiological Aspects

33. Environmental enrichment and physiological agingYulia K. Komleva, Vladimir V. Salmin, Olga L. Lopatina, Olga A. Belova and Alla B. Salmina

34. Treadmill exercise and neuroinflammation: links with agingCaroline Cristiano Real, Karina Henrique Binda and Anne Marlene Landau

35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyondLars Stiernman Jonasson, Chelsea Stillman and Kirk I. Erickson

36. The effects of cardiorespiratory fitness on brain and cognitive agingDaniel C. Bowie, Grace M. Clements, Gabriele Gratton and Monica Fabiani

37. Aging, babble noise, and the processing of speech perceptionHanani Abdul Manan, Noorazrul Azmie Yahya and Ahmad Nazlim Yusoff

38. The blood-brain barrier in agingLuca Anna Bors and Franciska Erdő

Part IVBehavior And Psychopathological Aspects

39. Linking aging, anticholinergic drug use, and cognitive impairmentMariangela Boccardi and Virginia Boccardi

40. Cognitive Frailty: Definitions, components and impact on disability, and mortalityFrancesco Panza, Maddalena La Montagna, Vincenzo Solfrizzi, Rodolfo Sardone, Vittorio Dibello, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Gianluigi Giannelli and Madia Lozupone

41. Cognitive impairment (brain) and (et) dynapenia (D) “BED” in older persons: role of arterial treeMarcello Maggio and Fulvio Lauretani

42. Disentangling the effects of aging and ovarian hormone loss on sleep: implications for health and diseaseGina Nicoll, Anne Almey and Nicole J. Gervais

43. Role of DNA methylation in aging-related cognitive functioningAnna Starnawska and Nicklas Heine Staunstrup

44. Depression in the elderly and psychobioticsElnaz Vaghef-Mehrabany, Mehrangiz Ebrahimi-Mameghani, Mahzad Sanayei and Leila Vaghef-Mehrabany

Part VDiet And Nutrition

45. Aging, dietary patterns and cognitionAngela Marie Abbatecola and Raffaele Marfella

46. Geriatric nutritional risk index: applications and limitationsMahzad Sanayei, Elnaz Vaghef-Mehrabany and Leila Vaghef-Mehrabany

47. Diet, inflammation, and neurocognitive agingYian Gu

48. The dietary approaches to stop hypertension (DASH) and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets and brain agingSamantha L. Gardener and Stephanie R. Rainey-Smith

49. The ketogenic diet and healthy brain agingGeorgia A.F. Rogerson and Victor R. Preedy

50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)Kurt A. Escobar and Trisha A. VanDusseldorp

51. Dietary Flavonoids and Brain Health in Ageing: food for ThoughtCatarina Rendeiro and Justin S. Rhodes

52. Antioxidant effects of curcumin and neuroagingShameemah Abrahams, Katelyn Cuttler, Minke Bekker, Jonathan Carr, Soraya Bardien and Okobi Ekpo

53. Lipoic acid and vitamin D3 and their use in preventing brain agingFrancesca Uberti, Sara Ruga, Vera Morsanuto, Mahitab Farghali and Claudio Molinari

54. Effects of β>hydroxy-β-methyl>butyrate (HMB) supplementation on biomarkers for cognitive function and electrophysiological processes in agingAmogh Belagodu, Shuo Kang, Joshua M. Gulley and Roberto Galvez

55. Hydration, the brain, and agingAgata Białecka-Debek

Colin R Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Affiliations and expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and WellbeingUniversity of Suffolk, Ipswich, UK

Victor R Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Affiliations and expertise

Professor in the Department of Clinical Biochemistry at King’s College Hospital, London, UK Emeritus Professor in Faculty of Life Sciences and Medicine at King’s College London, UK Visiting Professor at the University of Hull, UK

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise

Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia